Food Science & Nutrition,
Journal Year:
2024,
Volume and Issue:
12(8), P. 5632 - 5646
Published: May 15, 2024
Polycystic
Ovary
Syndrome
(PCOS),
which
is
common
among
women
of
reproductive
age,
characterized
by
low-grade
chronic
inflammation
and
associated
with
several
health
problems
dysbiosis.
Kefir
has
been
shown
to
have
many
beneficial
effects;
however,
its
effect
on
PCOS
unknown.
This
study
aimed
examine
the
kefir
intestinal
microbiota
outcomes
in
PCOS.
In
this
intervention
study,
17
consumed
250
mL/day
(containing
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 5842 - 5842
Published: May 27, 2024
This
study
provides
a
brief
discussion
of
the
major
nanopharmaceuticals
formulations
as
well
impact
nanotechnology
on
future
pharmaceuticals.
Effective
and
eco-friendly
strategies
biofabrication
are
also
highlighted.
Modern
approaches
to
designing
pharmaceutical
nanoformulations
(e.g.,
3D
printing,
Phyto-Nanotechnology,
Biomimetics/Bioinspiration,
etc.)
outlined.
paper
discusses
need
use
natural
resources
for
“green”
design
new
with
therapeutic
efficiency.
Nanopharmaceuticals
research
is
still
in
its
early
stages,
preparation
nanomaterials
must
be
carefully
considered.
Therefore,
safety
long-term
effects
not
overlooked.
The
testing
represents
an
essential
point
their
further
applications.
Vegetal
scaffolds
obtained
by
decellularizing
plant
leaves
represent
valuable,
bioinspired
model
nanopharmaceutical
that
avoids
using
animals.
Nanoformulations
critical
various
fields,
especially
pharmacy,
medicine,
agriculture,
material
science,
due
unique
properties
advantages
over
conventional
allows
improved
solubility,
bioavailability,
targeted
drug
delivery,
controlled
release,
reduced
toxicity.
have
transitioned
from
experimental
stages
being
vital
component
clinical
practice,
significantly
improving
outcomes
medical
fields
cancer
treatment,
infectious
diseases,
neurological
disorders,
personalized
advanced
diagnostics.
Here
key
points
highlighting
importance.
significant
challenges,
opportunities,
directions
mentioned
final
section.
Probiotics and Antimicrobial Proteins,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 3, 2024
Abstract
In
recent
years,
more
and
scientific
community,
food
producers,
industry
show
increased
interest
in
functional
foods
containing
probiotics,
which
is
a
big
challenge.
The
consumption
of
probiotics
the
context
balanced
diet
through
or
intake
pharmaceutical
preparations
has
proven
to
contribute
improvement
human
health,
even
contributing
prevention
diseases.
order
for
be
considered
suitable
consumption,
they
must
contain
minimum
concentration
viable
cells,
namely,
at
least
10
7
colony
forming
units
beneficial
microbes
per
gram.
Ensuring
viability
bacterial
cells
until
moment
overriding
priority
probiotic
manufacturers.
Probiotic
bacteria
are
subject
stress
conditions
not
only
during
manufacturing
but
also
gastrointestinal
passage,
limit
compromise
their
functionality.
This
paper
first
examines
all
stressful
faced
by
production
stages
related
present
bioreactor
fermentation
drying
processes
as
well
factors
matrix
storage.
situations
microorganisms
transit
especially
stomach
intestinal
residence
analyzed.
understand
adaptation
mechanisms
stress,
intrinsic
adaptive
identified
strains
response
acid
bile
addition,
strategies
multiple
tolerance
lactic
directions
dealing
with
accumulation
metabolites,
use
protectants,
regulation
technological
parameters
examined.
Finally,
definition
postbiotics,
inanimate
and/or
components
conferring
health
benefits,
introduced.
Postbiotics
include
cell
lysates,
enzymes,
wall
fragments
derived
from
may
represent
an
alternative
when
do
tolerate
conditions.
Foods,
Journal Year:
2025,
Volume and Issue:
14(3), P. 512 - 512
Published: Feb. 5, 2025
The
rapid
development
of
nanotechnology
provides
new
approaches
to
manufacturing
food-related
nanoparticles
in
various
food
industries,
including
formulation,
functional
foods,
packaging,
and
quality
control.
Once
ingested,
will
immediately
adsorb
proteins
the
biological
fluids,
forming
a
corona
around
them.
Protein
coronas
alter
properties
nanoparticles,
their
toxicity,
cellular
uptake,
targeting
characteristics,
by
altering
aggregation
state.
In
addition,
conformation
function
enzymes
are
also
influenced
formation
protein
coronas,
affecting
digestion
products.
Since
inevitable
application
industries
subsequent
digestion,
comprehensive
understanding
is
essential.
This
systematic
review
introduces
explains
with
interactions
between
nanoparticles.
Furthermore,
potential
origin
that
migrate
from
packaging
materials
fates
gastrointestinal
tract
has
been
reviewed.
Finally,
this
explores
possible
effects
on
bioactive
compounds,
probiotics
prebiotics.
Understanding
mechanisms
crucial,
as
it
enables
design
tailored
delivery
systems
optimize
bioavailability
compounds.
Drug Design Development and Therapy,
Journal Year:
2025,
Volume and Issue:
Volume 19, P. 585 - 598
Published: Jan. 1, 2025
The
beneficial
effects
of
probiotics
are
encountered
by
their
low
viability
in
gastrointestinal
conditions
and
insufficient
stability
during
manufacturing,
throughut
the
transit,
storage.
Therefore,
novel
systems
highly
required
to
improve
delivery.
In
this
study,
Lactobacillus
gasseri
(L),
Bifidobacterium
bifidum
(B),
a
combination
L+B
were
encapsulated
chitosan
(CS)-polyacrylic
acid
(PAA)
complex
(CS-PAA).
CS-PAA
analysed
on
basis
morphology,
size,
zeta
potential.
loaded
evaluated
for
particle
zetapotential,
vaiability
both
simulated
gastroic
intestinal
fluids,
at
4°C
storage
temparature.
Moreover,
antibiofilm
activity
probiotics-loaded
againt
Campylobacter
jejuni,
Pseudomonas
aeruginosa
Escherichia
coli.
Probiotic
strains
successfully
incorporated
into
porous
structures
systems,
either
individually
or
combination.
Loaded
L,
B,
showed
higher
size
than
unloaded
particles
excellent
gastric
where
free
probiotic
species
undetected.
Additionally
exhibited
an
anti-biofilm
effect
0.5
mg/mL
concentration
level.
complexes
demonstrate
promising
mechanism
effective
delivery
probiotics.
high
maintain
under
physiological
conditions,
remarkable
activity.
These
characteristics
suggest
that
could
serve
as
alternative
system
probiotics,
enhancing
gut
microbiota
health
offering
robust
protection
against
microbial
pathogens.
Designed Monomers & Polymers,
Journal Year:
2024,
Volume and Issue:
28(1), P. 1 - 34
Published: Dec. 31, 2024
This
review
paper
analyzes
recent
advancements
in
bio-polymer
coatings
for
probiotic
microencapsulation,
with
a
particular
emphasis
on
chitosan
and
its
synergistic
combinations
other
materials.
Probiotic
microencapsulation
is
essential
protecting
probiotics
from
environmental
stresses,
enhancing
their
stability,
ensuring
effective
delivery
to
the
gut.
The
begins
an
overview
of
highlighting
significance
safeguarding
through
processing,
storage,
gastrointestinal
transit.
Advances
chitosan-based
encapsulation
are
explored,
including
integration
bio-polymers
such
as
alginate,
gelatin,
pectin,
well
application
nanotechnology
innovative
techniques
like
spray
drying
layer-by-layer
assembly.
Detailed
mechanistic
insights
integrated,
illustrating
how
influences
gut
microbiota
by
promoting
beneficial
bacteria
suppressing
pathogens,
thus
role
prebiotic
or
synbiotic.
Furthermore,
delves
into
chitosan's
immunomodulatory
effects,
particularly
context
inflammatory
bowel
disease
(IBD)
autoimmune
diseases,
describing
immune
signaling
pathways
influenced
linking
changes
improvements
systemic
immunity.
Recent
clinical
trials
human
studies
assessing
efficacy
chitosan-coated
presented,
alongside
discussion
practical
applications
comparison
vitro
vivo
findings
highlight
real-world
relevance.
sustainability
sources
impact
addressed,
along
novel
concept
gut-brain
axis.
Finally,
emphasizes
future
research
needs,
development
personalized
therapies
exploration
techniques.
