Antimicrobial Properties of Colostrum and Milk

Antibiotics, Journal Year: 2024, Volume and Issue: 13(3), P. 251 - 251

Published: March 11, 2024

The growing number of antibiotic resistance genes is putting a strain on the ecosystem and harming human health. In addition, consumers have developed cautious attitude towards chemical preservatives. Colostrum milk are excellent sources antibacterial components that help to strengthen immunity offspring accelerate maturation immune system. It possible study these important defenses colostrum, such as lactoferrin, lysozyme, immunoglobulins, oligosaccharides, etc., biotherapeutic agents for prevention treatment numerous infections caused by microbes. Each has different mechanisms interactions in various places. compound’s action determine where activity appears. activation colostrum compounds can start infant’s mouth during lactation continue gastrointestinal regions. These properties possess potential therapeutic uses. order discover new perspectives methods bacterial infections, additional investigations complexes required.

Language: Английский

---

Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Biomimetics, Journal Year: 2024, Volume and Issue: 9(3), P. 154 - 154

Published: March 1, 2024

The incidence of microbial infections in orthopedic prosthetic surgeries is a perennial problem that increases morbidity and mortality, representing one the major complications such medical interventions. emergence novel technologies, especially 3D printing, represents promising avenue development for reducing risk eventualities. There are already host biomaterials, suitable being tested antimicrobial properties when they coated with bioactive compounds, as antibiotics, or combined hydrogels antioxidant properties, chitosan metal nanoparticles, among others. materials discussed context this paper comprise beta-tricalcium phosphate (β-TCP), biphasic calcium (BCP), hydroxyapatite, lithium disilicate glass, polyetheretherketone (PEEK), poly(propylene fumarate) (PPF), poly(trimethylene carbonate) (PTMC), zirconia. While recent research results promising, further required to address increasing antibiotic resistance exhibited by several common pathogens, potential fungal infections, toxicity some nanoparticles. Other solutions, like incorporation phytochemicals, should also be explored. Incorporating artificial intelligence (AI) certain implants use AI against bacterial might represent viable solutions these problems. Finally, there legal considerations associated biomaterials widespread which must taken into account.

Language: Английский

---

Time to Kill and Time to Heal: The Multifaceted Role of Lactoferrin and Lactoferricin in Host Defense

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(4), P. 1056 - 1056

Published: March 24, 2023

Lactoferrin is an iron-binding glycoprotein present in most human exocrine fluids, particularly breast milk. also released from neutrophil granules, and its concentration increases rapidly at the site of inflammation. Immune cells both innate adaptive immune system express receptors for lactoferrin to modulate their functions response it. On basis these interactions, plays many roles host defense, ranging augmenting or calming inflammatory pathways direct killing pathogens. Complex biological activities are determined by ability sequester iron highly basic N-terminus, via which binds a plethora negatively charged surfaces microorganisms viruses, as well mammalian cells, normal cancerous. Proteolytic cleavage digestive tract generates smaller peptides, such N-terminally derived lactoferricin. Lactoferricin shares some properties lactoferrin, but exhibits unique characteristics functions. In this review, we discuss structure, functions, potential therapeutic uses lactoferricin, other lactoferrin-derived bioactive peptides treating various infections conditions. Furthermore, summarize clinical trials examining effect supplementation disease treatment, with special focus on use COVID-19.

Language: Английский

---

In vitro and in silico studies of the structure and functional properties of the lactoferrin-chlorogenic acid complex

Food Hydrocolloids, Journal Year: 2023, Volume and Issue: 144, P. 109051 - 109051

Published: July 4, 2023

Language: Английский

---

Milk Bioactive Compounds and Gut Microbiota Modulation: The Role of Whey Proteins and Milk Oligosaccharides

Foods, Journal Year: 2024, Volume and Issue: 13(6), P. 907 - 907

Published: March 16, 2024

A strong correlation between the occurrence of various pathological conditions and intestinal dysbiosis is supported by a range evidence. Vice versa, many pathologies have been shown, in turn, to be responsible for alterations gut microbiota, condition that can worsen illness outcomes response therapies. For these reasons, great efforts made, studies are still ongoing, elucidate mechanisms underlying microbiota search pharmacologic or other strategies effectively restore microbiota. In this narrative review, we examined most significant literature on role some milk bioactive compounds, such as oligosaccharides whey proteins, modulating composition action, with aim investigating impact changes mediated molecules human health, their potential use therapeutics treat adjuvate treatment associated pathologies.

Language: Английский

---

Interaction between Dietary Lactoferrin and Gut Microbiota in Host Health

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(14), P. 7596 - 7606

Published: April 1, 2024

The gut microbiota are known to play an important role in host health and disease. Alterations the composition can disrupt stability of ecosystem, which may result noncommunicable chronic diseases (NCCDs). Remodeling through personalized nutrition is a novel therapeutic avenue for both disease control prevention. However, whether there commonly used microbiota-targeted diets how microbiota–diet interactions combat NCCDs improve remain questions be addressed. Lactoferrin (LF), broadly dietary supplements, acts not only as antimicrobial defense against enteropathogenic bacteria but also prebiotic propagate certain probiotics. Thus, LF-induced alterations harnessed induce changes physiology, underpinnings their relationships mechanisms beginning unravel studies involving humans animal models.

Language: Английский

---

Potentials of Natural Antioxidants in Reducing Inflammation and Oxidative Stress in Chronic Kidney Disease

Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 751 - 751

Published: June 20, 2024

Chronic kidney disease (CKD) presents a substantial global public health challenge, with high morbidity and mortality. CKD patients often experience dyslipidaemia poor glycaemic control, further exacerbating inflammation oxidative stress in the kidney. If left untreated, these metabolic symptoms can progress to end-stage renal disease, necessitating long-term dialysis or transplantation. Alleviating responses has become standard approach management. Medications such as statins, metformin, GLP-1 agonists, initially developed for treating dysregulation, demonstrate promising therapeutic benefits. The rising popularity of herbal remedies supplements, perceived natural antioxidants, spurred investigations into their potential efficacy. Notably, lactoferrin, Boerhaavia diffusa, Amauroderma rugosum, Ganoderma lucidum are known anti-inflammatory antioxidant properties may support function preservation. However, mechanisms underlying effectiveness Western medications alleviating occurring dysfunction not completely known. This review aims provide comprehensive overview treatment strategies preservation critically discusses existing literature’s limitations whilst offering insight effects interventions. could useful guide future clinical trials facilitate development effective functions.

Language: Английский

---

A sustainable sensitive spectrofluorimetric approach for the determination of the multipotent protein lactoferrin in different pharmaceuticals and infant milk formula: Compliance with greenness metrics

Luminescence, Journal Year: 2024, Volume and Issue: 39(5)

Published: May 1, 2024

Abstract The current study presents the first spectrofluorimetric approach for estimation of lactoferrin, depending on measurement its native fluorescence at 337 nm after excitation 230 nm, without need any hazardous chemicals or reagents. It was found that intensity versus concentration calibration plot linear over range 0.1–10.0 μg/mL with quantitation and detection limits 0.082 0.027 μg/mL, respectively. method accordingly validated according to ICH recommendations. developed applied lactoferrin in different dosage forms, including capsules sachets high percent recoveries (97.84–102.53) low %RSD values (<1.95). Lactoferrin is one key nutrients milk powder a significant nutritional fortifier. In order assess quality powder, it essential rapidly accurately quantify content product. Therefore, presented successfully selective acceptable (96.45–104.92) (≤3.607). Finally, green profile estimated using two assessment tools: Green Analytical Procedure Index (GAPI) GREEnness (AGREE), which demonstrated excellent greenness.

Language: Английский

---

Exploring the antimicrobial potentials and thermal stability of bovine lactoferrin against foodborne pathogens

International Journal of Food Science & Technology, Journal Year: 2025, Volume and Issue: 60(1)

Published: Jan. 1, 2025

Abstract The study was conducted to analyze the antimicrobial activity and sensitivity of bovine lactoferrin against foodborne pathogens evaluate pH range thermal stability lactoferrin. agar well diffusion test used check each pathogen. Bacterial samples were purified confirmed by biochemical tests. Three concentrations 0.5, 1, 10 mg/ml evaluated for antibacterial Escherichia coli, Salmonella enteritidis, Staphylococcus aureus. Our results indicated that all three pathogenic bacteria inhibited, even at 0.5 (p &lt; .05). E. coli most sensitive, S. aureus least sensitive. Lactoferrin remains effective 6, 7, 8, 9 pH, but no inhibition showed 3, 4, 5 change a pasteurization temperature 60–75 °C .05) inactivated higher temperatures. can inhibit from growth remain unchanged ranges 6–9.

Language: Английский

---

Molecular Docking of Lactoferrin with Apoptosis-Related Proteins Insights into Its Anticancer Mechanism

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2023 - 2023

Published: Feb. 26, 2025

Human Lactoferrin (hLf), a multifunctional glycoprotein, has been analyzed through molecular docking to evaluate its role in apoptosis regulation and potential as an anticancer agent. The results highlight XIAP (X-linked Inhibitor of Apoptosis Protein) Caspase-3 the most reliable targets, where hLf disrupts XIAP's inhibition Caspase-9, potentially restoring apoptotic signaling; also stabilizes Caspase-3, enhancing activation intrinsic extrinsic pathways. Weaker interactions were observed with Fas, Bcl-2, Akt. hLf's Fas signaling is likely due expression upregulation rather than direct binding. In contrast, binding Bcl-2 may disrupt anti-apoptotic function, interaction Akt suggests interference pro-survival signaling. These findings suggest that promote by caspase modulating key regulators, supporting use cancer treatment. However, further experimental validation needed confirm these their therapeutic implications.

Language: Английский

---