Biomaterials, Journal Year: 2021, Volume and Issue: 280, P. 121303 - 121303
Published: Dec. 1, 2021
Language: Английский
Emergent Materials, Journal Year: 2023, Volume and Issue: 6(3), P. 777 - 807
Published: Feb. 6, 2023
Language: Английский
Citations
43
Polymers, Journal Year: 2024, Volume and Issue: 16(6), P. 843 - 843
Published: March 19, 2024
Chemotherapy together with surgery and/or radiotherapy are the most common therapeutic methods for treating cancer. However, off-target effects of chemotherapy known to produce side and dose-limiting toxicities. Novel delivery platforms based on natural synthetic polymers enhanced pharmacokinetic potential treatment cancer have grown tremendously over past 10 years. Polymers can facilitate selective targeting, enhance prolong circulation, improve delivery, provide controlled release cargos through various mechanisms, including physical adsorption, chemical conjugation, internal loading. Notably, that biodegradable, biocompatible, physicochemically stable considered be ideal carriers. This biomimetic bio-inspired system offers a bright future effective drug overcome obstacles encountered. review focuses barriers impact success as well recent developments improving
Language: Английский
Citations
24
Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(7), P. 723 - 723
Published: July 4, 2024
Breast cancer remains the most prevalent among women worldwide, driving urgent need for innovative approaches to diagnosis and treatment. This review highlights pivotal role of nanoparticles in revolutionizing breast management through advancements interconnected including targeted therapy, imaging, personalized medicine. Nanoparticles, with their unique physicochemical properties, have shown significant promise addressing current treatment limitations such as drug resistance nonspecific systemic distribution. Applications range from enhancing delivery systems sustained release developing diagnostic tools early precise detection metastases. Moreover, integration into photothermal therapy synergistic use existing treatments, immunotherapy, illustrate transformative potential care. However, journey towards clinical adoption is fraught challenges, chemical feasibility, biodistribution, efficacy, safety concerns, scalability, regulatory hurdles. delves state nanoparticle research, applications diagnosis, obstacles that must be overcome integration.
Language: Английский
Citations
19
Molecules, Journal Year: 2024, Volume and Issue: 29(11), P. 2584 - 2584
Published: May 31, 2024
There is a myriad of diseases that plague the world ranging from infectious, cancer and other chronic with varying interventions. However, dynamism causative agents infectious incessant mutations accompanying forms like cancer, have worsened treatment outcomes. These factors often lead to failure via different drug resistance mechanisms. More so, cost developing newer drugs huge. This underscores need for paradigm shift in delivery approach order achieve desired intensified research nanomedicine, which has shown promises improving therapeutic outcome at preclinical stages increased efficacy reduced toxicity. Regardless huge benefits nanotechnology delivery, challenges such as regulatory approval, scalability, implication potential toxicity must be addressed streamlining hurdles funding. In conclusion, idea holds immense promise optimizing work presents opportunities revolutionize strategies, providing expert opinions on translating amount nanomedicine into clinical patients resistant infections cancer.
Language: Английский
Citations
18
Intelligent Pharmacy, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Citations
18
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 98, P. 105896 - 105896
Published: June 15, 2024
Language: Английский
Citations
17
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 16, 2024
Celastrol is a quinone methyl triterpenoid monomeric ingredient extracted from the root of Tripterygium wilfordii . shows potential pharmacological activities in various diseases, which include inflammatory, obesity, cancer, and bacterial diseases. However, application prospect celastrol largely limited by its low bioavailability, poor water solubility, undesired off-target cytotoxicity. To address these problems, number drug delivery methods technologies have been reported to enhance efficiency reduce toxicity celastrol. We classified current into two parts. The direct chemical modification includes nucleic acid aptamer–celastrol conjugate, aptamer–dendrimer–celastrol glucolipid–celastrol conjugate. indirect dendrimers, polymers, albumins, vesicular carriers. can covalently bond or encapsulate celastrol, improves selectivity. Here, we present review that focalizes recent advances strategies enhancing reducing
Language: Английский
Citations
16
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 670, P. 125186 - 125186
Published: Jan. 8, 2025
The blood-brain barrier (BBB) plays a vital role in protecting the central nervous system (CNS) by preventing entry of harmful pathogens from bloodstream. However, this also presents significant obstacle when it comes to delivering drugs for treatment neurodegenerative diseases and brain cancer. Recent breakthroughs nanotechnology have paved way creation wide range nanoparticles (NPs) that can serve as carriers diagnosis therapy. Regarding their promising properties, organic NPs potential be used effective drug delivery across BBB based on recent advancements. These remarkable ability penetrate using various mechanisms. This review offers comprehensive examination intricate structure distinct properties BBB, emphasizing its crucial function preserving balance regulating transport ions molecules. disruption conditions such stroke, Alzheimer's disease, Parkinson's disease highlights importance developing creative approaches drugs. Through encapsulation therapeutic molecules precise targeting processes vasculature, NP formulations present hopeful strategy improve BBB. We explore changes pathological investigate factors affect successful into brain. In addition, we most systems associated with shown positive results treating ischemic disorders. opens up new possibilities nanotechnology-based therapies cerebral diseases.
Language: Английский
Citations
8
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 134 - 134
Published: Jan. 19, 2025
Resveratrol is a natural polyphenol (stilbenoid), which can be found in grape skin, red wine, blueberries, peanuts and others. The biological properties of resveratrol, particular antioxidant, anti-inflammatory, anticancer, estrogenic, vasorelaxant cardioprotective activity, are the main reason for its importance medicine pharmacy. Despite all advantages, however, there many problems related to this polyphenolic substance, such as low stability, water insolubility, poor bioavailability fast metabolism. For reason, scientists currently searching different approaches dealing with these problematic improving therapeutic usage resveratrol. This review summarizes mechanisms effects determined vitro vivo, limitations drug. article emphasizes new improvement resveratrol delivery, nanoencapsulation, formation nanocrystals, prodrugs structure analogues.
Language: Английский
Citations
2
Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 178, P. 113908 - 113908
Published: Aug. 11, 2021
Drug delivery systems or vectors are usually needed to improve the bioavailability and effectiveness of a drug through improving its pharmacokinetics/pharmacodynamics at an organ, tissue cellular level. However, emerging technologies with sensitive readouts as well greater understanding physiological/biological have revealed that polymeric not biologically inert but can innate intrinsic biological actions. In this article, we review multiple biological/toxicological properties naked polyamidoamine (PAMAM) dendrimer in absence any cargo discuss their correlation defined physicochemical PAMAMs terms molecular size (generation), architecture, surface charge chemistry. Further, assess whether reported actions such antimicrobial activity ability sequester glucose modulate key protein interactions cell signaling pathways, be exploited clinically treatment diabetes complications.
Language: Английский
Citations
104