Lipid Peroxidation and Antioxidant Protection

Biomolecules, Journal Year: 2023, Volume and Issue: 13(9), P. 1291 - 1291

Published: Aug. 24, 2023

Lipid peroxidation (LP) is the most important type of oxidative-radical damage in biological systems, owing to its interplay with ferroptosis and role secondary other biomolecules, such as proteins. The chemistry LP consequences are reviewed focus on kinetics various processes, which helps understand mechanisms efficacy antioxidant strategies. main types antioxidants discussed terms structure–activity rationalization, mechanism kinetics, well their potential modulating ferroptosis. Phenols, pyri(mi)dinols, based heavy chalcogens (Se Te), diarylamines, ascorbate others addressed, along latest unconventional strategies double-sided superoxide/hydroperoxyl radical system.

Language: Английский

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Enhancing Industrial Hemp (Cannabis sativa) Leaf By-Products: Bioactive Compounds, Anti-Inflammatory Properties, and Potential Health Applications

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 548 - 548

Published: Jan. 10, 2025

The sustainable utilization of biomass-derived bioactives addresses the growing demand for natural health products and supports development goals by reducing reliance on synthetic chemicals in healthcare. Cannabis sativa biomass, particular, has emerged as a valuable resource within this context. This study focuses hydroethanolic extract C. leaves (CSE), which exhibited significant levels phenolic compounds contributing to robust antioxidant activity. Evaluation using potassium ferricyanide, ABTS, DPPH methods revealed potent radical scavenging activity comparable Trolox standard. UPLC-MS/MS profiling identified cannabinoids predominant secondary metabolites CSE, with flavonoids also present substantial quantities. investigated anti-inflammatory potential CSE RAW 264.7 macrophages IL-1β-stimulated C-20/A4 immortalized human chondrocytes, demonstrating protective effects without cytotoxic or mutagenic effects. Mechanistically, reduced inflammation inhibiting MAPK NF-κB signaling pathways. In silico approaches showed ability CSE's main bind influence activity, confirming vitro evidence. Incorporating leaf into hyaluronic acid-based formulation biotechnological promise treating joint inflammation. Future research should aim elucidate molecular mechanisms underlying these explore CSE-derived mitigating osteoarthritis progression. approach highlights significance utilizing annually increasing biomass waste bioactivity environmental impact reduction.

Language: Английский

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Optimized Hesperidin-Loaded Lipid Nanoparticles with Tea Tree Oil for Enhanced Wound Healing: Formulation, Characterization, and Evaluation

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 290 - 290

Published: Feb. 20, 2025

Objectives: This study aimed to develop hesperidin solid lipid nanoparticles (HESP-SLNs) enhance their stability, solubility, and sustained release for wound healing; further enhancement was achieved through prepared nanostructured carriers (HESP-NLCs) using Tea Tree Oil (TTO) explore synergistic efficacy. Methods: A factorial design of 24 trials established evaluate the influence type (X1), conc (%) (X2), surfactant (X3), sonication amplitude (X4) HESP-SLNs on particle size (nm) (Y1), polydispersibility index (Y2), zeta potential (Y3), encapsulation efficiency (Y4). The optimized formula selected utilizing Design Expert® software version 13, which additionally enhanced by preparing TTO-loaded HESP-NLCs. In vitro release, Raman spectroscopy, transmission electron microscopy were carried out both nanoparticles. Cytotoxicity, in vivo wound-healing assessments, skin irritancy tests performed performance TTO-incorporated HESP-NLCs compared HESP-SLNs. Results: demonstrated PS (280 ± 1.35 nm), ZP (−39.4 0.92 mV), PDI (0.239 0.012), EE% (88.2 2.09%). NLCs Q6% (95.14%) vs. (79.69%), SLNs showed superior antimicrobial Both exhibited spherical morphology compatibility between HESP excipients. highest closure percentage, supported histological analysis inflammatory biomarker outcomes. Cytotoxicity evaluation 87% cell viability untreated HSF cells, test confirmed safety NLCs. Conclusions: are promising candidates exhibiting capabilities, making them a therapeutic option cutaneous management.

Language: Английский

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Hepatoprotective effects of natural drugs: Current trends, scope, relevance and future perspectives

Phytomedicine, Journal Year: 2023, Volume and Issue: 121, P. 155100 - 155100

Published: Sept. 18, 2023

Language: Английский

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Polyphenol-Rich Extracts and Essential Oil from Egyptian Grapefruit Peel as Potential Antioxidant, Antimicrobial, and Anti-Inflammatory Food Additives

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(7), P. 2776 - 2776

Published: March 26, 2024

Grapefruit (GF) processing generates significant nutrient and economic losses due to the production of 50% by-products, primarily peels. GF peels are a rich sustainable source bioactive compounds (BCs), such as essential oils (EOs) phenolic compounds. Thus, finding value-added solutions based on circular economy is paramount. This research aims assess antioxidant, anti-inflammatory, antimicrobial properties hydroethanolic polyphenol-rich extract from crude (GF-CE), oil (GF-EO), after extraction (GF-PE). The GF-CE GF-PE showed high concentrations naringenin (7.71 48.60 mg/g dry (DE)), narirutin (15.03 28.73 DE), hesperidin (0.67 0.29 mg/mL), respectively. Extracting firstly EOs improved release acids (p-coumaric, ferulic, chlorogenic acid). exhibited stronger free radical scavenging activity mainly in DPPH (IC50 = 75.69 ± 0.81 µg/mL) than GF-EO (1271 0.85 (113.45 µg/mL). demonstrated moderate against Gram-positive bacteria compared reference standard (amoxicillin) strong yeast Candida albicans (inhibition zone 16 mm). major included D-limonene (25%), nootkatone (24%), β-pinene (8%). Both extracts promising activities COX1 COX2 inhibitors with IC50 values 25 0.1 0.28 0.00 µg/mL (compared celecoxib (97.5 0.31 0.01 indomethacin (6.25 0.52 standards), study concludes that valuable BCs bioactivities, offering multi-cascade approach recovering alignment principles open opportunities functional ingredients for food applications.

Language: Английский

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Food Proteins as Functional Ingredients in the Management of Chronic Diseases: A Concise Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2323 - 2323

Published: July 19, 2024

Chronic diseases have emerged as a formidable global health concern, with their prevalence steadily rising over the years. Several approaches to addressing these concerns include use of medications, which are often expensive, contain synthetic chemical substances, and reported adverse effects. The foods, especially proteins, an alternative approach chronic by treating managing is increasing. This review evaluates intriguing role food proteins in mitigating improving our understanding therapeutic potential different protein types, including those derived from legumes, nuts, seeds, dairy, fish, numerous other sources. They been offer promising avenues for diseases, cardiovascular diabetes, inflammation, weight management, bone health, glycemic control, muscle preservation, many benefits. Although exact mechanisms actions still not properly elucidated, it is, however, understood that exert health-beneficial effects unique nutritional bioactive profiles, peptides amino acids. Practical applications also discussed, dietary interventions tailored towards incorporating protein-rich foods development functional disease prevention management. Food combating can turn around public practices.

Language: Английский

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Recent Advances in Diagnosing and Treating Helicobacter pylori through Botanical Extracts and Advanced Technologies

Archives of Pharmacology and Therapeutics, Journal Year: 2023, Volume and Issue: 5(1), P. 53 - 66

Published: Nov. 4, 2023

Helicobacter pylori (H. pylori) infection is a major global health concern, with an estimated 50% of the world's population infected. The bacterium colonizes stomach and associated range gastrointestinal diseases, including chronic gastritis, peptic ulcers, gastric cancer. current standard care for H. involves combination antibiotics proton pump inhibitors (PPIs), but widespread use has led to development antibiotic-resistant strains pylori, making treatment more difficult. Recent advances in diagnostic strategies include non-invasive tests serological biomarkers. While PPIs remains primary approach, there growing interest alternative therapies, botanical extracts, natural products, traditional medicines. research also explored potential probiotics, phage therapy, novel antibiotics, such as rifabutin furazolidone, infection. studies have artificial intelligence (AI) diagnosis management AI-assisted screening methods identified extracts products anti-H. activity, providing new avenues therapeutic development. Additionally, AI can improve accuracy outcomes. Although these approaches show promise, further needed confirm their efficacy, safety, optimal dosing. Novel therapies therapy may provide treatments help overcome antimicrobial resistance.

Language: Английский

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Egyptian Citrus Essential Oils Recovered from Lemon, Orange, and Mandarin Peels: Phytochemical and Biological Value

Horticulturae, Journal Year: 2024, Volume and Issue: 10(2), P. 180 - 180

Published: Feb. 16, 2024

Citrus peels are an important by-product of citrus processing industries, but a large part is considered waste. There has been increased attention in the last five years on these industrial by-products, especially those containing residual essential oils (EOs). Lemon, orange, and mandarin from Egypt were subjected to hydro-distillation obtain EOs, which analyzed via mass spectrometry (GC/MS) by building Global Natural Products Social Molecular Networking (GNPS-MN) for purpose visually exploring volatile components species. The constructed MN revealed that D-Limonene, α-pinene, β-pinene dominant constituents three Egyptian EOs exhibited promising activities as antioxidants using two tested methods: 1,1-diphenyl-2-picryl-hydrazil (DPPH) nitric oxide (NO) compared with vitamin C. Lemon EO proved excellent antimicrobial activity against Gram-positive negative bacteria. Additionally, showed good yeast Candida albicans. Regarding anti-inflammatory assay, COX-1 COX-2 inhibitors. This study concludes extracted peel waste can be valorized innovative strategy food preservation or may incorporated cosmetics pharmaceutical formulations alignment circular economy principles.

Language: Английский

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Exploring the Antioxidant and Anti-Inflammatory Potential of Saffron (Crocus sativus) Tepals Extract within the Circular Bioeconomy

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1082 - 1082

Published: Sept. 4, 2024

Repurposing saffron (

Language: Английский

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The Biology and Biochemistry of Kynurenic Acid, a Potential Nutraceutical with Multiple Biological Effects

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 9082 - 9082

Published: Aug. 21, 2024

Kynurenic acid (KYNA) is an antioxidant degradation product of tryptophan that has been shown to have a variety cytoprotective, neuroprotective and neuronal signalling properties. However, mammalian transporters receptors display micromolar binding constants; these are consistent with its typically tissue concentrations but far above serum/plasma concentration (normally tens nanomolar), suggesting large gaps in our knowledge transport mechanisms action, the main influx characterized date equilibrative, not concentrative. In addition, it substrate known anion efflux pump (ABCC4), whose vivo activity largely unknown. Exogeneous addition L-tryptophan or L-kynurenine leads production KYNA also many other co-metabolites (including some such as 3-hydroxy-L-kynurenine quinolinic may be toxic). With exception chestnut honey, exists at relatively low levels natural foodstuffs. bioavailability reasonable, terminal element irreversible reaction most pathways, might added exogenously without disturbing upstream metabolism significantly. Many examples, which we review, show valuable bioactivity. Given above, review potential utility nutraceutical, finding significantly worthy further study development.

Language: Английский

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