Towards the sustainable discovery and development of new antibiotics

Nature Reviews Chemistry, Journal Year: 2021, Volume and Issue: 5(10), P. 726 - 749

Published: Aug. 19, 2021

An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast current level investment their development, particularly fields natural-product-derived and synthetic small molecules. New agents displaying innovative chemistry modes action are desperately needed worldwide tackle public health menace posed antimicrobial resistance. Here, our consortium presents a strategic blueprint substantially improve ability discover develop new antibiotics. We propose both short-term long-term solutions overcome most urgent limitations various sectors research funding, aiming bridge gap between academic, industrial political stakeholders, unite interdisciplinary expertise order efficiently fuel translational pipeline benefit future generations.

Language: Английский

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Antimicrobials and Antibiotic-Resistant Bacteria: A Risk to the Environment and to Public Health

Water, Journal Year: 2020, Volume and Issue: 12(12), P. 3313 - 3313

Published: Nov. 25, 2020

The release of antibiotics to the environment, and consequences presence persistent antimicrobial residues in ecosystems, have been subject numerous studies all parts world. overuse misuse is a common global phenomenon, which substantially increases levels environment rates their spread. Today, it can be said with certainty that mass production use for purposes other than medical treatment has an impact on both human health. This review aims track pathways environmental distribution antimicrobials identify biological effects subinhibitory concentration different compartments; also assesses associated public health risk government policy interventions needed ensure effectiveness existing antimicrobials. recent surge interest this issue driven by dramatic increase number infections caused drug-resistant bacteria worldwide. Our study line One Health approach.

Language: Английский

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Antibiotic Resistance: One Health One World Outlook

Frontiers in Cellular and Infection Microbiology, Journal Year: 2021, Volume and Issue: 11

Published: Nov. 25, 2021

Antibiotic resistance (ABR) is a growing public health concern worldwide, and it now regarded as critical One Health issue. Health's interconnected domains contribute to the emergence, evolution, spread of antibiotic-resistant microorganisms on local global scale, which significant risk factor for health. The persistence resistant microbial species, association determinants at human-animal-environment interface can alter genomes, resulting in superbugs various niches. ABR motivated by well-established link between three domains: human, animal, environmental As result, addressing through approach makes sense. Several countries have implemented national action plans based combat microbes, following Tripartite's Commitment Food Agriculture Organization (FAO)-World Animal (OIE)-World (WHO) guidelines. has been identified concern, efforts are being made mitigate this threat. To summarize, interdisciplinary unified approaches principles required limit dissemination cycle, raise awareness education about antibiotic use, promote policy, advocacy, antimicrobial stewardship.

Language: Английский

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Antibiotics in surface water of East and Southeast Asian countries: A focused review on contamination status, pollution sources, potential risks, and future perspectives

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 764, P. 142865 - 142865

Published: Oct. 9, 2020

Language: Английский

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Sulfonamide drugs: structure, antibacterial property, toxicity, and biophysical interactions

Biophysical Reviews, Journal Year: 2021, Volume and Issue: 13(2), P. 259 - 272

Published: March 29, 2021

Language: Английский

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Occurrence and Fate of Emerging Pollutants in Water Environment and Options for Their Removal

Water, Journal Year: 2021, Volume and Issue: 13(2), P. 181 - 181

Published: Jan. 13, 2021

Emerging pollutants (EPs) are chemicals known to cause major impacts on the terrestrial, aquatic life and human health as a result of their chronic acute toxicity. Although lots studies EPs behavior in environment currently available literature, an urgent requirement exists complete toxicological develop implement efficient ecological methods for removal. This paper raises some relevant problems related water pollution with EPs, risks they can generate humans opportunities reduce effects by Categories emerging concern environment, sources, fate impacts, examples discussed. Organic UV filters shortly presented relative new category, focus need extensive experimental environmental occurrence, Furthermore, sources resulting from discharging directly into rivers wastewater treatment plants examined. The incidence is also considered. removal solution risk mitigation addressed, emphasis several non-conventional processes involving biological EPs. provides critical look at current challenges posed presence comments recommendations further research impact improve performance developed

Language: Английский

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Antibiotic resistance: turning evolutionary principles into clinical reality

FEMS Microbiology Reviews, Journal Year: 2020, Volume and Issue: 44(2), P. 171 - 188

Published: Jan. 24, 2020

Antibiotic resistance is one of the major challenges facing modern medicine worldwide. The past few decades have witnessed rapid progress in our understanding multiple factors that affect emergence and spread antibiotic at population level individual patient. However, process translating this into health policy clinical practice has been slow. Here, we attempt to consolidate current knowledge about evolution ecology a roadmap for future research as well environmental control resistance. At level, examine emergence, transmission dissemination resistance, patient adaptation involving bacterial physiology host resilience. Finally, describe new approaches technologies improving diagnosis treatment minimizing

Language: Английский

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Mycoremediation: Expunging environmental pollutants

Biotechnology Reports, Journal Year: 2020, Volume and Issue: 26, P. e00452 - e00452

Published: April 10, 2020

The ever-increasing population, rapid rate of urbanization, and industrialization are exacerbating the pollution-related problems. Soil water pollution affect human health ecosystem. Thus, it is crucial to develop strategies combat this ever-growing problem. Mycoremediation, employing fungi or its derivatives for remediation environmental pollutants, a comparatively cost-effective, eco-friendly, effective method. It has advantages over other conventional bioremediation methods. In review, we have elucidated harmful effects common pollutants on public environment. role several in degrading these such as heavy metals, agricultural, pharmaceutical wastes, including polycyclic aromatic hydrocarbons, enumerated. Future improve efficiency mycoremediation suggested. manuscript describes which can be used future framework address global problem pollution.

Language: Английский

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Antibiofilm activity of host defence peptides: complexity provides opportunities

Nature Reviews Microbiology, Journal Year: 2021, Volume and Issue: 19(12), P. 786 - 797

Published: June 28, 2021

Language: Английский

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Fate of antibiotics and antibiotic resistance genes during conventional and additional treatment technologies in wastewater treatment plants

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 741, P. 140199 - 140199

Published: June 16, 2020

Information on the removal of antibiotics and ARGs in full-scale WWTPs (with or without additional treatment technology) is limited. However, it important to understand efficiency technologies removing under a variety conditions relevant for practice reduce their environmental spreading. Therefore, this study was performed evaluate conventional wastewater plant (WWTP A) two combined with technologies. WWTP B, activated sludge followed by an carbon filtration step (1-STEP® filter) as final step. C, using aerobic granular (NEREDA®) alternative treatment. Water were collected analysed 52 from four target antibiotic groups (macrolides, sulfonamides, quinolones, tetracyclines) (ermB, sul 1, 2 tetW) integrase gene class 1 (intI1). Despite high percentages (79–88%) total load all WWTPs, some detected various effluents. Additional technology C) showed up 99% (tetracyclines). For ARGs, C reduced 2.3 log A 2.0 log, B 1.3 log. This shows that are promising solutions reducing emissions plants. ARGS cannot be achieved types ARGs. In addition, more abundant compared effluent suggesting reservoir representing source later ARG upon reuse, i.e. fertilizer agriculture resource bioplastics bioflocculants. These aspects require further research.

Language: Английский

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