Plasma membrane-anchored fluorescent tracker based on boron-dipyrromethene DOI

Yucong Gong,

Xiangli Li,

Daqing Ma

et al.

Chinese Journal of Chemical Engineering, Journal Year: 2024, Volume and Issue: 72, P. 220 - 225

Published: June 18, 2024

Language: Английский

Advances in fluorescent probes for targeting organelles: Design strategies, applications and perspectives DOI
Meiqing Zhu, Wenze Li,

Long Sun

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 512, P. 215893 - 215893

Published: April 25, 2024

Language: Английский

Citations

25
Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence DOI Creative Commons

Zhirong He,

Kun Xu,

Yongming Li

et al.

Biosensors, Journal Year: 2023, Volume and Issue: 13(9), P. 838 - 838

Published: Aug. 23, 2023

Specific identification and monitoring of senescent cells are essential for the in-depth understanding regulation senescence-related life processes diseases. Fluorescent sensors providing real-time in situ information with spatiotemporal resolution unparalleled tools have contributed greatly to this field. This review focuses on recent progress fluorescent molecularly targeted imaging tracking cellular senescence. The molecular design, sensing mechanisms, biological activities discussed. categorized by types markers targeting ligands. Accordingly, their recognition performance towards senescence biomarkers summarized. Finally, perspective challenges field discussed, which expected assist future design next-generation

Language: Английский

Citations

9
Rational design of a near-infrared fluorescent probe for monitoring butyrylcholinesterase activity and its application in development of inhibitors DOI Creative Commons
Hao Li, Xiaodong Li,

Chao-Hua Yan

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: April 4, 2024

Butyrylcholinesterase (BChE) is widely expressed in multiple tissues and has a vital role several key human disorders, such as Alzheimer's disease tumorigenesis. However, the of BChE disorders not been investigated. Thus, to quantitatively detect visualize dynamical variations activity essential for exploring biological roles progression number disorders. Herein, based on substrate characteristics BChE, we customized synthesized three near-infrared (NIR) fluorescent probe substrates with cyanine-skeleton, finally selected NIR fluorescence named CYBA. The CYBA demonstrated significant increase when interacting but mainly avoided AChE. Upon addition could be specifically hydrolyzed TBO, resulting signal enhancement at 710 nm. Systematic evaluation revealed that exhibited exceptional chemical stability complex biosamples possessed remarkable selectivity sensitivity towards BChE. Moreover, was successfully applied real-time imaging endogenous two types nerve-related living cells. Additionally, detection samples plasma recovery studies (97.51%-104.01%). Furthermore, used construct high-throughput screening (HTS) method inhibitors using enzyme source. We evaluated inhibitory effects series natural products four flavonoids were identified potent Collectively, can serve practical tool track changes complicated environments due its excellent capabilities.

Language: Английский

Citations

3
Synthesis of non-modified near-infrared carbon dots for hypochlorite detection and cell membrane imaging DOI

Lan-Fang Pang,

Wen-Le Fang,

Bin Zhang

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 321, P. 124743 - 124743

Published: June 28, 2024

Language: Английский

Citations

3
Cell membrane targetable NIR fluorescent polarity probe for selective visualization of cancer cells and early tumor DOI
Wenlong Zhu, Qianhua Li,

Shengyi Gong

et al.

Analytica Chimica Acta, Journal Year: 2023, Volume and Issue: 1278, P. 341748 - 341748

Published: Aug. 22, 2023

Language: Английский

Citations

7
Molecular mapping of neuronal architecture using STORM microscopy and new fluorescent probes for SMLM imaging DOI Creative Commons
Victor Breton, Paul Nazac, David Boulet

et al.

Neurophotonics, Journal Year: 2024, Volume and Issue: 11(01)

Published: March 8, 2024

Imaging neuronal architecture has been a recurrent challenge over the years, and localization of synaptic proteins is frequent in neuroscience. To quantitatively detect analyze structure synapses, we recently developed free SODA software to association pre postsynaptic proteins. fully take advantage spatial distribution analysis complex cells, such as neurons, also selected some new dyes for plasma membrane labeling. Using Icy plugin, could both conventional single molecule microscopy, giving access molecular map at nanoscale level. replace those distributions within three-dimensional (3D) shape, used MemBright probes 3D STORM decipher entire shape various dendritic spine types single-molecule resolution We report here example mask, but these tools have broader spectrum interest since they can be whatever or cellular type. Altogether with thus provide perfect toolkit nanometric context.

Language: Английский

Citations

2
Synthesis of multi-stimuli-responsive solid-state red-emitting phenothiazine-based A-π-D-π-A' derivatives and their applications DOI
Reshma Kumari, Marilyn Daisy Milton

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1309, P. 138202 - 138202

Published: April 1, 2024

Language: Английский

Citations

2
Long-term tracking of lysosomal dynamics with highly stable fluorescent probe DOI
Lei Peng,

Chuan Dong,

Shaomin Shuang

et al.

Talanta, Journal Year: 2024, Volume and Issue: 280, P. 126707 - 126707

Published: Aug. 13, 2024

Language: Английский

Citations

2
Tetraanionic Oligo‐Dioxaborines: Strongly Absorbing Near‐Infrared Dyes DOI
Vladyslav Polishchuk, Andrii V. Kulinich, Mykola P. Shandura

et al.

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: unknown

Published: April 16, 2024

Polymethine dyes of tetraanionic nature comprising 1,3,2-dioxaborine rings in the polymethine chain and end-groups different electron-accepting abilities have been synthesized. They can be considered as oligomeric polymethines, where a linear conjugated π-system passes through three units number tri- dimethine π-bridges between two end-groups. The obtained exhibit near-infrared absorption fluorescence, with molar coefficients reaching high 564000 M

Language: Английский

Citations

1
Fluorescent probes for the visualization of membrane microdomain, deformation, and fusion DOI Creative Commons
Peihong Tong,

Tung-Kung Wu,

Mingle Li

et al.

Smart Molecules, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 30, 2024

Abstract The cell membrane, a fluid interface composed of self‐assembled phospholipid molecules, is vital component biological systems that maintains cellular stability and prevents the invasion foreign toxins. Due to its inherent fluidity, membrane can undergo bending, shearing, stretching, making deformation crucial in processes like adhesion, migration, phagocytosis, signal transduction. Within plasma are highly ordered dynamic structures formed by lipid known as “lipid rafts,” whose dissociation reorganization prerequisites for deformation. Fluorescent probes have emerged tools studying these processes, offering non‐destructive, situ, real‐time imaging method. By strategically designing probes, researchers image not only microdomains membranes but also explore more complex such fusion fission. This review systematically summarizes latest advancements application fluorescent imaging. It discusses current challenges provides insights into future research directions. We hope this inspires further studies on using ultimately advancing our understanding mechanisms underlying dissociation, reorganization, fusion, separation, fostering therapeutic development membrane‐associated diseases.

Language: Английский

Citations

1