Spatial multiplexed immunofluorescence analysis reveals coordinated cellular networks associated with overall survival in metastatic osteosarcoma DOI Creative Commons
Ryan A. Lacinski, Sebastian A. Dziadowicz,

Vincent K Melemai

et al.

Bone Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Sept. 27, 2024

Language: Английский

Molecular mechanisms and therapeutic significance of Tryptophan Metabolism and signaling in cancer DOI Creative Commons
Jing Yan, Di Chen, Zi Ye

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 30, 2024

Language: Английский

Citations

10
Napabucasin deactivates STAT3 and promotes mitoxantrone-mediated cGAS-STING activation for hepatocellular carcinoma chemo-immunotherapy DOI
Lingzhi Wang, Shengnan Bi, Zhuo Li

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 313, P. 122766 - 122766

Published: Aug. 22, 2024

Language: Английский

Citations

8
Immunotherapy Innovations in the Fight against Osteosarcoma: Emerging Strategies and Promising Progress DOI Creative Commons

Shigao Cheng,

Huiyuan Wang, Xuejia Kang

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 251 - 251

Published: Feb. 8, 2024

Immunosuppressive elements within the tumor microenvironment are primary drivers of tumorigenesis and malignant advancement. The presence, as well crosstalk between myeloid-derived suppressor cells (MDSCs), osteosarcoma-associated macrophages (OS-Ms), regulatory T (Tregs), endothelial (ECs) with osteosarcoma cause poor prognosis OS. In addition, consequent immunosuppressive factors favor loss treatment potential. Nanoparticles offer a means to dynamically locally manipulate immuno-nanoparticles, which present promising strategy for transforming OS-TME. Additionally, chimeric antigen receptor (CAR) technology is effective in combating This review summarizes essential mechanisms OS-TME current immune-associated strategies. last part highlights limitations existing therapies offers insights into future research directions.

Language: Английский

Citations

7
Advancements in osteosarcoma management: integrating immune microenvironment insights with immunotherapeutic strategies DOI Creative Commons
Hang Liang, Min Cui,

Jingyao Tu

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: June 10, 2024

Osteosarcoma, a malignant bone tumor predominantly affecting children and adolescents, presents significant therapeutic challenges, particularly in metastatic or recurrent cases. Conventional surgical chemotherapeutic approaches have achieved partial efficacy; however, the prognosis for long-term survival remains bleak. Recent studies highlighted imperative comprehensive exploration of osteosarcoma immune microenvironment, focusing on integration diverse immunotherapeutic strategies—including checkpoint inhibitors, microenvironment modulators, cytokine therapies, antigen-specific interventions, cancer vaccines, cellular antibody-based treatments—that are directly pertinent to modulating this intricate microenvironment. By targeting cells, activating host responses, these innovative demonstrated substantial potential enhancing effectiveness treatments. Although most novel strategies still research clinical trial phases, they already individuals with osteosarcoma, suggesting possibility developing new, more personalized effective treatment options. This review aims provide overview current advancements immunotherapy, emphasizing significance integrating various methods optimize outcomes. Additionally, it underscores subsequent further investigate interactions between system, aiming devise strategies. The present comprehensively addresses landscape delineating crucial scientific concerns thereby outlining directions.

Language: Английский

Citations

6
Nanoformulations of chemotherapeutic activators of the cGAS–STING pathway in tumor chemoimmunotherapy DOI
Lingzhi Wang, Zhuo Yu, Jihong Zhang

et al.

Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(3), P. 103892 - 103892

Published: Jan. 23, 2024

Language: Английский

Citations

5
Ultrasound-responsive metal–organic framework-based nanosystem for sonodynamic therapy/amplified ferroptosis/IDO-blockade osteosarcoma immunotherapy DOI

Qingjian Lei,

Wei Zhou, Shijie Gao

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 490, P. 151614 - 151614

Published: April 24, 2024

Language: Английский

Citations

5
Targeting metabolic pathways to counter cancer immunotherapy resistance DOI

Yuki Agarwala,

Timothy Brauns, Ann E. Sluder

et al.

Trends in Immunology, Journal Year: 2024, Volume and Issue: 45(7), P. 486 - 494

Published: June 13, 2024

Language: Английский

Citations

5
Nanoparticle targeting cGAS-STING signaling in disease therapy DOI
Zhou Lan,

Yu Huang,

Yuzhang Wu

et al.

Nano Research, Journal Year: 2024, Volume and Issue: 17(8), P. 7315 - 7336

Published: June 15, 2024

Language: Английский

Citations

4
Nanomedicines harnessing cGAS-STING pathway: sparking immune revitalization to transform ‘cold’ tumors into ‘hot’ tumors DOI Creative Commons

Xiaohong Ying,

Qiaohui Chen, Yongqi Yang

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Dec. 23, 2024

Language: Английский

Citations

4
Application of nanoparticles with activating STING pathway function in tumor synergistic therapy DOI
Yi Yang,

Yaning Fang,

Xin‐Yu Du

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114013 - 114013

Published: Jan. 18, 2025

Language: Английский

Citations

0