The Impact of Probiotics on Oral Cancer: Mechanistic Insights and Therapeutic Strategies

Oral Oncology Reports, Journal Year: 2025, Volume and Issue: unknown, P. 100715 - 100715

Published: Jan. 1, 2025

Language: Английский

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Antimicrobial Resistance in Equines: A Growing Threat to Horse Health and Beyond—A Comprehensive Review

Antibiotics, Journal Year: 2024, Volume and Issue: 13(8), P. 713 - 713

Published: July 29, 2024

The equine industry holds substantial economic importance not only in the USA but worldwide. occurrence of various infectious bacterial diseases horses can lead to severe health issues, losses, and restrictions on horse movement trade. Effective management control these are therefore crucial for growth sustainability industry. While antibiotics constitute primary treatment strategy any infections horses, developing resistance clinically important poses significant challenges welfare. adverse effects antimicrobial overuse escalating threat underscore critical stewardship within There is limited information epidemiology antimicrobial-resistant horses. In this comprehensive review, we focus history types antimicrobials used provide recommendations combating drug-resistant This review also highlights (AMR) emphasizing public significance transmission dynamics between other animals a One Health framework. By fostering responsible practices innovative measures, better help combat pressing AMR thus safeguard as well health.

Language: Английский

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The Most Promising Next-Generation Probiotic Candidates—Impact on Human Health and Potential Application in Food Technology

Fermentation, Journal Year: 2024, Volume and Issue: 10(9), P. 444 - 444

Published: Aug. 23, 2024

A substantial body of research indicates that the gut microbiota exerts a profound influence on host health. The purpose this work was to characterize selected, most promising, well-known next-generation probiotics (NGPs) and review potential applications bacteria in food technology. isolation with significant health benefits has led emergence NGPs. In contrast traditional probiotics, these originate directly from microbiota, thereby ensuring their optimal adaptation intestinal ecosystem. NGPs exert effects organism through variety mechanisms, including synthesis bioactive compounds, modulation metabolism substances provided by host. Several bacterial species have been identified as candidates for NGPs, Akkermansia muciniphila, Faecalibacterium prausnitzii, Bacteroides thetaiotaomicron, Christensenella minuta, many others. These demonstrated capacity beneficial effects, reduction obesity, type 2 diabetes, metabolic disorders, even cancers. greatest limitation commercialization is lack oxygen tolerance, which presents challenges not only but also application food. approach appears be microencapsulation. Further required establish safety NGP supplementation protect them environmental conditions.

Language: Английский

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Advances in bio-polymer coatings for probiotic microencapsulation: chitosan and beyond for enhanced stability and controlled release

Designed Monomers & Polymers, Journal Year: 2024, Volume and Issue: 28(1), P. 1 - 34

Published: Dec. 31, 2024

This review paper analyzes recent advancements in bio-polymer coatings for probiotic microencapsulation, with a particular emphasis on chitosan and its synergistic combinations other materials. Probiotic microencapsulation is essential protecting probiotics from environmental stresses, enhancing their stability, ensuring effective delivery to the gut. The begins an overview of highlighting significance safeguarding through processing, storage, gastrointestinal transit. Advances chitosan-based encapsulation are explored, including integration bio-polymers such as alginate, gelatin, pectin, well application nanotechnology innovative techniques like spray drying layer-by-layer assembly. Detailed mechanistic insights integrated, illustrating how influences gut microbiota by promoting beneficial bacteria suppressing pathogens, thus role prebiotic or synbiotic. Furthermore, delves into chitosan's immunomodulatory effects, particularly context inflammatory bowel disease (IBD) autoimmune diseases, describing immune signaling pathways influenced linking changes improvements systemic immunity. Recent clinical trials human studies assessing efficacy chitosan-coated presented, alongside discussion practical applications comparison vitro vivo findings highlight real-world relevance. sustainability sources impact addressed, along novel concept gut-brain axis. Finally, emphasizes future research needs, development personalized therapies exploration techniques.

Language: Английский

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Molecular Mechanisms of Intestinal Protection by Levilactobacillus brevis 23017 against Salmonella typhimurium C7731-Induced Damage: Role of Nrf2

Microorganisms, Journal Year: 2024, Volume and Issue: 12(6), P. 1135 - 1135

Published: June 1, 2024

The treatment and prevention of pathogenic diseases by lactic acid bacteria (LAB) has attracted more attention. As a special LAB,

Language: Английский

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Next-Generation Probiotics and Chronic Diseases: A Review of Current Research and Future Directions

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(50), P. 27679 - 27700

Published: Nov. 26, 2024

The burgeoning field of microbiome research has profoundly reshaped our comprehension human health, particularly highlighting the potential probiotics and fecal microbiota transplantation (FMT) as therapeutic interventions. While benefits traditional are well-recognized, efficacy mechanisms remain ambiguous, FMT's long-term effects still being investigated. Recent advancements in high-throughput sequencing have identified gut microbes with significant health benefits, paving way for next-generation (NGPs). These NGPs, engineered through synthetic biology bioinformatics, designed to address specific disease states enhanced stability viability. This review synthesizes current on NGP stability, challenges delivery, their applications preventing treating chronic diseases such diabetes, obesity, cardiovascular diseases. We explore physiological characteristics, safety profiles, action various strains while also addressing opportunities presented by integration into clinical practice. NGPs revolutionize microbiome-based therapies improve outcomes is immense, underscoring need further optimize ensure safety.

Language: Английский

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Revolutionizing Nanovaccines: A New Era of Immunization

Vaccines, Journal Year: 2025, Volume and Issue: 13(2), P. 126 - 126

Published: Jan. 27, 2025

Infectious diseases continue to pose a significant global health threat. To combat these challenges, innovative vaccine technologies are urgently needed. Nanoparticles (NPs) have unique properties and emerged as promising platform for developing next-generation vaccines. revolutionizing the field of development, offering new era immunization. They allow creation more effective, stable, easily deliverable Various types NPs, including lipid, polymeric, metal, virus-like particles, can be employed encapsulate deliver components, such mRNA or protein antigens. These NPs protect antigens from degradation, target them specific immune cells, enhance antigen presentation, leading robust durable responses. Additionally, simultaneously multiple antigens, adjuvants, in single formulation, simplifying production administration. Nanovaccines offer approach food- water-borne bacterial diseases, surpassing traditional formulations. Further research is needed address burden infections. This review highlights potential revolutionize platforms. We explore their mechanisms action, current applications, emerging trends. The discusses limitations nanovaccines, solutions role artificial intelligence effective accessible nanovaccines infectious diseases.

Language: Английский

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A Simplified Method for the Isolation of Extracellular Vesicles from Probiotic Bacteria and Their Characterization

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1058 - 1058

Published: Jan. 26, 2025

Probiotic bacteria are normal inhabitants of a healthy human gut, conferring multiple beneficial effects on the gut and beyond. Under various disease states, abundance diversity significantly decreased, process called dysbiosis. Among intra- extracellular components probiotics, vesicles (EVs) secreted by them have recently garnered significant attention as potential mediators probiotics’ host health. Further, these nanosized particles that encapsulate wide range bioactive molecules (proteins, lipids, RNA, DNA) standing out key factors could mediate microbiota–host communication confer ameliorating in experimental inflammatory, metabolic, cardiovascular models. However, standard protocol EV isolation from probiotic bacteria, not varying lab to lab, must be established achieve consistency results pre-clinical Our current study compared two commonly used methods for biological samples, ultracentrifugation precipitation, develop isolating EVs probiotics Lactobacillus acidophilus (LA), Gram-positive bacterium, Escherichia coli Nissle (EcN), Gram-negative bacterium. The method gave ~1.5-fold higher yield both LA EcN precipitation method. released level LA. were quantified characterized nanoparticle-tracking analysis (NTA) measuring specific surface biomarkers using Western blot. Here, we describe our standardized step-by-step their characterization.

Language: Английский

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Therapeutic Potential of Bifidobacterium longum subsp. infantis B8762 on Gut and Respiratory Health in Infant

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1323 - 1323

Published: Feb. 4, 2025

Respiratory tract and gastrointestinal infections in pediatric populations are major public health concerns. Addressing these challenges necessitates effective preventative therapeutic strategies. This study assessed the efficacy of probiotic Bifidobacterium longum subsp. infantis B8762 (0.5 × 1010 CFU) reducing duration frequency young children. In a randomized trial, 115 eligible children were assigned to either (n = 57; 3.51 ± 0.48 months old) or placebo 58; 2.78 0.51 group, with daily consumption for 4 weeks. The group demonstrated lower than (p < 0.05). also showed fewer clinical visits due respiratory problems as compared 0.009 & p 0.004, respectively). Oral swab samples revealed that had higher levels pro-inflammatory cytokine TNF-α after weeks 0.033), while balanced response, indicating modulation immune system. Genomic analysis harbors various genes synthesis proteins vitamins crucial gut Both genomic findings suggested offered effect on children, highlighting its potential managing common infections.

Language: Английский

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The Role of Probiotics in Modulating Gut Microbiota and Metabolic Health for Weight Management: A Mini Review

Deleted Journal, Journal Year: 2025, Volume and Issue: 70(1), P. 5 - 5

Published: Feb. 5, 2025

The rising global prevalence of obesity and its associated metabolic disorders highlights the urgent need for innovative, sustainable interventions. Probiotics, as modulators gut microbiota, have emerged promising agents in weight management by influencing health. This mini-review explores role probiotics modulating microbiota to support energy metabolism, appetite regulation, fat storage. Evidence underscores strain-specific benefits probiotics, such Lactobacillus gasseri SBT2055, Bifidobacterium breve B-3, Akkermansia muciniphila, reducing visceral fat, improving glucose mitigating obesity-related inflammation. mechanisms underlying these effects include short-chain fatty acid (SCFA) production, modulation appetite-regulating hormones, improvements barrier integrity. While findings are promising, variability outcomes importance tailored probiotic interventions standardized methodologies future research. By addressing challenges, can serve integral components personalized nutrition strategies, advancing both health public objectives.

Language: Английский

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