Multicomponent Synthesis of Unsymmetrical Derivatives of 4-Methyl-Substituted 5-Nitropyridines

Processes, Journal Year: 2023, Volume and Issue: 11(2), P. 576 - 576

Published: Feb. 14, 2023

The multicomponent reaction of 2-nitroacetophenone (or nitroacetone), acetaldehyde diethyl acetal, β-dicarbonyl compound, and ammonium acetate in an acetic acid solution allowed the acquisition previously undescribed 4-methyl-substituted derivatives 5-nitro-1,4-dihydropyridine satisfactory yields. oxidation obtained resulted corresponding 2,4-dimethyl-5-nitropyridines. In addition, for first time synthesis unsymmetrical 1,4-dihydropyridines by Hantzsch acetaldehyde, acetal was used as a source acetaldehyde. use more volatile sufficiently reactive this did not lead to controlled 5-nitro-1,4-dihydropyridines. proposed approach 5-nitro-1,4-dihydropyridines their subsequent aromatization into pyridines made it possible obtain hardly accessible substituted 5(3)-nitropyridines.

Language: Английский

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The vital use of isocyanide-based multicomponent reactions (MCR) in chemical synthesis

Physical Sciences Reviews, Journal Year: 2023, Volume and Issue: 9(2), P. 995 - 1032

Published: Feb. 22, 2023

Abstract Multicomponent (MCRs) reactions are classified as one-pot reaction where more than two starting materials employed to form a single product that contains the building blocks of components. MCRs considered convenient approach in synthetic chemistry and have many advantages over traditional one or two-component reaction, by reducing number sequential multiple steps required often producing better yields. This chapter dissects use isocyanide-based elegant they offer build useful scaffolds chemical field. In addition recognisable options for increasing “greenness” during synthesis pharmaceutical industrial products.

Language: Английский

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Synthesis and characterization of new 1,4-dihydropyran derivatives by novel Ta-MOF nanostructures as reusable nanocatalyst with antimicrobial activity

Frontiers in Chemistry, Journal Year: 2022, Volume and Issue: 10

Published: Sept. 27, 2022

Novel Ta- MOF was synthesized under mild conditions by ultrasound irradiations. The sample characterized SEM, FTIR, XRD, XPS, TG and BET technique. final structures showed high physicho-chemical properties including narrow particle size distribution, homogenous morphology, thermal stability remarkable surface area. in this study used as a catalyst the synthesis of 1,4-dihydropyran derivatives. results proved that it has capability. Its advantages include recyclability, less reaction time with higher efficiency new1,4-dihydropyran In following, antimicrobial activity antifungal antibacterial nanoparticles based on Minimum Inhibitory Concentration, Fungicidal Concentration Bactericidal were evaluated. MOF, addition to catalytic properties, MIC value between 16 −256 μg/ml, can be introduced an agent against bacteria fungi.

Language: Английский

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Six‐Component Reactions and Beyond: The Nuts and Bolts

European Journal of Organic Chemistry, Journal Year: 2022, Volume and Issue: 2022(34)

Published: Aug. 11, 2022

Abstract The deployment of multicomponent reactions (MCRs), defined as containing three or more reactants, not only enjoys pot, atom, and step‐economy in the synthesis novel complex molecules but also aligns with sustainable chemistry principles a green symphony. Generally, components lead to complexity, are taken an extreme ‘‘higher‐order’’ MCRs, where six even react one‐pot, have been developed, although they remain scarce compared their 3, 4 5‐component relatives. On this topic, rich footprint isocyanides MCRs has fruitful delivering higher order eight‐component through mechanistically similar pathways. present review encompasses brief history product utility, followed by thorough discussion reaction design that enabled discovery higher‐order spanning 6 8‐components. Future challenges opportunities will be elaborated.

Language: Английский

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3-(Propylthio)propane-1-sulfonic acid immobilized on functionalized magnetic nanoparticles as an efficient catalyst for one-pot synthesis of dihydrotetrazolo[1,5-a]pyrimidine and tetrahydrotetrazolo[5,1-b]quinazolinone derivatives

RSC Advances, Journal Year: 2022, Volume and Issue: 12(34), P. 22180 - 22187

Published: Jan. 1, 2022

An efficient and reusable catalyst, which is 3-(propylthio)propane-1-sulfonic acid immobillized on functionalized magnetic nanoparticles [PTPSA@SiO2-Fe3O4], has been synthesized. For the first time, it highlighted under solvent-free conditions for catalytic activity in multicomponent synthesis of dihydrotetrazolo[1,5-a]pyrimidines, dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylates tetrahydrotetrazolo[5,1-b]quinazolinones. The structure catalyst was well confirmed by characterization techniques, such as FT-IR, TGA, SEM-EDX, elemental mapping, TEM, VSM analysis. Besides, this unique found to be effectual up six cycles, made spotlighted. Recyclability excellent yield products, short reaction time clean profile are advantages present protocol.

Language: Английский

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