A Comprehensive Exploration of Superparamagnetic Nanoparticles: Applications and Regulatory Aspects in Medicine and Environmental Areas DOI
Danilo Waismann Losito,

Nicole Inhota do Nascimento Souza,

Tereza S. Martins

et al.

Published: Jan. 1, 2023

This review paper highlights the current toxicological aspects of magnetic nanomaterials in field medicine and environment, conducted through a comprehensive literature review. The main goal was to investigate analyze key challenges identified that impede effective utilization these systems, particularly focusing on iron oxide (Fe3O4) nanoparticles. We aimed factors influence their intended applications. sought understand how characteristics produced NPs could be enhanced improve biocompatibility compared existing samples literature. Additionally, we examined morphological directly linked physicochemical potential implications for toxicology ecotoxicology. Furthermore, evaluated regulatory impact nanostructured materials. Therefore, initial aspect this delved into historical evolution nanoparticles, investigating significant milestones have influenced exploration technology. discoveries, influencing choice synthesis methods, most prevalent approaches surface functionalization employed by scientists materials possessing superparamagnetic characteristics, such as oxide. second focused survey-based global regulation progress concerning nanoparticles throughout years. encountered establishing safety criteria diverse applications under investigation. encompassed an assessment impacts both human health environment.

Language: Английский

Synthesis of Quercetin-Loaded Silver Nanoparticles and Assessing Their Anti-Bacterial Potential DOI Creative Commons
Ritu Sharma,

Parakh Basist,

Abdulsalam Alhalmi

et al.

Micromachines, Journal Year: 2023, Volume and Issue: 14(12), P. 2154 - 2154

Published: Nov. 25, 2023

The study delves into the multifaceted potential of quercetin (Qu), a phytoconstituent found in various fruits, vegetables, and medicinal plants, combination with silver nanoparticles (AgNPs). research explores synthesis characterization AgNPs loaded Qu investigates their pharmaceutical applications, particularly focusing on antibacterial properties. meticulously evaluates Qu's identity, physicochemical properties, reaffirming its suitability for use. development Qu-loaded demonstrates high drug entrapment efficiency, ideal particle characteristics, controlled release kinetics, suggesting enhanced therapeutic efficacy reduced side effects. Furthermore, examines activity different solvents, revealing distinct outcomes. Qu, both methanol water formulations, exhibits against Escherichia coli, formulation displaying slightly stronger efficacy. In conclusion, this successfully synthesizes highlights as potent formulation. findings underscore influence solvent choice properties pave way further delivery systems antimicrobial agents. This innovative approach holds promise addressing microbial resistance advancing formulations improved

Language: Английский

Citations

7
Current development of theragnostic nanoparticles for women’s cancer treatment DOI

Ananya Kashyap,

Madhubala Kumari,

Arnika Singh

et al.

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(4), P. 042001 - 042001

Published: March 12, 2024

In the biomedical industry, nanoparticles (NPs-exclusively small particles with size ranging from 1-100 nanometres) are recently employed as powerful tools due to their huge potential in sophisticated and enhanced cancer theragnostic (i.e. therapeutics diagnostics). Cancer is a life-threatening disease caused by carcinogenic agents mutation cells, leading uncontrolled cell growth harming body's normal functioning while affecting several factors like low levels of reactive oxygen species, hyperactive antiapoptotic mRNA expression, reduced proapoptotic damaged DNA repair, so on. NPs extensively used early diagnosis functionalized target receptors overexpressing cells for effective treatment. This review focuses explicitly on how alone combined imaging techniques advanced treatment have been researched against 'women's cancer' such breast, ovarian, cervical which substantially occurring women. NPs, combination numerous (like PET, SPECT, MRI, etc) widely explored understanding tumor characteristics. Moreover, various magnetic hyperthermia, pH responsiveness, photothermal therapy, etc), stated be more targeted therapeutic strategies negligible side effects. Furthermore, this will further help improve outcomes patient quality life based application-based studies women's

Language: Английский

Citations

2
Enhancement of Cognitive Function by Andrographolide-Loaded Lactose β-Cyclodextrin Nanoparticles: Synthesis, Optimization, and Behavioural Assessment DOI Creative Commons

Debashish Paramanick,

Kagithala Naga Rani,

Vijay Kumar Singh

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(7), P. 966 - 966

Published: July 21, 2024

This study investigates whether Andrographolide-loaded Lactose β-Cyclodextrin (ALN-βCD) nanoparticles enhance cognitive function, particularly spatial learning and memory. The successful conjugation of lactose to β-cyclodextrin was confirmed via 1H NMR spectroscopy, facilitating neuronal cell entry. solvent evaporation method used create the nanoparticles, which were characterised for particle size, PDI, zeta potential, drug release. exhibited a size 247.9 ± 3.2 nm, PDI 0.5 0.02, potential 26.8 2.5 mV. FTIR TEM analyses, along with in vitro release BBB permeability studies, their stability efficacy. Behavioural tests, including Elevated Plus Maze, Y-Maze, Object Recognition, Locomotor Activity demonstrated significant improvements memory, motor coordination, exploration time nanoparticle-treated groups. group treated ALN-βCD at dose 100 mg/kg/p.o. showed superior performance compared receiving free andrographolides (AG). Biochemical assays indicated reduction acetylcholinesterase activity lipid peroxidation, suggesting increased acetylcholine levels reduced oxidative stress. Histopathological examination improved function without toxicity. results (p < 0.001) memory abilities experimental animals, highlighting as non-invasive treatment loss. These promising findings warrant further through clinical trials.

Language: Английский

Citations

1
A review of superparamagnetic nanoparticles applications and regulatory aspects in medicine and environmental areas DOI
Danilo Waismann Losito,

Nicole I. N. Souza,

Tereza S. Martins

et al.

Journal of Materials Science, Journal Year: 2024, Volume and Issue: 59(34), P. 16038 - 16068

Published: Sept. 1, 2024

Language: Английский

Citations

1
Exploring the Advanced Synthesis Strategies and Biomedical Applications of Iron Oxide-Based Nanozymes: A Comprehensive Review DOI

Tanawish,

Nazish Jahan,

Kousar Rasheed

et al.

Journal of Cluster Science, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 21, 2024

Language: Английский

Citations

1
Protein Conjugated Superparamagnetic Iron Oxide Nanoparticles for Efficient Vaccine Delivery Systems DOI
Aswan Al‐Abboodi, Salim Albukhaty, Ghassan M. Sulaiman

et al.

Plasmonics, Journal Year: 2023, Volume and Issue: 19(1), P. 379 - 388

Published: Aug. 17, 2023

Language: Английский

Citations

2
Synthesis of cotton-like FeCoNi-Nd(OH)3 nanoparticles via reactive mechanical milling: Investigating chemical properties for cellular signaling applications DOI Creative Commons
Yazmín Mariela Hernández-Rodríguez,

I. Torres-Sandoval,

O. Solorza‐Feria

et al.

Advanced Powder Technology, Journal Year: 2024, Volume and Issue: 35(11), P. 104651 - 104651

Published: Sept. 11, 2024

Language: Английский

Citations

0
Novel Therapeutic Applications of Nanoparticles and Bio-nanocomposites in Modern Biomedicine DOI
Sargol Aminnezhad, Tola Abdulsattar Faraj, Nabaz Hamarashid Hama

et al.

Nanostructure science and technology, Journal Year: 2024, Volume and Issue: unknown, P. 181 - 193

Published: Jan. 1, 2024

Language: Английский

Citations

0
Bacillus proteolyticus UPMC1508: A novel bacterial strain capable of biologically synthesize iron oxide nanoparticles DOI

Yusur Ramzi Hasan,

Fadzlie Wong Faizal Wong, Murni Halim

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Abstract Antibiotic resistance is a growing concern due to the overuse of antibiotics. Alternative treatments, such as nanoparticles, are being explored. Biological synthesis iron oxide nanoparticles (Fe3O4-NPs) via probiotics offers sustainable and cost-effective method over toxic chemical approaches, but there challenges regarding its heavy metal toxicity obtained nanoparticles. Thus, this research aims biologically synthesize Fe₃O₄-NPs new bacterial isolate evaluate toxicity. The objectives characterize novel with probiotic potential. Then, Fe3O4-NPs Transmission Electron Microscopy (TEM), Field Emission Scanning (FE-SEM), Powder Diffraction Techniques (XRD), Fourier Transform Infrared Spectroscopy (FT-IR), nanosizer. Finally, cytotoxicity potential MTT– (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays. A total 12 samples were collected from six different sites in Selangor, Malaysia. 16s rRNA sequencing came closest Bacillus proteolyticus UPMC1508 (99.87%). This strain has lower antibiotic high Fe-tolerance (MTC = 0.8 mg.mL− 1). It successfully synthesized Fe3O4-NPs, which exhibited absorption curves between 290–300 nm. TEM FE-SEM indicated spherical formed Fe3O4-NPs; average diameter was 5.12 ± 0.95 Meanwhile, XRD peaks revealed that grain size around 32.61 nanosizer hydrodynamic 104 nm good Polydispersity index (PDI) value (0.217). FT-IR satisfactory stability after 2 months. showed low at 0.031 1.The findings isolated B. Fe-heavy tolerance less resistance. Furthermore, it safety, making them suitable for therapeutic platforms, antibacterial anticancer. significance study lies offering an eco-friendly, low-cost approach while expanding applicability safe biomedical applications.

Language: Английский

Citations

0
Synthesis and characterization of superparamagnetic PEGylated zero valent iron gold (Fe0Au) nanoparticles DOI Creative Commons

María Ana Rivera Soto,

Geonel Rodríguez‐Gattorno, Marı́a Luisa López

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Iron-gold (Fe0-Au) nanoparticles are forefront agents in biomedicine because of their magnetic and plasmonic properties prime candidates for advanced biomedical applications such as hyperthermia, targeted drug delivery, bioimaging. Synthesizing biocompatible, stable iron phase, minimal borate-related cytotoxicity, Fe0-Au hybrid a great challenge, This study presents an optimized, two-step synthetic approach to produce PEGylated nanoparticles, employing NaBH4 reducing agent under strictly anaerobic conditions. UV-Vis spectroscopy confirmed nanoparticle formation, with absorbance peaks at 260 nm Fe0 526 Au, accompanied by discernible color shifts the colloidal suspension, indicative successful metal reduction. High Transmission electron microscopy (HRTEM) revealed uniform spherical morphology average diameter 50 nm, while X-ray photoelectron (XPS) demonstrated substantial minimization borate byproducts, these potentially cytotoxic residues 14 atomic percent. Magnetization assessments showed hysteresis-free superparamagnetic behavior saturation magnetization 75 Am²/kg NPs, validating suitability precision hyperthermia resonance imaging. These findings indicate that PEG functionalization enhances stability effectively mitigates toxicity risks, rendering highly viable preclinical translational applications.

Language: Английский

Citations

0