Combined Effect of Nanoparticles of Silver and Silica to HeLa Cells: Synergistic Internalization and Toxicity DOI Open Access

Chen‐Si Li,

Jie Liu,

Qiangqiang Zhang

et al.

Environmental Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

ABSTRACT The wide range of applications and the enormous production nanomaterials have raised possibility that humans may simultaneously contact with various through multiple routes. Although numerous toxicity studies been conducted on nanomaterials, knowledge combined remains limited. Herein, toxic effects two types most widely used silver silica, were studied HeLa cells. In addition, considering there possible interplay between nanoparticles different sizes, different‐sized silica (SNPs) used. results indicate compared individual exposure, exposure to 35 nm (Ag35) 40 or 120 SNPs (SNP40 SNP120) at non‐toxic concentrations causes more severe cytotoxicity, manifested by ROS overgeneration, decreased mitochondrial membrane potential ATP level, increased apoptosis/necrosis. internalized Ag35 its dissolved Ag ions are delivered into cells adsorbing identified as primary contributors toxicity. cytotoxicity mixed SNP40 is comparable SNP120, noticeable differences in their intracellular contents subcellular locations due size effects. This study provides in‐depth insights inorganic highlights importance effect nanotoxicity assessment.

Language: Английский

Antibacterial and Antiviral Activities of Silver Nanocluster/Silica Composite Coatings Deposited onto Air Filters DOI

Angelica Luceri,

Rachele Francese, Sergio Perero

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(3), P. 3955 - 3965

Published: Jan. 9, 2024

The indoor air quality should be better controlled and improved to avoid numerous health issues. Even if different devices are developed for filtration, the proliferation of microorganisms under certain conditions must controlled. For this purpose, a silver nanocluster/silica composite coating was deposited via cosputtering technique onto fiber glass polymeric based substrates. aim work is focused on evaluation antibacterial antiviral effects coating. preliminary results compositional morphological tests showed an evenly distributed filters surfaces. Several were performed, confirming strong effect both in qualitative quantitative methods, against S. epidermidis E. coli. To understand can stop bacteria colonies spread it, simulation everyday usage nebulizing solution with high concentration evaluating inhibition growth. Additionally, deep understanding virucidal action mechanism Ag nanoclusters performed. aqueous medium dry methods evaluated, comparison analysis ions release. performances assessed human coronavirus OC43 strain (HCoV-OC43).

Language: Английский

Citations

5

A Comprehensive Review on the Biomass-Mediated Synthesis of Silver Nanoparticles: Opportunities and Challenges DOI
Dinesh Kumar, Sunil Kumar,

Amol D. Gholap

et al.

Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: unknown, P. 115133 - 115133

Published: Dec. 1, 2024

Language: Английский

Citations

5

"Therapeutic Advancements in Nanomedicine: The Multifaceted Roles of Silver Nanoparticles" DOI Open Access

Karthik K Karunakar,

Binoy Varghese Cheriyan,

R Krithikeshvaran

et al.

Biotechnology Notes, Journal Year: 2024, Volume and Issue: 5, P. 64 - 79

Published: Jan. 1, 2024

Nanotechnology has the advantages of enhanced bioactivity, reduced toxicity, target specificity, and sustained release NPs can penetrate cell membranes. The small size silver nanoparticles, AgNPs, large surface area, unique physicochemical properties contribute to lysis increased permeability membranes used in field biomedicine. Functional precursors integrate with phytochemicals create distinctive therapeutic stability nanoparticles be by Surface coatings encapsulation methods, current study explores various synthesis methods characterization techniques (AgNPs) highlights their intrinsic activity applications, Anti-cancer noted at a concentration range 5-50 μg/ml angiogenesis is mitigated dosage 10-50 μg/ml, Diabetes controlled within same concentration. Wound healing improved concentrations typical 10-08 for bacteria antimicrobial capabilities. Advancement focus on future use AgNPs-coated wound dressings medical devices decrease risk infection. Chemotherapeutic drugs administered which reduces adverse effects an improvement treatment outcomes. AgNPs have been found improve proliferation differentiation, making them beneficial tissue engineering regenerative medicine. Our emerging patterns developments medicine, inferring potential paths.

Language: Английский

Citations

4

Antiviral Activity of Natural Compounds for Food Safety DOI Creative Commons
Irene Falcó, Walter Randazzo, Glòria Sánchez

et al.

Food and Environmental Virology, Journal Year: 2024, Volume and Issue: unknown

Published: June 17, 2024

Abstract Gastroenteritis and hepatitis are the most common illnesses resulting from consumption of food contaminated with human enteric viruses. Several natural compounds have demonstrated antiviral activity against viruses, such as norovirus A virus, while little information is available for E virus. Many in-vitro studies evaluated efficacy different viruses or their surrogates. However, only few investigated in applications. Among them, green tea extract, grape seed extract carrageenans been extensively to improve safety. Indeed, these extracts studied sanitizers on food-contact surfaces, produce washing solutions, active fractions food-packaging materials, edible coatings. The innovative applications include development coatings extend shelf life berries combination established technologies improved processes. This review summarizes existing knowledge underexplored field enhancing safety viral-contaminated foods underscores research needs be covered near future.

Language: Английский

Citations

4

Combined Effect of Nanoparticles of Silver and Silica to HeLa Cells: Synergistic Internalization and Toxicity DOI Open Access

Chen‐Si Li,

Jie Liu,

Qiangqiang Zhang

et al.

Environmental Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

ABSTRACT The wide range of applications and the enormous production nanomaterials have raised possibility that humans may simultaneously contact with various through multiple routes. Although numerous toxicity studies been conducted on nanomaterials, knowledge combined remains limited. Herein, toxic effects two types most widely used silver silica, were studied HeLa cells. In addition, considering there possible interplay between nanoparticles different sizes, different‐sized silica (SNPs) used. results indicate compared individual exposure, exposure to 35 nm (Ag35) 40 or 120 SNPs (SNP40 SNP120) at non‐toxic concentrations causes more severe cytotoxicity, manifested by ROS overgeneration, decreased mitochondrial membrane potential ATP level, increased apoptosis/necrosis. internalized Ag35 its dissolved Ag ions are delivered into cells adsorbing identified as primary contributors toxicity. cytotoxicity mixed SNP40 is comparable SNP120, noticeable differences in their intracellular contents subcellular locations due size effects. This study provides in‐depth insights inorganic highlights importance effect nanotoxicity assessment.

Language: Английский

Citations

0