Photodynamic activity of curcumin against Candida biofilms on toothbrushes DOI
João Salviano Simões Chagas da Silva,

Maria José Barbaresco,

Maria Gabriella Fernandes Ribeiro Eliseu

et al.

Caderno Pedagógico, Journal Year: 2024, Volume and Issue: 21(9), P. e8479 - e8479

Published: Sept. 30, 2024

Oral hygiene is necessary for maintaining human health, and regular brushing recommended to control oral microbial biofilm. Toothbrushes are manufactured free of microorganisms, but after the first use they become contaminated can represent a potential source cross-contamination. Regular replacement or decontamination toothbrushes recommended. In this context, antimicrobial photodynamic therapy (aPDT) technology based on production reactive oxygen species, when light-absorbing compounds (photosensitizers) react with light oxygen. The products these reactions have activity used in dentistry biofilms. Take into account, study evaluated curcumin photoactivated 450nm LED against Candida krusei Ck7 albicans ATCC 10231 biofilms adhered toothbrushes. Curcumin without photoactivation reduced number viable cells by 77.5% 91.73%, respectively. Photoactivated biofilm C. 97.94% 98.8%. Therefore, provided powerful reduction yeasts associated may promising complementary technique conventional agents.

Language: Английский

Biofilm Resilience: Molecular Mechanisms Driving Antibiotic Resistance in Clinical Contexts DOI Creative Commons
Ahmad Almatroudi

Biology, Journal Year: 2025, Volume and Issue: 14(2), P. 165 - 165

Published: Feb. 6, 2025

Healthcare-associated infections pose a significant global health challenge, negatively impacting patient outcomes and burdening healthcare systems. A major contributing factor to healthcare-associated is the formation of biofilms, structured microbial communities encased in self-produced extracellular polymeric substance matrix. Biofilms are critical disease etiology antibiotic resistance, complicating treatment infection control efforts. Their inherent resistance mechanisms enable them withstand therapies, leading recurrent increased morbidity. This review explores development biofilms their dual roles disease. It highlights structural protective functions EPS matrix, which shields populations from immune responses antimicrobial agents. Key molecular biofilm including restricted penetration, persister cell dormancy, genetic adaptations, identified as barriers effective management. implicated various clinical contexts, chronic wounds, medical device-associated infections, oral complications, surgical site infections. prevalence hospital environments exacerbates challenges underscores urgent need for innovative preventive therapeutic strategies. evaluates cutting-edge approaches such DNase-mediated disruption, RNAIII-inhibiting peptides, DNABII proteins, bacteriophage nanoparticle-based solutions, coatings, lock therapies. also examines associated with biofilm-related diagnostic difficulties, disinfectant economic implications. emphasizes multidisciplinary approach importance understanding dynamics, role pathogenesis, advancements strategies combat biofilm-associated effectively settings. These insights aim enhance reduce burden diseases.

Language: Английский

Citations

1
Smart Microneedles in Biomedical Engineering: Harnessing Stimuli‐Responsive Polymers for Novel Applications DOI

Farangis Shahi,

Hana Afshar,

Elmuez A. Dawi

et al.

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(12)

Published: Dec. 1, 2024

ABSTRACT This review aims to provide a comprehensive analysis of recent advancements in smart microneedles (MNs) within the biomedical field, focusing on integration stimuli‐responsive polymers for enhanced therapeutic and diagnostic applications. Conventional drug delivery methods are known face limitations precision, safety, patient compliance, which can be addressed by innovative features MNs. Through use various polymers, these MNs have been designed react environmental or physiological cues, allowing on‐demand release, biomarker sensing, localized interventions. Fundamental materials used fabrication MNs, including metals, composite hydrogels, reviewed, different categories stimuli‐responsiveness, such as photo, electro, thermal, mechanical, biochemical, explored. Application‐specific designs areas delivery, cancer therapy, diabetes management, skin disease treatments also examined. this discussion, it is highlighted that poised play significant role advancing personalized noninvasive medical treatments.

Language: Английский

Citations

4
3D-printed surface coated with natural photosensitizer for photodynamic inactivation of methicillin-resistant Staphylococcus aureus using visible light DOI

Paulo Jaeder Moraes Cervi,

Manoela Laflôr Nene,

Robson Dias Wouters

et al.

Lasers in Medical Science, Journal Year: 2025, Volume and Issue: 40(1)

Published: Feb. 24, 2025

Language: Английский

Citations

0
Beyond the Swipe: A Review of Photocatalytic Antimicrobial Biocompatible Touchscreen Technology DOI
Nelson Oshogwue Etafo, Abayomi Bamisaye, Muyideen Olaitan Bamidele

et al.

Applied Materials Today, Journal Year: 2025, Volume and Issue: 44, P. 102697 - 102697

Published: March 30, 2025

Language: Английский

Citations

0
Photodynamic activity of curcumin against Candida biofilms on toothbrushes DOI
João Salviano Simões Chagas da Silva,

Maria José Barbaresco,

Maria Gabriella Fernandes Ribeiro Eliseu

et al.

Caderno Pedagógico, Journal Year: 2024, Volume and Issue: 21(9), P. e8479 - e8479

Published: Sept. 30, 2024

Oral hygiene is necessary for maintaining human health, and regular brushing recommended to control oral microbial biofilm. Toothbrushes are manufactured free of microorganisms, but after the first use they become contaminated can represent a potential source cross-contamination. Regular replacement or decontamination toothbrushes recommended. In this context, antimicrobial photodynamic therapy (aPDT) technology based on production reactive oxygen species, when light-absorbing compounds (photosensitizers) react with light oxygen. The products these reactions have activity used in dentistry biofilms. Take into account, study evaluated curcumin photoactivated 450nm LED against Candida krusei Ck7 albicans ATCC 10231 biofilms adhered toothbrushes. Curcumin without photoactivation reduced number viable cells by 77.5% 91.73%, respectively. Photoactivated biofilm C. 97.94% 98.8%. Therefore, provided powerful reduction yeasts associated may promising complementary technique conventional agents.

Language: Английский

Citations

0