Effect of the Ultraviolet Radiation on the Lens

Current Protein and Peptide Science, Journal Year: 2023, Volume and Issue: 24(3), P. 215 - 228

Published: Jan. 9, 2023

The lens is a transparent, biconvex anatomical structure of the eyes responsible for light transmission and fine focusing on retina. It fundamentally constituted by water-soluble proteins called crystallins which are transparency due to their stable highly organized disposition in fiber cells. Some conformational changes subsequent aggregation lead loss beginning cataracts, most frequent cause reversible blindness world. Ultraviolet radiation considered one risk factors cataract development. exposed between 295 400 nm. This UV may induce several processes that destroy crystallins; significant oxidative stress increased free radicals formation. directly involved modifications crystallin leading formation high molecular weight aggregates then opacification lens, known as cataracts. review aims summarize current knowledge about damage caused ultraviolet its role developing

Language: Английский

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Dityrosine cross-linking and its potential roles in Alzheimer’s disease

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: March 22, 2023

Oxidative stress is a significant source of damage that accumulates during aging and contributes to Alzheimer's disease (AD) pathogenesis. Oxidation proteins can give rise covalent links between adjacent tyrosines known as dityrosine (DiY) cross-linking, amongst other modifications, this observation suggests DiY could serve biomarker accumulated oxidative over the lifespan. Many studies have focused on understanding contribution AD pathogenesis revealed crosslinks be found in both Aβ tau deposits - two key involved formation amyloid plaques tangles, respectively. However, there no consensus yet field impact function, aggregation, toxicity. Here we review current role gathered last 20 years since first observation, discuss effect modification for its potential AD.

Language: Английский

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Biomimetic Dual‐Network Collagen Fibers with Porous and Mechanical Cues Reconstruct Neural Stem Cell Niche via AKT/YAP Mechanotransduction after Spinal Cord Injury

Small, Journal Year: 2024, Volume and Issue: 20(32)

Published: March 18, 2024

Abstract Tissue engineering scaffolds can mediate the maneuverability of neural stem cell (NSC) niche to influence NSC behavior, such as self‐renewal, proliferation, and differentiation direction, showing promising application in spinal cord injury (SCI) repair. Here, dual‐network porous collagen fibers (PCFS) are developed neurogenesis by employing biomimetic plasma ammonia oxidase catalysis conventional amidation cross‐linking. Following optimizing mechanical parameters PCFS, well‐matched Young's modulus physiological dynamic adaptability PCFS (4.0 wt%) have been identified a neurogenetic exciter after SCI. Remarkably, topographies curving wall‐like protrusions generated on surface simple non‐toxic CO 2 bubble‐water replacement. As expected, with matched properties considerably activate cadherin receptor NSCs induce series serine‐threonine kinase/yes‐associated protein mechanotransduction signal pathways, encouraging cellular orientation, neuron differentiation, adhesion. In SCI rats, implanted further integrated into injured cords, inhibited inflammatory progression decreased glial fibrous scar formation. Wall‐like drive multiple subtypes formation even functional circuits, suggesting viable therapeutic strategy for nerve regeneration recovery

Language: Английский

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Oxidation of Supported Amines for CO₂ Direct Air Capture: Assessing Impact on Physical Properties and Mobility via NMR Relaxometry

Macromolecular Chemistry and Physics, Journal Year: 2024, Volume and Issue: 225(14)

Published: April 25, 2024

Abstract Aminopolymer‐based adsorbents are commonly investigated for CO 2 direct air capture (DAC). In the presence of high temperature and oxygen, which can occur during adsorption‐regeneration cycles, oxidative degradation significantly reduce adsorbent lifetime. Degradation is typically measured using adsorption performance metrics or chemical characterization. This work demonstrates that polymer's physical properties, as via nuclear magnetic resonance (NMR) relaxometry differential scanning calorimetry, be used to quantitatively track degradation. The extent oxidation an alumina‐poly(ethylenimine) sample, by reductions in amine efficiency (A.E.), correlated with proton T relaxation times. hypothesizes accurately tracks aminopolymers due reduction polymer mobility occurring process. ability use NMR a noninvasive technique probe demonstrated on 1‐inch square‐channel monolith exposed actual DAC service conditions. highlights potential evaluate state rapidly compared typical analytical methods.

Language: Английский

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Research Progress on the Mechanism of the Impact of Myofibrillar Protein Oxidation on the Flavor of Meat Products

Foods, Journal Year: 2024, Volume and Issue: 13(20), P. 3268 - 3268

Published: Oct. 15, 2024

Myofibrillar proteins primarily consist of myosin, actin, myogenin, and actomyosin. These form complex networks within muscle fibers are crucial to the physical chemical properties meat. Additionally, myofibrillar serve as significant substrates for adsorption volatile flavor compounds, including aldehydes, alcohols, ketones, sulfur nitrogen which contribute overall profile meat products. A series reactions occur during processing, storage, transportation Oxidation is one most reactions. Oxidative modification can alter proteins, ultimately impacting sensory quality products, flavor, taste, color. In recent years, considerable attention has been focused on effects protein oxidation its regulation. This study investigates impact attributes products by analyzing processes factors that initiate oxidation. it explores control implications providing theoretical insights relevant processing methods procedures.

Language: Английский

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