Neuroprotective and anti‐inflammatory effects of curcumin in Alzheimer's disease: Targeting neuroinflammation strategies

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(6), P. 3169 - 3189

Published: April 14, 2024

Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid‐beta plaques and neurofibrillary tangles, leading to neuronal loss. Curcumin, polyphenolic compound derived from Curcuma longa , has shown potential neuroprotective effects due its anti‐inflammatory antioxidant properties. This review aims synthesize current preclinical data on anti‐neuroinflammatory mechanisms curcumin in context AD, addressing pharmacokinetics, bioavailability, as therapeutic adjunct. An exhaustive literature search was conducted, focusing recent studies within last 10 years related curcumin's impact neuroinflammation role AD. The methodology included sourcing articles specialized databases using specific medical subject headings terms ensure precision relevance. Curcumin demonstrates significant properties modulating neuroinflammatory pathways, scavenging reactive oxygen species, inhibiting production pro‐inflammatory cytokines. Despite potential, challenges remain regarding limited bioavailability scarcity comprehensive human clinical trials. emerges promising adjunct AD multimodal benefits. However, further research required overcome establish effective dosing regimens subjects. Developing novel delivery systems formulations may enhance treatment.

Language: Английский

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Terpenes as Potential Anti-Alzheimer’s Disease Agents

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(9), P. 3898 - 3898

Published: May 2, 2024

Alzheimer’s disease (AD), a slowly progressive neurodegenerative disorder, is the main cause of dementia worldwide. However, currently, approved drugs to combat AD are effective only in treating its symptoms. In fact, an efficacious treatment for this complex and multifactorial disorder remains be discovered, demanding urgent development new therapeutic approaches disease, such as use bioactive secondary metabolites (SMs) from natural sources. Sessile organisms, like plants, unable escape adverse environmental conditions must therefore create their own defense. Their defense strategy chemical that includes production enormously diverse array SMs, terpenes derivatives. This largest most group plant SMs also provide several diseases due broad-spectrum bioactivities, example, anticancer, antioxidant, anti-inflammatory properties. Thus, evaluation neuroprotective potential imperative. It known major clinical indications (CIs) extracellular senile plaques amyloid-β (Aβ) protein, intracellular hyperphosphorylated tau (τ) neurofibrillary tangles (NFTs), uncommon neuroinflammatory response, oxidative stress, synaptic neuronal dysfunction. Therefore, may decrease these CIs might used treatment. Surely, targeting more than one pathogenic mechanism, multi-target drug ligands (MTDLs), have become leading review analyzes, each CI, scaffolds selected highest activity.

Language: Английский

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Antioxidant and anti-Alzheimer's potential of Tetragonisca angustula (Jataí) stingless bee pollen

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 3, 2024

Abstract Alzheimer's disease (AD) is considered the leading cause of dementia in elderly worldwide. It results progressive memory loss and impairment cognitive motor skills, to a high degree disability dependence. The development AD associated with accumulation senile plaques brain, caused by amyloidogenic pathway disease. Several genetic biochemical events are linked development, oxidative stress being one them. Due scarcity drugs aimed at treating AD, antioxidant compounds increasingly studied as therapeutic targets for In this study, we investigate anti-Alzheimer potential Tetragonisca angustula (Jataí) pollen extract Drosophila melanogaster model. For purpose, utilized D. AD-like model, which expresses genes related We explored floral origin collected pollen, conducted phytochemical prospecting, evaluated its capacity vitro. vivo experiments involved assessing survival climbing ability model various concentrations extract. Our findings revealed that exhibits significant response important phytochemicals, such flavonoids polyphenols. Furthermore, it enhanced rate , across all tested, improved flies after 15 days treatment methanolic Additionally, reduced neurodegeneration index histopathological analysis. Thus, our study demonstrates an subject further investigation, aiming isolate molecules could potentially serve

Language: Английский

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Natural drug delivery systems for the treatment of neurodegenerative diseases

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Feb. 10, 2025

Language: Английский

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Computational Insight of Oleracone L, Portulacatone B, and Portulacatal from Portulaca oleracea L. as Potential Anticholinesterase Inhibitors for Alzheimer’s

Processes, Journal Year: 2024, Volume and Issue: 12(7), P. 1456 - 1456

Published: July 12, 2024

Alzheimer’s disease, characterized by a decline in cognitive functions, is frequently associated with decreased levels of acetylcholine due to the overactivity acetylcholinesterase (AChE). Inhibiting AChE has been key therapeutic strategy treating yet search for effective inhibitors, particularly from natural sources, continues their potential fewer side effects. In this context, three new alkaloids—oleracone L, portulacatone B, and portulacatal—extracted Portulaca oleracea L., have recently shown promising anticholinesterase activity vitro. However, no experimental or computational studies explored binding potential. This study represents first comprehensive silico analysis these compounds, employing ADME prediction, molecular docking, dynamics simulations, MM-PBSA calculations assess The drug-likeness was evaluated based on Lipinski, Pfizer, Golden Triangle, GSK rules, all alkaloids meeting criteria. profiles suggested that can effectively cross blood–brain barrier, critical requirement treatment. Molecular docking revealed oleracone L had highest affinity (−10.75 kcal/mol) towards AChE, followed portulacatal demonstrating significant interactions crucial enzyme residues. simulations over 200 ns confirmed stability interactions, RMSD values below 2 Å complexes, indicating stable throughout simulation period. RMSF radius gyration analyses further corroborated minimal impact enzyme’s overall flexibility compactness. Moreover, provided additional support efficacy, showing most favorable energy, could be superior inhibitor, potentially its stronger more consistent hydrogen bonding electrostatic compared other studied alkaloids. These findings highlight efficiency viability as suggesting they candidates disease underscores importance validation through vitro vivo experiments confirm predictions.

Language: Английский

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Trojan Horse Delivery Strategies of Natural Medicine Monomers: Challenges and Limitations in Improving Brain Targeting

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 280 - 280

Published: Feb. 20, 2025

Central nervous system (CNS) diseases, such as brain tumors, Alzheimer’s disease, and Parkinson’s significantly impact patients’ quality of life impose substantial economic burdens on society. The blood–brain barrier (BBB) limits the effective delivery most therapeutic drugs, especially natural products, despite their potential effects. Trojan Horse strategy, using nanotechnology to disguise drugs “cargo”, enables them bypass BBB, enhancing targeting efficacy. This review explores applications products in treatment CNS discusses challenges posed by analyzes advantages limitations strategy. Despite existing technical challenges, future research is expected enhance application integrating nanotechnology, improving mechanisms, optimizing characteristics.

Language: Английский

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Systematic bibliometric and visualized analysis of research hotspots and trends in obstructive sleep apnea neuroimaging

Behavioral Sleep Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 23

Published: March 21, 2025

Obstructive sleep apnea (OSA) patients exhibit neurological symptoms, driving research in medicine and clinical neurology. Neurologists radiologists explore detection methods to identify unique neural features associated with OSA the atypical nervous system. Neuroimaging encompasses studying structural, functional connectivity (FC), neurometabolic aspects of brain. Limited resources OSA's heterogeneity pose challenges effective neuroimaging research. This study aims conduct a bibliometric analysis key trends emerging themes. utilizes various techniques, including MRI, structural diffusion tensor imaging, magnetic resonance spectroscopy, electroencephalography, among others. Publications from 1993 2023 were retrieved Web Science on neuroimaging. Analysis tools included Bibliometric.com, CiteSpace, VOSviewer, R4.3.2. A total 714 papers published 47 countries, 651 articles, 55 reviews, 8 meeting abstracts. The USA led publications, University California System contributing most, primarily "Sleep" journal. identified 2916 authors, Macey PM having highest publication count. Recent years highlighted burst keywords such as network, classification, staging, FC, brain activity. keyword clusters revealed "electroencephalography" longest temporal duration. has gained increased attention. Incorporating behavioral insights could enhance understanding impact function behavior. assist researchers identifying potential collaborators, institutions, themes, providing comprehensive perspective related disorders.

Language: Английский

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Acanthopanax Senticosus Saponins Prevent Cognitive Decline in Rats with Alzheimer’s Disease

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3715 - 3715

Published: April 14, 2025

Alzheimer’s disease (AD) is a progressive degenerative of the nervous system that affects older adults. Its main clinical manifestations include memory loss, cognitive dysfunction, abnormal behaviour, and social dysfunction. Neuroinflammation typical in most neurodegenerative diseases, such as AD. Therefore, suppressing inflammation may improve AD symptoms. This study investigated neuroprotective effects Acanthopanax senticosus saponins (ASS) an model induced by streptozotocin (STZ). Here, we characterised rat STZ-induced with parallel deterioration loss neuroinflammation. Following end treatment ASS (50 mg/kg for 14 consecutive days), behavioural tests (Morris water maze test, Y-maze test) were performed on rat, molecular parameters (DAPK1, Tau5, p-Tau, NF-κB, IL-1β, TNF-α, NLRP3) hippocampus also assessed. We demonstrated ASS, which has potent anti-inflammatory effects, can reduce neuroinflammation prevent impairment. In ASS-treated groups exhibited significantly increased average escape latency (p < 0.05), percentage stay target quadrant number times each group rats crossed platform 0.05) compared to negative control. And could phosphorylation Tau protein 0.001) death-associated kinase 1 p hippocampal tissue, improving impairment STZ-treated inflammatory response; analysis showed significant reduction pro-inflammatory markers like NLRP3, NF-κB 0.001). It was discovered inhibitor SN50 had same effect. present used through its treat highlights potential efficacy alleviating dysfunction

Language: Английский

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Unveiling the therapeutic role of Vibrio alginolyticus GH5 exopolysaccharide in Alzheimer's disease

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143479 - 143479

Published: April 1, 2025

Language: Английский

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Neuroprotective Effects of Ecklonia cava in a Chronic Neuroinflammatory Disease Model

Nutrients, Journal Year: 2023, Volume and Issue: 15(8), P. 2007 - 2007

Published: April 21, 2023

Inflammation is a natural defense mechanism against noxious stimuli, but chronic inflammation can lead to various diseases. Neuroinflammation in the central nervous system plays an important role development and progression of neurodegenerative Polyphenol-rich products, such as Ecklonia cava (E. cava), are known have anti-inflammatory antioxidant properties provide treatment strategies for diseases by controlling neuroinflammation. We investigated effects E. extract on neuroinflammation neurodegeneration under inflammatory conditions. Mice were pretreated with 19 days then exposed lipopolysaccharide (LPS) 1 week. monitored pro-inflammatory cytokines levels serum, inflammation-related markers, markers using Western blotting qRT-PCR mouse cerebrum hippocampus. reduced cytokine blood brain mice LPS-induced inflammation. also measured activity genes related neurodegeneration. Surprisingly, decreased associated (NF-kB STAT3) disease marker (glial fibrillary acidic protein, beta-amyloid) hippocampus mice. suggest that has potential protective agent

Language: Английский

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