PROTOPLASMA, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 3, 2024
Language: Английский
JSFA reports, Journal Year: 2025, Volume and Issue: unknown
Published: April 7, 2025
Abstract Background Vaccinium corymbosum berries represent a source of anthocyanins and polyphenols studied tested for their healthy potential. The present study was aimed at isolating, characterizing, quantifying the anthocyanin‐enriched fraction obtained from blueberry assessing its biological protective effects against head neck cell lines under inflammatory‐related conditions. V. extract subjected to colorimetric analysis, antioxidant evaluation, HPLC‐DAD analysis. This characterized by chlorogenic acid 12 glycosylated anthocyanins, being most abundant delphinidin‐3‐O‐galactoside, delphinidin‐3‐O‐arabinoside, malvidin‐3‐O‐galactoside, malvidin‐3‐O‐glucoside, malvidin‐3‐O‐arabinoside. (BL) further used in extensive evaluation. Head lines, namely CAL27 A253, were treated different concentrations order evaluate migration ability ErbB receptors enzymes gene expression. Results expression analysis highlighted capability BL reduce lines. same treatments induced an opposite effect A253 line ErbB2/ErbB3 receptors. Moreover, line, increased SOD2 levels reduced migration. action also ex vivo experimental model colon inflammation effective both reducing lipopolysaccharide‐induced proinflammatory biomarkers involved inflammation, among which tumor necrosis factor α, interleukin (IL)‐6, stimulating anti‐inflammatory cytokine IL‐10. Conclusion content specific can be considered responsible such activities providing new food supplement as coadjuvant standard therapies.
Language: Английский
Citations
0
Process Biochemistry, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Nutrients, Journal Year: 2023, Volume and Issue: 15(10), P. 2281 - 2281
Published: May 12, 2023
The cardiometabolic health of the population is a crucial indicator public health, considering significant impact cardiovascular disease (CVD) and diabetes on global mortality. Determining population's knowledge predictors these pathologies essential in developing effective educational clinical strategies for prevention management risk (CMR). Polyphenols are natural compounds with multitude beneficial effects health. This study explored current knowledge, understanding, awareness CMR, benefits polyphenols among Romanians, how sociodemographic characteristics influence this aspect. Five hundred forty-six subjects responded anonymously to an online questionnaire designed assess their knowledge. data were collected analyzed based gender, age, education level, BMI status. Most respondents expressed concern great or very extent about (78%) food (60%), differences (
Language: Английский
Citations
9
Plants, Journal Year: 2023, Volume and Issue: 12(12), P. 2330 - 2330
Published: June 15, 2023
Background: Oral cancer has a high prevalence worldwide, and this disease is caused by genetic, immunological, environmental factors. The main risk factors associated with oral are smoking alcohol. Results: There various strategies to reduce factors, including prevention programs as well the consumption of an adequate diet that includes phytochemical compounds derived from cranberries (Vaccinium macrocarpon A.) blueberries corymbosum L.); these exhibit antitumor properties. outcome review follows: properties phytochemicals were evaluated for protection against cancer. Conclusions: secondary metabolites promote biological effects provide alcoholism. An alternative can be blueberries.
Language: Английский
Citations
9
Foods, Journal Year: 2023, Volume and Issue: 12(19), P. 3544 - 3544
Published: Sept. 23, 2023
Interest in functional foods is continuously increasing, having the potential to be an ally reducing cardiometabolic risk factors. This study focuses on developing and evaluating oat- millet-based snack bars enriched with freeze-dried elderberry powder (FDEBP), aiming combine great taste enhanced nutritional value, antioxidant properties, prebiotic potential. The research encompassed a sensory evaluation, assessment, rheological analysis of bars. A hedonic test was conducted gauge consumer preferences overall liking, providing insights into taste, texture, acceptance. Sensory evaluation revealed positive feedback from participants, acceptance rating scores ranged 7 8.04, best score recorded by one 1% FDEBP. determined bars' dynamic storage modulus (G') loss (G″), assessing material's elasticity mechanical properties. Results showed that incorporation 0.5% FDEBP oat millet significantly impacted their enhancing structural strength. Nutritional demonstrated provided complete mix macronutrients required daily diet. sheds light FDEBP, offering delectable way access essential nutrients bioactive compounds minimally processed form, without addition sweeteners or additives, friendly gut microbiota.
Language: Английский
Citations
9
Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 17
Published: Jan. 16, 2024
Background Apoptosis after spinal cord injury (SCI) plays a pivotal role in the secondary mechanisms, which cause ultimate neurologic insults. A better understanding of molecular and cellular basis apoptosis SCI allows for improved glial neuronal survival via administrations anti-apoptotic biomarkers. The knowledge structure, development trends, research hotspots have not yet been systematically investigated. Methods Articles reviews on SCI, published from 1st January 1994 to Oct 2023, were retrieved Web Science™. Bibliometrix R was used evaluate annual publications, countries, affiliations, authors, sources, documents, key words, hot topics. Results total 3,359 publications accordance with criterions obtained, exhibited an ascending trend publications. most productive countries USA China. Journal Neurotrauma impactive journal; Wenzhou Medical University prolific affiliation; Cuzzocrea S influential author. “Apoptosis,” “spinal-cord-injury,” “expression,” “activation,” “functional recovery” frequent words. Additionally, “transplantation,” “mesenchymal stemness-cells,” “therapies,” “regeneration,” “repair,” “autophagy,” “exosomes,” “nlrp3 inflammasome,” “neuroinflammation,” “knockdown” latest emerging may inform hottest themes. Conclusions neurological damages. Development novel treatments mainly depends apoptosis-related mechanisms levels. Such therapeutic interventions involve application agents, free radical scavengers, as well anti-inflammatory drugs, can be targeted inhibit core events cascades pathway.
Language: Английский
Citations
3
Plants, Journal Year: 2024, Volume and Issue: 13(11), P. 1497 - 1497
Published: May 29, 2024
Vaccinium duclouxii, a wild blueberry species native to the mountainous regions of southwestern China, is notable for its exceptionally high anthocyanin content, surpassing that many cultivated varieties and offering significant research potential. Glutathione S-transferases (GSTs) are versatile enzymes crucial transport in plants. Yet, GST gene family had not been previously identified V. duclouxii. This study utilized genome-wide approach identify characterize revealing 88 genes grouped into seven distinct subfamilies. number significantly higher than found closely related species, with these distributed across 12 chromosomes exhibiting clustering. A total 46 members classified as tandem duplicates. The structure VdGST relatively conserved among showing closer phylogenetic relations bracteatum evidence purifying selection. Transcriptomic analysis qRT-PCR indicated VdGSTU22 VdGSTU38 were highly expressed flowers, VdGSTU29 leaves, VdGSTF11 showed expression ripe fully mature fruits, paralleling trends seen accumulation. Subcellular localization primarily plasma membrane, suggesting potential role accumulation duclouxii fruits. provides foundational basis further molecular-level functional anthocyanins enhancing our understanding molecular mechanisms underlying metabolism this valuable species.
Language: Английский
Citations
3
Horticulturae, Journal Year: 2023, Volume and Issue: 9(11), P. 1163 - 1163
Published: Oct. 24, 2023
This study explores the bioactive potential of young shoots from blackcurrant, European blueberry, and mountain cranberry, widely employed in gemmotherapy phytotherapy, as rich sources antioxidants, antimicrobial agents, anti-inflammatory components. The primary aims this were to enhance extraction conditions for compounds blackcurrant using Modde software experimental design, conduct a comprehensive phytochemical analysis cranberry shoot extracts through LC–MS analysis, evaluate vitro biological activities these optimized extracts. design comprised multiple variables: techniques, solvent type, time, apparent pH, solvent-to-vegetal product ratio. responses included total phenolic content, flavonoid condensed tannin antioxidant activity determined DPPH assay. Furthermore, was validated cell culture experiments, addition cytotoxicity assessments conducted on both normal cancer lines. Extracts obtained Ultra-Turrax 70% acetone displayed high levels polyphenolic enhanced potential, regardless origin. revealed predominant occurrence chlorogenic acid, hyperoside, isoquercitrin all examined samples. also significant when evaluated These results provide valuable insights into potent components present extracts, paving way further exploration therapeutic applications.
Language: Английский
Citations
8
Nutrients, Journal Year: 2023, Volume and Issue: 15(9), P. 2031 - 2031
Published: April 23, 2023
Diabetes mellitus is one of the most critical global health concerns, with a fast-growing prevalence. The incidence diabetic vascular complications also rapidly increasing, exacerbating burden on individuals diabetes and consumption public medical resources. Despite overall improvements in prevention, diagnosis, treatment microvascular recent years, safe effective alternative or adjunctive therapies are urgently needed. mechanisms underlying complex, hyperglycemia-induced oxidative stress inflammation being leading causes. Therefore, glycemic control, antioxidation, anti-inflammation considered main targets for its comorbidities. Vaccinium L. (Ericaceae) genus plants enriched polyphenolic compounds their leaves fruits. extracts have demonstrated good bioactivity reducing blood glucose, stress, inflammation, making them excellent candidates management complications. Here, we review preclinical clinical studies potential effect ameliorating complications, particularly kidney disease retinopathy.
Language: Английский
Citations
7
Agronomy, Journal Year: 2024, Volume and Issue: 14(6), P. 1109 - 1109
Published: May 23, 2024
Phosphorus availability is a serious problem for plants growing and grown in acidic soils of bogs, poor macronutrients. The application phosphorus fertilizers to such unprofitable because the physical chemical properties these soils, where phosphate firmly bound organic inorganic compounds becomes inaccessible plants. Plants Vaccinium genus both from natural stands commercial plantations may suffer deficiency, so they need have number adaptations that allow them efficiently extract phosphorus. This review addresses following issues relation genus: sources plants; release ions soil components; transport into importance mycorrhiza supplying Thus, we sought draw researchers’ attention routes supply its unexplored aspects.
Language: Английский
Citations
2