The Analysis of Selected miRNAs and Target MDM2 Gene Expression in Oral Squamous Cell Carcinoma DOI Creative Commons
Karolina Gołąbek, Dorota Hudy, Jadwiga Gaździcka

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(11), P. 3053 - 3053

Published: Nov. 14, 2023

MiRNAs could play an important role in tumorigenesis and progression. The oncoprotein MDM2 (murine double minute 2) was identified as a negative regulator of the tumour suppressor p53. This study aims to analyse expression target miRNA candidates (miR-3613-3p, miR-371b-5p miR-3658) gene oral squamous cell carcinoma margin samples their association with selected socio-demographic clinicopathological characteristics. group consisted 50 patients. miRNAs levels were assessed by qPCR. analysis showed only one them, i.e., miR-3613-3p. We found no statistically significant differences miR-3613-3p compared samples. When analysing effect smoking on expression, we demonstrated difference between smokers non-smokers. In addition, level some clinical parameters (T, N G). Our demonstrates that overexpression is involved progression OSCC. indicates possesses potential prognostic values.

Language: Английский

Associations of Lifestyle Factors with Oral Cancer Risk: An Umbrella Review DOI
Haiyang Xu, Zhiqiang Gao,

Hairong Liu

et al.

Journal of Stomatology Oral and Maxillofacial Surgery, Journal Year: 2025, Volume and Issue: unknown, P. 102234 - 102234

Published: Jan. 1, 2025

Language: Английский

Citations

4
Experimental Studies on the Therapeutic Potential of Vaccinium Berries in Breast Cancer—A Review DOI Creative Commons
Naser A. Alsharairi

Plants, Journal Year: 2024, Volume and Issue: 13(2), P. 153 - 153

Published: Jan. 5, 2024

Breast cancer (BC) is the largest contributor to deaths in women worldwide. Various parts of plants, including fruits, are known for their therapeutic properties and used traditional medicine. Fruit species exhibit anticancer activities due presence bioactive natural compounds such as flavonoids carotenoids. The Vaccinium spp. fleshy berry-like drupes rich compounds, with flavonols, flavanols, chalcones, phenolic acids major groups compounds. While there clear evidence linking berries a decreased risk BC both vivo vitro experiments, exact mechanisms involved protective effects extracts on cells not fully understood. Thus, purpose this review highlight action potential against experimental models.

Language: Английский

Citations

6
Epidemiology, Diagnostics, and Therapy of Oral Cancer—Update Review DOI Open Access
Julia Kijowska, J Grzegorczyk,

Katarzyna Gliwa

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(18), P. 3156 - 3156

Published: Sept. 14, 2024

Oral cavity and lip cancers are the 16th most common cancer in world. It is widely known that a lack of public knowledge about precancerous lesions, oral symptoms, risk factors leads to diagnostic delay therefore lower survival rate. Risk factors, which include drinking alcohol, smoking, HPV infection, pro-inflammatory factor-rich diet, poor hygiene, must be avoided by general population. Regular clinical examinations should enriched an search protocol for summarized this review. Moreover, new methods, some already available (vital tissue staining, optical imaging, cytology, salivary biomarkers, artificial intelligence, colposcopy, spectroscopy), newly researched techniques increase likelihood stopping pathological process at stage. Well-established treatments (surgery, radiotherapy, chemotherapy, immunotherapy) continuously being developed using novel technologies, increasing their success Additionally, researched. This review presents glance cancer—its current classification epidemiology—and will provide insights into development methods therapies.

Language: Английский

Citations

4
Association between decreased p53 expression, elevated serum CagA levels, and oral squamous cell carcinoma DOI Creative Commons

Minxiao Lin,

Jing Wang,

Xiaowu Yao

et al.

Clinics, Journal Year: 2025, Volume and Issue: 80, P. 100632 - 100632

Published: Jan. 1, 2025

Language: Английский

Citations

0
Dietary plants for oral cancer prevention and therapy: A review of preclinical and clinical studies DOI
Anupam Bishayee, A. Penn,

N. K. Bhandari

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(11), P. 5225 - 5263

Published: Aug. 28, 2024

Abstract Oral cancer is a disease with high mortality and rising incidence worldwide. Although fragmentary literature on the anti‐oral effects of plant products has been published, comprehensive analysis lacking. In this work, critical evaluation oral preventative or therapeutic dietary plants was conducted. An exhaustive available data supports that numerous exert anticancer effects, including suppression cell proliferation, viability, autophagy, angiogenesis, invasion, metastasis while promoting cycle arrest apoptosis. Plant extracts target several cellular mechanisms, such as reversal epithelial‐to‐mesenchymal transition promotion oxidative stress mitochondrial membrane dysfunction by modulation various signaling pathways. These agents were also found to regulate growth pathways action extracellular signal‐regulated kinase mitogen‐activated protein kinase, inflammation via cyclooxygenase (COX)‐1, COX‐2, nuclear factor‐κB p65, through influence cadherins matrix metalloproteinases. vivo studies support these findings demonstrate decrease in tumor burden, incidence, hyperplastic dysplastic changes. Clinical showed decreased risk. However, high‐quality should be conducted establish clinical efficacy plants. Overall, our study use plants, especially garlic, green tea, longan, peppermint, purple carrot, saffron, tomato, turmeric, for prevention intervention. further research required before application strategy.

Language: Английский

Citations

2
Nutritional Proteomics: A Key to Unlocking Optimal Human Health DOI Creative Commons

Hala Salim Sonbol

Archives of Pharmacy Practice, Journal Year: 2024, Volume and Issue: 15(1), P. 68 - 83

Published: Jan. 1, 2024

Proteomics is a scientific field dedicated to the investigation of protein structure function and interactions within living organisms.The review paper explores facets proteomics its diverse applications across various research domains.The sheds light on crucial role proteome an organism, influenced by factors such as physiological condition surroundings.Nutritional proteomics, referred neuroproteomics, employs proteomic methods delve into between proteins bioactive components found in food.Nutriproteomics nutrigenomics, enable comprehensive investigations how nutrients interact impact human genome.The highlights exploration alterations associated with diseases emphasizes nutritional disease treatment.It accentuates potential identifying biomarkers for unraveling intricate protein-level conditions, infectious diseases, cancer, cardiovascular disorders, neurodegenerative illnesses.The connection technologies drug discovery also discussed.The further underscores integration different 'omics' disciplines offers holistic understanding complex biological systems.Ultimately, concludes emphasizing promising advancing both healthcare.

Language: Английский

Citations

1
Molecular Targets of Plant-Derived Bioactive Compounds in Oral Squamous Cell Carcinoma DOI Open Access
Gabriela Mitea, Verginica Schröder, Irina Mihaela Iancu

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(21), P. 3612 - 3612

Published: Oct. 26, 2024

Background: With a significant increase in both incidence and mortality, oral cancer—particularly squamous cell carcinoma (OSCC)—is one of the main causes death developing countries. Even though there is evidence advances surgery, chemotherapy, radiotherapy, overall survival rate for patients with OSCC has improved, but by small percentage. This may be due, on hand, to fact that disease diagnosed when it at too-advanced stage, metastases are already present. Methods: review explores therapeutic potential natural herbal products their use as adjuvant therapies treatment cancer from online sources databases (PubMed, Web Science, Google Scholar, Research Gate, Scopus, Elsevier). Results: if classic known effective, they often produce many serious side effects can create resistance. Certain plant compounds offer complementary approach inducing apoptosis, suppressing tumor growth, improving chemotherapy effectiveness. The integration these conventional treatments obtain remarkable synergistic represents major point interest authors. highlights study molecular mechanisms efficiency vitro vivo models, well strategic ways which drugs administered optimize real contexts. Conclusions: have impact oncology community, creating new inspirations development more safer less toxic potential.

Language: Английский

Citations

1
Accurately Identifying Sound vs. Rotten Cranberries Using Convolutional Neural Network DOI Creative Commons
Sayed Mehedi Azim,

Austin Spadaro,

Joseph Kawash

et al.

Information, Journal Year: 2024, Volume and Issue: 15(11), P. 731 - 731

Published: Nov. 15, 2024

Cranberries, native to North America, are known for their nutritional value and human health benefits. One hurdle commercial production is losses due fruit rot. Cranberry rot results from a complex of more than ten filamentous fungi, challenging breeding resistance. Nonetheless, our collaborative program has resistance as significant target. This currently relies heavily on manual sorting sound vs. rotten cranberries. process labor-intensive time-consuming, prompting the need an automated classification (sound rotten) system. Although many studies have focused classifying different fruits vegetables, no such approach been developed cranberries yet, partly because datasets lacking conducting necessary image analyses. research addresses this gap by introducing novel dataset comprising facilitate computational analysis. In addition, we CARP (Cranberry Assessment Rot Prediction), convolutional neural network (CNN)-based model distinguish ones. With accuracy 97.4%, sensitivity 97.2%, specificity 97.2% training 94.8%, 95.4%, 92.7% independent dataset, respectively, proposed CNN shows its effectiveness in accurately differentiating between

Language: Английский

Citations

0
The Analysis of Selected miRNAs and Target MDM2 Gene Expression in Oral Squamous Cell Carcinoma DOI Creative Commons
Karolina Gołąbek, Dorota Hudy, Jadwiga Gaździcka

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(11), P. 3053 - 3053

Published: Nov. 14, 2023

MiRNAs could play an important role in tumorigenesis and progression. The oncoprotein MDM2 (murine double minute 2) was identified as a negative regulator of the tumour suppressor p53. This study aims to analyse expression target miRNA candidates (miR-3613-3p, miR-371b-5p miR-3658) gene oral squamous cell carcinoma margin samples their association with selected socio-demographic clinicopathological characteristics. group consisted 50 patients. miRNAs levels were assessed by qPCR. analysis showed only one them, i.e., miR-3613-3p. We found no statistically significant differences miR-3613-3p compared samples. When analysing effect smoking on expression, we demonstrated difference between smokers non-smokers. In addition, level some clinical parameters (T, N G). Our demonstrates that overexpression is involved progression OSCC. indicates possesses potential prognostic values.

Language: Английский

Citations

0