Recent Advancements in the Formulation of Nanomaterials-Based Nanozymes, Their Catalytic Activity, and Biomedical Applications

ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 6(9), P. 3577 - 3599

Published: Aug. 17, 2023

Nanozymes are nanoparticles with intrinsic enzyme-mimicking properties that have become more prevalent because of their ability to outperform conventional enzymes by overcoming drawbacks related stability, cost, and storage. the potential manipulate active sites natural enzymes, which is why they considered promising candidates function as enzyme mimetics. Several microscopy- spectroscopy-based techniques been used for characterization nanozymes. To date, a wide range nanozymes, including catalase, oxidase, peroxidase, superoxide dismutase, designed effectively mimic enzymes. The activity nanozymes can be controlled regulating structural morphological aspects multifaceted benefits, exploited on large scale application in biomedical sector. versatility aids monitoring treating cancer, other neurodegenerative diseases, metabolic disorders. Due compelling advantages significant research advancements made this area. Although act potent mimetics specificities suboptimal, there still room diversification analytical purposes. Designing diverse nanozyme systems sensitive one or substrates through specialized has subject an in-depth study. Hence, we believe stimuli-responsive may open avenues diagnosis treatment fusing catalytic nanomaterial systems.

Language: Английский

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Chitosan nanocomposite for tissue engineering and regenerative medicine: A review

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 254, P. 127660 - 127660

Published: Oct. 29, 2023

Language: Английский

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Challenges and Material Innovations in Drug Delivery to Central Nervous System Tumors

Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123180 - 123180

Published: Feb. 13, 2025

Language: Английский

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Progress in Drug Delivery Systems Based on Nanoparticles for Improved Glioblastoma Therapy: Addressing Challenges and Investigating Opportunities

Cancers, Journal Year: 2025, Volume and Issue: 17(4), P. 701 - 701

Published: Feb. 19, 2025

Glioblastoma multiforme (GBM) is a highly malignant brain tumor that has bleak outlook despite existing treatments such as surgery, radiation, and chemotherapy. The utilization of nanoparticles for drug delivery presents promising method by which to improve the effectiveness treatment while reducing harmful effects on entire body. This review examines application in GBM, focusing different types nanoparticles, including lipid-based, polymeric, metallic, those under development. Every variety analyzed its distinct characteristics therapeutic capacity. Lipid-based liposomes solid lipid enhance transport medicines are not soluble water have shown considerable potential preclinical investigations. Polymeric benefits terms controlled release targeted distribution, whereas metallic both therapy imaging. In current we would like emphasize ways medicine delivery, specifically enhancing penetration blood-brain barrier (BBB), targeting tumors, enabling release. Additionally, also discuss clinical discoveries, highlighting achievements obstacles process converting these technologies into effective GBM. study offers thorough examination present status prospects

Language: Английский

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Nanoparticle-Based Biomarkers for Neurological Disorders

Nanotechnology in the life sciences, Journal Year: 2025, Volume and Issue: unknown, P. 183 - 202

Published: Jan. 1, 2025

Language: Английский

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From Molecules to Mind: The Critical Role of Chitosan, Collagen, Alginate, and Other Biopolymers in Neuroprotection and Neurodegeneration

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1017 - 1017

Published: Feb. 22, 2025

Neurodegenerative disorders present significant therapeutic challenges, particularly due to the complex nature of drug delivery central nervous system. This review investigates applications various biopolymers in neuroprotection and their potential role treating neurodegeneration. We a critical analysis natural synthetic biopolymers, focusing primarily on chitosan, fish collagen/gelatin, alginate as key agents. The examines fundamental mechanisms brain development neurodegeneration, establishing framework for understanding how these interact with neural tissues. By analyzing recent experimental studies, we evaluate effectiveness different biopolymer-based systems crossing blood-brain barrier subsequent neuroprotective effects. Additionally, promising materials, including lignin, poly lactic-co-glycolic acid, glucose-modified bovine serum albumin/procyanidin complexes, are briefly explored provide comprehensive overview current developments field. Our reveals that approaches offer unique advantages both delivery, potentially opening new avenues neurodegenerative conditions. synthesizes knowledge identifies directions future research strategies.

Language: Английский

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Different applications of temperature responsive nanogels as a new drug delivery system mini review

Pharmaceutical Development and Technology, Journal Year: 2023, Volume and Issue: 28(5), P. 492 - 500

Published: May 2, 2023

Temperature-sensitive drug delivery systems (TSDDS) are one of the that have received more attention in medical science these days due to their advantages. As sensitive temperature, target becomes specific. nanogels many applications, including microbial infections, cancer therapy, transdermal use, and tissue repair. These characterized by minimal toxicity, improved therapeutic efficacy, reduced exposure normal cells. This mini-review is prepared with different types temperature-sensitive nanogel formation, release mechanisms, applications. Various reported under categories for targeted controlled classes drugs, such as anti-cancer antibiotic drugs special emphasis on healing, discussed this mini-review.

Language: Английский

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In vitro cytotoxic study of synthesized Ag and Ce dual-doped α-Fe2O3 nanoparticles on NIH/3T3 and U87 cell lines

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: unknown, P. 113236 - 113236

Published: Sept. 1, 2024

Language: Английский

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Free radical based nano cancer therapy

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 87, P. 104803 - 104803

Published: Aug. 4, 2023

Language: Английский

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Chitosan–sEPDM and Melatonin–Chitosan–sEPDM Composite Membranes for Melatonin Transport and Release

Membranes, Journal Year: 2023, Volume and Issue: 13(3), P. 282 - 282

Published: Feb. 27, 2023

Melatonin is the hormone that focuses attention of researchers in medical, pharmaceutical, materials, and membranes fields due to its multiple biomedical implications. The variety techniques methods for controlled release melatonin linked multitude applications, among which sports medicine occupies a special place. This paper presents preparation characterization composite based on chitosan (Chi) sulfonated ethylene-propylene-diene terpolymer (sEPDM). were obtained by vacuum evaporation from an 8% sEPDM solution toluene (w/w), was dispersed ultrasonic field (sEPDM:Chi = 1:1, w/w). For comparative evaluation membranes' performances, melatonin-chitosan-sulfonated (Mel:Chi:sEPDM 0.5:0.5:1.0, w/w/w) test membrane made. prepared morphologically structurally characterized scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), energy-dispersive analysis (EDAX), thermal (TG, DSC), coupled with chromatography analysis, contact angle measurements, but also point view performance process transport dedicated environments (aqueous solutions pH salinity). can amounts between 0.4 mg/cm2·per day (sEPDM), 1.6 mg/ cm2·per (Chi/sEPDM), 1.25 (Mel/Chi/SEPDM).

Language: Английский

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