Harnessing the Activity of Lytic Bacteriophages to Foster the Sustainable Development Goals and the “One Health” Strategy

Viruses, Journal Year: 2025, Volume and Issue: 17(4), P. 549 - 549

Published: April 9, 2025

As bacteriophages (phages) are viruses that infect and destroy bacterial cells, they can be considered natural bactericides either directly or indirectly contribute to the achievement of United Nations Sustainable Development Goals (UN SDGs) on health well-being, food production security, as well environmental protection climate change mitigation, thus contributing success European “One Health” strategy combat antimicrobial resistance in humans, animals, plants, environment. The biological activity lytic operate fields microbiology biotechnology for clinical, veterinary, agricultural, industrial applications, among others, achieve proposed goals, mainly because phages help increase crop productivity by reducing diseases; constitute alternative therapies against infections caused multidrug-resistant bacteria; reduce populations pathogenic bacteria contaminate soil water, therefore ensuring healthier safer production; pollution presence agrochemicals antibiotics. Phage-based developed through research innovation have potential promote greater global security a more environmentally friendly eco-sustainable way.

Language: Английский

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Virological and Pharmaceutical Properties of Clinically Relevant Phages

Antibiotics, Journal Year: 2025, Volume and Issue: 14(5), P. 487 - 487

Published: May 10, 2025

As antimicrobial resistance continues to undermine the efficacy of antibiotics, global medical community is increasingly turning alternative treatment modalities. Among these, phage therapy has re-emerged as a promising strategy for managing multidrug-resistant bacterial infections. Herein, we present and briefly discuss eight essential attributes clinically relevant phages therapy, which may be categorized broadly into virological pharmacological characteristics. Virological include broad host range, strictly lytic life cycle ability manage emergence phages. Comprehensive genomic proteomic characterization forms foundation selecting engineering such candidates, ensuring both safety predictability. From standpoint, should ideally show across formulations routes administration, favorable pharmacokinetics, stability during storage scalability in manufacturing. Advances analysis, artificial intelligence-driven selection formulation technologies have further accelerated translational potential therapy. By systematically addressing each these critical attributes, this work aims inform rational development therapeutic suitable integration clinical practice.

Language: Английский

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Advances in Diversity, Evolutionary Dynamics and Biotechnological Potential of Restriction-Modification Systems

Microorganisms, Journal Year: 2025, Volume and Issue: 13(5), P. 1126 - 1126

Published: May 14, 2025

Restriction–modification systems (RMS) are ubiquitous in prokaryotes and serve as primitive immune-like mechanisms that safeguard microbial genomes against foreign genetic elements. Beyond their well-known role sequence-specific defense, RMS also contribute significantly to genomic stability, drive evolutionary processes, mitigate the deleterious effects of mutations. This review provides a comprehensive synthesis current insights into RMS, emphasizing structural functional diversity, ecological roles, expanding applications biotechnology. By integrating recent advances with an analysis persisting challenges, we highlight critical contributions both fundamental microbiology practical biomedicine industrial Furthermore, discuss emerging research directions particularly light novel technologies increasing importance genetics addressing global health environmental issues.

Language: Английский

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The Evolution of Phage Therapy: A Comprehensive Review of Current Applications and Future Innovations

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 28, 2024

Phage therapy, using bacteriophages to target and destroy bacteria, has evolved significantly from its early 20th-century inception modern resurgence as a promising alternative antibiotics. This review explores the historical development of phage detailing initial successes, subsequent decline with rise antibiotics, recent revival in response increasing antibiotic resistance. We examine fundamental mechanisms including specificity phages for bacterial targets their ability combat resistant strains. Current applications are discussed, highlighting use therapy treating chronic infections, personalizing treatment strategies, role veterinary food safety contexts. Innovations driven by advancements genetic engineering synthetic biology, also reviewed, showcasing engineered phages, libraries, novel delivery systems. Despite potential, faces challenges such regulatory hurdles, concerns, issues related resistance phages. The underscores need ongoing research clinical trials address these integrate into paradigms. By offering detailed overview evolution, current status, future directions this aims highlight potential crucial component fight against antibiotic-resistant infections inform efforts.

Language: Английский

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Cryo-electron microscopy in the study of virus entry and infection

Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11

Published: July 24, 2024

Viruses have been responsible for many epidemics and pandemics that impacted human life globally. The COVID-19 pandemic highlighted both our vulnerability to viral outbreaks, as well the mobilization of scientific community come together combat unprecedented threat humanity. Cryo-electron microscopy (cryo-EM) played a central role in understanding SARS-CoV-2 during continues inform about this evolving pathogen. Cryo-EM with its two popular imaging modalities, single particle analysis (SPA) cryo-electron tomography (cryo-ET), has contributed immensely structure viruses interactions define their cycles pathogenicity. Here, we review how cryo-EM informed three distinct viruses, which - HIV-1 infect humans, third, bacteriophages, bacteria. For focus is on surface glycoproteins are mediating host receptor binding, cell membrane fusion, while structure, capsid maturation, attachment bacterial infection initiation mechanism.

Language: Английский

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Genomic insights into novel Erwinia bacteriophages: unveiling their Henunavirus membership and host infection strategies

Current Microbiology, Journal Year: 2024, Volume and Issue: 81(7)

Published: June 3, 2024

Language: Английский

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Emerging Bioactive Delivery Systems for Enhanced Wound Healing in Diabetes

BioNanoScience, Journal Year: 2024, Volume and Issue: 14(4), P. 4006 - 4019

Published: Aug. 2, 2024

Language: Английский

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Exploring advanced antimicrobial effects of Pediococcus pentosaceus and Lactococcus lactis derived from Bufo gargarizans: in vitro analysis and in vivo evaluation in mice

LWT, Journal Year: 2024, Volume and Issue: unknown, P. 116851 - 116851

Published: Oct. 1, 2024

Language: Английский

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Aeromonas Biocontrol Using Bacteriophages: A Promising Strategy

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

Aeromonas spp. are Gram-negative bacteria commonly found in aquatic environments, posing significant risks to aquaculture and human health. In aquaculture, infections cause substantial economic losses, while humans, can lead illnesses ranging from gastroenteritis severe like septicemia. The growing issue of antibiotic resistance highlights the need for alternative control methods. Bacteriophage-based biocontrol offers a promising approach, providing several advantages over traditional treatments. Research has focused on isolating characterizing Aeromonas-specific bacteriophages environments such as water bodies sewage. These phages have been analyzed their morphology, genome sequences, lytic activity against various strains. Laboratory field trials show that effectively lyse Aeromonas, making them strong candidates biocontrol. Phage therapy targeted eco-friendly solution, improving fish health sustainability. Additionally, be used food processing eliminate contamination, enhancing safety, treatment reduce water-borne infections. However, challenges phage stability, bacterial resistance, regulatory issues remain. Future research should focus developing cocktails, environmental optimizing delivery methods, scaling up production commercialization, ensuring widespread use phage-based Aeromonas.

Language: Английский

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Beyond Antibiotics: Exploring the Potential of Bacteriophages and Phage Therapy

PHAGE, Journal Year: 2024, Volume and Issue: 5(4), P. 186 - 202

Published: Oct. 24, 2024

The escalating global threat of antibiotic resistance has prompted a critical need for innovative approaches to bacterial infection treatment. In terms management, bacterial-associated disorders have reached point in the world due advent drug-resistant types bacteria. Nonetheless, continued bacteriophage research presents promising frontier battle against infections. this study, we explored effectiveness therapy antibiotic-resistant According our viewpoint, phage could replace antibiotics safety, efficacy, and specificity. Furthermore, offers versatility administering single phage, products, or modified various resistant Moreover, Phage cocktails, with their synergistic combinations, showcase holistic approach, mitigating risk expanding treatment possibilities. Similarly, synergy between phages holds promise overcoming forging path toward more effective sustainable antimicrobial strategies. review provides insights into transformative impact on current paradigms, its application methodological challenges limitations, as well scientists policymakers best areas study order combat resistance.

Language: Английский

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