Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019

The Lancet, Journal Year: 2022, Volume and Issue: 400(10369), P. 2221 - 2248

Published: Nov. 21, 2022

Reducing the burden of death due to infection is an urgent global public health priority. Previous studies have estimated number deaths associated with drug-resistant infections and sepsis found that remain a leading cause globally. Understanding common bacterial pathogens (both susceptible resistant antimicrobials) essential identify greatest threats health. To our knowledge, this first study present comprehensive estimates 33 across 11 major infectious syndromes.

Language: Английский

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Recent advances in targeted antibacterial therapy basing on nanomaterials

Exploration, Journal Year: 2023, Volume and Issue: 3(1)

Published: Feb. 1, 2023

Bacterial infection has become one of the leading causes death worldwide, particularly in low-income countries. Despite fact that antibiotics have provided successful management bacterial infections, long-term overconsumption and abuse contributed to emergence multidrug resistant bacteria. To address this challenge, nanomaterials with intrinsic antibacterial properties or serve as drug carriers been substantially developed an alternative fight against infection. Systematically deeply understanding mechanisms is extremely important for designing new therapeutics. Recently, nanomaterials-mediated targeted bacteria depletion either a passive active manner most promising approaches treatment by increasing local concentration around cells enhance inhibitory activity reduce side effects. Passive targeting approach widely explored searching nanomaterial-based alternatives antibiotics, while strategy relies on biomimetic biomolecular surface feature can selectively recognize In review article, we summarize recent developments field therapy based nanomaterials, which will promote more innovative thinking focusing multidrug-resistant

Language: Английский

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PLSDB: advancing a comprehensive database of bacterial plasmids

Nucleic Acids Research, Journal Year: 2021, Volume and Issue: 50(D1), P. D273 - D278

Published: Oct. 22, 2021

Plasmids are known to contain genes encoding for virulence factors and antibiotic resistance mechanisms. Their relevance in metagenomic data processing is steadily growing. However, with the increasing popularity scale of metagenomics experiments, number reported plasmids rapidly growing as well, amassing a considerable false positives due undetected misassembles. Here, our previously published database PLSDB provides reliable resource researchers quickly compare their sequences against selected annotated previous findings. Within two years, size this has more than doubled from initial 13,789 now 34,513 entries over course eight regular updates. For update, we aggregated community feedback major changes featuring new analysis functionality well performance, quality, accessibility improvements. New filtering steps, annotations, preprocessing existing records improve quality provided data. Additionally, features implemented web-server ease user interaction allow deeper understanding custom uploaded sequences, by visualizing similarity information. Lastly, an application programming interface was along python library, remote queries automated workflows. The latest release freely accessible under https://www.ccb.uni-saarland.de/plsdb.

Language: Английский

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Back to Nature: Medicinal Plants as Promising Sources for Antibacterial Drugs in the Post-Antibiotic Era

Plants, Journal Year: 2023, Volume and Issue: 12(17), P. 3077 - 3077

Published: Aug. 28, 2023

Undoubtedly, the advent of antibiotics in 19th century had a substantial impact, increasing human life expectancy. However, multitude scientific investigations now indicate that we are currently experiencing phase known as post-antibiotic era. There is genuine concern might regress to time before and confront widespread outbreaks severe epidemic diseases, particularly those caused by bacterial infections. These have demonstrated epidemics thrive under environmental stressors such climate change, depletion natural resources, detrimental activities wars, conflicts, antibiotic overuse, pollution. Moreover, bacteria possess remarkable ability adapt mutate. Unfortunately, current development insufficient, future appears grim unless abandon our approach generating synthetic rapidly lose their effectiveness against multidrug-resistant bacteria. Despite vital role modern medicine, medicinal plants served primary source curative drugs since ancient times. Numerous reports published over past three decades suggest could serve promising alternative ineffective combating infectious diseases. Over few years, phenolic compounds, alkaloids, saponins, terpenoids exhibited noteworthy antibacterial potential, primarily through membrane-disruption mechanisms, protein binding, interference with intermediary metabolism, anti-quorum sensing, anti-biofilm activity. optimize utilization effective drugs, further advancements omics technologies network pharmacology will be required order identify optimal combinations among these compounds or conjunction antibiotics.

Language: Английский

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Antibiotic Discovery and Resistance: The Chase and the Race

Antibiotics, Journal Year: 2022, Volume and Issue: 11(2), P. 182 - 182

Published: Jan. 30, 2022

The history of antimicrobial resistance (AMR) evolution and the diversity environmental resistome indicate that AMR is an ancient natural phenomenon. Acquired a public health concern influenced by anthropogenic use antibiotics, leading to selection resistant genes. Data show spreading globally at different rates, outpacing all efforts mitigate this crisis. search for new antibiotic classes one key strategies in fight against AMR. Since 1980s, newly marketed antibiotics were either modifications or improvements known molecules. World Health Organization (WHO) describes current pipeline as bleak, warns about scarcity leads. A quantitative qualitative analysis pre-clinical clinical indicates few may reach market years, predominantly not those fit innovative requirements tackle challenging spread Diversity innovation are mainstays cope with rapid discovery development must address old novel antibiotics. Here, we review challenges describe leads mechanisms expected replenish pipeline, while maintaining promising possibility shift chase race between AMR, preserving effectiveness, meeting requirements.

Language: Английский

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The IUPHAR/BPS Guide to PHARMACOLOGY in 2024

Nucleic Acids Research, Journal Year: 2023, Volume and Issue: 52(D1), P. D1438 - D1449

Published: Oct. 28, 2023

Abstract The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb; https://www.guidetopharmacology.org) is an open-access, expert-curated, online database that provides succinct overviews and key references for pharmacological targets their recommended experimental ligands. It includes over 3039 protein 12 163 ligand molecules, including approved drugs, small peptides antibodies. Here, we report recent developments the resource describe expansion in content six releases made during last two years. update section of this paper focuses on areas relating important global health challenges. first, SARS-CoV-2 COVID-19, remains a major concern our efforts expand include new family coronavirus proteins. second area antimicrobial resistance, which have extended coverage antibacterials partnership with AntibioticDB, collaboration has continued through support from GARDP. We discuss other curation also focus external links resources such as PubChem bring synergies resources.

Language: Английский

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Fighting antibiotic resistance—strategies and (pre)clinical developments to find new antibacterials

EMBO Reports, Journal Year: 2022, Volume and Issue: 24(1)

Published: Dec. 19, 2022

Language: Английский

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Mechanism of Action of Ribosomally Synthesized and Post-Translationally Modified Peptides

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(18), P. 14722 - 14814

Published: Sept. 1, 2022

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural product class that has undergone significant expansion due to the rapid growth in genome sequencing data recognition they made by biosynthetic pathways share many characteristic features. Their mode of actions cover wide range biological processes include binding membranes, receptors, enzymes, lipids, RNA, metals as well use cofactors signaling molecules. This review covers currently known modes action (MOA) RiPPs. In turn, mechanisms which these molecules interact with their targets provide rich set molecular paradigms can be used for design or evolution new improved activities given relative ease engineering this review, coverage is limited RiPPs originating from bacteria.

Language: Английский

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Nanophysical Antimicrobial Strategies: A Rational Deployment of Nanomaterials and Physical Stimulations in Combating Bacterial Infections

Advanced Science, Journal Year: 2022, Volume and Issue: 9(10)

Published: Jan. 27, 2022

The emergence of bacterial resistance due to the evolution microbes under antibiotic selection pressure, and their ability form biofilm, has necessitated development alternative antimicrobial therapeutics. Physical stimulation, as a powerful method disrupt microbial structure, been widely used in food industrial sterilization. With advances nanotechnology, nanophysical strategies (NPAS) have provided unprecedented opportunities treat antibiotic-resistant infections, via combination nanomaterials physical stimulations. In this review, NPAS are categorized according modes which include mechanical, optical, magnetic, acoustic, electrical signals. biomedical applications combating infections systematically introduced, with focus on design mechanisms. Current challenges further perspectives clinical treatment also summarized discussed highlight potential use settings. authors hope that review will attract more researchers advance promising field NPAS, provide new insights for designing combat resistance.

Language: Английский

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Current Clinical Landscape and Global Potential of Bacteriophage Therapy

Viruses, Journal Year: 2023, Volume and Issue: 15(4), P. 1020 - 1020

Published: April 21, 2023

In response to the global spread of antimicrobial resistance, there is an increased demand for novel and innovative antimicrobials. Bacteriophages have been known their potential clinical utility in lysing bacteria almost a century. Social pressures concomitant introduction antibiotics mid-1900s hindered widespread adoption these naturally occurring bactericides. Recently, however, phage therapy has re-emerged as promising strategy combatting resistance. A unique mechanism action cost-effective production promotes phages ideal solution addressing antibiotic-resistant bacterial infections, particularly lower- middle-income countries. As number phage-related research labs worldwide continues grow, it will be increasingly important encourage expansion well-developed trials, standardization storage cocktails, advancement international collaboration. this review, we discuss history, benefits, limitations bacteriophage its current role setting resistance with specific focus on active trials case reports administration.

Language: Английский

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