Gadolinium-Doped Carbon Nanodots as Potential Anticancer Tools for Multimodal Image-Guided Photothermal Therapy and Tumor Monitoring

ACS Applied Nano Materials, Journal Year: 2023, Volume and Issue: 6(18), P. 17206 - 17217

Published: Sept. 5, 2023

This study focuses on the synthesis and characterization of gadolinium-doped carbon nanodots (CDs-Gd) their potential applications in multimodal imaging precision cancer therapy. CDs-Gd were synthesized through a solvothermal decomposition method combining citric acid, GdCl3, urea. The incorporation Gd3+ ions within carbonaceous structure resulted stable with peculiar architecture that retained optical paramagnetic properties. Combined techniques confirmed presence pH-sensitive COOH functions surface along unique lattice induced by doping. properties exhibited tunable emission spectrum displaying blue-green pH-dependent behavior. Additionally, contrast-enhancing T1-weighted magnetic resonance (MRI) experiments. MRI acquisitions at different concentrations pH values demonstrated as contrast agents for monitoring changes an aqueous environment. We found relaxivity 5.5 (tumor, 11.3 mM-1 s-1) is roughly 3-fold higher than observed 7.4 (physiological, 5.0 outperformed clinical standards such γ-butyrol (3.3 s-1). Monitoring tumor microenvironment (TME) crucial evaluating effectiveness anticancer treatments understanding progression. Furthermore, concentration-dependent photothermal conversion ability near-infrared (NIR) region, allowing efficient heat generation under laser irradiation. indicates application image-guided therapy (IG-PTT) treatment. vitro studies MCF-7 (breast cancer) 16-HBE (healthy bronchial epithelium) cell lines high biocompatibility (cell viability >80%). However, upon NIR activation, they showed potent effects inhibiting proliferation inducing apoptosis selectively cells. In conclusion, nanoparticles possess optical, photothermal, properties, making them promising candidates imaging-guided applications.

Language: Английский

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Capped Plasmonic Gold and Silver Nanoparticles with Porphyrins for Potential Use as Anticancer Agents—A Review

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1268 - 1268

Published: Sept. 28, 2024

Photothermal therapy (PTT) and photodynamic (PDT) are potential cancer treatment methods that minimally invasive with high specificity for malignant cells. Emerging research has concentrated on the application of metal nanoparticles encapsulated in porphyrin their derivatives to improve efficacy these treatments. Gold silver have distinct optical properties biocompatibility, which makes them efficient materials PDT PTT. Conjugation increases light absorption singlet oxygen generation create a synergistic effect phototoxicity against Porphyrin encapsulation gold or improves solubility, stability, targeted tumor delivery. This paper provides comprehensive review design, functionalization, uses plasmonic biomedicine how they can be conjugated porphyrins therapeutic effects. Furthermore, it investigates this dual-modal therapy's advantages disadvantages offers perspectives future prospects. The possibility developing gold, silver, nanotechnology-enabled combination is also examined.

Language: Английский

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Design and Application of Near-Infrared Nanomaterial-Liposome Hybrid Nanocarriers for Cancer Photothermal Therapy

Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(12), P. 2070 - 2070

Published: Dec. 3, 2021

Liposomes are attractive carriers for targeted and controlled drug delivery receiving increasing attention in cancer photothermal therapy. However, the field of creating near-infrared nanomaterial-liposome hybrid nanocarriers (NIRN-Lips) is relatively little understood. The combine dual superiority nanomaterials liposomes, with more stable particles, enhanced photoluminescence, higher tumor permeability, better tumor-targeted delivery, stimulus-responsive release, thus exhibiting anti-tumor efficacy. Herein, this review covers liposomes supported various types nanomaterials, including gold-based carbon-based semiconductor quantum dots. Specifically, NIRN-Lips described terms their feature, synthesis, drug-release mechanism. design considerations highlighted. Further, we briefly introduced conversion mechanism NIRNs cell death induced by Subsequently, provided a brief conclusion NIRNs-Lips applied Finally, discussed synopsis associated challenges future perspectives applications

Language: Английский

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Carbon Nanomaterials: Emerging Roles in Immuno-Oncology

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6600 - 6600

Published: April 1, 2023

Cancer immunotherapy has made breakthrough progress in cancer treatment. However, only a subset of patients benefits from immunotherapy. Given their unique structure, composition, and interactions with the immune system, carbon nanomaterials have recently attracted tremendous interest roles as modulators antitumor immunity. Here, we focused on latest advances immunological effects nanomaterials. We also reviewed current preclinical applications these materials therapy. Finally, discussed challenges to be overcome before full potential can utilized therapies ultimately improve patient outcomes.

Language: Английский

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Fe₃O₄ SPIONs in cancer theranostics—structure versus interactions with proteins and methods of their investigation

Nanotechnology, Journal Year: 2024, Volume and Issue: 35(21), P. 212001 - 212001

Published: Feb. 22, 2024

As the second leading cause of death worldwide, neoplastic diseases are one biggest challenges for public health care. Contemporary medicine seeks potential tools fighting cancer within nanomedicine, as various nanomaterials can be used both diagnostics and therapies. Among those particular interest superparamagnetic iron oxide nanoparticles (SPIONs), due to their unique magnetic properties,. However, while number new SPIONs, suitably modified functionalized, designed medical purposes, has been gradually increasing, it not yet translated into approved clinical solutions. The presented review covers issues related SPIONs theranostic applications. It refers structural considerations (the nanoparticle core, most often modifications functionalizations) ways characterizing newly nanoparticles. discussion about phenomenon protein corona formation leads conclusion that scarcity proper investigate interactions between human serum proteins is reason difficulties in introducing them emphasizes importance understanding mechanism behind formation, a crucial impact on effectiveness physiological environment.

Language: Английский

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Nano-Proteolysis Targeting Chimeras (Nano-PROTACs) in Cancer Therapy

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 5739 - 5761

Published: June 1, 2024

Proteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules that have the capability to induce specific protein degradation. While playing a revolutionary role in effectively degrading of interest (POI), PROTACs encounter certain limitations impede their clinical translation. These encompass off-target effects, inadequate cell membrane permeability, and hook effect. The advent nanotechnology presents promising avenue surmount challenges associated with conventional PROTACs. utilization nano-proteolysis targeting (nano-PROTACs) holds potential enhance tissue accumulation, augment enable controlled release. Consequently, this approach has capacity significantly controllable degradation target proteins. Additionally, they synergistic effect by combining other therapeutic strategies. This review comprehensively summarizes structural basis, advantages, Furthermore, it highlights latest advancements nanosystems engineered for delivering PROTACs, as well development nano-sized employing nanocarriers linkers. Moreover, delves into underlying principles tailored specifically alongside current prospects research. In conclusion, integration harbors vast enhancing anti-tumor treatment response expediting

Language: Английский

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The Application of Carbon Nanomaterials in Sensing, Imaging, Drug Delivery and Therapy for Gynecologic Cancers: An Overview

Molecules, Journal Year: 2022, Volume and Issue: 27(14), P. 4465 - 4465

Published: July 13, 2022

Gynecologic cancers are one of the main health concerns women throughout world, and early diagnosis effective therapy gynecologic will be particularly important for survival female patients. As a current hotspot, carbon nanomaterials have attracted tremendous interest in tumor theranostics, their application has also been developed rapidly with great achievements recent years. This Overview Article summarizes latest progress diverse (e.g., graphenes, nanotubes, mesoporous carbon, dots, etc.) derivatives sensing, imaging, drug delivery, different cancers. Important research contributions highlighted terms relationships among fabrication strategies, architectural features, action mechanisms The challenges future strategies discussed from viewpoint real clinical carbon-based nanomedicines It is anticipated that this review attract more attention toward development theranostics

Language: Английский

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Metallic Nanoparticle-Doped Oxide Semiconductor Film for Bone Tumor Suppression and Bone Regeneration

ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(42), P. 47369 - 47384

Published: Oct. 13, 2022

Bone implants with the photothermal effect are promising for treatment of bone tumor defects. Noble metal-based nanoagents widely studied their stable effect, but they expensive and difficult to directly grow on implant surfaces. In contrast, non-noble metal economical unstable. Herein, develop a film implants, Ni nanoparticle-doped oxide semiconductor was grown in situ Nitinol via reduction Ni-Ti-layered double hydroxides. nanoparticles remained NiTiO3 structure even when immersed fluid 1 month, thus, presented reliable under near-infrared light irradiation. The also showed excellent vitro vivo antitumor performance. Moreover, nanostructure allowed differentiation mouse embryo cells (C3H10T1/2), released ions supported angiogenesis behavior human vein endothelial cells. implantation experiments further enhancement osteointegration modified vivo. This novel multifunctional design offers strategy therapy tumor-related

Language: Английский

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Synthesis of Au–Ag bimetallic nanoparticles using Korean red ginseng (Panax ginseng Meyer) root extract for chemo-photothermal anticancer therapy

Archives of Pharmacal Research, Journal Year: 2023, Volume and Issue: 46(8), P. 659 - 678

Published: Aug. 1, 2023

Language: Английский

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Nanomaterials for liver cancer targeting: research progress and future prospects

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 28, 2025

The incidence and mortality rates of liver cancer in China remain elevated. Although early-stage is amenable to surgical resection, a significant proportion patients are diagnosed at advanced stages. Currently, addition resection for hepatocellular carcinoma, the primary treatment modalities predominantly include chemotherapy. widespread use chemotherapy, which non-selectively targets both malignant healthy cells, often results substantial immunosuppression. Simultaneously, accumulation chemotherapeutic agents can readily induce drug resistance upon reaching physiological threshold, thereby diminishing efficacy these treatments. Besides there exist targeted therapy, immunotherapy other therapeutic approaches. Nevertheless, development remains an inevitable challenge. To address challenges, we turn nanomedicine, emerging widely utilized discipline that significantly influences medical imaging, antimicrobial strategies, delivery systems, related areas. Stable safe nanomaterials serve as effective carriers delivering anticancer drugs. They enhance precision targeting, improve bioavailability, minimize damage cells. This review focuses on common nanomaterial used carcinoma (HCC) over past five years. following summary three drugs: Sorafenib, Gefitinib, lenvatinib. Each employs distinct result varying levels release rates, efficacy.

Language: Английский

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