Predictors and Adverse Outcomes of Acute Kidney Injury in Hospitalized Renal Transplant Recipients DOI Creative Commons
Tammy Hod, Tsz‐Kwong Man,

Noa Scott

et al.

Transplant International, Journal Year: 2023, Volume and Issue: 36

Published: March 9, 2023

Data about in-hospital AKI in RTRs is lacking. We conducted a retrospective study of 292 RTRs, with 807 hospital admissions, to reveal predictors and outcomes during admission. In-hospital developed 149 patients (51%). previous admission was associated more than twofold increased risk subsequent admissions (OR 2.13, p < 0.001). Other major significant for included an infection as the diagnosis 2.93, = 0.015), medical history hypertension 1.91, 0.027), minimum systolic blood pressure 0.98, 0.002), maximum tacrolimus trough level 1.08, 0.005), hemoglobin 0.9, 0.016) albumin 0.51, 0.025) Compared no AKI, were longer length stay (median time 3.83 vs. 7.01 days, higher rates mortality admission, almost doubled odds rehospitalization within 90 days from discharge overall multivariable mixed effect models. common poor short- long-term outcomes. Strategies prevent should be implemented reduce re-admission improve patient survival.

Language: Английский

Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease DOI Creative Commons
Yan Qian, Shasha Liu, Yang Sun

et al.

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Aug. 2, 2023

Abstract Cardiovascular diseases (CVDs) continue to exert a significant impact on global mortality rates, encompassing conditions like pulmonary arterial hypertension (PAH), atherosclerosis (AS), and myocardial infarction (MI). Oxidative stress (OS) plays crucial role in the pathogenesis advancement of CVDs, highlighting its significance as contributing factor. Maintaining an equilibrium between reactive oxygen species (ROS) antioxidant systems not only aids mitigating oxidative but also confers protective benefits cardiac health. Herbal monomers can inhibit OS CVDs by activating multiple signaling pathways, such increasing activity endogenous decreasing level ROS expression. Given actions herbal significantly protect normal function heart reduce damage caused organism. Hence, it is imperative recognize prospective therapeutic interventions for CVDs. This paper aims comprehensively review origins mechanisms underlying OS, elucidate intricate association explore potential treatment utilizing monomers. Furthermore, particular emphasis will be placed examining cardioprotective effects evaluating their pathways subsequent treatment. Graphical

Language: Английский

Citations

69
The mechanism of ferroptosis and its related diseases DOI Creative Commons
Shijian Feng, Dan Tang, Yichang Wang

et al.

Molecular Biomedicine, Journal Year: 2023, Volume and Issue: 4(1)

Published: Oct. 16, 2023

Abstract Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation lipid peroxides, provides novel avenue for delving into intersection metabolism, oxidative stress, and disease pathology. We have witnessed mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, traumatic tissue injuries. By unraveling intricate underpinnings molecular machinery, contributors, signaling conduits, regulatory networks governing researchers aim bridge gap between intricacies this unique mode multifaceted implications health disease. In light rapidly advancing landscape ferroptosis research, we present comprehensive review aiming at extensive in origins progress human diseases. This concludes careful analysis potential treatment approaches carefully designed either inhibit or promote ferroptosis. Additionally, succinctly summarized therapeutic targets compounds that hold promise targeting within various facet underscores burgeoning possibilities manipulating as strategy. summary, enriched insights both investigators practitioners, while fostering an elevated comprehension latent translational utilities. revealing basic processes investigating possibilities, crucial resource scientists medical aiding deep understanding effects situations.

Language: Английский

Citations

62
New Drugs and Therapies in Pulmonary Arterial Hypertension DOI Open Access
Aangi J. Shah,

Taylor Beckmann,

Mounica Vorla

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5850 - 5850

Published: March 19, 2023

Pulmonary arterial hypertension is a chronic, progressive disorder of the pulmonary vasculature with associated and cardiac remodeling. PAH was uniformly fatal disease until late 1970s, but advent targeted therapies, life expectancy patients has now considerably improved. Despite these advances, inevitably remains significant morbidity mortality. Thus, there still an unmet need for development new drugs other interventional therapies treatment PAH. One shortcoming currently approved vasodilator that they do not target or reverse underlying pathogenesis process itself. A large body evidence evolved in past two decades clarifying role genetics, dysregulation growth factors, inflammatory pathways, mitochondrial dysfunction, DNA damage, sex hormones, neurohormonal iron deficiency This review focuses on newer targets modify pathways as well novel

Language: Английский

Citations

34
Molecular Mechanisms and Therapeutic Implications of Endothelial Dysfunction in Patients with Heart Failure DOI Open Access
Vasiliki Tsigkou, Evangelos Oikonomou, Artemis Anastasiou

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4321 - 4321

Published: Feb. 21, 2023

Heart failure is a complex medical syndrome that attributed to number of risk factors; nevertheless, its clinical presentation quite similar among the different etiologies. displays rapidly increasing prevalence due aging population and success treatment devices. The pathophysiology heart comprises several mechanisms, such as activation neurohormonal systems, oxidative stress, dysfunctional calcium handling, impaired energy utilization, mitochondrial dysfunction, inflammation, which are also implicated in development endothelial dysfunction. with reduced ejection fraction usually result myocardial loss, progressively ends remodeling. On other hand, preserved common patients comorbidities diabetes mellitus, obesity, hypertension, trigger creation micro-environment chronic, ongoing inflammation. Interestingly, dysfunction both peripheral vessels coronary epicardial microcirculation characteristic categories has been associated worse cardiovascular outcomes. Indeed, exercise training drug display favorable effects against apart from their established direct benefit.

Language: Английский

Citations

29
Salidroside protects pulmonary artery endothelial cells against hypoxia-induced apoptosis via the AhR/NF-κB and Nrf2/HO-1 pathways DOI Creative Commons
Wei Lei, Meihong Chen,

Zu-feng Huang

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155376 - 155376

Published: Jan. 18, 2024

: The apoptosis of pulmonary artery endothelial cells (PAECs) is an important factor contributing to the development hypertension (PH), a serious cardio-pulmonary vascular disorder. Salidroside (SAL) bioactive compound derived from herb Rhodiola, but potential protective effects SAL on PAECs and underlying mechanisms remain elusive. objective this study was determine role in hypoxia-induced dissect mechanisms. Male Sprague-Dawley (SD) rats were subjected hypoxia (10% O2) for 4 weeks establish model PH. Rats intraperitoneally injected daily with (2, 8, 32 mg/kg/d) or vehicle. To define molecular PAECs, vitro hypoxic cell injury also generated by exposed 1% O2 48 hours. Various techniques including hematoxylin eosin (HE) staining, immunofluorescence, flow cytometry, CCK8, Western blotting, qPCR, docking, surface plasmon resonance (SPR) used vitro. Hypoxia stimulation increases AhR nuclear translocation activates NF-κB signaling pathway, as evidenced upregulated expression CYP1A1, CYP1B1, IL-1β, IL-6, resulting oxidative stress inflammatory response ultimately PAECs. inhibited activation NF-κB, while promoted Nrf2 increased its downstream antioxidant proteins HO-1 NQO1 ameliorating Furthermore, lowered right ventricular systolic pressure, decreased remodeling hypertrophy hypoxia-exposed rats. may attenuate suppressing activating Nrf2/HO-1 pathways, thereby delaying progressive pathology

Language: Английский

Citations

9
The protective effects of baicalin for respiratory diseases: an update and future perspectives DOI Creative Commons

Siyu Song,

Lu Ding, Guangwen Liu

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: March 16, 2023

Background: Respiratory diseases are common and frequent diseases. Due to the high pathogenicity side effects of respiratory diseases, discovery new strategies for drug treatment is a hot area research. Scutellaria baicalensis Georgi (SBG) has been used as medicinal herb in China over 2000 years. Baicalin (BA) flavonoid active ingredient extracted from SBG that BA found exert various pharmacological against However, there no comprehensive review mechanism treating This aims summarize current pharmacokinetics BA, baicalin-loaded nano-delivery system, its molecular mechanisms therapeutical Method: reviewed databases such PubMed, NCBI, Web Science their inception 13 December 2022, which literature was related “baicalin”, “ Georgi”, “COVID-19”, “acute lung injury”, “pulmonary arterial hypertension”, “asthma”, “chronic obstructive pulmonary disease”, fibrosis”, “lung cancer”, “pharmacokinetics”, “liposomes”, “nano-emulsions”, “micelles”, “phospholipid complexes”, “solid dispersions”, “inclusion other terms. Result: The involves mainly gastrointestinal hydrolysis, enteroglycoside cycle, multiple metabolic pathways, excretion bile urine. poor bioavailability solubility liposomes, nano-emulsions, micelles, phospholipid complexes, solid dispersions, inclusion complexes have developed improve bioavailability, targeting, solubility. exerts potent by mediating upstream oxidative stress, inflammation, apoptosis, immune response pathways. It regulates NF-κB, PI3K/AKT, TGF-β/Smad, Nrf2/HO-1, ERK/GSK3β Conclusion: presents information on about pharmacokinetics, therapeutic potential available studies suggest excellent possible worthy further investigation development.

Language: Английский

Citations

15
Mitochondrial Dysfunction in Pulmonary Hypertension DOI Creative Commons
Gusty Rizky Teguh Ryanto, Ratoe Suraya, Tatsuya Nagano

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 372 - 372

Published: Feb. 3, 2023

Pulmonary hypertension (PH) is a multi-etiological condition with similar hemodynamic clinical sign and end result of right heart failure. Although its causes vary, link across all the classifications presence mitochondrial dysfunction. Mitochondria, as powerhouse cells, hold number vital roles in maintaining normal cellular homeostasis, including pulmonary vascular cells. As such, any disturbance functions mitochondria could lead to major pathological consequences. The Warburg effect has been established finding PH conditions, but other mitochondria-related metabolic oxidative stress factors have also reported, making important contributions progression remodeling that commonly found pathophysiology. In this review, we will discuss role vasculature, how it be altered during remodeling, therapeutic options available can treat

Language: Английский

Citations

14
Hypoxia Combined With Interleukin‐17 Regulates Hypoxia‐Inducible Factor‐1α/Endothelial Nitric Oxide Synthase Expression in Pulmonary Artery Endothelial Cells DOI Creative Commons
Shuai Sun, Jianjun Mao, Yuan Ding

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(2)

Published: Jan. 1, 2025

The pathogenesis of chronic thromboembolic pulmonary hypertension may be multifactorial and requires further studies. We explored alterations in artery endothelial cells under the hypoxic elevated interleukin-17 conditions that are commonly present patients with hypertension. measured serum levels 10 healthy control persons. expressions localisations hypoxia-inducible factor-1α nitric oxide synthase were detected tissues. factor-1α, synthase, oxide, reactive oxygen species cultured examined hypoxia and/or treatment. level was increased patients. Hypoxia-inducible increased, decreased vascular tissue. After receiving combined treatment, showed phospho-endothelial (Thr495) (p = 0.001 0.063, respectively) a < 0.001). In addition, significantly 0.001), whereas insignificantly cells. Chronic might experience inflammation due to dysregulation factor-1α/endothelial pathway hypoxia, contributing

Language: Английский

Citations

0
Role of Xuefu Zhuyu decoction in improving pulmonary vascular remodeling by inhibiting endothelial-to-mesenchymal transition DOI

Zuomei Zeng,

Xinyue Wang, Hongjuan Wang

et al.

Vascular Pharmacology, Journal Year: 2025, Volume and Issue: 158, P. 107467 - 107467

Published: Jan. 31, 2025

Language: Английский

Citations

0
18β-Glycyrrhetinic acid improves pulmonary hypertension by regulating the vascukar non-inflammatory molecule-1/L-arginine/nitric oxide signaling pathway DOI

Daliya Shanahati,

Tao Yang, Lei Fang

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177382 - 177382

Published: Feb. 1, 2025

Language: Английский

Citations

0