Nutrition strategies to prevent short-term adverse outcomes in preterm neonates DOI Creative Commons
Samantha Rodriguez, Diomel de la Cruz, Josef Neu

et al.

BMJ Nutrition Prevention & Health, Journal Year: 2024, Volume and Issue: unknown, P. e000801 - e000801

Published: Jan. 22, 2024

With preterm neonates surviving earlier gestational ages, comorbidities such as bronchopulmonary dysplasia, retinopathy of prematurity, delayed neuronal development, intestinal injury, osteopenia, and parenteral nutrition-associated liver disease have become more common. This has been a topic much deliberation research to identify mitigation strategies. We explore nutrition approaches risk factors for each condition individually, even though some strategies may overlap due similar mechanisms. These conditions long-lasting effects on neonates, calling ongoing assessment practical adjustable interventions. Recent studies elucidate the utility optimization prevention disease. Specifically, amino acids, lipids, breastmilk, Vitamins A, D, E shown effectively mitigate these common morbidities affection neonates. Further are needed targeted ranges macronutrients, vitamins, minerals essential varying ages high-risk populations.

Language: Английский

Exploring Molecular Mechanisms and Biomarkers in COPD: An Overview of Current Advancements and Perspectives DOI Open Access
Chin-Ling Li,

Shih-Feng Liu

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7347 - 7347

Published: July 4, 2024

Chronic obstructive pulmonary disease (COPD) plays a significant role in global morbidity and mortality rates, typified by progressive airflow restriction lingering respiratory symptoms. Recent explorations molecular biology have illuminated the complex mechanisms underpinning COPD pathogenesis, providing critical insights into progression, exacerbations, potential therapeutic interventions. This review delivers thorough examination of latest progress research related to COPD, involving fundamental pathways, biomarkers, targets, cutting-edge technologies. Key areas focus include roles inflammation, oxidative stress, protease-antiprotease imbalances, alongside genetic epigenetic factors contributing susceptibility heterogeneity. Additionally, advancements omics technologies-such as genomics, transcriptomics, proteomics, metabolomics-offer new avenues for comprehensive profiling, aiding discovery novel biomarkers targets. Comprehending foundation carries substantial creation tailored treatment strategies enhancement patient outcomes. By integrating clinical practice, there is promising pathway towards personalized medicine approaches that can improve diagnosis, treatment, overall management ultimately reducing its burden.

Language: Английский

Citations

13
Mitochondrial Dysfunction in Chronic Obstructive Pulmonary Disease: Unraveling the Molecular Nexus DOI Creative Commons
Chin-Ling Li,

Jui-Fang Liu,

Shih‐Feng Liu

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(4), P. 814 - 814

Published: April 7, 2024

Chronic obstructive pulmonary disease (COPD) is a prevalent and debilitating respiratory disorder characterized by persistent airflow limitation chronic inflammation. In recent years, the role of mitochondrial dysfunction in COPD pathogenesis has emerged as focal point investigation. This review endeavors to unravel molecular nexus between COPD, delving into intricate interplay oxidative stress, bioenergetic impairment, genetics, downstream cellular consequences. Oxidative consequence dysfunction, explored driving force behind inflammation, exacerbating cascade events leading progression. Bioenergetic impairment sheds light on systemic consequences impacting functions contributing overall energy imbalance observed patients. navigates through genetic landscape, elucidating DNA mutations, variations, haplogroups susceptibility severity. Cellular consequences, including apoptosis, autophagy, senescence, are examined, providing insights mechanisms which influences pathology. Therapeutic implications, spanning antioxidant strategies, mitochondria-targeted compounds, lifestyle modifications, discussed context translational research. Important future directions include identifying novel biomarkers, advancing therapies, embracing patient-centric approaches redefine management. abstract provides comprehensive overview our review, offering roadmap for understanding addressing with potential implications precision medicine improved patient outcomes.

Language: Английский

Citations

8
The integration of omics: A promising approach to personalized tuberculosis treatment DOI Creative Commons
Priyanka Guha, Siddhartha Dutta, Krishna Murti

et al.

Medicine in Omics, Journal Year: 2024, Volume and Issue: 12, P. 100033 - 100033

Published: Jan. 13, 2024

Tuberculosis (TB) continues to be a global health problem due its high morbidity and death rates. Standardized regimens have been used in traditional TB treatment methods, frequently leading less-than-ideal results the establishment of drug-resistant strains. The development personalized medicine provides potentially effective remedy individual patients' by adjusting therapeutic approaches particular genotypic phenotypic traits. Detecting strains, drug resistance indicators, host genetic variants that affect is made possible genomic molecular diagnostic approaches. These developments offer helpful information for predicting therapy outcomes choosing best plan each individual. Integrating data, such as clinical characteristics, immunological state, comorbidities, improves decision-making accuracy. use targeted therapies, innovative anti-TB medicines repurposed medications, which potential overcome boost effectiveness, can guided therapy. Personalized interventions based on factors improve patient identifying those at risk failure or disease progression. This article discusses importance patients. It specifically highlights benefits using "omics" data enhance decrease resistance.

Language: Английский

Citations

7
Macrophage biomimetic nanoparticle-targeted functional extracellular vesicle micro-RNAs revealed via multiomics analysis alleviate sepsis-induced acute lung injury DOI Creative Commons
G.Z. Wang,

Xiaoxin Ma,

Wei‐Chang Huang

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 23, 2024

Patients who suffer from sepsis typically experience acute lung injury (ALI). Extracellular vesicles (EVs) contain miRNAs, which are potentially involved in ALI. However, strategies to screen more effective EV-miRNAs as therapeutic targets yet be elucidated. In this study, functional were identified based on multiomics analysis of single-cell RNA sequencing targeted organs and serum EV (sEV) miRNA profiles patients with sepsis. The proportions neutrophils macrophages increased significantly the lungs mice receiving sEVs compared healthy controls. Macrophages released EVs than neutrophils. MiR-125a-5p delivery by inhibited Tnfaip3, while miR-221-3p Fos. Macrophage membrane nanoparticles (MM NPs) loaded an miR-125a-5p inhibitor or mimic attenuated response lipopolysaccharide (LPS)-induced Transcriptome profiling revealed that derived LPS-stimulated bone marrow-derived (BMDMs) induced oxidative stress Blocking toll-like receptor, CXCR2, TNFα signaling BMDM-EVs. This study presents a novel method highlights pivotal role macrophage-derived MM NPs, systems key sEV-miRNA mimics inhibitors, alleviated cellular responses observed sepsis-induced strategy can used reduce septic organ damage, particularly targeting EVs.

Language: Английский

Citations

5
Cell death in acute lung injury: caspase-regulated apoptosis, pyroptosis, necroptosis, and PANoptosis DOI Creative Commons
Jun Xiao,

Lichuan Wang,

Bohan Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 21, 2025

There has been abundant research on the variety of programmed cell death pathways. Apoptosis, pyroptosis, and necroptosis under action caspase family are essential for innate immune response. Caspases classified into inflammatory caspase-1/4/5/11, apoptotic caspase-3/6/7, caspase-2/8/9/10. Although is not caspase-dependent to transmit signals, it can cross-link with pyroptosis apoptosis signals regulation caspase-8. An increasing number studies have reiterated involvement in acute lung injuries caused by bacterial viral infections, blood transfusion, ventilation, which influenced noxious stimuli that activate or inhibit engagement pathways, leading subsequent injury. This article reviews role caspases implicated diverse mechanisms injury status relevant inhibitors against target proteins described mechanisms. The findings this review may help delineating novel therapeutic targets

Language: Английский

Citations

0
Nutrition strategies to prevent short-term adverse outcomes in preterm neonates DOI Creative Commons
Samantha Rodriguez, Diomel de la Cruz, Josef Neu

et al.

BMJ Nutrition Prevention & Health, Journal Year: 2024, Volume and Issue: unknown, P. e000801 - e000801

Published: Jan. 22, 2024

With preterm neonates surviving earlier gestational ages, comorbidities such as bronchopulmonary dysplasia, retinopathy of prematurity, delayed neuronal development, intestinal injury, osteopenia, and parenteral nutrition-associated liver disease have become more common. This has been a topic much deliberation research to identify mitigation strategies. We explore nutrition approaches risk factors for each condition individually, even though some strategies may overlap due similar mechanisms. These conditions long-lasting effects on neonates, calling ongoing assessment practical adjustable interventions. Recent studies elucidate the utility optimization prevention disease. Specifically, amino acids, lipids, breastmilk, Vitamins A, D, E shown effectively mitigate these common morbidities affection neonates. Further are needed targeted ranges macronutrients, vitamins, minerals essential varying ages high-risk populations.

Language: Английский

Citations

0