Bioactive Potential of Elderberry (Sambucus nigra L.): Antioxidant, Antimicrobial Activity, Bioaccessibility and Prebiotic Potential

Molecules, Journal Year: 2023, Volume and Issue: 28(7), P. 3099 - 3099

Published: March 30, 2023

Due to its abundance of physiologically active ingredients, one the oldest medicinal herbs, elderberry (EB) Sambucus nigra L., is beneficial for both therapeutic and dietary purposes. This study determined bioaccessibility phenolic compounds prebiotic potential polyphenols from freeze-dried EB powder (FDEBP), along with antioxidant antimicrobial activities this extract. The most significant in black are represented by anthocyanins (41.8%), predominating cyanidin-sambubiosides cyanidin-glucosides (90.1% identified anthocyanins). FRAP assay obtained highest activity value (185 ± 0.18 μmol Fe2+/g DW). sensitive extract was proven be Staphylococcus aureus, Pseudomonas aeruginosa had lowest minimum inhibitory concentration 1.95 mg/mL. To determine polyphenols, cell growth five probiotic strains (Lactobacillus plantarum, L. casei, rhamnosus, fermentum Saccharomyces boulardii) tested. influence on positive all used. Overall, increase (p < 0.05) recorded at 1.5% FDEBP, casei a index (GI) 152.44%, very closely followed GI 0.5% 1% concentrations. stability total through simulated gastronitestinal digestion increased (93%), also elevated (75%).

Language: Английский

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The Antioxidant and Anti-Inflammatory Properties of Wild Bilberry Fruit Extracts Embedded in Mesoporous Silica-Type Supports: A Stability Study

Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 250 - 250

Published: Feb. 19, 2024

Polyphenolic extracts from wild bilberries (Vaccinium myrtillus L.) have shown antioxidant and anti-inflammatory effects, but they are prone to degradation when exposed environmental factors, limiting their use in biomedical applications. To overcome this issue, study proposed the embedding of bilberry fruit ethanolic pristine mesoporous silica functionalized with organic groups (mercaptopropyl propionic acid), as well coated fucoidan, a biopolymer. Herein, we report stability free incorporated silica-type supports high-humidity atmospheres at 40 °C up 28 days, using HPLC analysis, thermal radical scavenging activity determination. Better chemical over time was observed were supports. After 12 months storage, higher values determined for extract embedded supports, modified mercaptopropyl (MCM-SH), fucoidan-coated (MCM-SH-Fuc) than that due synergistic between support extract. All encapsulated demonstrated remarkable effects reducing NO production LPS-stimulated RAW 264.7 cells. The treatment MCM-SH-Fuc dose 10 μg/mL surpassed effect same concentration. For an MCM-SH support, lower IC50 value (0.69 μg/mL) towards COX-2 obtained, comparable Indomethacin (0.6 μg/mL). Also, sample showed selectivity index (2.71) reference drug (0.98). developed formulations properties could be further used nutraceuticals.

Language: Английский

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Exploring two bioreactor systems for micropropagation of Vaccinium membranaceum and the antioxidant enzyme profiling in tissue culture-raised plants

Plant Growth Regulation, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

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Experimental Studies on the Therapeutic Potential of Vaccinium Berries in Breast Cancer—A Review

Plants, Journal Year: 2024, Volume and Issue: 13(2), P. 153 - 153

Published: Jan. 5, 2024

Breast cancer (BC) is the largest contributor to deaths in women worldwide. Various parts of plants, including fruits, are known for their therapeutic properties and used traditional medicine. Fruit species exhibit anticancer activities due presence bioactive natural compounds such as flavonoids carotenoids. The Vaccinium spp. fleshy berry-like drupes rich compounds, with flavonols, flavanols, chalcones, phenolic acids major groups compounds. While there clear evidence linking berries a decreased risk BC both vivo vitro experiments, exact mechanisms involved protective effects extracts on cells not fully understood. Thus, purpose this review highlight action potential against experimental models.

Language: Английский

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Bee Bread: A Promising Source of Bioactive Compounds with Antioxidant Properties—First Report on Some Antimicrobial Features

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 353 - 353

Published: March 15, 2024

Bee bread has received attention due to its high nutritional value, especially phenolic composition, which enhances life quality. The present study aimed evaluate the chemical and antimicrobial properties of bee (BB) samples from Romania. Initially, alcoholic extracts (BBEs) were obtained BB collected prepared by Apis mellifera carpatica bees. composition BBE was characterized Fourier Transform Infrared Spectroscopy (FTIR) total phenols flavonoid contents determined. Also, a UHPLC-DAD-ESI/MS analysis compounds (PCs) antioxidant activity evaluated. Furthermore, BBEs evaluated qualitative quantitative assessments. BBs studied in this paper are provided 31 families plant species, with content varying between 7.10 18.30 mg gallic acid equivalents/g 0.45 1.86 quercetin BB, respectively. Chromatographic revealed these had significant compounds, flavonoids much higher quantities than acids. All presented against all clinical standard pathogenic strains tested. Salmonella typhi, Candida glabrata, albicans, kefyr most sensitive, while BBEs’ antifungal on C. krusei not investigated any prior research. In addition, reports inhibitory microbial (bacterial fungi) adhesion capacity inert substratum for first time.

Language: Английский

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Antioxidant Properties of Cranberry Leaves and Walnut Meal and Their Effect on Nutritional Quality and Oxidative Stability of Broiler Breast Meat

Antioxidants, Journal Year: 2023, Volume and Issue: 12(5), P. 1084 - 1084

Published: May 11, 2023

Dietary sources of bioactive compounds in animal diets, are the natural way to produce food products with improved nutritional quality. The present study aimed test hypothesis a synergistic effect cranberry leaf powder and walnut meal on quality antioxidant broiler meat. An experiment was conducted 160 COBB 500 chickens, housed an experimental hall permanent wood shave litter boxes 3 m2. six dietary treatments were based corn soybean meal; three groups fed diets supplemented leaves (CLs) inclusion rates (0% control group CL 1% 2%); two (WM) WM 6%); combination selected supplements (CL 6% 2% 6%). results show that registered higher concentrations copper iron compared group. antagonist noticed lipophilic compounds, lutein zeaxanthin presented dose-dependent increasing under influence, while vitamin E decreased same manner. positively influenced deposits breast tissue. did not any primary oxidation products, but secondary influenced, maximum TBARS values recorded for 6%.

Language: Английский

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Anthocyanins and Type 2 Diabetes: An Update of Human Study and Clinical Trial

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1674 - 1674

Published: May 29, 2024

Anthocyanins are phenolic compounds occurring in fruits and vegetables. Evidence from pre-clinical studies indicates their role glucose level regulation, gut microbiota improvement, inflammation reduction under diabetic conditions. Therefore, incorporating these research advancements into clinical practice would significantly improve the prevention management of type 2 diabetes. This narrative review provides a concise overview 18 findings recent published over last 5 years that investigate therapeutic effects dietary anthocyanins on Anthocyanin supplementation has been shown to have regulatory effect fasting blood levels, glycated hemoglobin, other diabetes-related indicators. Furthermore, increased anthocyanin dosages had more favorable implications for diabetes treatment. evidence an anthocyanin-rich diet can outcomes, especially at-risk groups. Future should focus optimal intervention duration, consider multiple biomarkers, analyze among well-controlled versus poorly controlled groups patients with

Language: Английский

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Antibacterial properties and therapeutic potential of few medicinal plants: current insights and challenges

Discover Plants., Journal Year: 2025, Volume and Issue: 2(1)

Published: Jan. 28, 2025

Language: Английский

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Bioactive Metabolites Produced by Microorganisms and Plants with Potential Application in Agriculture and Medicine

Published: Jan. 1, 2025

Language: Английский

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Berries as Nature’s Therapeutics: Exploring the Potential of Vaccinium Metabolites in Gastric Cancer Treatment Through Computational Insights

Life, Journal Year: 2025, Volume and Issue: 15(3), P. 406 - 406

Published: March 5, 2025

Berries from the Vaccinium genus, known for their rich array of bioactive metabolites, are recognized antioxidant, anti-inflammatory, and anticancer properties. These compounds, including anthocyanins, flavonoids, phenolic acids, have attracted significant attention potential health benefits, particularly in cancer prevention treatment. Gastric (GC), a leading cause cancer-related deaths worldwide, remains challenging to treat, especially its advanced stages. This study investigates therapeutic species GC treatment using computational methods. RNA sequencing revealed upregulated genes associated with GC, while network pharmacology molecular docking approaches identified strong interactions between cyanidin 3-O-glucoside (C3G), key metabolite. Furthermore, dynamics simulations HSP90AA1-C3G complex demonstrated stable binding structural integrity, suggesting that C3G may inhibit HSP90AA1, protein involved progression. findings highlight offering novel approach by targeting pathways. research provides valuable insights into role berries as natural therapeutics, supporting integration future gastric strategies.

Language: Английский

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