Anales de la Real Academia Nacional de Farmacia,
Journal Year:
2022,
Volume and Issue:
88(88(05)), P. 489 - 499
Published: Dec. 31, 2022
The
pharmacological
interest
of
lichens
lies
in
their
ability
to
produce
bioactive
secondary
metabolites,
being
most
them
phenolic
compounds
with
reactive
hydroxyl
groups
which
confer
antioxidant
potential
through
multiple
mechanisms.
increasing
incidence
and
impact
oxidative
stress-related
diseases,
including
neurodegenerative
disorders,
has
promoted
the
search
new
strategies
for
control
purposes.
information
compiled
this
review
comes
from
vitro
research,
on
cell
substrates
animal
models,
allows
us
affirm
that
constitute,
field
natural
products,
a
promising
source
compounds,
many
phenolic,
activity.
Keywords:
lichens;
pharmacology;
antioxidant;
metabolites
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Nov. 1, 2023
The
objective
of
this
research
was
to
characterize
the
chemical
composition
ethanolic
extracts
lichen
species
Placopsis
contortuplicata,
Ochrolechia
frigida,
and
Umbilicaria
antarctica,
their
antioxidant
activity,
enzymatic
inhibition
through
in
vitro
molecular
docking
analysis.
In
total
phenol
content,
FRAP,
ORAC,
DPPH
assays,
showed
significant
assays
for
pancreatic
lipase,
α-glucosidase,
α-amylase
enzymes,
together
with
silico
studies
prediction
pharmacokinetic
properties,
toxicity
risks,
intermolecular
interactions
compounds,
evidenced
inhibitory
potential.
A
13
compounds
were
identified
by
UHPLC-ESI-QTOF-MS
P.
18
O.
12
U.
antarctica.
This
study
contributes
knowledge
pool
bioactive
present
lichens
temperate
polar
distribution
biological
characteristics
that
increase
interest
discovery
natural
products
offer
alternatives
treatment
diseases
related
oxidative
stress
metabolic
syndrome.
Antioxidants,
Journal Year:
2022,
Volume and Issue:
12(1), P. 10 - 10
Published: Dec. 21, 2022
The
lichen
species
Cladonia
chlorophaea
and
C.
gracilis
(Cladoniaceae)
are
widely
distributed
in
the
island
archipelago
of
maritime
Antarctica
represent
a
natural
resource
scientific
interest.
In
this
work,
metabolomic
characterization
ethanolic
extracts
these
determination
antioxidant
activity,
enzymatic
inhibition
anti-inflammatory
potential
selected
compounds
on
5-lipoxygenase
enzyme
by
molecular
docking
cytoprotective
activity
SH-SY5Y
cell
line
were
carried
out.
Nineteen
identified
liquid
chromatography
coupled
with
quadrupole-time-of-flight
mass
spectrometry
(UHPLC-ESI-QTOF-MS)
each
species.
contents
phenolic
compounds,
cholinesterases
(acetylcholinesterase
butyrylcholinesterase)
digestive
enzymes
(α-glucosidase
pancreatic
lipase)
variable
among
species,
better
results
chlorophaea.
Molecular
evidenced
significant
binding
affinities
some
for
enzyme,
together
outstanding
pharmacokinetic
properties.
Both
shown
to
promote
viability
reduction
reactive
oxygen
production
an
H2O2-induced
oxidative
stress
model.
This
study
contributes
chemical
knowledge
demonstrates
biological
prevention
promising
treatment
central
nervous
system
pathologies,
inflammatory
disorders
metabolic
alterations.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(12), P. 6782 - 6782
Published: June 20, 2024
Gyrophoric
acid
(GA),
a
lichen
secondary
metabolite,
has
attracted
more
attention
during
the
last
years
because
of
its
potential
biological
effects.
Until
now,
effect
in
vivo
not
yet
been
demonstrated.
The
aim
our
study
was
to
evaluate
basic
physicochemical
and
pharmacokinetic
properties
GA,
which
are
directly
associated
with
activities.
stability
GA
various
pH
assessed
by
conducting
repeated
UV-VIS
spectral
measurements.
Microsomal
rat
liver
microsomes
performed
using
Ultra-Performance
LC/MS.
Binding
human
serum
albumin
(HSA)
synchronous
fluorescence
spectra,
molecular
docking
analysis
used
reveal
binding
site
HSA.
In
experiment,
24
Sprague-Dawley
rats
(Velaz,
Únetice,
Czech
Republic)
were
used.
animals
divided
as
follows.
first
group
(
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(21), P. 11840 - 11840
Published: Nov. 4, 2024
Gyrophoric
acid
(GA)
is
a
secondary
metabolite
of
various
lichens.
It
exhibits
biological
activities
in
vitro,
but
only
one
study
has
been
carried
out
vivo.
Because
our
previous
showed
that
GA
stimulates
neurogenesis
healthy
rats,
the
current
aimed
to
explore
potential
during
stress-induced
depressive-like
states
male
Wistar
rats.
In
experiment,
pregnant
females
were
used.
last
week
pregnancy,
subjected
restraint
stress.
After
birth,
progeny
aged
60
days
stressed
repeatedly.
The
males
divided
into
three
groups:
control
animals
(CTR;
n
=
10),
with
depression-like
state
(DEP;
and
GA-treated
(GA;
10).
treated
(per
os
10
mg/kg)
daily
for
month,
starting
from
60th
postnatal
day.
Our
results
indicate
acts
as
an
antioxidant,
shown
by
lowered
ROS
level
leukocytes
(p
<
0.01).
Moreover,
it
prolonged
time
spent
open
arms
elevated
plus
maze
0.001).
Concomitantly,
stimulation
proliferative
activity
hippocampal
regions
was
seen
(hilus
p
0.01;
subgranular
zone
0.001)
when
compared
DEP
males.
Additionally,
number
mature
neurons
CA1
region
hippocampus
increased
markedly
0.01),
indicating
role
maturation
process
neurons.
Thus,
points
anxiolytic/antidepressant
GA.
However,
future
studies
are
needed
this
complex
area.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(22), P. 7824 - 7824
Published: Nov. 13, 2022
Oxidative
stress
is
one
of
the
potential
causes
nervous
system
disease.
Ginseng
extract
possesses
excellent
antioxidant
activity;
however,
little
research
on
function
ginseng
fibrous
root.
This
study
aimed
to
investigate
neuroprotective
effects
root
alleviate
pathogenesis
Alzheimer’s
disease
(AD)
against
oxidative
stress.
enzymatic
hydrolysate
(GFREH)
was
first
prepared
by
digesting
roots
with
alkaline
protease.
In
vitro,
GFREH
showed
activities
in
free
radical
scavenging
mechanisms.
With
a
cellular
model
AD,
inhibited
increase
Ca2+
levels
and
intracellular
ROS
content,
maintained
balance
mitochondrial
membrane
potential,
relieved
L-glutamic
acid-induced
neurotoxicity.
vivo,
improved
survival
rate
Caenorhabditis
elegans
(C.
elegans)
under
stress,
upregulated
SOD-3
expression,
reduced
reactive
oxygen
species
(ROS)
content.
Therefore,
our
findings
provide
evidence
for
alleviation
effect
neuroprotection,
which
may
accelerate
development
anti-Alzheimer’s
drugs
treatments
future.
Applied Sciences,
Journal Year:
2023,
Volume and Issue:
13(20), P. 11205 - 11205
Published: Oct. 12, 2023
The
extracts
of
Glaucium
grandiflorum
have
been
used
to
treat
neurodegenerative
diseases.
Nonetheless,
no
former
study
has
investigated
whether
the
alkaloid
G.
antioxidative
effects
against
oxidative
stress.
aim
present
was
determine
with
a
variety
targets
and
probable
mechanisms.
First,
we
spectrophotometry
investigate
respect
their
amounts.
Then,
determined
extracts’
impact
on
thiol/disulfide
homeostasis,
total
oxidant
status/total
antioxidant
status/oxidative
stress
index,
enzyme
activities.
Finally,
genes
in
NRF2-KEAP1
pathway
were
via
qRT-PCR.
We
conducted
molecular
docking
analyses
potential
binding
isoquinoline
alkaloids
found
within
target
proteins.
observed
best
results
from
chloroform
extract
methanol
extract.
Chloroform
prominent
DPPH
radical
scavenging
metal
ions
chelating,
showed
significant
hydroxyl
scavenging,
lipid
peroxidation,
superoxide
anion
activity.
Alkaloid
groups
substantially
increased
thiol
activity,
native
disulfide
status
level,
levels,
gene
expression
levels
(GCLC,
HO-1,
NRF2,
NQO1)
compared
H2O2
group.
Also,
led
drop
index
KEAP1
level
relative
According
our
results,
brought
about
by
regulated
extracts.
As
result,
phytochemical-based
therapeutic
that
regulates
H2O2-induced
neurochemical
field.
Natural Product Research,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 14
Published: May 30, 2024
Lichens
contain
different
types
of
chemical
compounds
with
multiple
biological
activities
that
demonstrate
their
potential
pharmacological
use.
This
research
aims
to
report
the
metabolomic
identification
ethanolic
extracts
P.
antarcticum
and
hypnorum,
antioxidant,
enzyme
inhibitory,
cytoprotection
activity.
Sixteen
metabolites
were
identified
in
twelve
hypnorum;
reported
variable
antioxidant
activity
IC50
>350
µg/mL
DPPH·,
values
>18
µmol
Trolox/g
ORAC
>40
FRAP
a
phenolic
compound
content
>10
mg
GAE/g,
as
well
significant
results
cholinesterases,
α-glucosidase,
pancreatic
lipase,
α-amylase,
tyrosinase
inhibition
ranging
from
18
510
µg/mL,
which
complemented
by
molecular
docking
experiments.
Both
showed
improved
at
concentrations
0.5
1.0
μg/mL.
study
contributes
knowledge
diversity
Antarctic
lichen
effectiveness
evaluation
related
neurodegenerative
diseases
metabolic
syndrome.
Genel Tıp Dergisi,
Journal Year:
2023,
Volume and Issue:
33(2), P. 162 - 168
Published: April 28, 2023
Aims:
In
this
study,
it
was
aimed
to
investigate
the
possible
neuroprotective
effect
of
Apigenin-7-Glycoside
(AP7Glu),
a
natural
product
with
known
anticancer
and
anti-inflammatory
activity,
against
hydrogen
proxide
(H2O2)-induced
oxidative
stress
in
SH-SY5Y
cells.
Methods:
The
H2O2
AP7Glu
on
cell
viability
determined
by
XTT
analysis.
SOD
catalase
analyzes
were
performed
determine
antioxidant
enzyme
activities.
Expression
levels
defense
system
related
genes
caspase
evaluated
qRT-PCR
Results:
After
treatment
300
µM
cells
for
24
hours,
as
63.18%
dose
used
induce
stress.
presence
different
concentrations
increased
compared
H2O2-treated
And,
decreased
activities
control
group.
With
AP7Glu,
an
increase
observed
these
enzymes
addition,
expression
associated
Caspase
genes.
CASP8
Conclusion:
has
H2O2-induced
neuronal
death.
