Bulletin of Integrative Psychiatry,
Journal Year:
2023,
Volume and Issue:
99(4), P. 43 - 48
Published: Dec. 15, 2023
This
short
review
aims
to
bring
new
data
regarding
the
prevalence
of
mental
manifestations/disorders
among
patients
with
IBD,
identify
bidirectional
relationships
between
psychiatric
symptoms,
course,
and
response
treatment
inflammatory
bowel
diseases,
mechanisms
involved
in
both
IBD
pathology,
which
would
allow
an
appropriate
management
a
distinct
approach
depending
on
associated
manifestations.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 2, 2024
More
than
20%
of
American
adults
live
with
a
mental
disorder,
many
whom
are
treatment
resistant
or
continue
to
experience
symptoms.
Other
approaches
needed
improve
health
care,
including
prevention.
The
role
the
microbiome
has
emerged
as
central
tenet
in
and
physical
their
interconnectedness
(well-being).
Under
normal
conditions,
healthy
promotes
homeostasis
within
host
by
maintaining
intestinal
brain
barrier
integrity,
thereby
facilitating
well-being.
Owing
multidirectional
crosstalk
between
neuro-endocrine-immune
systems,
dysbiosis
is
main
driver
immune-mediated
systemic
neural
inflammation
that
can
promote
disease
progression
detrimental
well-being
broadly
particular.
In
predisposed
individuals,
immune
dysregulation
shift
autoimmunity,
especially
presence
psychological
triggers.
chronic
stress
response
involves
system,
which
intimately
involved
gut
microbiome,
particularly
process
education.
This
interconnection
forms
microbiota-gut-immune-brain
axis
disorders.
this
brief
review,
we
aim
highlight
relationships
stress,
health,
along
ways
dysregulated
system
an
autoimmune
concomitant
neuropsychological
consequences
context
axis.
Finally,
review
evidenced-based
prevention
strategies
potential
therapeutic
targets.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 5676 - 5676
Published: May 23, 2024
Inflammatory
bowel
diseases
(IBDs)
are
characterized
by
chronic
gastrointestinal
inflammation
due
to
abnormal
immune
responses
gut
microflora.
The
gut–brain
axis
is
disrupted
in
IBDs,
leading
neurobiological
imbalances
and
affective
symptoms.
Systemic
IBDs
affects
the
brain’s
inflammatory
response
system,
hormonal
axis,
blood–brain
barrier
integrity,
influencing
microbiota.
This
review
aims
explore
association
between
dysregulations
serum
biomarkers,
development
of
cognitive
disorders.
Studies
suggest
a
potential
neurodegeneration.
mechanisms
include
systemic
inflammation,
nutritional
deficiency,
GBA
dysfunction,
effect
genetics
comorbidities.
objective
identify
correlations
propose
future
research
directions
understand
impact
altered
microbiomes
intestinal
functions
on
Serum
levels
vitamins,
neuronal
damage
growth
factors
have
been
investigated
for
their
predict
neurodegenerative
diseases,
but
current
results
inconclusive
require
more
studies.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(24), P. 4404 - 4404
Published: Dec. 22, 2024
Aim:
This
article
aims
to
explore
the
role
of
human
gut
microbiota
(GM)
in
pathogenesis
neurological,
psychiatric,
and
neurodevelopmental
disorders,
highlighting
its
influence
on
health
disease,
investigating
potential
therapeutic
strategies
targeting
GM
modulation.
Materials
Methods:
A
comprehensive
analysis
microbiota’s
composition
interaction
with
body,
particularly,
neurological
psychiatric
conditions,
is
provided.
The
review
discusses
factors
influencing
composition,
including
birth
mode,
breastfeeding,
diet,
medications,
geography.
Additionally,
it
examines
GM’s
functions,
such
as
nutrient
absorption,
immune
regulation,
pathogen
defense,
alongside
interactions
nervous
system
through
gut–brain
axis,
neurotransmitters,
short-chain
fatty
acids
(SCFAs).
Results:
Alterations
are
linked
various
Parkinson’s
multiple
sclerosis,
depression,
schizophrenia,
ADHD,
autism.
influences
cognitive
stress
responses,
mood
regulation.
Antibiotic
use
disrupts
diversity,
increasing
risk
metabolic
obesity,
allergic
diseases.
Emerging
therapies
probiotics,
prebiotics,
transplantation
show
promise
modulating
alleviating
symptoms
conditions.
Conclusions.
modulation
represents
a
promising
approach
for
personalized
treatment
strategies.
Further
research
needed
better
understand
underlying
mechanisms
develop
targeted
aimed
at
restoring
balance
improved
clinical
outcomes.
IBD,
encompassing
CD
and
UC,
are
characterized
by
chronic
gastrointestinal
inflammation
due
to
abnormal
immune
responses
gut
microflora.
The
bidirectional
communication
between
the
brain,
known
as
GBA,
is
disrupted
in
leading
neurobiological
imbalances
affective
symptoms.
Systemic
IBD
affects
brain's
inflammatory
response
system,
hormonal
axis,
BBB
integrity,
influencing
microbiota
clinical
probiotics.
This
review
aims
explore
links
dysregulations
serum
biomarkers,
development
of
MCI
NDDs.
objective
identify
potential
correlations
propose
future
research
directions
understand
impact
altered
microbiomes
intestinal
barrier
functions
on
Studies
suggest
a
link
extraintestinal
complications
such
Mechanisms
include
systemic
inflammation,
dysfunction,
autoimmune
responses,
GBA
medication
effects,
comorbidities.
Serum
including
vitamin
D3,
C-reactive
protein,
high-sensitivity
B12,
homocysteine,
amyloid,
neuron-specific
enolase,
neurofilament
light
chain,
S100
proteins,
brain-derived
neurotrophic
factor,
IL-6,
LP-2
associated
phospholipase,
prostaglandin
E2,
IL-1β,
TNF-α,
have
been
investigated
for
their
predict
but
current
results
lacking
clarity.
Cerebral Cortex,
Journal Year:
2024,
Volume and Issue:
34(4)
Published: April 1, 2024
Abstract
Crohn's
disease
is
an
acknowledged
“brain–gut”
disorder
with
unclear
physiopathology.
This
study
aims
to
identify
potential
neuroimaging
biomarkers
of
disease.
Gray
matter
volume,
cortical
thickness,
amplitude
low-frequency
fluctuations,
and
regional
homogeneity
were
selected
as
indices
interest
subjected
analyses
using
both
activation
likelihood
estimation
seed-based
d
mapping
permutation
subject
images.
In
comparison
healthy
controls,
patients
in
remission
exhibited
decreased
gray
volume
the
medial
frontal
gyrus
concurrently
increased
homogeneity.
Furthermore,
reduction
superior
anterior
cingulate/paracingulate
gyri,
median
gyrus,
paracentral
lobule,
insula
observed.
The
changes
confirmed
through
methods:
identified
by
images,
respectively.
meta-regression
showed
a
positive
correlation
between
alterations
patient
age
supplementary
motor
area
negative
patients’
anxiety
scores
gyrus.
These
anomalies
may
be
associated
clinical
manifestations
including
abdominal
pain,
psychiatric
disorders,
possibly
reflective
compensatory
mechanisms.
IntechOpen eBooks,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 10, 2024
This
comprehensive
chapter
examines
the
intricate
relationship
between
various
food
additives
and
nervous
system.
Across
10
detailed
sections,
it
explores
such
as
aspartame,
potassium
sorbate,
acesulfame
potassium,
dimethyl
dicarbonate
(DMDC),
starch
acetate,
monosodium
glutamate
(MSG),
phenylalanine,
sodium
benzoate,
artificial
dyes,
nitrite.
Each
delves
into
chemical
properties,
usage
in
foods,
potential
neurological
impacts
of
these
substances,
enriched
with
patient
case
studies.
The
pays
special
attention
to
conditions
mood
change,
headaches
including
migraine,
allergic
reactions,
cognitive
impairment,
ADHD,
autism,
phenylketonuria
(PKU),
hypersensitivity
additionally,
discusses
emerging
research
on
gut-brain
axis,
shedding
light
how
influence
health,
especially
individuals
specific
dietary
restrictions
health
concerns.
work
aims
provide
a
nuanced
understanding
everyday
can
affect
human
system,
both
general
population
those
particular
vulnerabilities.
Abstract:
The
VSI
represents
a
significant
advancement
in
the
assessment
of
gastrointestinal-specific
anxiety
among
patients
with
Irritable
Bowel
Syndrome
(IBS)
and
other
Chronic
Inflammatory
Diseases
(IBD).
However,
an
Italian
version
instrument
is
not
yet
available
for
reference
population.
This
study
utilized
national
sample
500
individuals,
including
healthy
controls
Ulcerative
Colitis
Crohn's
Disease,
to
test
validity
reliability
VSI.
Using
back-translation
methodology
ensure
translation
fidelity,
research
applied
questionnaire
through
online
format
participants.
Data
analysis
revealed
that
had
excellent
psychometric
properties,
demonstrating
high
internal
consistency
(Cronbach’s
α
=
0.95)
construct
validity.
scale
proved
sensitive
detecting
differences
visceral
sensitivity
groups,
highlighting
its
utility
as
clinical
tool.
Specifically,
exhibited
unidimensional
factorial
structure
maintained
strong
correlation
measures
severity
gastrointestinal
symptoms,
confirming
role
enhancing
understanding
management
IBS
IBD
Italy.
