Journal of Biomedical Materials Research Part A,
Journal Year:
2024,
Volume and Issue:
112(12), P. 2257 - 2272
Published: July 15, 2024
Abstract
As
the
cornerstone
of
tissue
engineering
and
regeneration
medicine
research,
developing
a
cost‐effective
bionic
extracellular
matrix
(ECM)
that
can
precisely
modulate
cellular
behavior
form
functional
remains
challenging.
An
artificial
ECM
combining
polysaccharides
fibrillar
proteins
to
mimic
structure
composition
natural
provides
promising
solution
for
cardiac
regeneration.
In
this
study,
we
developed
hydrogel
scaffold
by
quaternized
β
‐chitin
derivative
(QC)
fibrin‐matrigel
(FM)
in
different
ratios
ECM.
We
evaluated
stiffness
those
composite
hydrogels
with
mixing
their
effects
on
growth
human
umbilical
vein
endothelial
cells
(HUVECs).
The
optimal
hydrogels,
QCFM1
were
further
applied
load
HUVECs
into
nude
mice
vivo
angiogenesis.
Besides,
encapsulated
pluripotent
stem
cell‐derived
cardiomyocytes
(hPSC‐CMs)
QCFM
employed
3D
bioprinting
achieve
batch
fabrication
human‐engineered
heart
(hEHT).
Finally,
myocardial
electrophysiological
function
hEHT
immunofluorescence
optical
mapping.
Designed
has
tunable
modulus
(220–1380
Pa),
which
determines
when
these.
(800
Pa)
porous
architecture
finally
identified,
could
adapt
vitro
cell
spreading
angiogenesis
HUVECs.
Moreover,
successfully
both
ring‐shaped
patch‐shaped
hEHT.
These
hydrogels‐based
hEHTs
possess
organized
sarcomeres
advanced
characteristics
comparable
reported
hEHTs.
chitin‐derived
are
first
used
functionalized
myocardium.
Specifically,
these
novel
provided
reliable
economical
choice
serving
as
ideal
application
medicine.
Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(6), P. 2270 - 2270
Published: March 8, 2024
Regenerative
dentistry
has
experienced
remarkable
advancement
in
recent
years.
The
interdisciplinary
discoveries
stem
cell
applications
and
scaffold
design
fabrication,
including
novel
techniques
biomaterials,
have
demonstrated
immense
potential
the
field
of
tissue
engineering
regenerative
therapy.
Scaffolds
play
a
pivotal
role
by
facilitating
regeneration
restoring
damaged
or
missing
dental
structures.
These
biocompatible
biomimetic
structures
serve
as
temporary
framework
for
cells
to
adhere,
proliferate,
differentiate
into
functional
tissues.
This
review
provides
concise
overview
evolution
strategies
dentistry,
along
with
analysis
(Bard
v2.0
based
on
Gemini
neural
network
architecture)
most
commonly
employed
materials
used
fabrication
during
last
10
Additionally,
it
delves
bioprinting,
colonization
procedures,
outlines
prospects
regenerating
whole
tooth
future.
Moreover,
discusses
optimal
conditions
maximizing
mesenchymal
utilization
optimizing
personalization
through
precise
3D
bioprinting.
highlights
advancements
development,
particularly
advent
bioprinting
technologies,
is
comprehensive
literature
search
influential
publications
this
field.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 14, 2025
Electrospinning,
a
technique
for
creating
fabric
materials
from
polymer
solutions,
is
widely
used
in
various
fields,
including
biomedicine.
The
unique
properties
of
electrospun
fibrous
membranes,
such
as
large
surface
area,
compositional
versatility,
and
customizable
porous
structure,
make
them
ideal
advanced
biomedical
applications
like
tissue
engineering
wound
healing.
By
considering
the
high
biocompatibility
well-known
regenerative
potential
polylactic
acid
(PLA)
chitosan
(CH),
well
versatile
antibacterial
effect
silver
nanoparticles
(AgNPs),
this
study
explores
efficacy,
adhesive
properties,
cytotoxicity
membranes
with
nanofibrous
structure
varying
concentrations
AgNPs.
Silver
incorporated
at
25-50
μg/mL
or
above
significantly
enhanced
effectiveness,
especially
against
Staphylococcus
aureus
Escherichia
coli.
Biocompatibility
assessments
using
umbilical
cord
mesenchymal
stem
cells
demonstrated
nontoxic
nature
an
AgNP
concentration
12.5
μg/mL,
underscoring
their
applications.
This
provides
valuable
insights
into
developing
effective
antimicrobial
coatings
uses,
healing
patches
constructs
soft
replacement.
European Journal of Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
196, P. 106761 - 106761
Published: April 3, 2024
Inspired
by
nature,
tissue
engineering
aims
to
employ
intricate
mechanisms
for
advanced
clinical
interventions,
unlocking
inherent
biological
potential
and
propelling
medical
breakthroughs.
Therefore,
medical,
pharmaceutical
fields
are
growing
interest
in
organ
replacement,
repair,
regeneration
this
technology.
Three
primary
currently
used
engineering:
transplantation
of
cells
(I),
injection
growth
factors
(II)
cellular
seeding
scaffolds
(III).
However,
develop
presenting
highest
potential,
reinforcement
with
polymeric
materials
is
interest.
For
instance,
natural
synthetic
polymers
can
be
used.
Regardless,
chitosan
keratin
two
biopolymers
great
biocompatibility,
biodegradability
non-antigenic
properties
purposes
offering
restoration
revitalization.
combination
has
been
studied
results
exhibit
highly
porous
providing
optimal
environment
cultivation.
This
review
give
an
historical
as
well
current
overview
engineering,
involved
the
field.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(12), P. 1729 - 1729
Published: June 18, 2024
This
study
addresses
the
need
for
enhanced
antimicrobial
properties
of
electrospun
membranes,
either
through
surface
modifications
or
incorporation
agents,
which
are
crucial
improved
clinical
outcomes.
In
this
context,
chitosan—a
biopolymer
lauded
its
biocompatibility
and
extracellular
matrix-mimicking
properties—emerges
as
an
excellent
candidate
tissue
regeneration.
However,
fabricating
chitosan
nanofibers
via
electrospinning
often
challenges
preservation
their
structural
integrity.
research
innovatively
develops
a
chitosan/polycaprolactone
(CH/PCL)
composite
nanofibrous
membrane
by
employing
layer-by-layer
technique,
with
silver
nanoparticles
(AgNPs)
synthesized
wet
chemical
process.
The
antibacterial
efficacy,
adhesive
properties,
cytotoxicity
membranes
were
evaluated,
while
also
analyzing
hydrophilicity
structure
using
SEM.
resulting
CH/PCL-AgNPs
retain
porous
framework,
achieve
balanced
hydrophilicity,
display
commendable
biocompatibility,
exert
broad-spectrum
activity
against
both
Gram-negative
Gram-positive
bacteria,
efficacy
correlating
to
AgNP
concentration.
Furthermore,
our
data
suggest
that
efficiency
these
is
influenced
timed
release
ions
during
incubation
period.
Membranes
incorporated
starting
AgNPs
at
concentration
50
µg/mL
effectively
suppressed
growth
microorganisms
early
stages
up
8
h
incubation.
These
insights
underscore
potential
developed
superior
qualities,
serve
innovative
solutions
in
field
engineering.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: April 24, 2024
Periodontal
disease
is
the
most
common
type
of
oral
disease.
bone
defect
clinical
outcome
advanced
periodontal
disease,
which
seriously
affects
quality
life
patients.
Promoting
tissue
regeneration
and
repairing
defects
ultimate
treatment
goal
for
but
means
methods
are
very
limited.
Hydrogels
a
class
highly
hydrophilic
polymer
networks,
their
good
biocompatibility
has
made
them
popular
research
material
in
field
medicine
recent
years.
This
paper
reviews
current
mainstream
types
characteristics
hydrogels,
summarizes
relevant
basic
on
hydrogels
promoting
repair
The
possible
mechanisms
action
efficacy
evaluation
discussed
depth,
application
prospects
also
discussed.
