Cannabis: a multifaceted plant with endless potentials

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: June 15, 2023

Cannabis sativa , also known as “hemp” or “weed,” is a versatile plant with various uses in medicine, agriculture, food, and cosmetics. This review attempts to evaluate the available literature on ecology, chemical composition, phytochemistry, pharmacology, traditional uses, industrial toxicology of . So far, 566 compounds have been isolated from including 125 cannabinoids 198 non-cannabinoids. The psychoactive physiologically active part cannabinoid, mostly found flowers, but present smaller amounts leaves, stems, seeds. Of all phytochemicals, terpenes form largest composition plant. Pharmacological evidence reveals that plants contain which exhibit potential antioxidants, antibacterial agents, anticancer anti-inflammatory agents. Furthermore, reported applications food cosmetic industries. Significantly, cultivation has minimal negative impact environment terms cultivation. Most studies focused make-up, pharmacological effects, not much about toxic effects. Overall, enormous for biological well other medicinal uses. However, further research necessary fully understand explore beneficial properties

Language: Английский

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Recent trends in the use of bacteriophages as replacement of antimicrobials against food-animal pathogens

Frontiers in Veterinary Science, Journal Year: 2023, Volume and Issue: 10

Published: May 25, 2023

A major public health impact is associated with foodborne illnesses around the globe. Additionally, bacteria are becoming more resistant to antibiotics, which pose a global threat. Currently, many scientific efforts have been made develop and implement new technologies combat considering increasing emergence of multidrug-resistant bacteria. In recent years, there has considerable interest in using phages as biocontrol agents for pathogens animals used food production products themselves. Foodborne outbreaks persist, globally, foods, some lack adequate methods control any pathogenic contamination (like fresh produce). This may be attributed both consumers’ desire natural fact that continue occur foods. Poultry most common animal treated phage therapy pathogens. large number worldwide caused by Salmonella spp. Campylobacter , found poultry egg products. Conventional bacteriophage-based can prevent humans from various infectious diseases. this context, describing bacteriophage based on bacterial cells offer breakthrough treating infections. Large-scale pheasants economically challenging meet needs market. It also possible produce scale at reduced cost. Recently, they provided an ideal platform designing producing immune-inducing phages. Emerging will likely targeted future. review article, we mainly focus Bacteriophages (phages) proposed alternative strategy antibiotics their use safety.

Language: Английский

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A narrative review of the therapeutic and remedial prospects of cannabidiol with emphasis on neurological and neuropsychiatric disorders

Journal of Cannabis Research, Journal Year: 2024, Volume and Issue: 6(1)

Published: March 18, 2024

Abstract Background The treatment of diverse diseases using plant-derived products is actively encouraged. In the past few years, cannabidiol (CBD) has emerged as a potent cannabis-derived drug capable managing various debilitating neurological infections, diseases, and their associated complications. CBD demonstrated anti-inflammatory curative effects in neuropathological conditions, it exhibits therapeutic, apoptotic, anxiolytic, neuroprotective properties. However, more information on reactions ability to alleviate brain-related disorders neuroinflammation that accompanies them needed. Main body This narrative review deliberates therapeutic remedial prospects with an emphasis neuropsychiatric disorders. An extensive literature search followed several scoping searches available online databases such PubMed, Web Science, Scopus main keywords: CBD, pro-inflammatory cytokines, cannabinoids. After purposive screening retrieved papers, 170 (41%) articles (published English) aligned objective this study retained for inclusion. Conclusion antagonist against cytokines cytokine storm infections/disorders. regulates adenosine/oxidative stress aids downregulation TNF-α, restoration BDNF mRNA expression, recovery serotonin levels. Thus, involved immune suppression anti-inflammation. Understanding metabolites response imperative understand phenotype. We propose metabolomics will be next scientific frontier reveal novel CBD’s tendencies neurological/neuropsychiatric

Language: Английский

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Industrial Hemp As a Multi-Purpose Crop: Last Achievements and Research in 2018−2023

Journal of Natural Fibers, Journal Year: 2024, Volume and Issue: 21(1)

Published: June 27, 2024

Industrial hemp cultivation was restricted years ago in most countries, thus wiping out centuries of science and genetic resources. It is only since the 1990s that has been experiencing its renaissance, which nowadays driven by new strategies. The objective review to compile summarize latest research achievements. focus on from 2018 2023. VOSviewer software used define main areas trends. Most articles were discussed, among others determination average yield loss due water stress (8.7 Mg ha−1) low temperatures (0.4 ha−1); increase up 25% achieving rejecting smallest seeds; or definition optimum dose sewage sludge application (25 ha−1). Regarding composition properties: identification caflanone flavonoid (selective activity against certain neoplasms); 71 compounds (monoterpenes, sesquiterpenes CBs) EO; antioxidant capacity EO (63 mg TE g−1 438 g−1); comparison content monoicous, female male inflorescences (0.10%, 0.15% 0.07% respectively). current possibilities using, e.g. for phytoremediation bioenergy, presented. Also knowledge gaps future identified.

Language: Английский

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Bacteriophages as Biocontrol Agents in Livestock Food Production

Microorganisms, Journal Year: 2022, Volume and Issue: 10(11), P. 2126 - 2126

Published: Oct. 27, 2022

Bacteriophages have been regarded as biocontrol agents that can be used in the food industry. They various applications, such pathogen detection and bio-preservation. Their potential to improve quality of prevent foodborne illness is widespread. These bacterial viruses also utilized preservation other products. The specificity high sensitivity bacteriophages when they lyse targets important factors contribute their great utility This review will provide an overview current applications.

Language: Английский

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Biosynthesis of Phytocannabinoids and Structural Insights: A Review

Metabolites, Journal Year: 2023, Volume and Issue: 13(3), P. 442 - 442

Published: March 17, 2023

Cannabis belongs to the family Cannabaceae, and phytocannabinoids are produced by

Language: Английский

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Research Progress on Cannabinoids in Cannabis (Cannabis sativa L.) in China

Molecules, Journal Year: 2023, Volume and Issue: 28(9), P. 3806 - 3806

Published: April 29, 2023

Cannabis (Cannabis sativa L.) is an ancient cultivated plant that contains less than 0.3% tetrahydrocannabinol (THC). It widely utilized at home and abroad economic crop with great development utilization value. There are 31 countries legalizing industrial cannabis cultivation. fiber has been used for textile production in China 6000 years. the largest producer exporter of cannabis. may still play a leading role fiber. long history cultivation rich germplasm resources. Yunnan, Heilongjiang, Jilin three Chinese provinces where can be grown legally. Cannabinoids terpenoid phenolic compounds produced during growth, which found glandular hairs female flowers anthesis. They active chemical components main exert pharmacological activity. At same time, research on use food industry shown oil 13–20% oleic acid, 40–60% omega-6 linoleic 15–30% omega-3 α-linolenic acid. present, more 100 cannabinoids have identified analyzed China, among objects. For instance, substances represented by cannabidiol (CBD) effects. relatively little cannabinoids, comprehensive introduction to progress this area needed. This paper reviews domestic foreign sativa, expected support cannabis-related development.

Language: Английский

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Evaluating the Metabolomic Profile and Anti-Pathogenic Properties of Cannabis Species

Metabolites, Journal Year: 2024, Volume and Issue: 14(5), P. 253 - 253

Published: April 26, 2024

The Cannabis species is one of the potent ancient medicinal plants acclaimed for its properties and recreational purposes. plant parts are used exploited all over world several agricultural industrial applications. For many years spp. has proven to present a highly diverse metabolomic profile with pool bioactive metabolites numerous pharmacological purposes ranging from anti-inflammatory antimicrobial. sativa since been an extensive subject investigation, monopolizing research. Hence, there fewer studies comprehensive understanding composition grown in different environmental conditions, especially C. indica few other strains. These mostly attributed phytocannabinoids some phytochemicals such as terpenoids or essential oils which have tested antimicrobial properties. Many discovered compounds yet be series useful including anti-insecticidal, anti-acaricidal, anti-nematicidal, anti-bacterial, anti-fungal, anti-viral Research reported excellent antibacterial activity against Gram-positive Gram-negative multidrug-resistant bacteria well methicillin-resistant Staphylococcus aureus (MRSA). Although investigation on Cannabis, phytopathogens aquatic animal pathogens, those affecting fish, remain under-researched. Therefore, current review intends investigate existing body research anti-microbial whilst trying expand scope benefit health crops, particularly agriculture.

Language: Английский

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CBD resistant Salmonella strains are susceptible to epsilon 34 phage tailspike protein

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: March 7, 2023

The rise of antimicrobial resistance is a global public health crisis that threatens the effective control and prevention infections. Due to emergence pandrug-resistant bacteria, most antibiotics have lost their efficacy. Bacteriophages or components are known target bacterial cell walls, membranes, lipopolysaccharides (LPS) hydrolyze them. being natural predators pathogenic inevitably categorized as "human friends", thus fulfilling adage "the enemy my friend". Leveraging on lethal capabilities against researchers searching for more ways overcome current antibiotic challenge. In this study, we expressed purified epsilon 34 phage tailspike protein (E34 TSP) from E34 TSP gene, then assessed ability bacteriophage in killing two CBD-resistant strains Salmonella spp. We also cause bacteria membrane disruption, dehydrogenase depletion. observed combined treatment with CBD showed poor whereas monotreatment considerably higher efficiency. This study demonstrates inhibition by was due part inactivation protein. results work provides an interesting background highlight crucial role such could play control.

Language: Английский

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Physiochemical properties of hemp extract (Cannabis sativa L) inflorescences grown in Northern Alabama

Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(2)

Published: Feb. 1, 2025

Medicinal plants are an excellent source of bioactive components and gaining significant attention for food protection due to their properties. In this context, hemp (Cannabis sp.) is being explored such applications because its well-known antibacterial antioxidant activities. However, the efficacy cultivars currently grown in Northern Alabama has not been widely studied. Therefore, purpose study was evaluate physicochemical properties two (Hemp 5 Hemp 17). inflorescences at Winfred Thomas Agricultural Research Station were used study. The activity content extracts determined by ferric reducing power, radical scavenging activity, total phenolic content, flavonoid content. Antibacterial against cocktails Listeria monocytogenes (LM) Salmonella enterica (SE) evaluated optical density disc diffusion. All treatments analyzed triplicate, analysis variance conducted with statistical significance based on p ≤ 0.05. Results indicated that defatting significantly affected (p 0.05) properties, 17 DF (defatted) having highest RSA (70.51 ± 4.24%) compared positive control ascorbic acid (83.81 5.85%). results had a lower negative controls (LM SE). These findings suggest can potentially be utilized enhance safety quality. PRACTICAL APPLICATION: extract enhancement quality application inherent antimicrobial

Language: Английский

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