Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(8), P. 672 - 672
Published: April 12, 2024
Curcumin,
an
organic
phenolic
molecule
that
is
extracted
from
the
rhizomes
of
Curcuma
longa
Linn,
has
undergone
extensive
evaluation
for
its
diverse
biological
activities
in
both
animals
and
humans.
Despite
favorable
characteristics,
curcumin
encounters
various
formulation
challenges
stability
issues
can
be
effectively
addressed
through
application
nanotechnology.
Nano-based
techniques
specifically
focused
on
enhancing
solubility,
bioavailability,
therapeutic
efficacy
while
mitigating
toxicity,
have
been
explored
curcumin.
This
review
systematically
presents
information
improvement
curcumin’s
beneficial
properties
when
incorporated,
either
individually
or
conjunction
with
other
drugs,
into
nanosystems
such
as
liposomes,
nanoemulsions,
polymeric
micelles,
dendrimers,
nanoparticles,
solid-lipid
nanostructured
lipid
carriers.
Additionally,
examines
ongoing
clinical
trials
recently
granted
patents,
offering
a
thorough
overview
dynamic
landscape
delivery.
Researchers
are
currently
exploring
nanocarriers
crucial
features
surface
modification,
substantial
loading
capacity,
biodegradability,
compatibility,
autonomous
targeting
specificity
selectivity.
Nevertheless,
utilization
delivery
still
initial
phases,
regulatory
approval
pending
persistent
safety
concerns
surrounding
their
use.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(5), P. 3403 - 3413
Published: May 3, 2024
The
delivery
of
drugs
to
the
brain
in
therapy
diseases
central
nervous
system
(CNS)
remains
a
continuing
challenge
because
lack
systems
that
can
cross
blood-brain
barrier
(BBB).
Therefore,
there
is
need
develop
an
innovative
method
for
treatment
CNS
diseases.
Thus,
we
have
investigated
interaction
γ-aminobutyric
acid
(GABA)
and
S-(−)-γ-amino-α-hydroxybutyric
(GAHBA)
with
GABA
receptor
by
performing
docking
study.
Both
GAHBA
show
comparable
binding
affinities
toward
receptor.
In
this
study,
developed
surface-modified
solid
lipid
nanoparticles
(SLNs)
using
GAHBA-derived
lipids
BBB.
CLB-loaded
SLNs
were
characterized
number
methods
including
differential
scanning
calorimetry,
dynamic
light
scattering,
UV–vis
spectroscopy,
transmission
electron
microscopy.
blank
SLN
suspensions
found
exhibit
good
storage
stability.
Also,
showed
higher
encapsulation
efficiency
CLB
drugs.
vitro
release
kinetics
at
physiological
temperature
was
also
investigated.
results
cell
cytotoxicity
assay
flow
cytometry
studies
human
glioma
U87MG
line
prostate
cancer
PC3
suggested
efficacy
GAHBA-modified
cells.
transcription
level
expression
target
organ
analyzed
reverse
polymerase
chain
reaction
vivo
biodistribution
uptake
C57BL6
mice
SPECT/CT
imaging
Wistar
rats
99mTc-labeled
autoradiography
suggest
increasing
uptake.
We
demonstrated
anticancer
drug
chlorambucil
(CLB)
glioma.
Journal of Biomedical Materials Research Part B Applied Biomaterials,
Journal Year:
2025,
Volume and Issue:
113(2)
Published: Jan. 22, 2025
ABSTRACT
Microfluidics‐based
droplets
have
emerged
as
a
powerful
technology
for
biomedical
research,
offering
precise
control
over
droplet
size
and
structure,
optimal
mixing
of
solutions,
prevention
cross‐contamination.
It
is
major
branch
microfluidic
with
applications
in
diagnostic
testing,
imaging,
separation,
gene
amplification.
This
review
discusses
the
different
aspects
devices,
generation
techniques,
types,
production
micro/nano
particles,
along
their
advantages
limitations.
Passive
active
methods
formation
are
discussed,
well
manipulation
shape
content.
also
highlights
potential
microfluidics
tissue
engineering,
cancer
therapy,
drug
delivery
systems.
The
use
lipid
nanoparticles
polymeric
microparticles
presented,
emphasis
on
research.
Finally,
contributions
to
vaccines,
personalized
medicine,
future
perspectives
emphasizing
need
continuous
innovation
integration
other
technologies,
such
AI
wearable
further
enhance
its
medicine
delivery.
However,
it
noted
that
challenges
commercialization
widespread
adoption
still
be
addressed.
Small Methods,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 11, 2025
Abstract
Elucidating
in
vivo
lipolysis
is
crucial
for
clarifying
the
underlying
mechanisms
and
fates
of
lipid‐based
nanocarriers,
which
are
essential
oral
drug
delivery
carriers.
Current
mainstream
methodologies
use
various
vitro
digestion
models
to
predict
performance
lipid
formulations;
however,
their
accuracy
often
impeded
by
complicated
environment
gastrointestinal
tract.
Although
fluorescence
labeling
with
conventional
probes
partly
reveals
translocation
it
fails
elucidate
process
because
poor
signal
discrimination
among
free
probes,
mixed
micelles
(lipolysis
end‐products).
Here,
a
polarity‐sensitive
probe
(PN‐C18)
aggregation‐caused
quenching
properties
nanocarriers
developed
optimized.
PN‐C18
successfully
eliminates
interference
from
both
during
lipolysis.
In
representative
model,
shows
stronger
correlation
between
intensity
progression
than
those
previous
methods.
vivo,
nanoparticles
clearly
visualized
effectively
monitored,
owing
high
tissue‐penetrating
capability
NIR‐II
photons.
This
study
provides
practical
means
elucidating
fate
systems
offers
valuable
insights
reference
further
studies
this
domain.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(14), P. 10547 - 10556
Published: Jan. 1, 2025
In
this
study,
we
developed
a
nanoformulation
with
sustained
release
and
improved
stability
by
encapsulating
curcumin,
poorly
soluble
drug,
into
solid
lipid
nanoparticles
high
encapsulation
efficiency
using
microfluidic
approach.
Langmuir,
Journal Year:
2024,
Volume and Issue:
40(29), P. 14811 - 14822
Published: July 9, 2024
Cancer
is
a
major
public
health
problem
worldwide,
and
it
the
second
leading
cause
of
death
humans
in
world.
The
present
study
has
been
directed
toward
preparation
methotrexate-loaded
surface-modified
solid
lipid
nanoparticles
(SLNs)
for
potential
use
as
chemotherapeutic
formulation
cancer
therapy.
A
(C
ChemBioChem,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 30, 2024
Abstract
Curcumin
is
a
bright
yellow
naturally
occurring
polyphenol
which
the
principal
component
of
turmeric.
It
used
as
herbal
supplement,
cosmetics
ingredient,
and
food
coloring
agent.
Over
years,
therapeutic
properties
natural
product
curcumin
have
gone
unexploited
but
not
unnoticed.
cannot
be
employed
drug
due
to
limitations
such
low
aqueous
solubility
limited
bioavailability.
Many
attempts
been
made
overcome
these
by
confining
in
various
confined
media
enhance
its
The
biomolecule
emissive
undergoes
fundamental
excited
state
processes
solvation
dynamics
intramolecular
proton
transfer
(ESIPT).
based
biomaterials
nanomaterials
are
also
fast
advancing
field
where
an
intrinsic
necessary
for
formation
materials
no
longer
added
external
free
drug.
In
this
review,
we
will
summarize
recent
research
on
photophysical
photochemical
bio‐mimicking
systems.
At
same
time
wish
incorporate
applications
curcumin,
especially
biology.
Lastly
growing
importance
science,
briefly
discuss
some
advances
nanomaterials.
We
believe
compilation
surrounding
provide
overall
understanding
potentialities
different
areas.
