Russian Chemical Bulletin, Journal Year: 2024, Volume and Issue: 73(1), P. 179 - 188
Published: Jan. 1, 2024
Language: Английский
Medical Oncology, Journal Year: 2024, Volume and Issue: 41(6)
Published: May 4, 2024
Language: Английский
Citations
7
Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 303, P. 120439 - 120439
Published: Dec. 10, 2022
Language: Английский
Citations
23
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115023 - 115023
Published: June 16, 2023
Dual-receptor targeted (DRT) nanoparticles which contain two distinct targeting agents may exhibit higher cell selectivity, cellular uptake, and cytotoxicity toward cancer cells than single-ligand nanoparticle systems without additional functionality. The purpose of this study is to prepare DRT poly(lactic-co-glycolic acid) (PLGA) for the delivery docetaxel (DTX) EGFR PD-L1 receptor positive such as human glioblastoma multiform (U87-MG) non-small lung (A549) lines. Anti-EGFR anti-PD-L1 antibody were decorated on DTX loaded PLGA DRT-DTX-PLGA via. single emulsion solvent evaporation method. Physicochemical characterizations DRT-DTX-PLGA, particle size, zeta-potential, morphology, in vitro release also evaluated. average size was 124.2 ± 1.1 nm with spherical smooth morphology. In uptake study, endocytosed by U87-MG A549 ligand nanoparticle. From cytotoxicity, apoptosis studies, we reported that exhibited high enhanced apoptotic compared ligand-targeted dual mediated endocytosis showed a binding affinity effect leads intracellular concentration cytotoxic properties. Thus, have potential improve therapy providing selectivity over single-ligand-targeted nanoparticles.
Language: Английский
Citations
14
ACS Omega, Journal Year: 2023, Volume and Issue: 8(23), P. 20779 - 20791
Published: May 31, 2023
Multifunctional nanosized metal-organic frameworks (NMOFs) have advanced rapidly over the past decade to develop drug delivery systems (DDSs). These material still lack precise and selective cellular targeting, as well fast release of quantity drugs that are simply adsorbed within on external surface nanocarriers, which hinders their application in delivery. Herein, we designed a biocompatible Zr-based NMOF with an engineered core hepatic tumor-targeting ligand, glycyrrhetinic acid grafted polyethyleneimine (PEI) shell. The improved core-shell serves superior nanoplatform for efficient controlled active anticancer doxorubicin (DOX) against cancer cells (HepG2 cells). In addition high loading capacity 23%, developed nanostructure DOX@NMOF-PEI-GA showed acidic pH-stimulated response extended time 9 days enhanced selectivity toward tumor cells. Interestingly, DOX-free nanostructures minimal toxic effect both normal human skin fibroblast (HSF) cell line (HepG2), but DOX-loaded exhibited killing tumor, thus opening way achieving therapy applications.
Language: Английский
Citations
13
Journal of Cellular and Molecular Medicine, Journal Year: 2023, Volume and Issue: 28(1)
Published: Dec. 22, 2023
Abstract Breast cancer is the most prevalent worldwide and its incidence increases with age, posing a significant threat to women's health globally. Due clinical heterogeneity of breast cancer, majority patients develop drug resistance metastasis following treatment. Ferroptosis, form programmed cell death dependent on iron, characterized by accumulation lipid peroxides, elevated levels iron ions peroxidation. The underlying mechanisms signalling pathways associated ferroptosis are intricate interconnected, involving various proteins enzymes such as cystine/glutamate antiporter, glutathione peroxidase 4, inhibitor 1 dihydroorotate dehydrogenase. Consequently, emerging research suggests that may offer novel target for treatment; however, in urgently require resolution. Additionally, certain natural compounds have been reported induce ferroptosis, thereby interfering cancer. Therefore, this review not only discusses molecular multiple mediate (including metastasis, invasion proliferation) but also elaborates which Furthermore, summarizes potential compound types serve inducers future tumour cells, providing lead development ferroptosis‐inducing agents. Last, proposes synergy combining traditional drugs treatment suggesting directions offering new insights.
Language: Английский
Citations
13
Current Cancer Drug Targets, Journal Year: 2024, Volume and Issue: 24(11), P. 1089 - 1103
Published: Jan. 29, 2024
Chronic inflammation is associated with a prolonged increase in various inflammatory factors. According to clinical data, it can be linked both cancer and autoimmune diseases the same patients. This raises critical question of how chronic relates seemingly opposing - tumors, which there immunosuppression, diseases, over-activation immune system. In this review, we consider as prerequisite for suppression an increased likelihood damage. We also discuss potential disease-modifying therapies targeting inflammation, helpful autoimmunity. On one hand, pro-inflammatory factors persisting areas stimulate production anti-inflammatory due negative feedback loop, eliciting suppression. other bring baseline immunity closer threshold level required triggering response using bystander activation cells. Focusing on role may open prospects more intensive drug discovery inflammation.
Language: Английский
Citations
4
ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 11, 2025
Language: Английский
Citations
0
Biochemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 24, 2025
Nanoparticles (NPs) are beneficial for delivery of drugs in a variety settings, serving to protect their cargo and allow sustained release. Polymeric NPs offer several advantages as therapeutics carriers due tunable characteristics like size shape, ease manufacturing, biocompatibility. Despite this, there no polymeric that approved treatment liver diseases. This is surprising since─when administered intravenously─the majority accumulate cells the liver. NP surface charge can be altered affect distribution liver, even cellular distribution, but conjugation targeting ligands onto specific receptors on an important approach enhancing cell delivery. Enhancing cell-specific conjugated has two major hurdles: 1) avoiding accumulation resident macrophages known Kupffer cells, which optimized phagocytose particulates, 2) overcoming transport barriers associated with architectural changes diseased To identify structures mechanisms most design, administration during ex vivo perfusion (EVP)─achieved by anatomically isolating organ perfusing it outside body─may efficient approach. However, EVP currently underutilized field, limited research published delivered EVP, therefore representing opportunity future investigations.
Language: Английский
Citations
0
Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(4)
Published: April 1, 2025
ABSTRACT Smart polymeric micelles have emerged as versatile nanocarriers in targeted drug delivery, driven by their unique ability to encapsulate therapeutic agents and deliver them with precision specific sites. This review delves into the recent advancements design, functionality, biomedical applications of these nanostructures, emphasizing role enhancing efficacy while minimizing systemic toxicity. The begins discussing principles behind stimuli‐responsive micelles, exploring mechanisms triggered pH, redox conditions, temperature, light achieve controlled release. It highlights advances functionalization strategies, including surface modifications targeting ligands stimuli‐sensitive linkages, which enhance specificity adaptability pathological microenvironments. Subsequent sections focus on cutting‐edge applications, particularly cancer therapy, regenerative medicine, theranostics, showcasing potential addressing complex clinical challenges. Emerging technologies, such multi‐stimuli‐responsive systems hybrid are explored for overcome limitations loading, stability, release profiles. Despite significant progress, current technologies still face challenges, achieving consistent reproducible loading efficiencies, maintaining stability physiological environments, controlling precise kinetics, ensuring scalable cost‐effective production methods. concludes a discussion challenges future perspectives field, need integrating advanced polymer chemistry, nanotechnology, biomedicine develop next‐generation smart micelles. By providing comprehensive overview, this article aims underscore transformative advancing medicine interventions.
Language: Английский
Citations
0
Clinical and Experimental Medicine, Journal Year: 2025, Volume and Issue: 25(1)
Published: May 10, 2025
This study examines the impact of continuous infusion chemotherapy via femoral artery catheterization on Golgi protein 73 (GP73) and alpha fetoprotein heterogeneity (AFP-L3) in liver cancer patients. A retrospective analysis was conducted 108 patients treated from January 2020 to December 2022, divided into two groups: transarterial chemoembolization (TACE) regional arterial (CIFAC), with 54 each group. Serum tumor markers, function, adverse reactions, quality life, 1-year survival rate were analyzed compared between groups Prior treatment, no significant differences observed life (P > 0.05). After 60 90 days, CIFAC group exhibited significantly lower levels GP73, AFP, AFP-L3 TACE < Additionally, had alanine aminotransferase (ALT), aspartate transaminase (AST), indocyanine green (ICG15) 0.05), reduced reactions (nausea, vomiting, etc.), higher Karnofsky scores The one-year than that Continuous through can help reduce serum marker levels, improve
Language: Английский
Citations
0