Progress in Biophysics and Molecular Biology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Food Chemistry Advances, Journal Year: 2023, Volume and Issue: 2, P. 100239 - 100239
Published: March 13, 2023
Language: Английский
Citations
50
Phytomedicine Plus, Journal Year: 2023, Volume and Issue: 3(4), P. 100501 - 100501
Published: Nov. 1, 2023
: Resveratrol (RVL) is a polyphenol-containing natural product found in variety of plants, including peanuts, grapes, and berry fruits. The use RVL linked great deal research to number therapeutic properties. In an attempt improve these properties, five RVL-based coumarins, abbreviated YF1-YF5, were synthesized structurally constructed pathway. molecular architecture our coumarins was confirmed by analyzing their FTIR NMR spectra. biomedical effects the investigated compared with precursor. first dual 5-LOX/COX inhibitory effect, which tested versus three related enzymes. second free-radical neutralizing estimated against two radical phenotypes. third apoptotic-inducing evaluated four tumorous cell lines. fourth high blood-glucose regulatory effect assessed corresponding Finally, bacterial growth-suppressing pathogenic strains. pharmacokinetic identifiers compounds also silico matched analyze chemical functionalization. findings indicated that exhibited enhanced building moiety. best reported for YF3, lowest attributed YF5. This improvement coupled advancements identifiers. According outcomes, authors concluded provide intriguing modification improving its effects.
Language: Английский
Citations
38
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116294 - 116294
Published: Feb. 23, 2024
Lung cancer, a leading global cause of mortality, poses significant public health challenge primarily linked to tobacco use. While contributes over 90% cases, factors like dietary choices and radiation exposure also play role. Despite potential benefits from early detection, cancer patients face hurdles, including drug resistance, chemotherapy side effects, high treatment costs, limited healthcare access. Traditional medicinal plant knowledge has recently unveiled diverse chemopreventive agents terrestrial marine sources. These phytochemicals regulate intricate molecular processes, influencing the immune system, apoptosis, cell cycle, proliferation, carcinogen elimination, antioxidant levels. In pursuing cutting-edge strategies combat forms technological advancements have spurred innovative approaches. Researchers focused on green synthesis metallic nanoparticles using metabolites. This method offers distinct advantages conventional physical chemical techniques, such as cost-effectiveness, biocompatibility, energy efficiency. Metallic nanoparticles, through various pathways generation reactive oxygen species, modulation enzyme activity, DNA fragmentation, disruption signaling pathways, perturbation membranes, interference with mitochondrial function resulting in damage, cycle arrest, exhibit for preventive applications. Thus, amalgamation phytocompounds holds promise novel approach lung therapy. However, further refinements are necessary enhance environmentally friendly process nanoparticle synthesis.
Language: Английский
Citations
11
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(5), P. 598 - 598
Published: May 8, 2024
In the current work, synergy between natural compounds and conventional chemotherapeutic drugs is comprehensively reviewed in light of preclinical research findings. The prognosis for lung cancer patients poor, with a 5-year survival rate 18.1%. use combination has gained significant attention as potential novel approach treatment cancer. present work highlights importance finding more effective therapies to increase rates. Chemotherapy primary option but it limitations such reduced effectiveness because cells become resistant. Natural isolated from medicinal plants have shown promising anticancer or chemopreventive properties their synergistic effect been observed when combined therapies. an anti-cancer drug compound exhibits effects, enhancing overall therapeutic actions against cells. conclusion, this provides overview latest on plant-derived alternative complementary options chemotherapy discusses treating minimal side effects.
Language: Английский
Citations
11
Plants, Journal Year: 2024, Volume and Issue: 13(16), P. 2295 - 2295
Published: Aug. 18, 2024
In recent years, the supercritical CO
Language: Английский
Citations
10
Advances in Redox Research, Journal Year: 2024, Volume and Issue: 13, P. 100113 - 100113
Published: Aug. 31, 2024
Language: Английский
Citations
9
Journal of Herbal Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100991 - 100991
Published: Feb. 1, 2025
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 7863 - 7863
Published: April 26, 2023
Phytochemicals are chemical compounds that exist in plants and serve various functions such as protecting against pests, UV radiation, diseases [...].
Language: Английский
Citations
20
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: July 22, 2024
Cancer refers to the proliferation and multiplication of aberrant cells inside human body, characterized by their capacity proliferate infiltrate various anatomical regions. Numerous biochemical pathways signaling molecules have an impact on cancer auto biogenesis process. The regulation crucial cellular processes necessary for cell survival proliferation, which are triggered phytochemicals, is significantly influenced pathways. These or components regulated phytochemicals. Medicinal plants a significant reservoir diverse anticancer medications employed in chemotherapy. effects phytochemicals mediated several methods, including induction apoptosis, cessation cycle, inhibition kinases, prevention carcinogenic substances. This paper analyzes phytochemistry seven prominent plant constituents, namely, alkaloids, tannins, flavonoids, phenols, steroids, terpenoids, saponins, focusing involvement MAPK/ERK pathway, TNF signaling, death receptors, p53, p38, actin dynamics. Hence, this review has examined range encompassing structural characteristics potential mechanisms. It underscored significance plant-derived bioactive compounds cancer, utilizing molecular In addition, endeavor also seeks incentivize scientists carry out clinical trials derived from plants.
Language: Английский
Citations
7
Pharmacognosy Journal, Journal Year: 2024, Volume and Issue: 15(6), P. 1105 - 1111
Published: Jan. 1, 2024
Cancer is regarded as a nightmare for humanity and challenging task medical professionals. Twelve hydrides (2a-2l), made of trifunctionalized coumarin various substituted indoles, were created in an effort to realize the hope cancer cure. The 4,5-dimethoxysalicylaldehyde ethyl acetoacetate combined Knoevenagel reaction create component. construction indole component involved converting aminoindoles through diazotization Sandmeyer reactions twelve indoles (1a-1l). These two components Michael addition desired hybrids. Investigating their spectra released from spectroscopical instruments allowed researchers determine 2D molecular frameworks these Studying survival nine tumor cell types after treatment with synthesized hybrids enabled estimate there vitro impact cytotoxic candidates. By checking viability using MTT marker, it was possible see that this effect antiproliferative. cytotoxicity measurements, IC50 scores, revealed number intriguing facts. To start, synthetic displayed relatively similar pattern against cancerous lines under investigation. Second, compared chloride, hydroxyl, or methoxy substituents, fluorinated are more toxic cells. Finally, at position-6 (2i-2l) have highest among those functionalized position-4 (2a-2d) position-5 (2e-2h). From facts, authors concluded can represent potential candidates antiproliferative applicants. Moreover, hybrid 2i may serve valuable model creating potent anti-breast therapies.
Language: Английский
Citations
6