Retos,
Journal Year:
2025,
Volume and Issue:
64, P. 615 - 628
Published: Jan. 23, 2025
Introduction:
Mechanical
stress
and
inflammation
contribute
to
exercise-induced
muscle
damage.
Objective:
This
research
analyzed
the
potential
of
polyphenolic
compounds
in
grapes
prevent
lower
oxidative
after
exercise.
Methodology:
employed
a
systematic
review
guide
researchers
achieving
objectives.
It
involved
thorough
search
global
databases,
such
as
Web
Science,
Scopus,
Embase,
Pubmed.
The
inclusion
criteria
were
articles
investigating
grapes,
inflammation,
stress,
physical
exercise
published
within
last
five
years.
On
other
hand,
that
not
reputable
or
indexed
by
these
databases
excluded
from
search.
initial
process
generated
2947
articles.
After
undertaking
several
screening
processes,
8
finally
selected
analyzed.
Results:
shows
polyphenol
content
has
antioxidant
inflammatory
properties
which
can
reduce
levels
inflammation.
Discussion:
works
reducing
ROS,
MDA,
TBARS
increasing
GSH
levels.
Furthermore,
also
have
anti-inflammatory
uncontrolled
result
intense
In
this
case,
work
blocking
pathways
decreasing
markers.
vivo
studies
confirmed
benefits
stimulating
eNOS
gene
expression
CAT,
SOD,
GPx4
Conclusions:
potentially
due
its
properties.
Besides,
properties,
are
responsible
for
lowering
alleviating
pain
fierceness.
Applied Sciences,
Journal Year:
2025,
Volume and Issue:
15(6), P. 3220 - 3220
Published: March 15, 2025
Industrial
waste
management
is
a
growing
concern,
and
the
valorization
of
by-products
through
circular
economy
approaches
represents
sustainable
solution.
In
this
context,
dextran–grape
conjugates
(PLG–GRAPE)
were
obtained
via
grafting
reaction
grape
pomace
extract
dextran
under
aqueous
conditions.
To
compare
properties
polymeric
graft
with
those
free
extract,
total
polyphenol
content
was
assessed
using
Folin–Ciocalteu
assay,
along
stability
diffusion
studies.
addition,
in
vitro
safety
evaluations,
including
Neutral
Red
Uptake,
h-CLAT,
skin
irritation
tests
performed
to
assess
biocompatibility.
evaluate
antioxidant,
anti-inflammatory,
anti-aging
PLG–GRAPE,
efficacy
assays
on
keratinocyte
fibroblast
cell
lines
full-thickness
reconstructed
human
tissues
exposed
damaging
agents,
such
as
UV
radiation
pollutants.
The
results
showed
that
technology
preserved
phenolic
antioxidant
activity
while
improving
properties.
As
demonstrated
by
studies,
favorable
biocompatibility
profile
observed,
addition
significant
capacity
reduce
oxidative
stress
inflammation
aged
cells,
thus,
attenuating
cellular
aging
senescence.
conclusion,
study
suggests
PLG–GRAPE
has
potential
bioactive
ingredient
for
cosmetic
dermatological
applications,
offering
effective
approach
utilizing
industrial
products.
Diseases,
Journal Year:
2025,
Volume and Issue:
13(5), P. 132 - 132
Published: April 24, 2025
Background:
Grape
pomace
(GP),
a
by-product
of
winemaking,
is
rich
source
bioactive
polyphenols
known
for
their
antioxidant
and
anti-inflammatory
properties.
While
the
cardiovascular
benefits
red
grape
have
received
significant
scientific
attention,
therapeutic
potential
white
remains
largely
unexplored,
particularly
in
glucocorticoid-induced
hypertension.
Given
rising
prevalence
hypertension
oxidative-inflammatory
mechanisms
underlying
its
progression,
this
study
investigates
effects
GP
on
blood
pressure
regulation,
oxidative
stress,
pro-inflammatory
cytokine
expression
an
experimental
model
dexamethasone
(DEXA)-induced
(HTN).
By
focusing
GP,
research
addresses
gap
current
knowledge
proposes
novel,
sustainable
approach
to
managing
through
valorising
winemaking
by-products.
Methods:
The
first
concentration
used,
GP1,
was
795
mg
polyphenols/kg
bw,
while
second
concentration,
GP2,
397.5
bw.
Results:
White
extract
DEXA_GP1
group
had
reduced
systolic
diastolic
pressure.
with
higher
content
(GP1)
prevented
elevation
serum
levels
total
stress
(TOS),
malondialdehyde
(MDA),
index
(OSI),
lower
(GP2)
slightly
MDA.
Both
concentrations
increased
NO
Total
Thiols,
significantly
(p
<
0.05)
than
treated
lisinopril.
tumour
necrosis
factor-alpha
(TNF-α)
all
groups
where
HTN
induced.
doses
TNF-α.
Heart
tissue
studied
cytokines
(TNF-α,
interleukin
(IL)-1β,
IL-6
were
not
influenced
>
by
either
induction
or
treatment
administered.
Conclusions:
These
findings
suggest
that
may
serve
as
promising
nutraceutical
intervention
management,
conditions
associated
stress.
Deleted Journal,
Journal Year:
2025,
Volume and Issue:
7(5)
Published: May 6, 2025
Abstract
Marine
algae,
a
reservoir
of
bioactive
compounds,
offer
immense
therapeutic
potential,
especially
when
harnessed
through
nanotechnology.
This
review
comprehensively
explores
the
synthesis,
characterization,
and
applications
marine
algae-derived
nanoparticles
(MADNs),
with
particular
focus
on
their
antioxidant
properties.
notably
red
possess
unique
biochemical
compositions
rich
in
polyphenols,
flavonoids,
polysaccharides,
carotenoids.
These
compounds
confer
robust
capacities,
protecting
algae
from
oxidative
stress
induced
by
environmental
extremities.
The
details
how
these
molecules
can
be
synthesized
into
nanoparticles,
leveraging
green
synthesis
methods
that
utilize
algae's
intrinsic
reducing
stabilizing
agents,
promoting
sustainable
nanoparticle
production.
integration
nanotechnology
amplifies
efficacy
MADNs
demonstrating
superior
reactivity,
stability,
bioavailability.
Characterization
advanced
techniques
like
TEM,
XRD,
FTIR
has
underscored
potential
mitigating
damage
cellular
models.
By
scavenging
reactive
oxygen
species
(ROS),
show
promise
interventions
for
conditions
linked
to
stress,
including
cancer
neurodegenerative
diseases.
highlights
dual
benefits
sustainability
enhanced
provided
MADNs.
approach
not
only
minimizes
footprint
but
also
ensures
bioactivity
nanoparticles.
clinical
implications
are
profound,
suggesting
new
paradigm
development
eco-friendly
agents.
findings
presented
herein
aim
stimulate
further
research
underscore
pivotal
role
advancing
nanomedicine.
Journal of Applied Polymer Science,
Journal Year:
2023,
Volume and Issue:
140(38)
Published: July 17, 2023
Abstract
This
work
aims
to
evaluate
the
effect
of
extrusion
temperature
poly(lactic
acid)
(PLA)
with
different
grape
pomace
(GP)
content
for
development
active
biocomposite
films.
Two
GP
concentrations
(10
and
15
wt.%)
were
used
obtain
GP/PLA
composites
through
at
three
profiles.
The
biocomposites
characterized
optical,
thermal,
structural,
mechanical
tests.
In
addition,
antimicrobial
antioxidant
capacity
materials
evaluated.
Results
showed
components
are
stable
up
180°C.
incorporation
in
PLA
resulted
red‐color
films
a
high
color
difference
(Δ
E
>
30).
glass
transition,
cold
crystallization,
melting
temperatures
as
well
tensile
strength
decreased
by
increasing
concentration
films;
however,
elastic
modulus
elongation
break
increased.
lowest
had
better
activity
against
Escherichia
coli
Listeria
innocua
.
Contrary,
15%
composite
highest
activity.
Nevertheless,
profile
reduced
bioactivity
due
degradation.
These
results
feasibility
best
develop
using
wine
by‐products,
which
could
be
applied
food
packaging.
Fermentation,
Journal Year:
2023,
Volume and Issue:
9(9), P. 838 - 838
Published: Sept. 13, 2023
The
plethora
of
bio-functional
compounds
present
in
fermented
alcoholic
beverages
like
wine,
as
well
the
valorisation
bioactives
from
wineries’/breweries’
by-products
grape
pomace
and
seed,
has
gained
significant
interest
functional
foods
sector.
This
beverage,
always
accompanied
humanity,
for
religion
or
health,
especially
Mediterranean,
while
benefits
its
moderate
consumption
were
documented
even
by
Greek
physician
Hippocrates
Kos
(460–370
BC).
After
a
big
gap,
an
outbreak
research
on
wine
surfaced
only
since
1990s,
when
term
“French
paradox”
was
introduced
to
US
public
during
CBS
show,
recent
evidence
outlined
that
beneficial
effects
are
derived
synergisms
their
digestion-derived
metabolites.
Within
this
article,
proposed
health
consumption,
component
balanced
diet
(i.e.,
Mediterranean
diet)
against
inflammation-related
chronic
disorders,
is
thoroughly
reviewed.
various
both
wineries’
by-products,
such
bioactive
phenolics,
unsaturated
fatty
acids,
polar
lipids
dietary
fibres,
antioxidant,
anti-inflammatory
antithrombotic
health-promoting
properties,
also
evaluated.
mechanisms
action
synergism,
which
elicited,
explored.
Functional
properties
non-alcoholic
products
introduced.
Emphasis
given
applications
bioactives,
ingredients
foods,
supplements
nutraceuticals.
Limitations
future
perspectives
popular
beverage
(wine)
rich
addressed.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(22), P. 7538 - 7538
Published: Nov. 11, 2023
With
the
increase
in
world
population,
overexploitation
of
planet’s
natural
resources
is
becoming
a
worldwide
concern.
Changes
way
humankind
thinks
about
production
and
consumption
must
be
undertaken
to
protect
our
planet
living.
For
this
change
occur,
sustainable
development
together
with
circular
economic
approach
responsible
are
key
points.
Agriculture
activities
for
more
than
10%
greenhouse
gas
emissions;
moreover,
by
2050,
it
expected
that
food
will
60%.
The
valorization
waste
therefore
high
importance
decrease
environmental
footprint
agricultural
activities.
Fruits
vegetables
wildly
consumed
worldwide,
grapes
one
main
producers
gases.
Grape
biomass
rich
bioactive
compounds
can
used
food,
pharmaceutical
cosmetic
industries,
their
extraction
from
residue
has
been
target
several
studies.
Among
techniques
recovery
waste,
subcritical
water
(SWE)
least
explored.
SWE
advantages
over
other
such
as
microwave
ultrasound
extraction,
allowing
yields
use
only
solvent.
Therefore,
considered
green
method
following
two
principles
chemistry:
less
hazardous
synthesis
(principle
number
3)
safer
solvents
auxiliaries
5).
In
addition,
products
also
followed:
alternative
or
2)
reduced,
robust,
controlled
safe
unit
operation
This
review
an
overview
process
using
grape
perspective
economy
through
extracted.
Future
perspectives
applied
discussed,
well
its
ability
technique.
Chemistry & Biodiversity,
Journal Year:
2024,
Volume and Issue:
21(7)
Published: May 20, 2024
Grape
pomace
(GP),
a
by-product
of
wine
production,
contains
bioactive
polyphenols
with
potential
health
benefits.
This
study
investigates
the
anti-inflammatory
properties
polyphenolic
fraction
derived
from
GP,
obtained
by
ultrasound-microwave
hybrid
extraction
and
purified
using
ion-exchange
chromatography.
In
inflammation
model,
mice
were
divided
into
six
groups:
intact,
carrageenan,
indomethacin,
three
GP
treatment
groups.
Paw
edema
was
induced
subplantar
injection
administered
intraperitoneally
at
doses
10,
20,
40
mg/kg.
The
effect
evaluated
measuring
paw
volume,
expression
inflammatory
markers:
cyclooxygenase-2
(COX-2),
myeloperoxidase
(MPO),
cytokines
(IL-1β
IL-6),
along
lipid
peroxidation
levels.
significantly
reduced
levels
COX-2,
MPO,
in
dose-dependent
manner
effect,
highest
dose
showing
greatest
reduction.
Additionally,
also
decreased
10
20
These
findings
suggest
that
combined
amberlite
purification
proved
to
be
effective
obtaining
polyphenolic-rich
GP.
Thus,
may
serve
as
natural
antioxidant
agent
for
treating
oxidative
stress-related
diseases.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(13), P. 3122 - 3122
Published: June 30, 2024
This
study
presents
properties
of
hydroethanolic
extracts
prepared
from
Pinot
Noir
(PN)
grape
pomace
through
conventional,
ultrasound-assisted
or
solvothermal
extraction.
The
components
the
were
identified
by
HPLC.
total
content
polyphenols,
flavonoids,
anthocyanins,
and
condensed
tannins,
as
well
antioxidant
activity
α-glucosidase
inhibitory
evaluated
using
UV-vis
spectroscopy.
All
rich
in
phenolic
compounds,
proving
a
good
radical
scavenging
activity.
extract
obtained
conventional
extraction
at
80
°C
showed
best
close
to
that
(-)-epigallocatechin
gallate.
To
improve
chemical
stability
chosen
was
incorporated
porous
silica-based
supports:
amine
functionalized
silica
(MCM-NH
