Nanomaterials and nanomaterials-based drug delivery to promote cutaneous wound healing

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 193, P. 114670 - 114670

Published: Dec. 17, 2022

Language: Английский

---

Influence of the Alcohols on the ZnO Synthesis and Its Properties: The Photocatalytic and Antimicrobial Activities

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(12), P. 2842 - 2842

Published: Dec. 18, 2022

Zinc oxide (ZnO) nanomaterials are used in various health-related applications, from antimicrobial textiles to wound dressing composites and sunscreens packaging. Purity, surface defects, size, morphology of the nanoparticles main factors that influence properties. In this study, we comparing properties ZnO obtained by solvolysis using a series alcohols: primary methanol 1-hexanol, secondary (2-propanol 2-butanol), tertiary (tert-butanol). While synthesis is successfully accomplished all alcohols, use or alcohols does not lead as final product, underlining importance solvent. The shape depends on alcohol used, quasi-spherical rods, consequently, different reported, including photocatalytic activities. 1-butanol exhibited best performance against methylene blue (MB) dye solution, attaining degradation efficiency 98.24%. comparative study among usual model dyes revealed triarylmethane less susceptible photo-degradation. present strong activity broad range microorganisms (bacterial fungal strains), size being important factors. This permits further tailoring for medical applications.

Language: Английский

---

Antibacterial Activity of Solvothermal Obtained ZnO Nanoparticles with Different Morphology and Photocatalytic Activity against a Dye Mixture: Methylene Blue, Rhodamine B and Methyl Orange

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5677 - 5677

Published: March 16, 2023

In this paper, we report the synthesis of ZnO nanoparticles (NPs) by forced solvolysis Zn(CH3COO)2·2H2O in alcohols with a different number -OH groups. We study influence alcohol type (n-butanol, ethylene glycol and glycerin) on size, morphology, properties obtained NPs. The smallest polyhedral NPs (<30 nm) were n-butanol, while measured average 44 nm rounded. Polycrystalline particles 120 glycerin only after water refluxing. addition, here, photocatalytic activity, against dye mixture, three model pollutants: methyl orange (MO), methylene blue (MB), rhodamine B (RhB), closer to real situations where is polluted many chemicals. All samples exhibited good activity degradation efficiency reaching 99.99%. sample maintained high >90%, over five catalytic cycles. Antibacterial tests conducted Gram-negative strains Salmonella enterica serovar Typhimurium, Pseudomonas aeruginosa, Escherichia coli, Gram-positive Enterococcus faecalis, Bacillus subtilis, Staphylococcus aureus, cereus. presented strong inhibition planktonic growth for all tested strains, indicating that they can be used antibacterial applications, such as purification.

Language: Английский

---

Spotlight on therapeutic efficiency of green synthesis metals and their oxide nanoparticles in periodontitis

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 5, 2024

Abstract Periodontitis, one of the most prevalent dental diseases, causes loss bone and gum tissue that hold teeth in place. Several bacteria, commonly present clinically healthy oral cavities, may induce perpetuate periodontitis when their concentration rises gingival sulcus. Antibacterial effect against various Gram-negative Gram-positive including pathogenic drug-resistant ones, has been shown for several distinct transient metal oxide NPs. Therefore, NPs be used biomedicine to treat periodontal problems nanotechnology inhibit development microorganisms. Instead using harmful chemicals or energy-intensive machinery, biosynthesis nanoparticles (NPs) suggested. To produce NPs, ideal technique is “Green” synthesis because its low toxicity safety human health environment. Gold (AuNPs) appear less toxic mammalian cells than other nanometals antibacterial activity not dependent on reactive oxygen species (ROS). AgNPs also possess chemical stability, catalytic activity, superior electrical thermal conductivity, name a few advantageous characteristics. It was observed zinc (ZnO) copper (Cu) exhibited discernible inhibitory effects gram-positive gram-negative bacterial strains, respectively. ZnO demonstrated bactericidal microorganisms responsible periodontitis. Medications containing magnetic are highly effective multidrug-resistant fungal infections. The titanium dioxide (TiO 2 ) implicated elevating salivary peroxidase individuals diagnosed with chronic Furthermore, specific metallic have potential enhance antimicrobial efficacy treatments combined. these as well only some metals oxides synthesized environmentally friendly ways therapeutic benefits Graphical

Language: Английский

---

Antimicrobial Compounds in Food Packaging

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2457 - 2457

Published: Jan. 27, 2023

This review presents current knowledge on antimicrobial agents that are already used in the food packaging industry. At beginning, innovative ways of were discussed, including how smart differs from active packaging, and what functions they perform. Next, focus was one groups bioactive components these namely agents. Among agents, we selected those have been promise to be elsewhere, e.g., production biomaterials. Main (i.e., metals metal oxides, organic acids, peptides bacteriocins, plant origin, enzymes, lactoferrin, chitosan, allyl isothiocyanate, reuterin system bacteriophages) incorporated or combined with various types materials extend shelf life described. The further development perspectives setting new research directions also presented.

Language: Английский

---

Metal Nanoparticles to Combat Candida albicans Infections: An Update

Microorganisms, Journal Year: 2023, Volume and Issue: 11(1), P. 138 - 138

Published: Jan. 5, 2023

Candidiasis is an opportunistic mycosis with high annual incidence worldwide. In these infections, Candida albicans the chief pathogen owing to its multiple virulence factors. C. infections are usually treated azoles, polyenes and echinocandins. However, antifungals may have limitations regarding toxicity, relapse of cost, emergence antifungal resistance. Thus, development nanocarrier systems, such as metal nanoparticles, has been widely investigated. Metal nanoparticles particulate dispersions or solid particles 10–100 nm in size, unique physical chemical properties that make them useful biomedical applications. this review, we focus on activity silver, gold, iron against albicans. We discuss use delivery vehicles for drugs natural compounds increase their biocompatibility effectiveness. Promisingly, most exhibit potential through multi-target mechanisms cells biofilms, which can minimize The cytotoxicity a concern, adjustments synthesis approaches coating techniques addressed overcome limitations, great emphasis green synthesis.

Language: Английский

---

Nanomaterials-Based Wound Dressing for Advanced Management of Infected Wound

Antibiotics, Journal Year: 2023, Volume and Issue: 12(2), P. 351 - 351

Published: Feb. 8, 2023

The effective prevention and treatment of bacterial infections is imperative to wound repair the improvement patient outcomes. In recent years, nanomaterials have been extensively applied in infection control healing due their special physiochemical biological properties. Incorporating antibacterial into dressing has associated with improved biosafety enhanced outcomes compared naked nanomaterials. this review, we discuss progress application nanomaterial-based dressings for advanced management infected wounds. Focus given therapy as well all-in-one detection infections. Notably, highlight use nanoparticles intrinsic performances, such metals metal oxide that are capable killing bacteria reducing drug-resistance through multiple antimicrobial mechanisms. addition, proven be ideal drug carriers delivery release antimicrobials either passive or stimuli-responsive manners. ability kill based on photo-triggered heat (photothermal therapy) ROS (photodynamic therapy), unparalleled advantages control. Moreover, examples intelligent can detect in-situ while providing timely Finally, challenges current provide further perspectives future healing.

Language: Английский

---

Oxidative stress and potential effects of metal nanoparticles: A review of biocompatibility and toxicity concerns

Environmental Pollution, Journal Year: 2024, Volume and Issue: 346, P. 123617 - 123617

Published: Feb. 21, 2024

Language: Английский

---

Bone Tissue Engineering and Nanotechnology: A Promising Combination for Bone Regeneration

Biology, Journal Year: 2024, Volume and Issue: 13(4), P. 237 - 237

Published: April 2, 2024

Large bone defects are the leading contributor to disability worldwide, affecting approximately 1.71 billion people. Conventional graft treatments show several disadvantages that negatively impact their therapeutic outcomes and limit clinical practice. Therefore, much effort has been made devise new more effective approaches. In this context, tissue engineering (BTE), involving use of biomaterials which able mimic natural architecture bone, emerged as a key strategy for regeneration large defects. However, although different types have developed investigated, date, none them completely fulfill requirements an ideal implantable material. in recent years, field nanotechnology application nanomaterials regenerative medicine gained significant attention from researchers. Nanotechnology revolutionized BTE due possibility generating nanoengineered particles overcome current limitations strategies, including reduced cell proliferation differentiation, inadequate mechanical strength biomaterials, poor production extrinsic factors necessary efficient osteogenesis. review, we report on latest vitro vivo studies BTE, focusing effects nanoparticles properties cells regeneration.

Language: Английский

---

Metal nanoparticle hybrid hydrogels: the state-of-the-art of combining hard and soft materials to promote wound healing

Theranostics, Journal Year: 2024, Volume and Issue: 14(4), P. 1534 - 1560

Published: Jan. 1, 2024

Wounds represent a grave affliction that profoundly impacts human well-being.Establishing barriers, preventing infections, and providing conducive microenvironment constitute the crux of wound therapy.Hydrogel, polymer with an intricate three-dimensional lattice, serves as potent tool in erecting physical barriers nurturing environment to healing.This enables effective control over exudation, hemostasis, accelerated closure, diminished scar formation.As result, hydrogels have gained extensive traction realm treatment.Metallic nanoparticle carriers, characterized by their multifaceted responses encompassing acoustics, optics, electronics, demonstrated efficacy management.Nevertheless, these carriers encounter challenges associated swift clearance nonuniform effectiveness.The hybridization metallic overcomes shortcomings inherent nanoparticle-based therapy.This amalgamation not only addresses limitations but also augments mechanical robustness hydrogels.It confers upon them attributes such environmental responsiveness multifunctionality, thereby synergizing strengths compensating for weaknesses.This integration culminates precise intelligent management wounds.This review encapsulates structural classifications, design strategies, therapeutic applications, underlying mechanisms metal hybrid context acute chronic treatment.The discourse delves into generation novel or enhanced arising from how current paradigm therapy leverages attributes.Amidst this continually evolving frontier, potential revolutionize treatment is underscored.

Language: Английский

---