Dietary flavonoid actions on senescence, aging, and applications for health

The Journal of Nutritional Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 109862 - 109862

Published: Feb. 1, 2025

Language: Английский

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Effect of Antioxidants on the Gut Microbiome Profile and Brain Functions: A Review of Randomized Controlled Trial Studies

Foods, Journal Year: 2025, Volume and Issue: 14(2), P. 176 - 176

Published: Jan. 8, 2025

Antioxidants are widely recognized for their potential health benefits, including impact on cognitive function and gut microbiome modulation. Understanding these effects is essential exploring broader clinical applications. This review aims to evaluate the of antioxidants function, with a focus findings from randomized controlled trials (RCTs). The studies involved human participants across range age groups, interventions encompassing natural antioxidant sources, such as berries, well specific vitamins. An extensive search PubMed, SCOPUS, Web Science databases identified six relevant RCTs, each evaluated bias. These focused variety antioxidant-rich products, both naturally derived sources supplemental forms. Antioxidants, vitamins C, B2, D, along polyphenols xanthohumol, fermented papaya, peanuts, berry extracts, demonstrate support promote through mechanisms that modulate diversity reduce inflammation. However, observed changes in were modest inconsistent studies. While preliminary evidence suggests may benefit heterogeneity existing limits immediate applicability. Additionally, more robust RCTs needed substantiate guide future interventions.

Language: Английский

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Nutrients and Nutraceuticals from Vitis vinifera L. Pomace: Biological Activities, Valorization, and Potential Applications

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 583 - 583

Published: Feb. 5, 2025

Grape pomace, also known as wine is a by-product of winemaking that has traditionally been discarded. However, recent studies have highlighted its rich nutritional and bioactive potential, positioning it promising resource for various applications in the functional food, pharmaceutical, cosmetic sectors. This review explores nutrient nutraceutical contents grape including high levels polyphenols, dietary fiber, vitamins, minerals, melatonin. The biological activities such antioxidant, anti-inflammatory, antimicrobial, anticancer effects, are discussed, emphasizing potential raw material endowed with multifunctional properties. Additionally, valorization pomace food supplement development cosmetics examined, focusing on incorporation into products skincare formulations. growing interest sustainable utilization underscored, highlighting significant role promoting human health contributing to circular economy.

Language: Английский

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Gut–Brain Axis in Focus: Polyphenols, Microbiota, and Their Influence on α-Synuclein in Parkinson’s Disease

Nutrients, Journal Year: 2024, Volume and Issue: 16(13), P. 2041 - 2041

Published: June 27, 2024

With the recognition of importance gut-brain axis in Parkinson's disease (PD) etiology, there is increased interest developing therapeutic strategies that target α-synuclein, hallmark abhorrent protein PD pathogenesis, which may originate gut. Research has demonstrated inhibiting aggregation, oligomerization, and fibrillation α-synuclein are key for modification. Polyphenols, rich fruits vegetables, drawing attention their potential role this context. In paper, we reviewed how polyphenols influence composition functional capabilities gut microbiota resulting microbial metabolites potentially enhance modulation aggregation. Understanding interaction between identifying specific microbes efficacy crucial precision nutrition based on microbiome.

Language: Английский

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Postbiotics as Molecules Targeting Cellular Events of Aging Brain—The Role in Pathogenesis, Prophylaxis and Treatment of Neurodegenerative Diseases

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2244 - 2244

Published: July 12, 2024

Aging is the most prominent risk factor for neurodegeneration occurrence. The common neurodegenerative diseases (NDs), Alzheimer’s (AD) and Parkinson’s (PD) diseases, are characterized by incidence of proteinopathy, abnormal activation glial cells, oxidative stress, neuroinflammation, impaired autophagy cellular senescence excessive patient’s age. Moreover, mitochondrial disfunction, epigenetic alterations neurogenesis inhibition, together with increased blood–brain barrier permeability gut dysbiosis, have been linked to ND pathogenesis. Since NDs still lack curative treatment, recent research has sought therapeutic options in restoring microbiota supplementing probiotic bacteria-derived metabolites beneficial action host—so called postbiotics. current review focuses on literature explaining mechanisms involved pathogenesis addressing impact that postbiotics as a whole mixture particular metabolites, such short-chain fatty acids (SCFAs), lactate, polyamines, polyphenols, tryptophan exopolysaccharides bacterial extracellular vesicles, ageing-associated processes underlying also discusses issue implementing into prophylaxis therapy, depicting them compounds senescence-triggered dysfunctions worth translating from bench pharmaceutical market response “silver consumers” demands.

Language: Английский

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Mechanism of Action and Therapeutic Potential of Xanthohumol in Prevention of Selected Neurodegenerative Diseases

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 694 - 694

Published: Feb. 5, 2025

Xanthohumol (XN), a bioactive plant flavonoid, is an antioxidant, and as such, it exhibits numerous beneficial properties, including anti-inflammatory, antimicrobial, antioxidative effects. The main dietary source of XN beer, where introduced through hops. Although the concentration in beer low, large quantities hop-related post-production waste present opportunity to extract residues for technological or pharmaceutical purposes. presented study focuses on role prevention neurodegenerative diseases, analyzing its effect at molecular level signal transduction metabolism. paper brings up XN’s mechanism action, potential effects, experimental clinical studies Alzheimer’s disease (AD), Parkinson’s (PD), amyotrophic lateral sclerosis (ALS). Additionally, challenges future research directions XN, bioavailability, safety, tolerance, have been discussed.

Language: Английский

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Regulation of Intestinal Barrier Function and Gut Microbiota by Hot Melt Extrusion-Drug Delivery System-Prepared Mulberry Anthocyanin in an Inflammatory Bowel Disease Model

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 475 - 475

Published: March 27, 2025

Background/Objectives: Anthocyanins (ACNs) derived from mulberry (Morus alba L.) exhibit potent antioxidant and anti-inflammatory activities. However, their low stability bioavailability in physiological environments limit therapeutic potential. This study aimed to enhance the controlled release ACNs using a hot-melt extrusion drug delivery system (HME-DDS) formulation, HME-MUL-F2, evaluate its effects on gut barrier function microbiota composition DSS-induced colitis model. Methods: The anthocyanin content of HME-MUL-F2 was quantified compared with that raw extract. formulation’s protective were assessed Caco-2 RAW 264.7 cells, confirming biocompatibility properties. efficacy further evaluated dextran sulfate sodium (DSS)-induced inflammatory bowel disease (IBD) model, focusing integrity, cytokine modulation, composition. Results: significantly improved by upregulating tight junction proteins reducing levels Moreover, formulation modulated composition, promoting beneficial bacteria while suppressing pathogenic strains. administration led significant increase Bacteroidetes-to-Firmicutes ratio, which is associated health. These results indicate enhances bioavailability, leading health potential applications for conditions. Conclusions: highlights HME technology improving stability, anthocyanins. sustained-release modulates intestinal microbial balance findings strongly suggest observed are primarily due enhanced targeted colon, although clinical studies will provide more definitive confirmation.

Language: Английский

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Effect of polyphenols on inflammation related to cognitive function: a systematic review and meta-analysis of human randomized controlled trials

Nutrition and Healthy Aging, Journal Year: 2024, Volume and Issue: 9(1), P. 113 - 131

Published: Sept. 5, 2024

BACKGROUND: The decline of cognitive function could in part be caused by an increase inflammation. Polyphenols have been widely investigated due to their anti-inflammatory property which may promote therapeutic effects on the brain and performance. OBJECTIVE: To evaluate impact polyphenols interventions inflammation related humans. METHODS: Three electronic databases: PubMed/Medline, Web Science PsycINFO were systematically searched until 30th May 2024 find study that effect both inflammatory response human randomized controlled trials. outcomes pooled calculated using inverse variance as mean difference (MD) with 95% confidence intervals (95% CI) for markers standardized (SMD) CI domains. RESULTS: Ten studies (451 participants, aged 20–81 years) assessed tests responding included this review meta-analysis. Supplementation demonstrated a significant improvement verbal memory (SMD: 0.33, CI: 0.12 0.54, P = 0.002), executive 0.38, 0.03 0.72, 0.03) attenuation blood interleukin-6 (MD: – 1.23 pg/ml, –2.34, –0.12, 0.03). No differences observed working 0.13, –0.18 0.44, 0.42), attention –0.19, –0.84 0.46, 0.57), psychomotor skill 0.09, –0.32 0.50, 0.66) well c-reactive protein –0.10 mg/l, –0.28 0.30), tumor necrosis factor-α 0.11 –1.25 1.47, 0.87). CONCLUSION: supplementation decreases IL-6 enhances function. Regular consumption might prevent decline.

Language: Английский

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A critical appraisal of geroprotective activities of flavonoids in terms of their bio-accessibility and polypharmacology

Neurochemistry International, Journal Year: 2024, Volume and Issue: 180, P. 105859 - 105859

Published: Sept. 10, 2024

Language: Английский

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(Poly)phenol-rich grape and blueberry extract prevents LPS-induced disruption of the blood-brain barrier through the modulation of the gut microbiota-derived uremic toxins

Neurochemistry International, Journal Year: 2024, Volume and Issue: 180, P. 105878 - 105878

Published: Oct. 9, 2024

The dynamic protective capacity of (poly)phenols, attributed to their potent antioxidant and anti-inflammatory properties, has been consistently reported. Due alter gut microbiome composition, further actions (poly)phenols may be exerted through the modulation microbiota-gut-brain axis. However, underlying mechanisms remain poorly defined. Here, we investigated effect a (poly)phenol-rich grape blueberry extract (Memophenol™), on axis in model chronic low-grade inflammation (0.5 mg/kg/wk lipopolysaccharide (LPS) for 8 weeks). Dietary supplementation male C57BL/6 J mice with Memophenol™ prevented LPS-induced increases microbe-derived uremia-associated molecules, indoxyl sulfate (IS) trimethylamine N-oxide (TMAO). These changes coincided shifts notably Romboutsia Desulfovibrio abundance, respectively. In brain, LPS exposure disrupted marginal localisation endothelial tight junction ZO-1 downregulated mRNA expression an extent closely correlated TMAO IS levels; process by intake. Hippocampal sequencing analysis revealed significant downregulation regulatory pathways neurodegeneration findings indicate novel role component ZO-1, acting microbial metabolism.

Language: Английский

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