Global Strategies to Combat Antimicrobial Resistance: A One Health Perspective

Pharmacology &amp Pharmacy, Journal Year: 2023, Volume and Issue: 14(08), P. 271 - 328

Published: Jan. 1, 2023

Background: Antimicrobial resistance (AMR) is a global health challenge that has escalated due to the inappropriate use of antimicrobials in humans, animals, and environment. Developing implementing strategies reduce combat AMR critical. Purpose: This study aimed highlight some can be implemented address using One Health approach. Methods: employed narrative review design included studies published from January 2002 July 2023. The searched for literature on antimicrobial stewardship (AMS) PubMed Google Scholar 2020 PRISMA guidelines. Results: reveals remains significant public problem. Its severity been markedly exacerbated by broader ecological Several have developed AMR, including Global Action Plan (GAP), National Plans (NAPs), AMS programs, implementation AWaRe classification antimicrobials. These also involve strengthening surveillance consumption resistance, encouraging development new antimicrobials, enhancing regulations around prescribing, dispensing, usage. Additional measures include promoting partnerships, combating substandard falsified advocating vaccinations, sanitation, hygiene biosecurity, as well exploring alternatives However, these faces various challenges. challenges low awareness knowledge shortage human resources capacity building AMS, adequate funding initiatives, limited laboratory capacities surveillance, behavioural change issues, ineffective leadership multidisciplinary teams. Conclusion: In conclusion, this established prevalent among Successfully addressing calls collaborative, multifaceted Despite this, gaps remain effectively currently recommended AMR. As result, it essential reinforce are deployed counter across human, animal, environmental sectors.

Language: Английский

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An Overview of the Recent Advances in Antimicrobial Resistance

Microorganisms, Journal Year: 2024, Volume and Issue: 12(9), P. 1920 - 1920

Published: Sept. 21, 2024

Antimicrobial resistance (AMR), frequently considered a major global public health threat, requires comprehensive understanding of its emergence, mechanisms, advances, and implications. AMR’s epidemiological landscape is characterized by widespread prevalence constantly evolving patterns, with multidrug-resistant organisms (MDROs) creating new challenges every day. The most common mechanisms underlying AMR (i.e., genetic mutations, horizontal gene transfer, selective pressure) contribute to the emergence dissemination resistant strains. Therefore, mitigation strategies (e.g., antibiotic stewardship programs—ASPs—and infection prevention control strategies—IPCs) emphasize importance responsible antimicrobial use surveillance. A One Health approach interconnectedness human, animal, environmental health) highlights necessity for interdisciplinary collaboration holistic in combating AMR. Advancements novel therapeutics alternative agents vaccines) offer promising avenues addressing challenges. Policy interventions at international national levels also promote ASPs aiming regulate use. Despite all observed progress, remains pressing concern, demanding sustained efforts address emerging threats sustainability. Future research must prioritize innovative approaches complex socioecological dynamics This manuscript resource researchers, policymakers, healthcare professionals seeking navigate develop effective mitigation.

Language: Английский

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Microbes Saving Lives and Reducing Suffering

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 1, 2025

Language: Английский

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From Data to Decisions: Leveraging Artificial Intelligence and Machine Learning in Combating Antimicrobial Resistance – a Comprehensive Review

Journal of Medical Systems, Journal Year: 2024, Volume and Issue: 48(1)

Published: Aug. 1, 2024

Abstract The emergence of drug-resistant bacteria poses a significant challenge to modern medicine. In response, Artificial Intelligence (AI) and Machine Learning (ML) algorithms have emerged as powerful tools for combating antimicrobial resistance (AMR). This review aims explore the role AI/ML in AMR management, with focus on identifying pathogens, understanding patterns, predicting treatment outcomes, discovering new antibiotic agents. Recent advancements enabled efficient analysis large datasets, facilitating reliable prediction trends responses minimal human intervention. ML can analyze genomic data identify genetic markers associated resistance, enabling development targeted strategies. Additionally, techniques show promise optimizing drug administration developing alternatives traditional antibiotics. By analyzing patient clinical these technologies assist healthcare providers diagnosing infections, evaluating their severity, selecting appropriate therapies. While integration settings is still its infancy, quality algorithm suggest that widespread adoption forthcoming. conclusion, holds improving management outcome.

Language: Английский

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A concept for international societally relevant microbiology education and microbiology knowledge promulgation in society

Microbial Biotechnology, Journal Year: 2024, Volume and Issue: 17(5)

Published: May 1, 2024

Executive summary Microbes are all pervasive in their distribution and influence on the functioning well‐being of humans, life general planet. Microbially‐based technologies contribute hugely to supply important goods services we depend upon, such as provision food, medicines clean water. They also offer mechanisms strategies mitigate solve a wide range problems crises facing humanity at levels, including those encapsulated sustainable development goals (SDGs) formulated by United Nations. For example, microbial can multiple ways decarbonisation hence confronting global warming, provide sanitation water billions people lacking them, improve soil fertility food production develop vaccines other reduce some cases eliminate deadly infections. foundation biotechnology, an increasingly growing business sector source employment, centre bioeconomy , Green Deal etc. But, because microbes largely invisible, they not familiar most people, so opportunities effectively prevent often missed decision‐makers, with negative consequences this entrains. To correct lack vital knowledge, International Microbiology Literacy Initiative–the IMiLI–is recruiting from microbiology community making freely available, teaching resources for curriculum societally relevant that be used levels learning. Its goal is society literate and, consequence, able take full advantage potential minimise activities. In addition about microbes, almost every lesson discusses have sustainability SDGs ability pressing societal inequalities. The thus teaches sustainability, needs citizenship. lessons reveal impacts activities our daily lives personal, family, community, national relevance decisions levels. And, effective, evidence‐based require only information but critical systems thinking, teach these key generic aspects deliberation. IMiLI learner‐centric, academic microbiology‐centric deal everyday issues. These span topics diverse owning caring companion animal, vast foods produced via processes, impressive geological formations created childhood illnesses how managed waste pollution. leverage exceptional excitement exploration discovery typifies much progress capture interest, inspire motivate educators learners alike. establishing Regional Centres translate into regional languages adapt them cultures, promote use assist employing them. Two now operational. constitute interface between resource creators educators–learners. As such, will collect analyse feedback end‐users transmit materials improved refined, new added response demand: thereby directly involved evolution resources. interactions educators–learners mediated establish dynamic synergistic relationships–a education ecosystem–in which become learners, optimised players/stakeholders empowered motivation increased. concept embraces principle embedded wider context societal, biosphere planetary needs, inequalities, confront us need decisioning, should ultimately lead better citizenship more resilient. Abstract planet Earth world: reactor countless microbially driven chemical transformations energy transfers push pull many geochemical cycling elements life, or amplify climate change (e.g., Nature Reviews Microbiology, 2019, 17, 569) impact organisms, humans. both ancestors chemistry allowed evolve Life's engines: How made earth habitable, 2023). understand functions, humans its live sustainably organisms sharing it, microbes. recent editorial (Environmental 21, 1513), advocated literacy society. Our based knowledge subject microbiology, multitude component topics, plus number additional disciplines vitally current microbiology. Rather it focused us–individuals/communities/nations/the human world–and reaching informed issues regularly us, ranging personal importance. words, understanding essential adulthood transition must acquired early school. 2019 Editorial marked launch Initiative, IMiLI. Here, present may achieved rationale underpinning it; type being realise framing treated responsibilities decision‐making; role local languages, according cultural serve hubs networks. featuring learner‐centric been selected inherent relevance, interest excite engage. Importantly, coherently integrate emphasise overarching stewardship thinking interdependencies processes. More broadly, emphasises multifarious applications leveraged human/animal, plant, environmental health, social equity, alleviate humanitarian deficits causes conflicts among peoples increase (Microbial Biotechnology, 2023, 16(6), 1091–1111). although primary target available (CC BY‐NC 4.0) schoolchildren educators, philosophy intended ages, abilities spectra worldwide: university education, lifelong learning, curiosity‐driven, web‐based acquisition public outreach. aim ecosystem democratises knowledge.

Language: Английский

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Synthesis and evaluation of novel ring-conjugated coumarins as biosafe broad-spectrum antimicrobial candidates

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1309, P. 138192 - 138192

Published: March 30, 2024

Language: Английский

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Toward a cure – Advancing HIV/AIDs treatment modalities beyond antiretroviral therapy: A Review

Medicine, Journal Year: 2024, Volume and Issue: 103(27), P. e38768 - e38768

Published: July 5, 2024

Antiretroviral therapy, also known as antiretroviral therapy (ART), has been at the forefront of ongoing battle against human immunodeficiency virus/acquired syndrome (HIV/AIDs). ART is effective, but it drawbacks such side effects, medication resistance, and difficulty getting access to treatment, which highlights urgent need for novel treatment approaches. This review explores complex field HIV/AIDS covering both established alternative modalities orthodox therapy. Numerous reliable databases were reviewed, including PubMed, Web Science, Scopus, Google Scholar. The results a thorough literature search revealed numerous therapeutic options, stem cell transplantation, immunotherapy, gene latency reversal agents, pharmaceutical vaccinations. While promise altering cellular resistance infection targeting HIV-positive cells, immunotherapy treatments seek strengthen immune system’s ability combat HIV. Latency agents offer promising method breaking viral making infected cells vulnerable system destruction or drugs. Furthermore, there potential improving responses HIV using medical stresses vital significance research innovation in hunt successful through examination recent developments lingering challenges. assessment notes that even though tremendous progress treating illness, still more work be done addressing current barriers investigating various options order achieve ultimate objective putting an end pandemic.

Language: Английский

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Advancements in Antibacterial Therapy: Feature Papers

Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 557 - 557

Published: March 1, 2025

Antimicrobial resistance (AMR) is a growing global health crisis that threatens the efficacy of antibiotics and modern medical interventions. The emergence multidrug-resistant (MDR) pathogens, exacerbated by misuse in healthcare agriculture, underscores urgent need for innovative solutions. (1) Background: AMR arises from complex interactions between human, animal, environmental health, further aggravated overuse inadequate regulation antibiotics. Conventional treatments are increasingly ineffective, necessitating alternative strategies. Emerging approaches, including bacteriophage therapy, antimicrobial peptides (AMPs), nanotechnology, microbial extracellular vesicles (EVs), CRISPR-based antimicrobials, provide novel mechanisms complement traditional combating resistant pathogens. (2) Methods: This review critically analyzes advanced antibacterial strategies conjunction with systemic reforms such as stewardship programs, One Health framework, surveillance tools. These methods can enhance detection, guide interventions, promote sustainable practices. Additionally, economic, logistical, regulatory challenges impeding their implementation evaluated. (3) Results: technologies, CRISPR exhibit promising potential targeting mechanisms. However, disparities resource distribution barriers hinder widespread adoption. Public–private partnerships agriculture practices critical to overcoming these obstacles. (4) Conclusions: A holistic integrated approach essential mitigating impact AMR. By aligning therapeutic policies, fostering interdisciplinary collaboration, ensuring equitable distribution, we develop response this 21st-century challenge.

Language: Английский

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Green Synthesis and Characterization of Ag/CuO Nanoparticles: Exploring Their Antifungal, Antimicrobial, and Cytotoxic Properties

Environmental Technology & Innovation, Journal Year: 2025, Volume and Issue: unknown, P. 104147 - 104147

Published: March 1, 2025

Language: Английский

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Secondary Metabolites, Biological Activities, and Industrial and Biotechnological Importance of Aspergillus sydowii

Marine Drugs, Journal Year: 2023, Volume and Issue: 21(8), P. 441 - 441

Published: Aug. 5, 2023

Marine-derived fungi are renowned as a source of astonishingly significant and synthetically appealing metabolites that proven new lead chemicals for chemical, pharmaceutical, agricultural fields.

Language: Английский

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