Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science

Cancer Medicine, Journal Year: 2019, Volume and Issue: 8(5), P. 1958 - 1975

Published: April 3, 2019

Traditional Chinese medicine (TCM) has been practiced for thousands of years and at the present time is widely accepted as an alternative treatment cancer. In this review, we sought to summarize molecular cellular mechanisms underlying chemopreventive therapeutic activity TCM, especially that herbal medicine-derived phytochemicals curcumin, resveratrol, berberine. Numerous genes have reported be involved when using TCM treatments so selectively highlighted role a number oncogene tumor suppressor in therapy. addition, impact on DNA methylation, histone modification, regulation noncoding RNAs discussed. Furthermore, studies therapy modulate microenvironment eliminate cancer stem cells. The information compiled review will serve solid foundation formulate hypotheses future TCM-based

Language: Английский

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Worldwide Research Trends on Medicinal Plants

International Journal of Environmental Research and Public Health, Journal Year: 2020, Volume and Issue: 17(10), P. 3376 - 3376

Published: May 12, 2020

The use of medicinal plants has been done since ancient times and may even be considered the origin modern medicine. Compounds plant have still are an important source compounds for drugs. In this study a bibliometric all works indexed in Scopus database until 2019 carried out, analyzing more than 100,000 publications. On one hand, main countries, institutions authors researching topic identified, as well their evolution over time. other links between authors, countries topics under research analyzed through detection communities. last two periods, from 2009 to 2014 2015 2019, examined terms topics. It observed that areas or clusters reduced, those period being engaged unclassified drug, traditional medicine, cancer, vivo study-antidiabetic activity, animals-anti-inflammatory activity. summary, it trend global is focused on search new medicines active rather cultivation domestication species with demonstrated potential.

Language: Английский

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Cellular and molecular mechanisms of curcumin in prevention and treatment of disease

Critical Reviews in Food Science and Nutrition, Journal Year: 2019, Volume and Issue: 60(6), P. 887 - 939

Published: Jan. 11, 2019

Curcumin is a naturally occurring polyphenolic compound present in rhizome of Curcuma longa belonging to the family zingiberaceae. Growing experimental evidence revealed that curcumin exhibit multitarget biological implications signifying its crucial role health and disease. The current review highlights recent progress mechanisms underlying wide range pharmacological effects against numerous diseases like neuronal, cardiovascular, metabolic, kidney, endocrine, skin, respiratory, infectious, gastrointestinal cancer. ability modulate functions multiple signal transductions are linked with attenuation acute chronic diseases. Numerous preclinical clinical studies have modulates several molecules cell transduction pathway including PI3K, Akt, mTOR, ERK5, AP-1, TGF-β, Wnt, β-catenin, Shh, PAK1, Rac1, STAT3, PPARγ, EBPα, NLRP3 inflammasome, p38MAPK, Nrf2, Notch-1, AMPK, TLR-4 MyD-88. has potential prevent and/or manage various due anti-inflammatory, anti-oxidant anti-apoptotic properties an excellent safety profile. In contrast, anti-cancer reflected induction growth arrest apoptosis premalignant malignant cells. This also carefully emphasized pharmacokinetics interaction other drugs. Clinical shown safe at doses 12 g/day but exhibits poor systemic bioavailability. use adjuvant piperine, liposomal curcumin, nanoparticles phospholipid complex enhanced bioavailability therapeutic potential. Further warranted prove ailments.

Language: Английский

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Immune modulation by curcumin: The role of interleukin-10

Critical Reviews in Food Science and Nutrition, Journal Year: 2017, Volume and Issue: 59(1), P. 89 - 101

Published: Aug. 11, 2017

Cytokines are small secreted proteins released by different types of cells with specific effects on cellular signaling and communication via binding to their receptors the cell surface. IL-10 is known be a pleiotropic potent anti-inflammatory immunosuppressive cytokine that produced both innate adaptive immunity including dendritic cells, macrophages, mast natural killer eosinophils, neutrophils, B CD8+ T TH1, TH2, TH17 regulatory cells. Both direct indirect activation stress axis promotes secretion. deregulation plays role in development large number inflammatory diseases such as neuropathic pain, Parkinson's disease, Alzheimer's osteoarthritis, rheumatoid arthritis, psoriasis, systemic lupus erythematosus, type 1 diabetes, bowel allergy. Curcumin compound able induce expression production enhancing its action tissues. In vitro pre-clinical models curcumin modulate disease pathophysiology conditions pain neurodegenerative diseases, inflammation, allergy, but also infections cancer through effect humans, at least one part positive health could related ability enhance -mediated effects.

Language: Английский

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Curcumin as a functional food-derived factor: degradation products, metabolites, bioactivity, and future perspectives

Food & Function, Journal Year: 2017, Volume and Issue: 9(2), P. 705 - 714

Published: Nov. 23, 2017

Curcumin is a polyphenol found in turmeric (Curcuma longa), used as spice, food coloring, and traditional herbal medicine. It has been shown that curcumin health benefits such antioxidant, anti-inflammatory, anticancer properties, improvement of brain function, control obesity diabetes. However, native easily degrades low oral bioavailability, recent report expressed doubt about curcumin's various effects. To overcome its formulations with enhanced bioavailability are currently being developed. This review discusses the chemistry, metabolism, absorption curcumin, to which reported have ascribed, well degradation products metabolites their possible functions. Moreover, research trend towards obesity- diabetes-preventing/suppressing aspects latest case studies on highly water-dispersible bioavailable will be discussed. We summarize challenges concerning follows: clarifying relationship between formation curcumin-derived oxidation metabolites, determining whether itself or other components responsible for effects, conducting further human trials multiple groups employ same samples conditions. High-bioavailability would useful future studies.

Language: Английский

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PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: April 15, 2021

Alzheimer’s disease (AD) and Parkinson’s (PD) are two typical neurodegenerative diseases that increased with aging. With the emergence of aging population, health problem economic burden caused by also increase. Phosphatidylinositol 3-kinases/protein kinase B (PI3K/AKT) signaling pathway regulates signal transduction biological processes such as cell proliferation, apoptosis metabolism. According to reports, it neurotoxicity mediates survival neurons through different substrates forkhead box protein Os (FoxOs), glycogen synthase kinase-3β (GSK-3β), caspase-9. Accumulating evidences indicate some natural products can play a neuroprotective role activating PI3K/AKT pathway, providing an effective resource for discovery potential therapeutic drugs. This article reviews relationship between AKT AD PD, discusses based on treat in recent years, hoping provide guidance reference this field. Further development Chinese herbal medicine is needed these diseases.

Language: Английский

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Clinical effects of curcumin in enhancing cancer therapy: A systematic review

BMC Cancer, Journal Year: 2020, Volume and Issue: 20(1)

Published: Aug. 24, 2020

Abstract Background Curcumin is herbal compound that has been shown to have anti-cancer effects in pre-clinical and clinical studies. The of curcumin include inhibiting the carcinogenesis, angiogenesis, tumour growth. This study aims determine Clinical different types cancers using systematic review approach. Methods A methodology adopted for undertaking detailed analysis cancer therapy. results presented this paper an outcome extracting findings studies selected from articles published international databases including SID, MagIran, IranMedex, IranDoc, Google Scholar, ScienceDirect, Scopus, PubMed Web Science (ISI). These were thoroughly searched, relevant publications based on plausible keywords, accordance with aims, as follows: prevalence, curcumin, features, cancer. Results are derived several consumption chemotherapy drugs, highlighting increases effectiveness radiotherapy which improving patient’s survival time, increasing expression anti-metastatic proteins along reducing their side effects. Conclusion comprehensive confirms reduces or radiotherapy, resulting patients’ quality life. number reported that, increased patient time decreased tumor markers’ level.

Language: Английский

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Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Current Progress, Challenges, and Perspectives

Nutrients, Journal Year: 2018, Volume and Issue: 10(10), P. 1553 - 1553

Published: Oct. 19, 2018

Curcumin is a principal curcuminoid of turmeric (Curcuma longa), which commonly used as spice in cooking and yellow pigment the food processing industry. Recent studies have demonstrated that curcumin has variety biological activities pharmacological performances, providing protection promotion human health. In addition to presenting an overview gut metabolism curcumin, this paper reviews current research progress on its versatile bioactivity, such antioxidant, anti-inflammatory, immune-regulatory activities, also intensively discusses health benefits, including protective or preventive effects cancers diabetes, well liver, nervous system, cardiovascular systems, highlighting potential molecular mechanisms. Besides, beneficial are further stated based clinical trials. Considering there still debate we discuss related challenges prospects. Overall, promising ingredient novel functional foods, with efficacy preventing certain diseases. We hope comprehensive updated review will be helpful for promoting human-based facilitate use diseases future.

Language: Английский

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Highly Bioavailable Forms of Curcumin and Promising Avenues for Curcumin-Based Research and Application: A Review

Molecules, Journal Year: 2020, Volume and Issue: 25(6), P. 1397 - 1397

Published: March 19, 2020

Curcumin exerts a wide range of beneficial physiological and pharmacological activities, including antioxidant, anti-amyloid, anti-inflammatory, anti-microbial, anti-neoplastic, immune-modulating, metabolism regulating, anti-depressant, neuroprotective tissue protective effects. However, its poor solubility absorption in the free form gastrointestinal tract rapid biotransformation to inactive metabolites greatly limit utility as health-promoting agent dietary supplement. Recent advances micro- nano-formulations curcumin with enhanced resulting desirable blood levels active forms now make it possible address potential applications, pain management, protective. Using these highly bioavailable enable broad spectrum appropriate studies be conducted. This review discusses formulations designed enhance bioavailability, curcumin, relationships between particle size relative human pharmacokinetic involving formulated products, widely used but inappropriate practice hydrolyzing plasma samples for quantification current applications promising directions health maintenance applications.

Language: Английский

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The Problem of Curcumin and Its Bioavailability: Could Its Gastrointestinal Influence Contribute to Its Overall Health-Enhancing Effects?

Advances in Nutrition, Journal Year: 2018, Volume and Issue: 9(1), P. 41 - 50

Published: Jan. 1, 2018

Language: Английский

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