Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases DOI Open Access
Bahare Salehi, Marí­a Luisa Del Prado-Audelo, Hernán Cortés

et al.

Journal of Clinical Medicine, Journal Year: 2020, Volume and Issue: 9(3), P. 746 - 746

Published: March 10, 2020

Cardiovascular diseases (CVD) compromises a group of heart and blood vessels disorders with high impact on human health wellbeing. Curcumin (CUR) have demonstrated beneficial effects these that represent global burden prevalence continues increasing progressively. Pre- clinical studies the CUR in CVD through its anti-hypercholesterolemic anti-atherosclerotic protective properties against cardiac ischemia reperfusion. However, therapeutic limitation is bioavailability. New nanomedicine formulations are developed to solve this problem. The present article aims discuss different approaches looking into promising role nanotechnology-based drug delivery systems deliver derivatives treatment, an emphasis their formulation properties, experimental evidence, bioactivity, as well challenges opportunities developing systems.

Language: Английский

A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin DOI Creative Commons
Shivkanya Fuloria, Jyoti Mehta,

Aditi Chandel

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: March 25, 2022

Linn. (

Language: Английский

Citations

245
ATP-citrate lyase (ACLY) in lipid metabolism and atherosclerosis: An updated review DOI
Xiaojun Feng, Lei Zhang, Suowen Xu

et al.

Progress in Lipid Research, Journal Year: 2019, Volume and Issue: 77, P. 101006 - 101006

Published: Sept. 6, 2019

Language: Английский

Citations

190
Potential of Curcumin in Skin Disorders DOI Open Access
Laura Vollono, Mattia Falconi, Roberta Gaziano

et al.

Nutrients, Journal Year: 2019, Volume and Issue: 11(9), P. 2169 - 2169

Published: Sept. 10, 2019

Curcumin is a compound isolated from turmeric, plant known for its medicinal use. Recently, there growing interest in the medical community identifying novel, low-cost, safe molecules that may be used treatment of inflammatory and neoplastic diseases. An increasing amount evidence suggests curcumin represent an effective agent several skin conditions. We examined most relevant vitro vivo studies published to date regarding use inflammatory, neoplastic, infectious diseases, providing information on bioavailability safety profile. Moreover, we performed computational analysis about curcumin's interaction towards major enzymatic targets identified literature. Our results suggest well-tolerated, However, bypass limitations (low oral bioavailability, metabolism) essential order conduct larger clinical trials could confirm these observations. The possible combination with traditional drugs formulations novel delivery systems very promising field future applicative research.

Language: Английский

Citations

186
Targeting Foam Cell Formation in Atherosclerosis: Therapeutic Potential of Natural Products DOI Open Access
Dongdong Wang, Yang Yang,

Yingnan Lei

et al.

Pharmacological Reviews, Journal Year: 2019, Volume and Issue: 71(4), P. 596 - 670

Published: Sept. 25, 2019

Foam cell formation and further accumulation in the subendothelial space of vascular wall is a hallmark atherosclerotic lesions. Targeting foam lesions can be promising approach to treat prevent atherosclerosis. The cells determined by balanced effects three major interrelated biologic processes, including lipid uptake, cholesterol esterification, efflux. Natural products are source for new lead structures. Multiple natural pharmaceutical agents inhibit thus exhibit antiatherosclerotic capacity suppressing and/or promoting ester hydrolysis This review summarizes recent findings on these processes with demonstrated potential target such processes. Discussed also future directions studying mechanisms development cell-targeted therapeutic strategies.

Language: Английский

Citations

174
Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trial DOI Creative Commons

Seyed Ali Jazayeri-Tehrani,

Seyed Mahdi Rezayat, Siavash Mansouri

et al.

Nutrition & Metabolism, Journal Year: 2019, Volume and Issue: 16(1)

Published: Jan. 28, 2019

Since lifestyle changes are main therapies for non-alcoholic fatty liver disease (NAFLD), changing dietary components (nutritional or bioactive) may play a parallel important role. Few studies have assessed the effects of curcumin on NAFLD (mainly antioxidant and anti-inflammatory effects). We aimed to determine nano-curcumin (NC) overweight/obese patients by assessing glucose, lipids, inflammation, insulin resistance, function indices, especially through nesfatin. This double-blind, randomized, placebo-controlled clinical trial was conducted in Oil Company Central Hospital, Tehran. 84 with diagnosed using ultrasonography were recruited according eligibility criteria (age 25-50 yrs., body mass index [BMI] 25-35 kg/m2). The randomly divided into two equal NC (n = 42) placebo groups. Interventions 40 mg capsules/day after meals 3 months. Lifestyle advised. A general questionnaire, 24-h food recall (at beginning, middle end), short-form international physical activity questionnaire beginning end) completed. Also, blood pressure, degree, anthropometrics, fasting sugar (FBS) (FBI), glycated hemoglobin (HbA1c), homeostasis model assessment-insulin resistance (HOMA-IR), quantitative sensitivity check (QUICKI), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-c), high-density (HDL-c), tumor necrosis factor-alpha (TNF-α), high sensitive c-reactive protein (hs-CRP), interleukin-6 (IL-6), transaminases, nesfatin determined at end. compared significantly increased HDL, QUICKI, decreased waist circumference (WC), FBS, FBI, HbA1c, TG, TC, LDL, HOMA-IR, TNF-α, hs-CRP, IL-6 (P < 0.05). mean weight, BMI, composition (BC), pressure not significant > After adjustment confounders, similar unadjusted model. supplementation improved glucose WC, nesfatin, degree. Accordingly, proposed mechanism ameliorating approved serum likely consequent improvements profile. Further trials nano-curcumin's suggested. Iranian Registry Clinical Trials, IRCT2016071915536N3. Registered 2016-08-02.

Language: Английский

Citations

165
Curcumin Activates the Nrf2 Pathway and Induces Cellular Protection Against Oxidative Injury DOI
Milad Ashrafizadeh, Zahra Ahmadi, Reza Mohammadinejad

et al.

Current Molecular Medicine, Journal Year: 2019, Volume and Issue: 20(2), P. 116 - 133

Published: Oct. 17, 2019

Curcumin is a naturally occurring polyphenol that isolated from the rhizome of Curcuma longa (turmeric). This medicinal compound has different biological activities, including antioxidant, antibacterial, antineoplastic, and anti-inflammatory. It also therapeutic effects on neurodegenerative disorders, renal diabetes mellitus. safe well-tolerated at high concentrations without inducing toxicity. seems curcumin capable targeting Nrf2 signaling pathway in protecting cells against oxidative damage. Besides, this strategy advantageous cancer therapy. Accumulating data demonstrates applies four distinct ways to stimulate pathway, inhibition Keap1, affecting upstream mediators Nrf2, influencing expression target genes, finally, improving nuclear translocation Nrf2. In present review, exert its activities been discussed.

Language: Английский

Citations

164
Impacts of turmeric and its principal bioactive curcumin on human health: Pharmaceutical, medicinal, and food applications: A comprehensive review DOI Creative Commons
Mohamed T. El‐Saadony, Tao Yang, Sameh A. Korma

et al.

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 9

Published: Jan. 10, 2023

The yellow polyphenolic pigment known as curcumin, originating from the rhizome of turmeric plant Curcuma longa L., has been utilized for ages in ancient medicine, well cooking and food coloring. Recently, biological activities curcumin have thoroughly investigated. studies mainly focused on their antioxidant, antitumor, anti-inflammatory, neuroprotective, hepatoprotective, cardioprotective impacts. This review seeks to provide an in-depth, detailed discussion usage within processing industries its effect health support disease prevention. Curcumin’s bioavailability, bio-efficacy, bio-safety characteristics, side effects quality standards, are also discussed. Finally, curcumin’s multifaceted uses, appeal enhancement, agro-industrial techniques counteracting instability low nanotechnology drug delivery systems increase prospective clinical use tactics all

Language: Английский

Citations

143
The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic Disorders DOI Creative Commons
Priti Tagde,

Pooja Tagde,

Fahadul Islam

et al.

Molecules, Journal Year: 2021, Volume and Issue: 26(23), P. 7109 - 7109

Published: Nov. 24, 2021

Curcumin is the primary polyphenol in turmeric's curcuminoid class. It has a wide range of therapeutic applications, such as anti-inflammatory, antioxidant, antidiabetic, hepatoprotective, antibacterial, and anticancer effects against various cancers, but poor solubility low bioavailability. Objective: To improve curcumin's bioavailability, plasma concentration, cellular permeability processes. The nanocurcumin approach over curcumin been proven appropriate for encapsulating or loading (nanocurcumin) to increase its potential. Conclusion: Though incorporating into form may be viable method overcoming intrinsic limitations, there are reasonable concerns regarding toxicological safety once it enters biological pathways. This review article mainly highlights benefits curcumin.

Language: Английский

Citations

124
The effects of foods on LDL cholesterol levels: A systematic review of the accumulated evidence from systematic reviews and meta-analyses of randomized controlled trials DOI Creative Commons

Malin Schoeneck,

David Iggman

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2021, Volume and Issue: 31(5), P. 1325 - 1338

Published: Jan. 18, 2021

AimsTo systematically evaluate the evidence regarding effects of foods on LDL cholesterol levels and to compare findings with current guidelines.Data synthesisFrom inception through June 2019, we searched PubMed, Cochrane Database Systematic Reviews, Central Register Controlled Trials for guidelines, systematic reviews, RCTs (for coffee intake only) at least 13 days duration. Additionally, Trip database guidelines from 2009 Oct 2019. Language was restricted English. The strength evaluated using Grading Recommendations Assessment, Development, Evaluation (GRADE). A total 37 108 20 were included. With high evidence, in unsaturated low saturated trans fatty acids (e.g. rapeseed/canola oil), added plant sterols/stanols, soluble fiber oats, barley, psyllium) caused moderate (i.e. 0.20–0.40 mmol/L) reductions cholesterol. Unfiltered a large increase. Soy protein, tomatoes, flaxseeds, almonds small reductions. avocados turmeric Pulses, hazelnuts, walnuts, high-fiber/wholegrain foods, green tea reductions, whereas sugar Other identified either neutral or had very their effects.ConclusionsSeveral distinctly modify levels. results may aid future dietary advice hypercholesterolemia.

Language: Английский

Citations

114
Curcumin‐piperine co‐supplementation and human health: A comprehensive review of preclinical and clinical studies DOI
Hajar Heidari, Mohammad Bagherniya, Muhammed Majeed

et al.

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(4), P. 1462 - 1487

Published: Jan. 31, 2023

Abstract Curcumin is extracted from the rhizomes Curcuma longa L. It known for its anti‐inflammatory and anti‐oxidant activities. Despite safety potential use against various diseases, curcumin's utility restricted due to low oral bioavailability. Co‐administration of curcumin along with piperine could potentially improve bioavailability curcumin. The present review aimed provide an overview efficacy curcumin‐piperine co‐supplementation in human health. findings this comprehensive show beneficial effects improving glycemic indices, lipid profile antioxidant status diabetes, inflammatory caused by obesity metabolic syndrome, reducing oxidative stress depression chronic neurological disorders, also respiratory asthma COVID‐19. Further high‐quality clinical trial studies are needed firmly establish supplement.

Language: Английский

Citations

82