Military Medical Research,
Journal Year:
2024,
Volume and Issue:
11(1)
Published: Jan. 23, 2024
Abstract
Antimicrobial
resistance
is
a
global
public
health
threat,
and
the
World
Health
Organization
(WHO)
has
announced
priority
list
of
most
threatening
pathogens
against
which
novel
antibiotics
need
to
be
developed.
The
discovery
introduction
are
time-consuming
expensive.
According
WHO’s
report
antibacterial
agents
in
clinical
development,
only
18
have
been
approved
since
2014.
Therefore,
critically
needed.
Artificial
intelligence
(AI)
rapidly
applied
drug
development
its
recent
technical
breakthrough
dramatically
improved
efficiency
antibiotics.
Here,
we
first
summarized
recently
marketed
antibiotics,
antibiotic
candidates
development.
In
addition,
systematically
reviewed
involvement
AI
utilization,
including
small
molecules,
antimicrobial
peptides,
phage
therapy,
essential
oils,
as
well
mechanism
prediction,
stewardship.
The Lancet,
Journal Year:
2022,
Volume and Issue:
400(10369), P. 2221 - 2248
Published: Nov. 21, 2022
Reducing
the
burden
of
death
due
to
infection
is
an
urgent
global
public
health
priority.
Previous
studies
have
estimated
number
deaths
associated
with
drug-resistant
infections
and
sepsis
found
that
remain
a
leading
cause
globally.
Understanding
common
bacterial
pathogens
(both
susceptible
resistant
antimicrobials)
essential
identify
greatest
threats
health.
To
our
knowledge,
this
first
study
present
comprehensive
estimates
33
across
11
major
infectious
syndromes.
Exploration,
Journal Year:
2023,
Volume and Issue:
3(1)
Published: Feb. 1, 2023
Bacterial
infection
has
become
one
of
the
leading
causes
death
worldwide,
particularly
in
low-income
countries.
Despite
fact
that
antibiotics
have
provided
successful
management
bacterial
infections,
long-term
overconsumption
and
abuse
contributed
to
emergence
multidrug
resistant
bacteria.
To
address
this
challenge,
nanomaterials
with
intrinsic
antibacterial
properties
or
serve
as
drug
carriers
been
substantially
developed
an
alternative
fight
against
infection.
Systematically
deeply
understanding
mechanisms
is
extremely
important
for
designing
new
therapeutics.
Recently,
nanomaterials-mediated
targeted
bacteria
depletion
either
a
passive
active
manner
most
promising
approaches
treatment
by
increasing
local
concentration
around
cells
enhance
inhibitory
activity
reduce
side
effects.
Passive
targeting
approach
widely
explored
searching
nanomaterial-based
alternatives
antibiotics,
while
strategy
relies
on
biomimetic
biomolecular
surface
feature
can
selectively
recognize
In
review
article,
we
summarize
recent
developments
field
therapy
based
nanomaterials,
which
will
promote
more
innovative
thinking
focusing
multidrug-resistant
Nucleic Acids Research,
Journal Year:
2021,
Volume and Issue:
50(D1), P. D273 - D278
Published: Oct. 22, 2021
Plasmids
are
known
to
contain
genes
encoding
for
virulence
factors
and
antibiotic
resistance
mechanisms.
Their
relevance
in
metagenomic
data
processing
is
steadily
growing.
However,
with
the
increasing
popularity
scale
of
metagenomics
experiments,
number
reported
plasmids
rapidly
growing
as
well,
amassing
a
considerable
false
positives
due
undetected
misassembles.
Here,
our
previously
published
database
PLSDB
provides
reliable
resource
researchers
quickly
compare
their
sequences
against
selected
annotated
previous
findings.
Within
two
years,
size
this
has
more
than
doubled
from
initial
13,789
now
34,513
entries
over
course
eight
regular
updates.
For
update,
we
aggregated
community
feedback
major
changes
featuring
new
analysis
functionality
well
performance,
quality,
accessibility
improvements.
New
filtering
steps,
annotations,
preprocessing
existing
records
improve
quality
provided
data.
Additionally,
features
implemented
web-server
ease
user
interaction
allow
deeper
understanding
custom
uploaded
sequences,
by
visualizing
similarity
information.
Lastly,
an
application
programming
interface
was
along
python
library,
remote
queries
automated
workflows.
The
latest
release
freely
accessible
under
https://www.ccb.uni-saarland.de/plsdb.
Plants,
Journal Year:
2023,
Volume and Issue:
12(17), P. 3077 - 3077
Published: Aug. 28, 2023
Undoubtedly,
the
advent
of
antibiotics
in
19th
century
had
a
substantial
impact,
increasing
human
life
expectancy.
However,
multitude
scientific
investigations
now
indicate
that
we
are
currently
experiencing
phase
known
as
post-antibiotic
era.
There
is
genuine
concern
might
regress
to
time
before
and
confront
widespread
outbreaks
severe
epidemic
diseases,
particularly
those
caused
by
bacterial
infections.
These
have
demonstrated
epidemics
thrive
under
environmental
stressors
such
climate
change,
depletion
natural
resources,
detrimental
activities
wars,
conflicts,
antibiotic
overuse,
pollution.
Moreover,
bacteria
possess
remarkable
ability
adapt
mutate.
Unfortunately,
current
development
insufficient,
future
appears
grim
unless
abandon
our
approach
generating
synthetic
rapidly
lose
their
effectiveness
against
multidrug-resistant
bacteria.
Despite
vital
role
modern
medicine,
medicinal
plants
served
primary
source
curative
drugs
since
ancient
times.
Numerous
reports
published
over
past
three
decades
suggest
could
serve
promising
alternative
ineffective
combating
infectious
diseases.
Over
few
years,
phenolic
compounds,
alkaloids,
saponins,
terpenoids
exhibited
noteworthy
antibacterial
potential,
primarily
through
membrane-disruption
mechanisms,
protein
binding,
interference
with
intermediary
metabolism,
anti-quorum
sensing,
anti-biofilm
activity.
optimize
utilization
effective
drugs,
further
advancements
omics
technologies
network
pharmacology
will
be
required
order
identify
optimal
combinations
among
these
compounds
or
conjunction
antibiotics.
Antibiotics,
Journal Year:
2022,
Volume and Issue:
11(2), P. 182 - 182
Published: Jan. 30, 2022
The
history
of
antimicrobial
resistance
(AMR)
evolution
and
the
diversity
environmental
resistome
indicate
that
AMR
is
an
ancient
natural
phenomenon.
Acquired
a
public
health
concern
influenced
by
anthropogenic
use
antibiotics,
leading
to
selection
resistant
genes.
Data
show
spreading
globally
at
different
rates,
outpacing
all
efforts
mitigate
this
crisis.
search
for
new
antibiotic
classes
one
key
strategies
in
fight
against
AMR.
Since
1980s,
newly
marketed
antibiotics
were
either
modifications
or
improvements
known
molecules.
World
Health
Organization
(WHO)
describes
current
pipeline
as
bleak,
warns
about
scarcity
leads.
A
quantitative
qualitative
analysis
pre-clinical
clinical
indicates
few
may
reach
market
years,
predominantly
not
those
fit
innovative
requirements
tackle
challenging
spread
Diversity
innovation
are
mainstays
cope
with
rapid
discovery
development
must
address
old
novel
antibiotics.
Here,
we
review
challenges
describe
leads
mechanisms
expected
replenish
pipeline,
while
maintaining
promising
possibility
shift
chase
race
between
AMR,
preserving
effectiveness,
meeting
requirements.
Nucleic Acids Research,
Journal Year:
2023,
Volume and Issue:
52(D1), P. D1438 - D1449
Published: Oct. 28, 2023
Abstract
The
IUPHAR/BPS
Guide
to
PHARMACOLOGY
(GtoPdb;
https://www.guidetopharmacology.org)
is
an
open-access,
expert-curated,
online
database
that
provides
succinct
overviews
and
key
references
for
pharmacological
targets
their
recommended
experimental
ligands.
It
includes
over
3039
protein
12
163
ligand
molecules,
including
approved
drugs,
small
peptides
antibodies.
Here,
we
report
recent
developments
the
resource
describe
expansion
in
content
six
releases
made
during
last
two
years.
update
section
of
this
paper
focuses
on
areas
relating
important
global
health
challenges.
first,
SARS-CoV-2
COVID-19,
remains
a
major
concern
our
efforts
expand
include
new
family
coronavirus
proteins.
second
area
antimicrobial
resistance,
which
have
extended
coverage
antibacterials
partnership
with
AntibioticDB,
collaboration
has
continued
through
support
from
GARDP.
We
discuss
other
curation
also
focus
external
links
resources
such
as
PubChem
bring
synergies
resources.
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
122(18), P. 14722 - 14814
Published: Sept. 1, 2022
Ribosomally
synthesized
and
post-translationally
modified
peptides
(RiPPs)
are
a
natural
product
class
that
has
undergone
significant
expansion
due
to
the
rapid
growth
in
genome
sequencing
data
recognition
they
made
by
biosynthetic
pathways
share
many
characteristic
features.
Their
mode
of
actions
cover
wide
range
biological
processes
include
binding
membranes,
receptors,
enzymes,
lipids,
RNA,
metals
as
well
use
cofactors
signaling
molecules.
This
review
covers
currently
known
modes
action
(MOA)
RiPPs.
In
turn,
mechanisms
which
these
molecules
interact
with
their
targets
provide
rich
set
molecular
paradigms
can
be
used
for
design
or
evolution
new
improved
activities
given
relative
ease
engineering
this
review,
coverage
is
limited
RiPPs
originating
from
bacteria.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(10)
Published: Jan. 27, 2022
The
emergence
of
bacterial
resistance
due
to
the
evolution
microbes
under
antibiotic
selection
pressure,
and
their
ability
form
biofilm,
has
necessitated
development
alternative
antimicrobial
therapeutics.
Physical
stimulation,
as
a
powerful
method
disrupt
microbial
structure,
been
widely
used
in
food
industrial
sterilization.
With
advances
nanotechnology,
nanophysical
strategies
(NPAS)
have
provided
unprecedented
opportunities
treat
antibiotic-resistant
infections,
via
combination
nanomaterials
physical
stimulations.
In
this
review,
NPAS
are
categorized
according
modes
which
include
mechanical,
optical,
magnetic,
acoustic,
electrical
signals.
biomedical
applications
combating
infections
systematically
introduced,
with
focus
on
design
mechanisms.
Current
challenges
further
perspectives
clinical
treatment
also
summarized
discussed
highlight
potential
use
settings.
authors
hope
that
review
will
attract
more
researchers
advance
promising
field
NPAS,
provide
new
insights
for
designing
combat
resistance.
Viruses,
Journal Year:
2023,
Volume and Issue:
15(4), P. 1020 - 1020
Published: April 21, 2023
In
response
to
the
global
spread
of
antimicrobial
resistance,
there
is
an
increased
demand
for
novel
and
innovative
antimicrobials.
Bacteriophages
have
been
known
their
potential
clinical
utility
in
lysing
bacteria
almost
a
century.
Social
pressures
concomitant
introduction
antibiotics
mid-1900s
hindered
widespread
adoption
these
naturally
occurring
bactericides.
Recently,
however,
phage
therapy
has
re-emerged
as
promising
strategy
combatting
resistance.
A
unique
mechanism
action
cost-effective
production
promotes
phages
ideal
solution
addressing
antibiotic-resistant
bacterial
infections,
particularly
lower-
middle-income
countries.
As
number
phage-related
research
labs
worldwide
continues
grow,
it
will
be
increasingly
important
encourage
expansion
well-developed
trials,
standardization
storage
cocktails,
advancement
international
collaboration.
this
review,
we
discuss
history,
benefits,
limitations
bacteriophage
its
current
role
setting
resistance
with
specific
focus
on
active
trials
case
reports
administration.