Cited by Enantiomeric Separation of Chiral Hyper-Crosslinked Polymer Based Nanotube Membranes

Recent Advances in Enantiorecognition and Enantioseparation Techniques of Chiral Molecules in the Pharmaceutical Field DOI

Kuladip Barman,

Md. Shafiqul Islam, Kalyan Kumar Das

et al.

Biomedical Chromatography, Journal Year: 2025, Volume and Issue: 39(2)

Published: Jan. 2, 2025

ABSTRACT Enantioseparation and enantiorecognition are crucial in the pharmaceutical analysis of chiral substances, impacting safety, efficacy, regulatory compliance. refers to process separating enantiomers from a mixture, typically achieved through chromatography techniques like HPLC SFC. In contrast, involves identification based on their interaction with selector without need for separation. Recent advancements these have significantly improved enantioseparation efficiency resolution. Chiral stationary phases (CSPs) evolved, offering better selectivity, including hybrid organic–inorganic materials miniaturization. The use green solvents has also reduced environmental impact. Non‐chromatographic methods, such as circular dichroism (CD) nuclear magnetic resonance (NMR) spectroscopy, enable interactions polarized light or solvents. However, methods face challenges, high costs, limited solvent compatibility, shorter operational lifespans compared chromatographic techniques. developments solvent‐tolerant CSPs aim address limitations. This review highlights innovations, focusing relevance industry, pollution control, quality assurance, emphasizes growing importance production regulation drugs.

Language: Английский

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Top drugs and companies by sales in 2018 DOI

Lisa Urquhart

Nature Reviews Drug Discovery, Journal Year: 2019, Volume and Issue: unknown

Published: March 12, 2019

Language: Английский

Citations

Approaches to Synthesis and Isolation of Enantiomerically Pure Biologically Active Atropisomers DOI

Anna‐Carin C. Carlsson, Staffan Karlsson, Rachel H. Munday

et al.

Accounts of Chemical Research, Journal Year: 2022, Volume and Issue: 55(20), P. 2938 - 2948

Published: Oct. 4, 2022

ConspectusAtropisomerism is a stereochemical phenomenon exhibited by molecules containing rotationally restricted σ bond. Contrary to classical point chirality, the two atropisomeric stereoisomers exist as dynamic mixture and can be interconverted without requirement of breaking reforming Although this feature increases structural complexity, atropisomers have become frequent targets in medicinal chemistry projects. Their axial e.g., from axially chiral biaryl motifs, gives access unique 3D structures. It often desirable both enantiomers via nonselective reaction during early discovery phase it allows team probe structure activity relationship directions. However, once single atropisomer selected, presents several problems. First, pure may interconvert undesired stereoisomer under certain conditions. Second, separation nontrivial requires expensive stationary phases using chromatography or additives if salt resolution approach chosen. Other options kinetic enzymes catalysts. apart high cost associated with latter methods, maximum yield only 50% desired obtained. The ideal install axis enantioselectively employing approach. In theory, approaches potential provide quantitative yield. This Account will discuss successes/failures challenges we experienced developing methods for resolution/separation asymmetric synthesis drug candidates one our development Suitability different at various stages discussed. Depending on scale time available, was sometimes preferred, whereas asymmetric- were long-term supply. With use chromatography, impact efficiency solvent consumption, depending nature substrate, We hope that readers get better view process chemists meet when designing new processes manufacture atropisomer.

Language: Английский

Citations

Recent update on application of dihydromyricetin in metabolic related diseases DOI

Yirong Wang, Junmin Wang,

Hongjiao Xiang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 148, P. 112771 - 112771

Published: March 2, 2022

As a new type of natural flavonoids, dihydromyricetin (DMY) has attracted more and attention. It series pharmacological effects, such as anti-inflammatory, anti-tumor, anti-oxidation, antibacterial so on, it is almost no toxicity with excellent safety. Therefore, even if the bioavailability poor, often added to daily food, beverages medicines. In recent years, some researchers have found that DMY can treat diseases by anti-inflammation, promoting cell death regulate activity lipid glucose metabolism. addition, mechanism on these was also related signal pathway AMPK, PI3K/Akt, PPAR participation microRNAs. This review describes in metabolic from three aspects: diseases, liver cancers, hoping provide ideas for clinical researches.

Language: Английский

Citations

Separation of chiral drugs through dual chiral ionic liquid functionalized composite membrane and study on chiral recognition mechanism DOI

Xin Qiu,

Wenbei Chen, Yuting Chen

et al.

Journal of Membrane Science, Journal Year: 2023, Volume and Issue: 687, P. 122087 - 122087

Published: Sept. 14, 2023

Language: Английский

Citations

Chiral polymeric membranes: Recent applications and trends DOI

Priscila Vedovello, Caio Márcio Paranhos, Carla Fernandes

et al.

Separation and Purification Technology, Journal Year: 2021, Volume and Issue: 280, P. 119800 - 119800

Published: Sept. 27, 2021

Language: Английский

Citations

β-Cyclodextrin covalent organic framework modified-cellulose acetate membranes for enantioseparation of chiral drugs DOI

Huan Luo,

Xiaoping Bai,

Huixian Liu

et al.

Separation and Purification Technology, Journal Year: 2021, Volume and Issue: 285, P. 120336 - 120336

Published: Dec. 20, 2021

Language: Английский

Citations

Recent developments in preparative-scale supercritical fluid- and liquid chromatography for chiral separations DOI

David Speybrouck,

Michael Howsam, Emmanuelle Lipka

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2020, Volume and Issue: 133, P. 116090 - 116090

Published: Oct. 26, 2020

Language: Английский

Citations

Chiral Flavonoids as Antitumor Agents DOI

Cláudia Pinto, Honorina Cidade, Madalena Pinto

et al.

Pharmaceuticals, Journal Year: 2021, Volume and Issue: 14(12), P. 1267 - 1267

Published: Dec. 5, 2021

Flavonoids are a group of natural products with great structural diversity, widely distributed in plant kingdom. They play an important role growth, development and defense against aggressors. show huge variety biological activities such as antioxidant, anti-inflammatory, anti-mutagenic, antimicrobial antitumor, being able to modulate large diversity cellular enzymatic activities. Among flavonoids, some classes comprise chiral molecules including flavanones, flavan-3-ols, isoflavanones, rotenoids, which have one or more stereogenic centers. Interestingly, cases, individual compounds enantiomeric pairs shown different antitumor activity. In nature, these mainly biosynthesized pure enantiomers. Nevertheless, they often isolated racemates, necessary carry out their separation perform enantioselectivity studies. Synthetic flavonoids promising activity also been obtained using diverse synthetic approaches. fact, several new bioactive synthesized by enantioselective synthesis. Particularly, flavopiridol was the first cyclin-dependent kinase (CDK) inhibitor entered clinical trials. The pool approaches amino acid building blocks reported achieve small libraries chrysin derivatives potent vitro growth inhibitory effect than chrysin, reinforcing importance introduction moieties improve this work, literature review is for time.

Language: Английский

Citations

Nanocrystalline Porous Materials for Chiral Separation: Synthesis, Mechanisms, and Applications DOI

Qixuan Mu,

Wanting Tian,

Jiale Zhang

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(20), P. 7864 - 7879

Published: Feb. 6, 2024

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTNanocrystalline Porous Materials for Chiral Separation: Synthesis, Mechanisms, and ApplicationsQixuan MuQixuan MuDepartment of Analytical Chemistry, China Pharmaceutical University, Nanjing 210009, ChinaKey Laboratory Drug Quality Control Pharmacovigilance, Ministry Education, ChinaMore by Qixuan MuView Biography, Wanting TianWanting TianDepartment TianView Jiale ZhangJiale ZhangDepartment ZhangView Ruijun Li*Ruijun LiDepartment China*Email: [email protected]More LiView Biographyhttps://orcid.org/0000-0002-6987-1256, Yibing Ji*Yibing JiDepartment China*E-mail: protected]. Tel: +86 25 86185150. Fax: 86185160.More JiView Biographyhttps://orcid.org/0000-0001-7437-3756Cite this: Anal. Chem. 2024, 96, 20, 7864–7879Publication Date (Web):February 6, 2024Publication History Received17 March 2023Accepted16 January 2024Revised14 October 2023Published online6 February 2024Published inissue 21 May 2024https://pubs.acs.org/doi/10.1021/acs.analchem.3c01178https://doi.org/10.1021/acs.analchem.3c01178review-articleACS PublicationsCopyright © 2024 American Chemical SocietyRequest reuse permissionsArticle Views782Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chirality,Covalent organic frameworks,Materials,Membranes,Molecular structure Get e-Alerts

Language: Английский

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