Phytochemicals as Chemo-Preventive Agents and Signaling Molecule Modulators: Current Role in Cancer Therapeutics and Inflammation

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(24), P. 15765 - 15765

Published: Dec. 12, 2022

Cancer is one of the deadliest non communicable diseases. Numerous anticancer medications have been developed to target molecular pathways driving cancer. However, there has no discernible increase in overall survival rate cancer patients. Therefore, innovative chemo-preventive techniques and agents are required supplement standard treatments boost their efficacy. Fruits vegetables should be tapped into as a source compounds that can serve therapy. Phytochemicals play an important role sources new medication treatment. Some synthetic natural chemicals effective for chemoprevention, i.e., use exogenous medicine inhibit or impede tumor development. They help regulate linked development spread enhance antioxidant status, inactivating carcinogens, suppressing proliferation, inducing cell cycle arrest death, regulating immune system. While focusing on four main categories plant-based agents, epipodophyllotoxin, camptothecin derivatives, taxane diterpenoids, vinca alkaloids mode action, we review effects phytochemicals, like quercetin, curcumin, piperine, epigallocatechin gallate (EGCG), gingerol. We examine different signaling associated with how inflammation key mechanism growth.

Language: Английский

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Flavonoids as promising molecules in the cancer therapy: An insight

Current Research in Pharmacology and Drug Discovery, Journal Year: 2023, Volume and Issue: 6, P. 100167 - 100167

Published: Dec. 8, 2023

Cancer continues to increase global morbidity and mortality rates. Despite substantial progress in the development of various chemically synthesized anti-cancer drugs, poor prognosis disease still remains a big challenge. The most common drawback conventional cancer therapies is emergence drug resistance eventually leading discontinuation chemotherapy. Moreover, advanced target-specific including immunotherapy stem cell therapy are expensive enough unaffordable for patients poorer nations. Therefore, alternative cheaper therapeutic strategies needed complement current treatment approaches. Phytochemicals bioactive compounds produced naturally by plants have great potential human health disease. These possess antiproliferative, anti-oxidant, immunomodulatory properties. Among phytochemicals, flavonoids very effective treating wide range diseases from cardiovascular immunological disorders cancer. They scavenge reactive oxygen species (ROS), inhibit metastasis, modulate immune system induce apoptotic or autophagic death cancers. This review will discuss phytochemicals particularly attempts target

Language: Английский

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Apigenin: Molecular Mechanisms and Therapeutic Potential against Cancer Spreading

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5569 - 5569

Published: May 20, 2024

Due to its propensity metastasize, cancer remains one of the leading causes death worldwide. Thanks in part their intrinsic low cytotoxicity, effects flavonoid family prevention and treatment various human cancers, both vitro vivo, have received increasing attention recent years. It is well documented that Apigenin (4′,5,7-trihydroxyflavone), among other flavonoids, able modulate key signaling molecules involved initiation cell proliferation, invasion, metastasis, including JAK/STAT, PI3K/Akt/mTOR, MAPK/ERK, NF-κB, Wnt/β-catenin pathways, as oncogenic non-coding RNA network. Based on these premises, aim this review emphasize some events through which suppresses focusing specifically ability target molecular pathways angiogenesis, epithelial-to-mesenchymal transition (EMT), maintenance stem cells (CSCs), cycle arrest, death.

Language: Английский

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Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression

Neuroscience, Journal Year: 2025, Volume and Issue: 569, P. 161 - 183

Published: Feb. 7, 2025

Language: Английский

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Mitophagy—A New Target of Bone Disease

Biomolecules, Journal Year: 2022, Volume and Issue: 12(10), P. 1420 - 1420

Published: Oct. 4, 2022

Bone diseases are usually caused by abnormal metabolism and death of cells in bones, including osteoblasts, osteoclasts, osteocytes, chondrocytes, bone marrow mesenchymal stem cells. Mitochondrial dysfunction, as an important cause cell metabolism, is widely involved the occurrence progression multiple diseases, osteoarthritis, intervertebral disc degeneration, osteoporosis, osteosarcoma. As selective mitochondrial autophagy for damaged or dysfunctional mitochondria, mitophagy closely related to quality control homeostasis. Accumulating evidence suggests that plays regulatory role disease, indicating regulating level may be a new strategy bone-related diseases. Therefore, reviewing relevant literature recent years, this paper reviews potential mechanism osteosarcoma, provide theoretical basis research

Language: Английский

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Phytochemical Analysis and Evaluation of Antioxidant and Antimicrobial Properties of Essential Oils and Seed Extracts of Anethum graveolens from Southern Morocco: In Vitro and In Silico Approach for a Natural Alternative to Synthetic Preservatives

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(7), P. 862 - 862

Published: July 1, 2024

Anethum graveolens is an aromatic plant traditionally used as antispasmodic and carminative. The objective of this study to analyze the chemical composition essential oils extracts obtained from seeds gathered in Errachidia, southern Morocco. Additionally, antioxidant antimicrobial properties these will be evaluated. GC-MS analysis EO isolated by hydrodistillation revealed that its main compounds were E-anethole (38.13%), estragole (29.32%), fenchone (17.21%), α-pinene (7.37%). phenolic components extracted using methods decoction Soxhlet. assay showed A. contained considerable amounts polyphenols, flavonoids, condensed tannins, with variable levels depending on extract analyzed. HPLC/UV-ESI-MS analyses performed a structural diversity molecules present extract, most important which umbelliferone (12.35%), 3-hydroxyflavone (11.23%), rosmanol (8.95%), biotin (8.36%), emmotin H (4.91%), coumarin (4.21%). activity, determined three techniques (DPPH•, FRAP, CAT), demonstrated (EOs) had potent capacity counteract detrimental free radicals, control generation reactive oxygen species, mitigate oxidative damages. activity Eos was carried out liquid medium against five strains (E. cloacae, K. pneumoniae, E. coli, S. aureus, epidermidis) four candidiasis (C. albicans, C. dubliniensis, tropicalis, parapsilosis) Aspergillus niger. results effectiveness EOs compared aqueous, ethanolic, microorganisms tested. In addition, ethanolic antifungal distinguished other extracts. efficacy under can primarily attributed synergistic interactions among principal constituents (E-anethole, estragole, fenchone). Furthermore, molecular docking dynamics simulation reveal significant stability between selected bioactive different target proteins involved activities. Compounds like 3-hydroxyflavone, H, trans-caftaric acid, methyl rosmarinate, 1-caffeoyl-beta-D-glucose, kaempferol exhibited better binding energies explored proteins, indicating their potential agents. Finally, our findings emphasize significance promising reservoir advantageous health serve organic substitutes for presently employed synthetic preservatives.

Language: Английский

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Anti-Inflammatory Mechanisms of Dietary Flavones: Tapping into Nature to Control Chronic Inflammation in Obesity and Cancer

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(24), P. 15753 - 15753

Published: Dec. 12, 2022

Flavones are natural phytochemicals broadly distributed in our diet. Their anti-inflammatory properties provide unique opportunities to control the innate immune system and inflammation. Here, we review role of flavones chronic inflammation with an emphasis on their impact molecular mechanisms underlying inflammatory diseases including obesity cancer. can influence cell repertoire restoring landscape. impinge NF-κB, STAT, COX-2, or NLRP3 inflammasome pathways reestablishing homeostasis. Devoid adverse side effects, could present alternative for treatment prevention that contributes

Language: Английский

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Probiotic and Antioxidant Potential of the Lactobacillus Spp. Isolated from Artisanal Fermented Pickles

Fermentation, Journal Year: 2022, Volume and Issue: 8(7), P. 328 - 328

Published: July 13, 2022

The present study was based on bacterial isolation with probiotic potential from artisanal fermented pickles. A total of 36 strains were isolated 50 different pickle samples. Nine isolates promising (PCR99, PCR100, PCR118, PCR119, PCR121, PCR125, PCR137, PCR140 and PCR141) selected. showed varied protease, amylase, lipase cellulase patterns. displayed responses towards various antibiotic classes, i.e., resistance to penicillin G, polymyxin B, Metronidazole Streptomycin. highest bile salt concentrations (0.3% 0.5%) acidic conditions (pH 3 pH 4) when exposed mimicked gastrointestinal conditions. cell viability against enzymes produced in stomach intestines patterns as pepsin the range 94.32–91.22%, pancreatic 97.32–93.11% lysozyme detected at 99.12–92.55%. Furthermore, auto-aggregation capability 46.11–33.33% surface hydrophobicity 36.55–31.33%. PCR 140 maximum antioxidant activity lyophilized cells well potential. phylogenetic analysis 16S rRNA gene sequencing confirmed that (NMCC91) higher vitro belongs genus Lactobacillus 97% similarity Lacticaseibacillus paracasei. This work demonstrated isolate is suitable for use food medical industries.

Language: Английский

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Resources for Human Health from the Plant Kingdom: The Potential Role of the Flavonoid Apigenin in Cancer Counteraction

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 251 - 251

Published: Dec. 23, 2023

Apigenin is one of the most widespread flavonoids in plant kingdom. For centuries, apigenin-containing preparations have been used traditional medicines to treat diseases that an inflammatory and/or degenerative component. In 1980s, apigenin was proposed interfere with process carcinogenesis. Since then, more and evidence has demonstrated its anticancer efficacy, both vitro vivo. shown target signaling pathways involved development progression cancer, such as PI3K/Akt/mTOR, MAPK/ERK, JAK/STAT, NF-κB, Wnt/β-catenin pathways, modulate different hallmarks cell proliferation, metastasis, apoptosis, invasion, migration. Furthermore, modulates PD1/PD-L1 expression cancer/T killer cells regulates percentage T regulatory cells. Recently, studied for synergic additive effects when combined chemotherapy, minimizing side effects. Unfortunately, low bioavailability high permeability limit therapeutic applications. Based on micro- nanoformulations enhance physical stability drug-loading capacity increase apigenin, novel drug-delivery systems investigated improve solubility.

Language: Английский

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A comprehensive view on the apigenin impact on colorectal cancer: Focusing on cellular and molecular mechanisms

Food Science & Nutrition, Journal Year: 2023, Volume and Issue: 11(11), P. 6789 - 6801

Published: Aug. 28, 2023

Abstract Colon cancer (CC) is one of the most common and deadly cancers worldwide. Oncologists are facing challenges such as development drug resistance lack suitable options for CC treatment. Flavonoids a group natural compounds found in fruits, vegetables, other plant‐based foods. According to research, they have potential role prevention treatment cancer. Apigenin flavonoid that present many fruits vegetables. It has been used antioxidant long time considered due its anticancer effects low toxicity. The results this review study show apigenin on cells through various mechanisms. In comprehensive review, we cellular targets signaling pathways indicated date vivo vitro models. Among important modulated pathways, Wnt/β‐catenin, PI3K/AKT/mTOR, MAPK/ERK, JNK, STAT3, Bcl‐xL Mcl‐1, PKM2, NF‐kB described. Furthermore, suppresses cell cycle G2/M phase cells. cells, apigenin‐induced apoptosis increased by inhibiting formation autophagy. study, appears be promising agent therapy, but more research required field pharmacology pharmacokinetics establish dosage clinical studies.

Language: Английский

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