Dietary (Poly)phenols and the Gut–Brain Axis in Ageing

Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1500 - 1500

Published: May 16, 2024

As the population ages, incidence of age-related neurodegenerative diseases is rapidly increasing, and novel approaches to mitigate this soaring prevalence are sorely needed. Recent studies have highlighted importance gut microbial homeostasis its impact on brain functions, commonly referred as gut–brain axis, in maintaining overall health wellbeing. Nonetheless, mechanisms by which system acts remains poorly defined. In review, we will explore how (poly)phenols, a class natural compounds found many plant-based foods beverages, can modulate thereby promote neural health. While evidence indicates beneficial role (poly)phenol consumption part balanced diet, human scarce mechanistic insight still lacking. regard, make case that dietary (poly)phenols should be further explored establish their therapeutic efficacy through modulation with much greater emphasis carefully designed interventions.

Language: Английский

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Integrating the milk microbiome signatures in mastitis: milk-omics and functional implications

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(2)

Published: Jan. 18, 2025

Mammalian milk contains a variety of complex bioactive and nutritional components microorganisms. These microorganisms have diverse compositions functional roles that impact host health disease pathophysiology, especially mastitis. The advent use high throughput omics technologies, including metagenomics, metatranscriptomics, metaproteomics, metametabolomics, as well culturomics in microbiome studies suggest strong relationships between phenotype signatures While single undoubtedly contributed to our current understanding mastitis, they often provide limited information, targeting only biological viewpoint which is insufficient system-wide information necessary for elucidating the footprints molecular mechanisms driving mastitis dysbiosis. Therefore, integrating multi-omics approach research could generate new knowledge, improve structural ecosystem, insights sustainable control management.

Language: Английский

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Placebo-resistant gut bacteria: Akkermansia muciniphila spp. and Familial Mediterranean fever disease

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Feb. 23, 2024

Introduction Despite numerous investigations into the impact of drugs/probiotics on gut microbiota composition in Familial Mediterranean Fever (FMF) patients, question as to whether there exists a significant bacterial diversity(ies) independent placebo effect that can be reliably considered clinical and nutritional trials remains unresolved. Methods This study represents augural analysis placebo’s influence both healthy individuals FMF afflicted men, utilizing previously collected data from PhyloChip™ DNA microarray experiments. A total 15 male volunteers, aged 18 50, participated this partially randomized trial, which is accessible through GEO Series accession number GSE111835. Results Discussion Key findings current include i. anticipated divergence bacteria resistance between individuals, ii. minor diversities with Enterobacteriaceae identified placebo-resistant among “healthy” bacteria, iii. comprehensive all phyla microbiome extending nearly genera, except for resilience Akkermansia muciniphila spp. patients. underscores susceptibility Faecalibacterium , Blautia Clostridium genera placebo. Consequently, investigation holds significance proper design placebo-controlled establishes foundation further exploration gut-brain axis. Furthermore, it contributes valuable insights discussions regarding proposals probiotic therapies, particularly focusing spp.,

Language: Английский

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Metagenomic driven isolation of poorly culturable species in food

Food Microbiology, Journal Year: 2025, Volume and Issue: 129, P. 104722 - 104722

Published: Jan. 31, 2025

Language: Английский

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Diversity analysis and function prediction of lactic acid bacteria in natural fermented milk in Mongolia

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106067 - 106067

Published: Feb. 1, 2025

Language: Английский

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Consequences of Domestication on Gut Microbiome: A Comparative Analysis Between Wild Boars and Domestic Pigs

Animals, Journal Year: 2025, Volume and Issue: 15(5), P. 747 - 747

Published: March 5, 2025

The gut microbiota plays a vital role in the physiological functions and health of animals. Domestic pigs (Sus scrofa domesticus) wild boars scrofa), which share common ancestor, present unique model for exploring evolutionary changes due to domestication. Comparing these two groups provides opportunity identify microorganisms that may have been lost or altered during This study employed 16S rRNA sequencing compare compositions domestic boars, analyzing 69 fecal samples from both groups. Our results indicate significant differences taxonomic profiles between Specifically, genera Bifidobacterium Lactobacillus, were found higher abundance boars. In contrast, exhibited decreased variety potentially health-enhancing bacteria, likely factors such as simplified diets antibiotic use. Functional gene analysis revealed pathways related carbohydrate metabolism, lipid immune response, environmental adaptability more enriched These findings demonstrate composition underscoring impact domestication on microbial diversity. Further research is necessary explore potential transferring beneficial microbes populations.

Language: Английский

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High-throughput workflow for cultivation and characterization of gut microbiota strains with anti-inflammatory properties and metabolite signature associated with gut-brain communication

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 13, 2025

The gut microbiota is deeply interconnected with the brain, a phenomenon often referred to as gut-brain axis. Dysfunction in microbiota-gut-brain axis can cause various neurological and psychiatric disorders associated chronic inflammation dysbiosis. Therefore, cultivation of anaerobic human strains, characterization their safety status immunomodulatory potential could contribute deciphering molecular mechanisms underlying communication revealed biotherapeutic potential. However, poor cultivability members, makes research into physiological role challenging. Hence, we report high-throughput workflow based on targeted linked metagenome sequencing, combined bioinformatic search for members anti-inflammatory properties which produce most important microbial metabolites that affect brain function. With this approach, isolated 147 bacterial 41 were characterized 12 strains showing immunosuppressive features ability producing metabolites. Through established best growing conditions essential cultivation, archiving, phenotyping, bacteria microbiota-gut-brain-axis research, probiotic 7 extremely oxygen-sensitive strains.

Language: Английский

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COMPARATIVE ANALYSIS OF CONTEMPORARY METHODS FOR INVESTIGATING THE COMPOSITION OF THE HUMAN GUT MICROBIOME

Bulletin of Problems Biology and Medicine, Journal Year: 2025, Volume and Issue: 1(1), P. 373 - 373

Published: Jan. 1, 2025

Language: Английский

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The effect of the female genital tract and gut microbiome on reproductive dysfunction

BioScience Trends, Journal Year: 2023, Volume and Issue: 17(6), P. 458 - 474

Published: Dec. 16, 2023

Microorganisms are ubiquitous in the human body; they present various areas including gut, mouth, skin, respiratory tract, and reproductive tract. The interaction between microbiome health has become an increasingly compelling area of study. Disruption female genital tract can significantly impact metabolism amino acids, carbohydrates, lipids, increasing susceptibility to diseases such as vaginitis, chronic endometritis, endometrial polyps, endometriosis, polycystic ovary syndrome. gut microbiome, considered endocrine organ, plays a crucial role system by interacting with hormones like estrogen androgens. Imbalances composition lead conditions, syndrome, cancer, although research on their mechanisms remains limited. This review highlights latest advancements understanding microbiomes gynecological diseases. It also explores potential microbial communities treatment Future should focus identifying molecular underlying association develop new effective strategies for disease prevention, diagnosis, related organs.

Language: Английский

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Signal amplification strategy of DNA self-assembled biosensor and typical applications in pathogenic microorganism detection

Talanta, Journal Year: 2024, Volume and Issue: 272, P. 125759 - 125759

Published: Feb. 12, 2024

Language: Английский

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