Enhancing the Bioavailability of Resveratrol: Combine It, Derivatize It, or Encapsulate It?

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(4), P. 569 - 569

Published: April 22, 2024

Overcoming the limited bioavailability and extensive metabolism of effective in vitro drugs remains a challenge that limits translation promising into clinical trials. Resveratrol, despite its well-reported therapeutic benefits, is not metabolically stable thus has been utilized as an drug. This because it needs to be consumed large amounts overcome burdens conversion less metabolites. Herein, we summarize more relevant approaches modify resveratrol, aiming increase biological efficacy. We discuss combination therapies, derivatization, use resveratrol nanoparticles. Interestingly, with established chemotherapeutic shown effects on colon cancer (with oxaliplatin), liver cisplatin, 5-FU), gastric doxorubicin). On other hand, derivatizing including hydroxylation, amination, amidation, imidation, methoxylation, prenylation, halogenation, glycosylation, oligomerization, differentially modifies could used for preferential outcomes. Moreover, encapsulation allows trapping within different forms shells targeted therapy. Depending nanoparticle used, can enhance solubility absorption, increasing These include polymers, metals, solid lipids, nanoparticles have preclinical results, adding “hype” research resveratrol. review provides platform compare allow directed better treatment options

Language: Английский

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Unlocking longevity: the role of telomeres and its targeting interventions

Frontiers in Aging, Journal Year: 2024, Volume and Issue: 5

Published: Jan. 25, 2024

Average life expectancy has been steadily increasing in developed countries worldwide. These demographic changes are associated with an ever-growing social and economic strain to healthcare systems as well society. The aging process typically manifests a decline physiological cognitive functions, accompanied by rise chronic diseases. Consequently, strategies that both mitigate age-related diseases promote healthy urgently needed. Telomere attrition, characterized the shortening of telomeres each cell division, paradoxically serves protective mechanism contributor tissue degeneration ailments. Based on essential role telomere biology aging, research efforts aim develop approaches designed counteract aiming delay or reduce In this review, its is summarized along recent interfere at well- healthy-aging longevity. As enters new era, review emphasizes telomere-targeting therapeutics, including telomerase activators tankyrase inhibitors, while also exploring effects antioxidative anti-inflammatory agents, indirectly related like statins.

Language: Английский

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Metabolic and epigenetic regulation of macrophage polarization in atherosclerosis: molecular mechanisms and targeted therapies

Pharmacological Research, Journal Year: 2025, Volume and Issue: 212, P. 107588 - 107588

Published: Jan. 7, 2025

Atherosclerosis, a multifactorial progressive inflammatory disease, is the common pathology underlying cardiovascular and cerebrovascular diseases. The macrophage plasticity involved in pathogenesis of atherosclerosis. With advance metabolomics epigenetics, metabolites/metabolic epigenetic modification such as DNA methylation, histone noncoding RNA, play crucial role polarization progression Herein, we provide comprehensive review essential metabolic regulation, well crosstalk between two regulating We also highlight potential therapeutic strategies via modifications for atherosclerosis, offer recommendations to our knowledge roles metabolic-epigenetic context Fundamental studies that elucidate mechanisms by which regulation influence atherosclerosis will pave way novel approaches.

Language: Английский

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Resveratrol—A Promising Therapeutic Agent with Problematic Properties

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 134 - 134

Published: Jan. 19, 2025

Resveratrol is a natural polyphenol (stilbenoid), which can be found in grape skin, red wine, blueberries, peanuts and others. The biological properties of resveratrol, particular antioxidant, anti-inflammatory, anticancer, estrogenic, vasorelaxant cardioprotective activity, are the main reason for its importance medicine pharmacy. Despite all advantages, however, there many problems related to this polyphenolic substance, such as low stability, water insolubility, poor bioavailability fast metabolism. For reason, scientists currently searching different approaches dealing with these problematic improving therapeutic usage resveratrol. This review summarizes mechanisms effects determined vitro vivo, limitations drug. article emphasizes new improvement resveratrol delivery, nanoencapsulation, formation nanocrystals, prodrugs structure analogues.

Language: Английский

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Therapeutic potential and underlying mechanisms of phytoconstituents: emphasizing on resveratol, curcumin, quercetin, berberine, and hesperidin in ulcerative colitis

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

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