Metabolites,
Journal Year:
2021,
Volume and Issue:
11(3), P. 151 - 151
Published: March 7, 2021
Dynamic
changes
in
circulating
and
tissue
metabolites
lipids
occur
response
to
exercise-induced
cellular
whole-body
energy
demands
maintain
metabolic
homeostasis.
The
metabolome
lipidome
a
given
biological
system
provides
molecular
snapshot
of
these
rapid
complex
perturbations.
application
metabolomics
lipidomics
map
the
responses
an
acute
bout
aerobic/endurance
or
resistance
exercise
has
dramatically
expanded
over
past
decade
thanks
major
analytical
advancements,
with
most
exercise-related
studies
date
focused
on
analyzing
human
biofluids
tissues.
Experimental
considerations,
as
well
complementary
using
animal
model
systems,
are
warranted
help
overcome
challenges
associated
large
interindividual
variability
decipher
breadth
mechanisms
underlying
health-promoting
effects
exercise.
In
this
review,
we
provide
guide
for
researchers
regarding
techniques
experimental
workflows
commonly
used
lipidomics.
Furthermore,
discuss
advancements
mammalian
research
utilizing
metabolomic
lipidomic
approaches
last
decade,
highlight
key
technical
considerations
remaining
knowledge
gaps
continue
expanding
landscape
biology.
Frontiers in Molecular Neuroscience,
Journal Year:
2018,
Volume and Issue:
11
Published: Jan. 23, 2018
Lipids
are
a
fundamental
class
of
organic
molecules
implicated
in
wide
range
biological
processes
related
to
their
structural
diversity,
and
based
on
this
can
be
broadly
classified
into
five
categories;
fatty
acids,
triacylglycerols
(TAGs),
phospholipids,
sterol
lipids
sphingolipids.
Different
lipid
classes
play
major
roles
neuronal
cell
populations;
they
used
as
energy
substrates,
act
building
blocks
for
cellular
machinery,
serve
bioactive
molecules,
or
combination
each.
In
amyotrophic
lateral
sclerosis
(ALS),
dysfunctions
metabolism
function
have
been
identified
potential
drivers
pathogenesis.
particular,
aberrant
is
proposed
underlie
denervation
neuromuscular
junctions,
mitochondrial
dysfunction,
excitotoxicity,
impaired
transport,
cytoskeletal
defects,
inflammation
reduced
neurotransmitter
release.
Here
we
review
current
knowledge
the
CNS
discuss
how
modulating
these
pathways
may
offer
novel
therapeutic
options
treating
ALS.
Scientific Reports,
Journal Year:
2017,
Volume and Issue:
7(1)
Published: April 11, 2017
Abstract
Wide-scale
profiling
technologies
including
metabolomics
broaden
the
possibility
of
novel
discoveries
related
to
pathogenesis
type
2
diabetes
(T2D).
By
applying
non-targeted
approach,
we
investigated
here
whether
serum
metabolite
profile
predicts
T2D
in
a
well-characterized
study
population
with
impaired
glucose
tolerance
by
examining
two
groups
individuals
who
took
part
Finnish
Diabetes
Prevention
Study
(DPS);
those
either
early
developed
(n
=
96)
or
did
not
convert
within
15-year
follow-up
104).
Several
metabolites
were
associated
lower
likelihood
developing
T2D,
indole
and
lipid
metabolites.
Higher
indolepropionic
acid
was
reduced
DPS.
Interestingly,
remained
free
various
species
better
insulin
secretion
sensitivity,
respectively.
Furthermore,
these
negatively
correlated
low-grade
inflammation.
We
replicated
association
between
risk
one
Swedish
population.
suggest
that
acid,
gut
microbiota-produced
metabolite,
is
potential
biomarker
for
development
may
mediate
its
protective
effect
preservation
β-cell
function.
Novel
exert
their
effects
partly
through
enhancing
sensitivity.
Disease Markers,
Journal Year:
2015,
Volume and Issue:
2015, P. 1 - 18
Published: Jan. 1, 2015
Gamma-glutamyltransferase
(GGT)
is
a
well-established
serum
marker
for
alcohol-related
liver
disease.
However,
GGT’s
predictive
utility
applies
well
beyond
disease:
elevated
GGT
linked
to
increased
risk
multitude
of
diseases
and
conditions,
including
cardiovascular
disease,
diabetes,
metabolic
syndrome
(MetS),
all-cause
mortality.
The
literature
from
multiple
population
groups
worldwide
consistently
shows
strong
power
GGT,
even
across
different
gender
ethnic
categories.
Here,
we
examine
the
relationship
other
markers
such
as
ferritin
(SF)
levels,
suggest
link
exposure
environmental
endogenous
toxins,
resulting
in
oxidative
nitrosative
stress.
We
observe
general
upward
trend
levels
over
time,
particularly
US
Korea.
Since
late
1970s,
both
incident
MetS
its
related
disorders
have
risen
virtual
lockstep.
an
early
atherosclerosis,
heart
failure,
arterial
stiffness
plaque,
gestational
various
diseases,
viral
hepatitis,
infectious
several
life-threatening
cancers.
review
medical
sciences
life
insurance
industries
demonstrating
that
superior
future
disease
risk,
when
compared
against
known
mortality
factors.
Plant Cell & Environment,
Journal Year:
2015,
Volume and Issue:
39(4), P. 787 - 803
Published: Oct. 5, 2015
Abstract
Understanding
how
wheat
(
Triticum
aestivum
L.)
plants
under
high
temperature
(HT)
regulate
lipid
composition
is
critical
to
developing
climate‐resilient
varieties.
We
measured
165
glycerolipids
and
sterol
derivatives
optimum
day
night
temperatures
in
leaves
using
electrospray
ionization‐tandem
mass
spectrometry.
Levels
of
polar
fatty
acyl
chain
unsaturation
were
lower
both
heat‐tolerant
genotype
Ventnor
susceptible
Karl
92
HT,
compared
with
temperature.
The
was
predominantly
because
levels
18:3
chains
higher
18:1
16:0
chains.
18:3‐containing
triacylglycerols
increased
threefold/more
consistent
their
possible
role
sequestering
acids
during
membrane
remodelling.
Phospholipids
containing
odd‐numbered
or
oxidized
accumulated
HT.
Sterol
glycosides
(SG)
16:0‐acylated
(ASG)
HT
than
temperatures.
had
amounts
phospholipids
SG
16:0‐ASG
92.
Taken
together,
the
data
demonstrate
that
leaf
altered
by
which
some
lipids
are
particularly
responsive
two
genotypes,
chosen
for
differing
physiological
responses
differ
profile
Journal of the American Society for Mass Spectrometry,
Journal Year:
2017,
Volume and Issue:
28(5), P. 908 - 917
Published: March 6, 2017
Untargeted
omics
analyses
aim
to
comprehensively
characterize
biomolecules
within
a
biological
system.
Changes
in
the
presence
or
quantity
of
these
can
indicate
important
perturbations,
such
as
those
caused
by
disease.
With
current
technological
advancements,
entire
genome
now
be
sequenced;
however,
burgeoning
fields
lipidomics,
only
subset
lipids
identified.
The
recent
emergence
high
resolution
tandem
mass
spectrometry
(HR-MS/MS),
combination
with
ultra-high
performance
liquid
chromatography,
has
resulted
an
increased
coverage
lipidome.
Nevertheless,
identifications
from
MS/MS
are
generally
limited
number
precursors
that
selected
for
fragmentation
during
chromatographic
elution.
Therefore,
we
developed
software
IE-Omics
automate
iterative
exclusion
(IE),
where
using
data-dependent
topN
excluded
sequential
injections.
In
each
injection,
unique
fragmented
until
HR-MS/MS
spectra
all
ions
above
user-defined
intensity
threshold
acquired.
was
applied
lipidomic
Red
Cross
plasma
and
substantia
nigra
tissue.
Coverage
lipidome
drastically
improved
IE.
When
applying
lipid
extracts
positive
ion
mode,
69%
40%
more
molecular
were
obtained,
respectively.
addition,
lipidomics
workflow
trace
species,
including
odd-chained
short-chained
diacylglycerides
oxidized
species.
By
increasing
lipidome,
IE
increases
probability
finding
biomarkers
provides
additional
information
determining
etiology
Nature Communications,
Journal Year:
2018,
Volume and Issue:
9(1)
Published: Feb. 12, 2018
Gut
microbiota
dysbiosis
and
metabolic
dysfunction
in
infancy
precedes
childhood
atopy
asthma
development.
Here
we
examined
gut
maturation
over
the
first
year
of
life
infants
at
high
risk
for
(HR),
whether
it
is
modifiable
by
early-life
Lactobacillus
supplementation.
We
performed
a
longitudinal
comparison
stool
samples
collected
from
HR
randomized
to
daily
oral
rhamnosus
GG
(HRLGG)
or
placebo
(HRP)
6
months,
healthy
(HC)
infants.
Meconium
HRP
participants
distinct,
follows
delayed
developmental
trajectory,
primarily
glycolytic
depleted
range
anti-inflammatory
lipids
months
age.
These
deficits
are
partly
rescued
HRLGG
infants,
but
this
effect
was
lost
12
age,
after
cessation
Thus
show
that
microbial
development
plastic,
Our
findings
offer
novel
strategy
preventative
interventions.
