Microorganisms,
Journal Year:
2022,
Volume and Issue:
10(9), P. 1778 - 1778
Published: Sept. 3, 2022
The
growing
increase
in
antibiotic-resistant
bacteria
has
led
to
the
search
for
new
antibacterial
agents
capable
of
overcoming
resistance
problem.
In
recent
years,
nanoparticles
(NPs)
have
been
increasingly
used
target
as
an
alternative
antibiotics.
most
promising
nanomaterials
biomedical
applications
are
metal
and
oxide
NPs,
due
their
intrinsic
activity.
Although
NPs
show
interesting
properties,
mechanisms
underlying
action
still
poorly
understood,
limiting
use
clinical
applications.
this
review,
overview
activity
will
be
provided,
relating
efficacy
to:
(i)
bacterial
strain;
(ii)
higher
microbial
organizations
(biofilm);
(iii)
physico-chemical
properties
NPs.
addition,
strategies
also
discussed
better
evaluate
feasibility
different
treatments
adopted
safety
fields.
Finally,
a
wide
analysis
on
with
provided.
Antibiotics,
Journal Year:
2021,
Volume and Issue:
10(11), P. 1277 - 1277
Published: Oct. 20, 2021
Antimicrobial
resistance
(AMR)
is
a
global
crisis
for
human
public
health
which
threatens
the
effective
prevention
and
control
of
ever-increasing
infectious
diseases.
The
advent
pandrug-resistant
bacteria
makes
most,
if
not
all,
available
antibiotics
invalid.
Meanwhile,
pipeline
novel
development
stagnates,
prompts
scientists
pharmacists
to
develop
unconventional
antimicrobials.
Bacteriophage-derived
endolysins
are
cell
wall
hydrolases
could
hydrolyze
peptidoglycan
layer
from
within
outside
bacterial
pathogens.
With
high
specificity,
rapid
action,
efficiency,
low
risk
development,
believed
be
among
best
alternative
therapeutic
agents
treat
multidrug
resistant
(MDR)
bacteria.
As
now,
have
been
applied
diverse
aspects.
In
this
review,
we
comprehensively
introduce
structures
activities
summarize
latest
application
progress
recombinant
in
fields
medical
treatment,
pathogen
diagnosis,
food
safety,
agriculture.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(9), P. 4595 - 4595
Published: April 27, 2021
The
development
of
drug-resistant
microorganisms
has
become
a
critical
issue
for
modern
medicine
and
drug
discovery
with
severe
socio-economic
ecological
implications.
Since
standard
conventional
treatment
options
are
generally
inefficient,
leading
to
infection
persistence
spreading,
novel
strategies
fundamentally
necessary
in
order
avoid
serious
global
health
problems.
In
this
regard,
both
metal
oxide
nanoparticles
(NPs)
demonstrated
increased
effectiveness
as
nanobiocides
due
intrinsic
antimicrobial
properties
nanocarriers
drugs.
Among
them,
gold,
silver,
copper,
zinc
oxide,
titanium
magnesium
iron
NPs
the
most
preferred,
owing
their
proven
mechanisms
bio/cytocompatibility.
Furthermore,
inorganic
can
be
incorporated
or
attached
organic/inorganic
films,
thus
broadening
application
within
implant
catheter
coatings
wound
dressings.
context,
paper
aims
provide
an
up-to-date
overview
recent
studies
investigating
integration
into
composite
films
designed
therapies.
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(1), P. 111 - 111
Published: Jan. 5, 2022
Skin
is
the
largest
mechanical
barrier
against
invading
pathogens.
Following
skin
injury,
healing
process
immediately
starts
to
regenerate
damaged
tissues
and
avoid
complications
that
usually
include
colonization
by
pathogenic
bacteria,
leading
fever
sepsis,
which
further
impairs
complicates
process.
So,
there
an
urgent
need
develop
a
novel
pharmaceutical
material
promotes
of
infected
wounds.
The
present
work
aimed
prepare
evaluate
efficacy
azithromycin-loaded
zinc
oxide
nanoparticles
(AZM-ZnONPs)
in
treatment
Box-Behnken
design
response
surface
methodology
were
used
loading
efficiency
release
characteristics
prepared
NPs.
minimum
inhibitory
concentration
(MIC)
formulations
was
determined
Staphylococcus
aureus
Escherichia
coli.
Moreover,
anti-bacterial
wound-healing
activities
AZM-loaded
ZnONPs
impregnated
into
hydroxyl
propyl
methylcellulose
(HPMC)
gel
evaluated
excisional
wound
model
rats.
loaded
with
AZM
adsorption.
fully
characterized
XRD,
EDAX,
SEM,
TEM,
FT-IR
analysis.
Particle
size
distribution
for
ZnO
AZM-ZnONPs
found
be
34
39
nm,
respectively.
mechanism
adsorbed
on
best
fit
Freundlich
maximum
load
capacity
160.4
mg/g.
Anti-microbial
studies
showed
more
effective
than
other
controls.
Using
experimental
infection
rats,
HPMC
enhanced
bacterial
clearance
epidermal
regeneration,
stimulated
tissue
formation.
In
conclusion,
-loaded
are
promising
platform
rapid
Pharmaceutics,
Journal Year:
2021,
Volume and Issue:
13(12), P. 1995 - 1995
Published: Nov. 24, 2021
Antimicrobial
photodynamic
therapy
(aPDT)
has
become
a
fundamental
tool
in
modern
therapeutics,
notably
due
to
the
expanding
versatility
of
photosensitizers
(PSs)
and
numerous
possibilities
combine
aPDT
with
other
antimicrobial
treatments
combat
localized
infections.
After
revisiting
basic
principles
aPDT,
this
review
first
highlights
current
state
art
curative
or
preventive
applications
relevant
clinical
trials.
In
addition,
most
recent
developments
photochemistry
photophysics
as
well
advanced
carrier
systems
context
are
provided,
focus
on
latest
generations
efficient
versatile
PSs
progress
towards
hybrid-multicomponent
systems.
particular,
deeper
insight
into
combinatory
approaches
is
afforded,
involving
non-radiative
light-based
modalities.
Selected
perspectives
outlined,
pointing
out
new
strategies
target
treat
microorganisms.
Finally,
works
evolution
conceptually
simple
PDT
methodology
much
more
sophisticated,
integrated,
innovative
technology
an
important
element
potent
strategies.
Antibiotics,
Journal Year:
2021,
Volume and Issue:
10(5), P. 473 - 473
Published: April 21, 2021
Wounds
continue
to
be
a
serious
medical
concern
due
their
increasing
incidence
from
injuries,
surgery,
burns
and
chronic
diseases
such
as
diabetes.
Delays
in
the
healing
process
are
influenced
by
infectious
microbes,
especially
when
they
biofilm
form,
which
leads
persistent
infection.
Biofilms
well
known
for
increased
antibiotic
resistance.
Therefore,
development
of
novel
wound
dressing
drug
formulations
materials
with
combined
antibacterial,
antibiofilm
properties
required.
Nanomaterials
(NM)
have
unique
size
very
large
surface
area
that
wide
range
applications.
Several
NMs
antimicrobial
activity
regeneration
features
thus
give
them
promising
applicability
variety
types.
The
idea
NM-based
antibiotics
has
been
around
decade
at
least
there
many
recent
reviews
use
nanomaterials
antimicrobials.
However,
far
less
attention
given
exploring
if
these
actually
improve
outcomes.
In
this
review,
we
present
an
overview
different
types
explored
specifically
infection
control.
Biomedical Materials,
Journal Year:
2022,
Volume and Issue:
17(2), P. 022003 - 022003
Published: Feb. 2, 2022
Nearly
80%
of
human
chronic
infections
are
caused
due
to
bacterial
biofilm
formation.
This
is
the
most
leading
cause
for
failure
medical
implants
resulting
in
high
morbidity
and
mortality.
In
addition,
biofilms
also
known
serious
problems
food
industry.
Biofilm
impart
enhanced
antibiotic
resistance
become
recalcitrant
host
immune
responses
persistent
recurrent
infections.
It
makes
clinical
treatment
very
difficult.
Reduced
penetration
molecules
through
EPS,
mutation
target
site,
accumulation
degrading
enzymes,
expression
efflux
pump
genes
probable
causes
antibiotics
resistance.
Accordingly,
strategies
like
administration
topical
combined
therapy
with
antimicrobial
peptides
considered
alternate
options
overcome
A
number
other
remediation
both
inhibition
dispersion
established
have
been
developed.
The
metallic
nanoparticles
(NPs)
their
oxides
recently
gained
a
tremendous
thrust
as
antibiofilm
unique
features.
present
comprehensive
review
gives
understanding
mechanisms
provides
an
overview
various
currently
available
strategies,
focusing
primarily
on
applications
NPs
oxides.
Journal of Materials Chemistry B,
Journal Year:
2022,
Volume and Issue:
10(14), P. 2384 - 2429
Published: Jan. 1, 2022
The
design
of
antimicrobial
peptide-based
materials
for
biomedical
applications
such
as
fighting
infections
in
various
organs,
cancer
therapy,
gene
delivery
and
detection
bacteria.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(29)
Published: Aug. 28, 2022
Due
to
the
continuous
rise
in
biofilm-related
infections,
biofilms
seriously
threaten
human
health.
The
formation
of
makes
conventional
antibiotics
ineffective
and
dampens
immune
clearance.
Therefore,
it
is
important
understand
mechanisms
biofilm
develop
novel
strategies
treat
more
effectively.
This
review
article
begins
with
an
introduction
various
clinical
scenarios
their
corresponding
therapy.
Established
models
used
research
are
then
summarized.
potential
targets
which
may
assist
development
new
for
combating
further
discussed.
technologies
developed
recently
prevention
treatment
including
antimicrobial
surface
coatings,
physical
removal
biofilms,
molecules,
delivery
agents
subsequently
presented.
Finally,
directions
future
studies
pointed
out.
