Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel

Nutrition Reviews, Journal Year: 2017, Volume and Issue: 75(9), P. 731 - 767

Published: Aug. 3, 2017

In recent years, there has been growing interest in the possible use of nutraceuticals to improve and optimize dyslipidemia control therapy. Based on data from available studies, might help patients obtain theraputic lipid goals reduce cardiovascular residual risk. Some have essential lipid-lowering properties confirmed studies; some also positive effects nonlipid risk factors shown early markers vascular health such as endothelial function pulse wave velocity. However, clinical evidence supporting a single nutraceutical or combination them is largely variable and, for many nutraceuticals, very limited therefore, often debatable. The purpose this position paper provide consensus-based recommendations optimal manage who are still not statin therapy, therapy but achieved goals, with intolerance. This statement intended physicians other healthcare professionals engaged diagnosis management disorders, especially primary care setting.

Language: Английский

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Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review

Neuroscience, Journal Year: 2019, Volume and Issue: 406, P. 1 - 21

Published: Feb. 28, 2019

Language: Английский

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Smart edible films based on gelatin and curcumin

Food Hydrocolloids, Journal Year: 2016, Volume and Issue: 66, P. 8 - 15

Published: Nov. 9, 2016

Language: Английский

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Lipid lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel

Archives of Medical Science, Journal Year: 2017, Volume and Issue: 5, P. 965 - 1005

Published: Jan. 1, 2017

1.1. Cardiovascular disease and dyslipidemia: prevalence global economic impact Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, reaching 31% deaths in 2012 [1]. In particular, atherosclerosis ischemic heart (IHD) main causes premature death Europe responsible for 42% women 38% men under 75 years old [2]. The impact CVD is estimated to have been US $906 billion 2015 expected rise by 22% 2030 [3]. also represent major disability developed countries. It has that their growing burden could lead a increase loss disability-adjusted life (DALYs), from 85 million DALYs 1990 ~150 2020, becoming non-psychological lost productivity [4]. Several risk factors contribute etiology development CVD; they divided into those modifiable through lifestyle changes or taking pharmacologic treatment (e.g. hypertension, smoking, diabetes mellitus, hypercholesterolemia) not (age, male gender, family history) [5]. Elevated total cholesterol (TC) low-density lipoprotein (LDL-C) blood concentrations coronary (CHD), whereas high plasma high-density (HDL-C) certain conditions considered protective [6]. Moreover, LDL-C remains fundamental CV factor (and target therapy) even when statins largely used general population [7]. An examination data 18 053 participants aged ≥ 20 who participated National Health Nutrition Examination Surveys (NHANES) 1999 2006 showed unadjusted hypercholesterolemia ranged 53.2% 56.1% United States adults [8]. Differences related gender race ethnicity were observed; lower rate control was found among than rates having check being told about reported African Americans Mexican whites [8]. A recent report American Heart Association confirmed only 75.7% children 46.6% present targeted TC levels (TC < 170 mg/dl 200 adults, untreated individuals) [9]. pattern similar other Western countries [10, 11].

Language: Английский

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Cellular Red-Ox system in health and disease: The latest update

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114606 - 114606

Published: March 28, 2023

Cells are continually exposed to reactive oxygen species (ROS) generated during cellular metabolism. Apoptosis, necrosis, and autophagy biological processes involving a feedback cycle that causes ROS molecules induce oxidative stress. To adapt exposure, living cells develop various defense mechanisms neutralize use as signaling molecule. The redox networks combine pathways regulate cell metabolism, energy, survival, death. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) essential antioxidant enzymes required for scavenging in compartments response stressful situations. Among the non-enzymatic defenses, vitamin C, (GSH), polyphenols, carotenoids, E, etc., also essential. This review article describes how produced byproducts of oxidation/reduction (redox) antioxidants system is directly or indirectly engaged ROS. In addition, we used computational methods determine comparative profile binding energies several with enzymes. analysis demonstrates high affinity their structures.

Language: Английский

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Antioxidant Potential of Curcumin—A Meta-Analysis of Randomized Clinical Trials

Antioxidants, Journal Year: 2020, Volume and Issue: 9(11), P. 1092 - 1092

Published: Nov. 6, 2020

Antioxidant potential is defined as the ability to neutralize oxygen free radicals that are generated in excess due environmental influences. The body's defense mechanisms often require support preventing effects of oxidative stress. literature data suggest curcumin has antioxidant activity can significantly reduce stress levels. aim was assess impact on markers.PubMed and Embase were searched from database inception until 27 September 2019 for randomized clinical trials >20 patients treated with supplements placebo/no intervention/physical verify curcumin.Four studies included meta-analysis, three which double-blind one single-blind. A total 308 participants took part research. 40% respondents men. average age 27.60 ± 3.79 years. supplementation time 67 days dose administered 645 mg/24 h. Curcumin increased capacity (TAC) (SMD = 2.696, Z 2.003, CI 95%, p 0.045) had a tendency decrease malondialdehyde (MDA) concentration -1.579, -1.714, 0.086).Pure MDA increase capacity.

Language: Английский

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Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials

Nutrition Journal, Journal Year: 2017, Volume and Issue: 16(1)

Published: Oct. 11, 2017

Dyslipidemia is an important and common cardiovascular risk factor in the general population. The lipid-lowering effects of turmeric curcumin are unconfirmed. We performed a meta-analysis to assess efficacy safety lowering blood lipids patients at disease (CVD). A comprehensive literature search was conducted on PubMed, Embase, Ovid, Medline Cochrane Library databases identify randomized controlled trials (published as November 2016) that assessed effect lipid levels including total cholesterol (TC), low-density lipoprotein (LDL-C), high-density (HDL-C), triglycerides (TG). Pooled standardized mean difference (SMD) with 95% confidence interval (CI) used effect. analysis included 7 eligible studies (649 patients). Turmeric significantly reduced serum LDL-C (SMD = −0.340, [CI]: −0.530 −0.150, P < 0.0001) TG −0.214, CI: −0.369 −0.059, 0.007) compared those control group. These may be effective TC metabolic syndrome (MetS, SMD −0.934, −1.289 −0.579, 0.0001), extract could possibly have greater reducing −0.584, −0.980 −0.188, 0.004); however, yet confirmed. Serum HDL-C were not obviously improved. appeared safe, no serious adverse events reported any studies. protect CVD through improving levels. Curcumin well-tolerated dietary adjunct conventional drugs. Further research required resolve uncertainties related dosage form, dose medication frequency curcumin.

Language: Английский

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Curcumin Combination Chemotherapy: The Implication and Efficacy in Cancer

Molecules, Journal Year: 2019, Volume and Issue: 24(14), P. 2527 - 2527

Published: July 10, 2019

Many chemotherapeutic drugs have been used for the treatment of cancer, instance, doxorubicin, irinotecan, 5-fluorouracil, cisplatin, and paclitaxel. However, effectiveness chemotherapy is limited in cancer therapy due to drug resistance, therapeutic selectivity, undesirable side effects. The combination therapies with natural compounds likely increase as well reduce adverse outcomes. Curcumin, a polyphenolic isolated from

Language: Английский

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Nutritional Factors Affecting Adult Neurogenesis and Cognitive Function

Advances in Nutrition, Journal Year: 2017, Volume and Issue: 8(6), P. 804 - 811

Published: Nov. 1, 2017

Language: Английский

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Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin

Nutrients, Journal Year: 2020, Volume and Issue: 12(9), P. 2499 - 2499

Published: Aug. 19, 2020

Curcumin, a lipophilic polyphenol contained in the rhizome of Curcuma longa (turmeric), has been used for centuries traditional Asian medicine, and nowadays it is widely food as dietary spice worldwide. It received considerable attention its pharmacological activities, which appear to act primarily through anti-inflammatory antioxidant mechanisms. For this reason, proposed tool management many diseases, among are gastrointestinal neurological diabetes, several types cancer. However, pharmacology curcumin remains be elucidated; indeed, discrepancy exists between well-documented vitro vivo activities poor bioavailability chemical instability that should limit any therapeutic effect. Recently, hypothesized could exert direct regulative effects tract, where high concentrations have detected after oral administration. Consequently, might directly exerts regulatory on gut microbiota, thus explaining paradox low systemic wide activities. well known microbiota important roles human physiology, composition can influenced by multitude environmental lifestyle factors. Accordingly, perturbations microbiome profile or dysbiosis key role disease progression. Interestingly, metabolites shown influence microbiota. worth noting from interaction two different phenomena arise: regulation intestinal microflora biotransformation both them potentially crucial activity. This review summarizes most recent studies topic, highlighting strong connection with final aim adding new insight into potential mechanisms effects.

Language: Английский

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