Trapa natans L. Extract Attenuates Inflammation and Oxidative Damage in Cisplatin‐Induced Cardiotoxicity in Rats by Promoting M2 Macrophage Polarization DOI Creative Commons
Vesna Matović, Biljana Ljujić, Ivana D. Radojević

et al.

Mediators of Inflammation, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Background:Trapa natans L. fruits and leaf extracts have a broad range of immunomodulatory, anti-inflammatory, antioxidant effects; however, their effects on cardiac protection not been investigated. Objective: The study aims to test the biological activity Trapa extract (TNE) in cisplatin (CDDP)-induced cardiotoxicity. Methods: Wistar albino rats received single dose CDDP intraperitoneally TNE ones per day for 2 weeks orally. Cardiac inflammation, necrosis, fibrosis were determined by histological immunohistochemical analyses. Cytokines rat sera tissue detected enzyme-linked immunosorbent assay (ELISA) quantitative real-time (qRT)-PCR. Rat macrophages cultured presence 48 h harvested flow cytometry, while supernatants collected cytokine reactive oxygen species (ROS) measurement. Results: Application significantly attenuated induced cardiotoxicity as demonstrated biochemical histopathological analysis. Administration once daily 14 days decreased level proinflammatory (TNF-α, IFN-γ, IL-6) prooxidative parameters (NO2, O2, H2O2), increased immunosuppressive IL-10 antioxidative glutathione (GSH), catalase (CAT) uperoxide dismutase (SOD) systemic circulation. treatment resulted heart inflammation accompanied with reduced infiltration expression profibrotic genes CDDP-treated animals. In vitro lipopolysaccharide (LPS)-stimulated adopted phenotype characterized production cytokines mediators. Conclusion: Our provides evidence that ameliorates cisplatin-induced reducing oxidative stress via promoting M2 macrophage polarization.

Language: Английский

Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence DOI Creative Commons
Zohra Nausheen Nizami, Hanan E. Aburawi, Abdelhabib Semlali

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(6), P. 1159 - 1159

Published: May 26, 2023

Reactive oxygen species (ROS) are metabolic byproducts that regulate various cellular processes. However, at high levels, ROS induce oxidative stress, which in turn can trigger cell death. Cancer cells alter the redox homeostasis to facilitate protumorigenic processes; however, this leaves them vulnerable further increases levels. This paradox has been exploited as a cancer therapeutic strategy with use of pro-oxidative drugs. Many chemotherapeutic drugs presently clinical use, such cisplatin and doxorubicin, one their mechanisms action. Further, drugs, including phytochemicals small molecules, being investigated preclinical studies attribute anticancer activity induction. Consistently, review aims highlight selected whose potential characterized specific focus on phytochemicals, induction, effects downstream

Language: Английский

Citations

30
Tumor Microenvironment Specific Regulation Ca‐Fe‐Nanospheres for Ferroptosis‐Promoted Domino Synergistic Therapy and Tumor Immune Response DOI
Xu Chu,

Hua‐Ying Hou,

Meng‐Die Duan

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: May 27, 2024

Abstract Reactive oxygen species (ROS)‐mediated emerging treatments exhibit unique advantages in cancer therapy recent years. While the efficacy of ROS‐involved tumor is greatly restricted by complex microenvironment (TME). Herein, a dual‐metal CaO 2 @CDs‐Fe (CCF) nanosphere, with TME response and regulation capabilities, are proposed to improve ROS lethal power multiple cascade synergistic therapeutic strategy domino effect. In weak acidic TME, CCF will decompose, accompanied intracellular Ca 2+ upregulated abundant H O produced reverse antitherapeutic TME. Then exposed CF cores can act as both Fenton agent sonosensitizer generate excessive regulated for enhanced CDT/SDT. combination calcium overloading, augmented induced oxidative stress cause more severe mitochondrial damage cellular apoptosis. Furthermore, also reduce GPX4 expression enlarge lipid peroxidation, causing ferroptosis apoptosis parallel. These signals finally initiate damage‐associated molecular patterns activate immune realize excellent antitumor This outstanding ROS/calcium loading effect endows anticancer efficiently eliminate apoptosis/ferroptosis/ICD vitro vivo.

Language: Английский

Citations

9
Inhibition of palmitoyltransferase ZDHHC12 sensitizes ovarian cancer cells to cisplatin through ROS‐mediated mechanisms DOI Creative Commons
Xining Zhang,

Xingming Liao,

Min Wang

et al.

Cancer Science, Journal Year: 2024, Volume and Issue: 115(4), P. 1170 - 1183

Published: Jan. 29, 2024

Abstract Platinum‐based therapies have revolutionized the treatment of high‐grade serous ovarian cancer (HGSOC). However, high rates disease recurrence and progression remain a major clinical concern. Impaired mitochondrial function dysregulated reactive oxygen species (ROS), hallmarks cancer, hold potential as therapeutic targets for selectively sensitizing cisplatin treatment. Here, we uncover an oncogenic role palmitoyltransferase ZDHHC12 in regulating ROS homeostasis HGSOC cells. Analysis The Cancer Genome Atlas (TCGA) data revealed significantly elevated expression, demonstrating strongest positive association with pathways among all ZDHHC enzymes. Transcriptomic analysis independent datasets SNU119 cell model corroborated this association, highlighting strong link between expression signature involving oxidative metabolism regulation. Knockdown disrupted leading to increased cellular complexity, ATP levels, activity, both ROS. This dysregulation, achieved by siRNA knockdown or general palmitoylation inhibitor 2BP fatty acid synthase C75, enhanced cytotoxicity 2D 3D spheroid models through ROS‐mediated mechanisms. Markedly, inhibition augmented anti‐tumor activity xenograft tumor model, well ascites‐derived organoid line platinum‐resistant cancer. Our suggest promising target improve outcome HGSOCs response platinum‐based chemotherapy.

Language: Английский

Citations

8
Therapeutic potential of AMPK signaling targeting in lung cancer: Advances, challenges and future prospects DOI
Milad Ashrafizadeh, Sepideh Mirzaei, Kiavash Hushmandi

et al.

Life Sciences, Journal Year: 2021, Volume and Issue: 278, P. 119649 - 119649

Published: May 24, 2021

Language: Английский

Citations

55
Targeted regulation of autophagy using nanoparticles: New insight into cancer therapy DOI Creative Commons
Mahshid Deldar Abad Paskeh, Maliheh Entezari,

Courtney Clark

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2021, Volume and Issue: 1868(3), P. 166326 - 166326

Published: Dec. 20, 2021

Language: Английский

Citations

54
Mitochondrial Superoxide Dismutase in Cisplatin-Induced Kidney Injury DOI Creative Commons
Kranti A. Mapuskar, Emily J. Steinbach, Amira Zaher

et al.

Antioxidants, Journal Year: 2021, Volume and Issue: 10(9), P. 1329 - 1329

Published: Aug. 24, 2021

Cisplatin is a chemotherapy agent commonly used to treat wide variety of cancers. Despite the potential for both severe acute and chronic side effects, it remains preferred therapeutic option many malignancies due its potent anti-tumor activity. Common cisplatin-associated side-effects include kidney injury (AKI) disease (CKD). These renal injuries may cause delays potentially cessation cisplatin therapy have long-term effects on function reserve. Thus, developing mechanism-based interventional strategies that minimize without reducing efficacy would be great benefit. In addition action cross-linking DNA, has been shown affect mitochondrial metabolism, resulting in mitochondrially derived reactive oxygen species (ROS). Increased ROS formation proximal convoluted tubule cells associated with cisplatin-induced AKI CKD. We review mechanisms by which induce CKD discuss superoxide dismutase mimetics prevent platinum-associated nephrotoxicity.

Language: Английский

Citations

42
Combination of IDO inhibitors and platinum(IV) prodrugs reverses low immune responses to enhance cancer chemotherapy and immunotherapy for osteosarcoma DOI Creative Commons

Dongquan Xiang,

Xin-Li Han,

Jianxiong Li

et al.

Materials Today Bio, Journal Year: 2023, Volume and Issue: 20, P. 100675 - 100675

Published: May 24, 2023

In recent years, immune checkpoint blockades (ICBs) have made great progress in the treatment of cancer. However, most ICBs not yet been observed to be satisfactory osteosarcoma. Herein, we designed composite nanoparticles (NP–Pt-IDOi) from a reactive oxygen species (ROS) sensitive amphiphilic polymer (PHPM) with thiol-ketal bonds main chain encapsulate Pt(IV) prodrug (Pt(IV)–C12) and an indoleamine-(2/3)-dioxygenase (IDO) inhibitor (IDOi, NLG919). Once NP-Pt-IDOi enter cancer cells, polymeric could dissociate due intracellular ROS, release Pt(IV)–C12 NLG919. induces DNA damage activates cGAS-STING pathway, increasing infiltration CD8+ T cells tumor microenvironment. addition, NLG919 inhibits tryptophan metabolism enhances cell activity, ultimately activating anti-tumor immunity enhancing effects platinum-based drugs. were shown superior anti-cancer activity vitro vivo mouse models osteosarcoma, providing new clinical paradigm for combining chemotherapy immunotherapy

Language: Английский

Citations

21
Bazedoxifene-induced ROS promote mitochondrial dysfunction and enhance osimertinib sensitivity by inhibiting the p-STAT3/SOCS3 and KEAP1/NRF2 pathways in non-small cell lung cancer DOI
Yunchong Meng, Wei Lin, Na Wang

et al.

Free Radical Biology and Medicine, Journal Year: 2023, Volume and Issue: 196, P. 65 - 80

Published: Jan. 13, 2023

Language: Английский

Citations

17
Distinct mechanisms by which Nrf1 and Nrf2 as drug targets contribute to the anticancer efficacy of cisplatin on hepatoma cells DOI
Reziyamu Wufuer, Keli Liu, Jing Feng

et al.

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 213, P. 488 - 511

Published: Jan. 24, 2024

Language: Английский

Citations

7
Fluorogenic Rhodamine-Based Chemigenetic Biosensor for Monitoring Cellular NADPH Dynamics DOI

Huimin Chang,

Simon Clemens,

Pingting Gao

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(30), P. 20569 - 20576

Published: July 22, 2024

Ratiometric biosensors employing Förster Resonance Energy Transfer (FRET) enable the real-time tracking of metabolite dynamics. Here, we introduce an approach for generating a FRET-based biosensor in which changes apparent FRET efficiency rely on analyte-controlled fluorogenicity rhodamine rather than commonly used distance change between donor-acceptor fluorophores. Our fluorogenic, rhodamine-based, chemigenetic (

Language: Английский

Citations

7