Nano-drug Delivery System: a Promising Approach Against Breast Cancer

Therapeutic Delivery, Journal Year: 2023, Volume and Issue: 14(5), P. 357 - 381

Published: May 1, 2023

Breast cancer (BC) is among the most frequent malignancies women face around globe. Nanotherapeutics are constantly evolving to overcome limitations of conventional diagnostic and therapeutic approaches. Nanotechnology-based nanocarriers have a higher entrapment efficiency, low cytotoxicity, greater stability improved half-life than therapy. Nano-drug delivery systems pharmacokinetics pharmacodynamics parameters because nanomeric size. Currently, various nano-formulations in preclinical clinical settings for breast cancer, like polymeric nanoparticles, micelles, nanobodies, magnetic liposomes, niosomes, gold-nanoparticles, dendrimers carbon-nanotubes. This review highlights recent advancement developing nano-drug BC treatment. will open gateway researchers understand current approaches nano-formulation improving problems associated with

Language: Английский

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Overview of Solid Lipid Nanoparticles in Breast Cancer Therapy

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(8), P. 2065 - 2065

Published: July 31, 2023

Lipid nanoparticles (LNPs), composed of ionized lipids, helper and cholesterol, provide general therapeutic effects by facilitating intracellular transport avoiding endosomal compartments. LNP-based drug delivery has great potential for the development novel gene therapies effective vaccines. Solid lipid (SLNs) are derived from physiologically acceptable components remain robust at body temperature, thereby providing high structural stability biocompatibility. By enhancing through blood vessels, SLNs have been used to improve efficacy cancer treatments. Breast cancer, most common malignancy in women, a declining mortality rate but remains incurable. Recently, as an anticancer system, widely breast improving drugs. In this review, we discuss latest advances treatment their clinical use.

Language: Английский

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WZB117 Decorated Metformin-Carboxymethyl Chitosan Nanoparticles for Targeting Breast Cancer Metabolism

Polymers, Journal Year: 2023, Volume and Issue: 15(4), P. 976 - 976

Published: Feb. 16, 2023

The “Warburg effect” provides a novel method for treating cancer cell metabolism. Overexpression of glucose transporter 1 (GLUT1), activation AMP-activated protein kinase (AMPK), and downregulation mammalian target rapamycin (mTOR) have been identified as biomarkers abnormal Metformin (MET) is an effective therapy breast (BC), but its efficacy largely reliant on the concentration at tumor site. We propose WZB117 (a GLUT1 inhibitor)-OCMC (O-carboxymethyl-chitosan)-MET combo strategy simultaneous mTOR targeting alteration BC conjugated polymeric nanoparticles were 225.67 ± 11.5 nm in size, with PDI 0.113 0.16, encapsulation 72.78 6.4%. OCMC pH-dependently selectively releases MET targets pathway cells, BCL2 to alter WZB117-OCMC-MET overcomes limitations monotherapy by synergistically. activates AMPK suppresses Western blot experiment, indicating growth-inhibitory apoptotic characteristics. AO/EB cycle enhance cellular internalization compared alone. affects cells’ metabolism promising therapeutic strategy.

Language: Английский

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Solid Lipid Nanoparticles, an Alternative for the Treatment of Triple-Negative Breast Cancer

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10712 - 10712

Published: Oct. 5, 2024

Within the field of nanomedicine, which is revolutionizing cancer treatment, solid lipid nanoparticles (SLNs) have shown advantages over conventional chemotherapy when tested on cells in preclinical studies. SLNs proven to be an innovative strategy for treatment triple-negative breast cells, providing greater efficiency than existing treatments various The encapsulation antineoplastic drugs has facilitated a sustained, controlled, and targeted release, enhances therapeutic reduces adverse effects. Moreover, surface can modified increase efficiency. For instance, coating these particles with polyethylene glycol (PEG) decreases their opsonization, resulting longer life circulatory system. creation positively charged cationic (cSLNs), achieved by utilization surfactants or ionic lipids structural groups, increases affinity cell membranes plasma proteins. Hyaluronic acid been added so that distinct pH tumor would stimulate release drug and/or genetic material. current review summarizes recent research SLNs, focusing transport agents cytotoxic effect cancer.

Language: Английский

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Combinatorial Delivery of Docetaxel- and Erlotinib-Loaded Functionalized Nanostructured Lipid Carriers for the Treatment of Triple-Negative Breast Cancer Using Quality-by-Design Approach

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(7), P. 926 - 926

Published: July 11, 2024

This study explored the combined administration of docetaxel (DOC) and erlotinib (ERL) using nanostructured lipid carriers (NLCs), with folic acid (FA) conjugation to enhance their synergistic anticancer efficacy against triple-negative breast cancer. NLCs were developed through hot melt homogenization–ultrasound dispersion, optimized by a quality-by-design (QbD) approach Plackett–Burman design Box–Behnken design. Plots generated based on maximum desirability. Spherical, nanosized dispersions (<200 nm) zeta potential ranging from −16.4 −14.15 mV observed. These nanoformulations demonstrated ~95% entrapment efficiency around 5% drug loading. Stability tests revealed that remained stable for 6 months under storage conditions at 4 °C. In vitro release studies indicated sustained over 24 h, following Higuchi Korsmeyer–Peppas models FA NLCs, respectively. Additionally, an in pH-stat lipolysis model exhibited nearly fivefold increase bioaccessibility compared drug-loaded suspensions. The DOC–ERL-loaded formulations dose- time-dependent cytotoxicity, revealing synergism 1:3 molar ratio MDA-MB-231 4T1 cells, combination indices 0.35 0.37, Co-treatment effects various assays.

Language: Английский

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Targeted Delivery of Pennyroyal via Methotrexate Functionalized PEGylated Nanostructured Lipid Carriers into Breast Cancer Cells; A Multiple Pathways Apoptosis Activator

Advanced Pharmaceutical Bulletin, Journal Year: 2023, Volume and Issue: 13(4), P. 747 - 760

Published: April 29, 2023

Pennyroyal is a species of the Lamiaceae family with potent anti-cancer and antioxidant properties. Combining this chemotherapeutic agents enhances effectiveness these by inducing more apoptosis in cancerous cells.Here, methotrexate (MTX) combined pennyroyal oil based on PEGylated nanostructured lipid carriers (NLCs) was assessed. These nanoparticles were physiochemically characterized, their effects targeting efficiency investigated folate receptor-positive human breast cancer cell line (MCF-7) negative alveolar basal epithelial cells (A549).Results showed mean size 97.4 ± 12.1 nm for non-targeted NLCs 220.4 11.4 targeted NLCs, an almost small distribution assessed TEM imaging. Furthermore, vitro molecular activity investigations that pennyroyal-NLCs pennyroyal-NLCs/MTX activate autophagy pathway changing related mRNA expression levels. cellular studies changes level gene could lead to rise rate from 15.6 8.1 25.0 3.2 (P<0.05) MCF-7 treated pennyroyal-NLCs/MTX, respectively. Autophagy reactive oxygen (ROS) evaluation indicated treating significantly increase intensity cells.Our results present new NLCs-based approach enhance delivery MTX tissues.

Language: Английский

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Physicochemical Characterization, Stability, and In Vitro Evaluation of Curcumin-Loaded Solid Lipid Nanoparticles Prepared Using Biocompatible Synthetic Lipids

ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 6(7), P. 2785 - 2794

Published: July 5, 2023

Solid lipid nanoparticles (SLNs) are promising drug delivery vehicles for the of various drugs, especially poorly water-soluble drugs. However, aqueous stability, release, and biocompatibility SLNs some issues that need attention. In this work, curcumin-loaded were prepared, morphology, particle size, entrapment efficiency studied. For this, two amino acid-derived lipids developed. The effect polarity head on stability SLN dispersion was investigated. Based polydispersity, an optimum formulation obtained. curcumin found to be greater than those reported in literature. entrapped curcumin, as well suspensions, exhibited improved storage stability. vitro release kinetics indicated enhanced rate case consisting containing −OH groups at head. pure blank have no significant cytotoxicity, but induced cell death a concentration-dependent manner both human prostatic adenocarcinoma PC3 line breast carcinoma MCF7 line. This study has proposed potential semisynthetic stable suspension curcumin.

Language: Английский

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A comprehensive review on nanocarriers as a targeted delivery system for the treatment of breast cancer

Intelligent Pharmacy, Journal Year: 2024, Volume and Issue: 2(3), P. 415 - 426

Published: April 5, 2024

Breast cancer is the most common malignant tumour in women worldwide, as well leading cause of death from tumours. All across world, incidence breast steadily rising. Although numerous drugs acting through various mechanisms action are available market conventional formulations for treatment cancer, they face significant challenges terms bioavailability, dosing, and associated adverse effects, which severely limit their therapeutic efficacy. Several studies have shown that nanocarriers can significantly improve drug's reducing need frequent dosing toxicity linked to high drug doses. The current review provides insight into with oral nanoparticulate systems overcome problems formulations. This focuses on topics, such an in-depth analysis potential anticancer used nanocarrier technology treat successfully.

Language: Английский

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Smart Delivery Vehicles for Cancer: Categories, Unique Roles and Therapeutic Strategies

Nanoscale Advances, Journal Year: 2024, Volume and Issue: 6(17), P. 4275 - 4308

Published: Jan. 1, 2024

Chemotherapy and surgery remain the primary treatment modalities for cancers; however, these techniques have drawbacks, such as cancer recurrence toxic side effects, necessitating more efficient strategies. Recent advancements in research medical technology provided novel insights expanded our understanding of development; consequently, scholars investigated several delivery vehicles therapy to improve efficiency patient outcomes. Herein, we summarize types smart therapeutic carriers elaborate on mechanism underlying drug delivery. We reveal advantages treatment, focus their effectiveness immunotherapy, discuss application combination with other emerging strategies treatment. Finally, bottlenecks encountered development suggest directions future research. This review will promote progress facilitate related

Language: Английский

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Phytocompounds and Nanoformulations for Anticancer Therapy: A Review

Molecules, Journal Year: 2024, Volume and Issue: 29(16), P. 3784 - 3784

Published: Aug. 9, 2024

Cancer is a complex disease that affects millions of people and remains major public health problem worldwide. Conventional cancer treatments, including surgery, chemotherapy, immunotherapy, radiotherapy, have limited achievements multiple drawbacks, among which are healthy tissue damage multidrug-resistant phenotype onset. Increasing evidence shows many plants’ natural products, as well their bioactive compounds, promising anticancer activity exhibit minimal toxicity compared to conventional drugs. However, widespread use in therapy severely restricted by limitations terms water solubility, absorption, lack stability, bioavailability, selective targeting. The nanoformulations for product transportation delivery could be helpful overcoming these limitations, thus enhancing therapeutic efficacy providing the basis improved treatment strategies. present review aimed at an update on some phytocompounds (curcumin, resveratrol, quercetin, cannabinoids, others) main showing antitumor activities, both vitro vivo, against such different human types breast colorectal cancer, lymphomas, malignant melanoma, glioblastoma multiforme, osteosarcoma. intracellular pathways underlying phytocompound advantages nanoformulation employment also examined. Finally, this critically analyzes research gaps causing success phytocompounds’ nanoformulations’ clinical translation.

Language: Английский

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