From the Gut to the Brain: Is Microbiota a New Paradigm in Parkinson’s Disease Treatment? DOI Creative Commons
Cristiana Vilela, Bruna Araújo, Carla Guedes

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(9), P. 770 - 770

Published: April 30, 2024

Parkinson’s disease (PD) is recognized as the second most prevalent primary chronic neurodegenerative disorder of central nervous system. Clinically, PD characterized a movement disorder, exhibiting an incidence and mortality rate that increasing faster than any other neurological condition. In recent years, there has been growing interest concerning role gut microbiota in etiology pathophysiology PD. The establishment brain–gut axis now real, with evidence denoting bidirectional communication between brain through metabolic, immune, neuronal, endocrine mechanisms pathways. Among these, vagus nerve represents direct form gut. Given potential interactions bacteria drugs, it observed therapies for can have impact on composition microbiota. Therefore, scope present review, we will discuss current understanding whether this may be new paradigm treating devastating disease.

Language: Английский

The Microbiota–Gut–Brain Axis and Neurological Disorders: A Comprehensive Review DOI Creative Commons

Mohammed M. Nakhal,

Lidya K. Yassin,

Rana Alyaqoubi

et al.

Life, Journal Year: 2024, Volume and Issue: 14(10), P. 1234 - 1234

Published: Sept. 26, 2024

Microbes have inhabited the earth for hundreds of millions years longer than humans. The microbiota-gut-brain axis (MGBA) represents a bidirectional communication pathway. These communications occur between central nervous system (CNS), enteric (ENS), and emotional cognitive centres brain. field research on gut-brain has grown significantly during past two decades. Signalling occurs gut microbiota brain through neural, endocrine, immune, humoral pathways. A substantial body evidence indicates that MGBA plays pivotal role in various neurological diseases. include Alzheimer's disease (AD), autism spectrum disorder (ASD), Rett syndrome, attention deficit hyperactivity (ADHD), non-Alzheimer's neurodegeneration dementias, fronto-temporal lobe dementia (FTLD), Wilson-Konovalov (WD), multisystem atrophy (MSA), Huntington's chorea (HC), Parkinson's (PD), multiple sclerosis (MS), amyotrophic lateral (ALS), temporal epilepsy (TLE), depression, schizophrenia (SCZ). Furthermore, correlation therapeutics will be discussed. Conversely, mood delivery, exercise, psychotropic agents, stress, neurologic drugs can influence MGBA. By understanding MGBA, it may possible to facilitate into microbial-based interventions therapeutic strategies

Language: Английский

Citations

8
Health and aging trajectories: shared and competing risks and resiliencies for chronic diseases associated with aging. A NIH-wide workshop DOI Creative Commons
Ilsa I. Rovira, Arya Biragyn,

LaVerne L. Brown

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: May 1, 2025

Language: Английский

Citations

0
From the Gut to the Brain: Is Microbiota a New Paradigm in Parkinson’s Disease Treatment? DOI Creative Commons
Cristiana Vilela, Bruna Araújo, Carla Guedes

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(9), P. 770 - 770

Published: April 30, 2024

Parkinson’s disease (PD) is recognized as the second most prevalent primary chronic neurodegenerative disorder of central nervous system. Clinically, PD characterized a movement disorder, exhibiting an incidence and mortality rate that increasing faster than any other neurological condition. In recent years, there has been growing interest concerning role gut microbiota in etiology pathophysiology PD. The establishment brain–gut axis now real, with evidence denoting bidirectional communication between brain through metabolic, immune, neuronal, endocrine mechanisms pathways. Among these, vagus nerve represents direct form gut. Given potential interactions bacteria drugs, it observed therapies for can have impact on composition microbiota. Therefore, scope present review, we will discuss current understanding whether this may be new paradigm treating devastating disease.

Language: Английский

Citations

3