Use of injectable platelet rich fibrin (IPRF) as LDD vehicle containing doxycycline in periodontal Therapy – In vitro study DOI Open Access

Ashwin Jaikumar Ram,

Thamaraiselvan Murugan,

Jayakumar Nd

et al.

Journal of Population Therapeutics and Clinical Pharmacology, Journal Year: 2023, Volume and Issue: 30(12)

Published: Jan. 1, 2023

Purpose: Local drug delivery systems (LLD) are preferred over systemic antibiotic therapy in indicated cases to avoid unnecessary large doses of drug, development resistance etc.The search for the more suitable novel vehicle local that can render controlled release at periodontally infected sites widely researched.i-PRF being autologous and injectable could be a drugs.This study aims evaluate possibility using i-PRF as periodontal therapy.Methods: obtained from centrifugation 10 ml blood collected volunteers mixed with known concentration doxycycline allowed become gel.The loaded gel is dispensed artificial saliva degrade.At specific time intervals (1 hr, 3 5 7 3d, 5d, 7d, 9d, 14d) aliquot 200 microliter were each sample subjected spectrophotometric analysis. Results:The results show was detected all samples 1 hr 14th day.Final eluted seem gradually reducing th hour steep downward pattern absorbed rd day until day.Conclusions: The profile shows its potential LDD system therapy.Additionally, properties like syringeability, in-situ formation, fibrin nature may facilitate direct into pocket, getting moulded pocket shape attachment soft hard tissue thereby ensuring retention confined environment.

Language: Английский

A review on plant extract mediated green synthesis of zinc oxide nanoparticles and their biomedical applications DOI Creative Commons
Mouhaned Y. Al-darwesh, Sattar S. Ibrahim,

Mohammed A. Mohammed

et al.

Results in Chemistry, Journal Year: 2024, Volume and Issue: 7, P. 101368 - 101368

Published: Jan. 1, 2024

Zinc oxide nanoparticles (ZnO NPs) exhibit distinctive characteristics, making them highly sought-after in many sectors. Nevertheless, conventional techniques for producing ZnO-NPs are linked to environmental and health hazards due toxic substances. In this review, we study zinc synthesized from plant extracts their subsequent biomedical uses detail. Research shows that several different employed manufacturing ZnO nanoparticles. Leaves, fruits, seeds, roots, complete plants all included these extracts. Phytochemicals such as phenolic compounds, alkaloids, flavonoids, terpenoids a part of biological matrices. compounds show bioreduction mechanism, act stabilizing reducing agent. The attributes (NPs), including size, shape, crystallinity, may be altered by adjusting the extract variety, concentration, synthesis conditions. Consequently, formed display notable diversity physical chemical subsequently impacting functionality. manufactured using green methods extensive, beneficial effects antibacterial activity against various pathogens, anti-inflammatory possible anticancer activities. Nanoparticles have been integrated into wound dressings, used carriers medication delivery, utilized biosensing imaging applications. enhanced biocompatibility reduced toxicity green-processed techniques, comparison those made approaches, make very appealing use contexts. Moreover, paper examines mechanisms, explicitly focusing on involvement phytochemicals processes reduction stabilization. Additionally, emphasizes difficulties potential future directions optimizing processes, increasing capacity, facilitating therapeutic

Language: Английский

Citations

72
Formulation and evaluation of azithromycin-loaded silver nanoparticles for the treatment of infected wounds DOI Creative Commons
Mohammed S. Saddik,

Mostafa F. Al-Hakkani,

Ahmed M. Abu‐Dief

et al.

International Journal of Pharmaceutics X, Journal Year: 2024, Volume and Issue: 7, P. 100245 - 100245

Published: April 9, 2024

Infected wounds pose a significant challenge in healthcare, requiring innovative therapeutic strategies. Therefore, there is critical need for pharmaceutical materials to improve wound healing and combat bacterial growth. This study examined the efficacy of azithromycin-loaded silver nanoparticles (AZM-AgNPs) treating infected wounds. AgNPs synthesized using green method with Quinoa seed extract were loaded AZM. Characterization techniques, including X-ray Powder Diffraction (XRD), scanning electron microscope (SEM), transmission (TEM), Uv-Vis analysis utilized. The agar diffusion assay determination MIC used assess initial antibacterial impact formulations on both MRSA E. coli. In addition, antimicrobial, wound-healing effects histological changes following treatment AZM-AgNPs assessed an rat model. had size 24.9 ± 15.2 nm 34.7 9.7 AZM-AgNPs. Langmuir model accurately characterized adsorption AZM onto AgNP surface, indicating maximum loading capacity 162.73 mg/g. exhibited superior properties vivo vitro compared controls. Using technique, showed enhanced zones inhibition against coli MRSA, which was coupled decreased levels. studies that AZM-AgNP treated rats best outcome by improved process, lower counts epithelialization, control group. conclusion, can be successful azithromycin nanoparticles. suggest promising use as effective agent

Language: Английский

Citations

16
Valorization of non-edible fruit seeds into valuable products: A sustainable approach towards circular bioeconomy DOI
Harsh Kumar, Neetika Kimta,

Shivani Guleria

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 922, P. 171142 - 171142

Published: Feb. 20, 2024

Language: Английский

Citations

12
Facile biosynthesis of zinc oxide nanoparticles (ZnO NPs) using Lupinus albus L (Gibto) seed extract for antibacterial and photocatalytic applications DOI Creative Commons

Teshiwal Bizuayen Adamu,

Aklilu Melese Mengesha,

Mekuriaw Assefa Kebede

et al.

Results in Chemistry, Journal Year: 2024, Volume and Issue: 10, P. 101724 - 101724

Published: Aug. 1, 2024

Language: Английский

Citations

11
Biomaterials for inflammatory bowel disease: treatment, diagnosis and organoids DOI
Jia Wang, Yuying Shi,

Bei Mao

et al.

Applied Materials Today, Journal Year: 2024, Volume and Issue: 36, P. 102078 - 102078

Published: Jan. 20, 2024

Language: Английский

Citations

9
Preparation of a Herbal Mouthwash With Lemongrass and Mint-Mediated Zinc Oxide Nanoparticles and Evaluation of Its Antimicrobial and Cytotoxic Properties DOI Open Access

Rajeshkumar Shanmugam,

Sulochana Govindharaj,

Padmapriya Arunkumar

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 5, 2024

Introduction Nanotechnology holds considerable importance in biomedical and dental applications. Nanoparticles synthesized using green synthesis methods with herbal formulations offer various benefits to humans. Zinc oxide nanoparticles (ZnONPs), being semiconductors, exhibit potent antibacterial properties. Notably, treatments utilizing lemongrass mint ensure potentially lower toxicity qualities for oral infections. The goal of the study is prepare a mouthwash mediated by ZnONPs assess its cytotoxic potential efficacy. Materials A formulation was used ZnONPs, prepared nanoparticles. produced were tested their antimicrobial activity agar well diffusion technique against pathogens, ZnONPs-mediated evaluated effect brine shrimp lethality assay compared commercial mouthwash. Results green-synthesized initially confirmed UV-visible spectrophotometer exhibited maximum peak at 362 nm. which showed zone inhibition 22 mm Enterococcus faecalis 23 Candida albicans, as estimated technique. Additionally, ZnONPs-based demonstrated cytotoxicity than assay. Conclusion In current study, mint-mediated an effective E. antifungal C. albicans. Furthermore, This suggests that could be alternative synthetic

Language: Английский

Citations

7
Facile “Green” synthesis of a novel Co–W–B catalyst from Rheum ribes shell extract and its effect on sodium borohydride hydrolysis: Kinetic mechanism DOI
Arzu Ekinci,

Nasrettin Genli,

Ömer Şahi̇n

et al.

International Journal of Hydrogen Energy, Journal Year: 2023, Volume and Issue: 51, P. 796 - 808

Published: July 24, 2023

Language: Английский

Citations

14
Green synthesis, characterization, and antibacterial activity investigation of zinc oxide nanoparticles using Rumex Nervosus Vahl Leaf extract DOI Creative Commons

Tadesse Bizuayehu,

Bidir Kassaw,

Mihret Kendie

et al.

Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102046 - 102046

Published: Jan. 1, 2025

Language: Английский

Citations

0
Green Nanoparticles Synthesized from Damask Rose Petals: Evaluation of their Antioxidant, Antimicrobial, Anti-Diabetic, Anti-Alzheimer, and Photocatalytic Properties DOI Creative Commons

Zeinab Alizadeh,

Mohammad Fattahi,

Alireza Farokhzad

et al.

Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e42557 - e42557

Published: Feb. 1, 2025

Highlights•Green ZnO nanoparticles were synthesized using hydro-alcoholic extract of rose petals.•ZnO confirmed by FTIR, XRD, UV visible, SEM and EDX.•Synthesized Nano zinc oxide showed photocatalyst properties against methylene blue.•Nano anti-diabetic, anti-Alzheimer, antibacterial antioxidant effects.•Biological effects Green found to be superior those their synthetic counterparts.AbstractGreen synthesis, an approach that has gained widespread recognition in recent years due environmental health concerns, was employed synthesize green (G-ZnO NPs) a derived from dried damask petals. The X-ray diffractometer, UV-visible, Fourier transform infrared spectrometry. A morphological examination with field emission scanning electron microscope revealed the G-ZnO NPs had diameter ranging 44.66 83.74 nm purity 93.2%. Furthermore, antioxidant, photocatalytic, antimicrobial, anti-diabetic investigated compared two commercial different sizes (C-ZnO NPs1 (10-30 nm) C-ZnO NPs2 (50-60 nm)). demonstrated highest activity (46.49%). In terms photocatalytic blue, exhibited higher degradation rate (61%) than (53.65 25.63%). ability inhibit growth bacteria Escherichia coli Staphylococcus aureus displayed inhibition bacterial for both strains. Finally, inhibitory effect on α-glucosidase acetylcholinesterase enzymes examined, revealing significant inhibition. (600 μg/ml) stronger enzymes.Graphical abstract

Language: Английский

Citations

0
Green Synthesis of Ag-Cu NPs using Black Eggplant Extract as the Reducing and Stabilizing Agents: Characterization and Energy Band Gap DOI Open Access

Adyan Abdizadeh challoob,

Najwa J. Jubier

Journal of Physics Conference Series, Journal Year: 2025, Volume and Issue: 2974(1), P. 012032 - 012032

Published: March 1, 2025

Abstract The study successfully demonstrated an eco-friendly approach to synthesizing Ag, Cu nanoparticles, and Ag-Cu nanoparticle composites using Black eggplant extract as both a reducing stabilizing agent, with calcination at 400°C. research revealed distinct plasmonic properties through Surface Plasmon Resonance (SPR) bands observed specific wavelengths: 400 nm for 524 Cu, dual 406 (SPR1) 600 (SPR2) composites. energy gap values were identified 1.8eV, 2.5eV, 3.7eV. XRD analysis confirmed polycrystalline structure face-centered cubic (FCC) phase pattern, while FE-SEM EDX examinations homogeneous morphology nanoparticles being larger than Ag nanoparticles. composite exhibited similar size shape characteristics average of 46.5nm. These findings demonstrate the successful synthesis discrete stable nano-sized particles superior properties, suggesting potential applications in enhancing electron transfer efficiency metal surfaces various sensing detection applications.

Language: Английский

Citations

0