Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(1), P. 124 - 124
Published: Jan. 18, 2024
The
extraction
of
bioactive
compounds
pharmaceutical
interest
from
natural
sources
has
been
significantly
explored
in
recent
decades.
However,
the
techniques
used
were
not
very
efficient
terms
time
and
energy
consumption;
additionally,
solvents
for
harmful
environment.
To
improve
environmental
impact
extractions
at
same
increase
yields,
several
new
developed.
Among
most
ones
are
ultrasound-assisted
microwave-assisted
extraction.
These
increased
yield
selectivity
a
smaller
amount
with
decrease
consumption.
Nevertheless,
high
volume
organic
was
still
extraction,
causing
subsequent
problem.
Neoteric
appeared
as
green
alternatives
to
solvents.
neoteric
solvents,
deep
eutectic
evidenced
be
one
best
due
their
intrinsic
characteristics.
considered
because
they
made
up
such
sugars,
amino
acids,
carboxylic
acids
having
low
toxicity
degradability.
In
addition,
simple
prepare,
an
atomic
economy
100%,
attractive
physicochemical
properties.
Furthermore,
huge
number
that
can
synthesize
these
make
them
useful
since
tailored
selective
towards
specific
component
or
class
components.
main
aim
this
paper
is
give
comprehensive
review
which
describes
properties,
characteristics,
production
methods
well
its
application
extract
interest.
Additionally,
overview
more
sustainable
also
given.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(3), P. 355 - 355
Published: March 9, 2024
The
methods
and
solvents
employed
in
routine
extraction
protocols
essentially
impact
the
composition
of
resulting
extracts,
i.e.,
relative
abundances
individual
biologically
active
metabolites
quality
stability
isolates.
Natural
deep
eutectic
(NADESs)
represent
a
new
class
environmentally
friendly
solvents,
which
are
recognized
as
promising
extractants
alternative
to
conventional
organic
liquids.
However,
their
efficiencies
when
applied
different
workflows
still
poorly
characterized.
Therefore,
here,
we
compare
potential
three
for
natural
products
from
Aralia
elata
var.
mandshurica
with
selected
using
non-targeted
metabolomics
approach.
metabolite
profiling
relied
on
reversed-phase
ultra-high-performance
liquid
chromatography–high-resolution
mass
spectrometry
(RP-UHPLC-HR-MS).
roots
A.
were
extracted
by
maceration,
ultrasound-assisted
(UAE),
vibrocavitation-assisted
(VAE).
Principal
component
analysis
(PCA)
revealed
clear
separation
extracts
obtained
NADES1
(choline
chloride/malic
acid)
NADES2
(sorbitol/malic
acid/water).
Based
results
hierarchical
clustering
normalized
further
statistical
evaluation
t-test,
it
could
be
concluded
that
showed
superior
efficiency
all
addressed.
this
NADES
was
more
detail.
PCA
followed
t-test
yielded
only
3
efficiently
whereas
46
compounds
abundant
VAE.
When
VAE
UAE
compared,
108
appeared
VAE,
1
recovered
UAE.
These
facts
clearly
indicate
advantage
method
over
maceration
Seven
twenty-seven
tentatively
identified
tandem
(MS/MS)
found
first
time.
Additional
studies
necessary
understand
applicability
other
plant
materials.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(11), P. 2600 - 2600
Published: June 1, 2024
Saffron
(Crocus
sativus)
floral
by-products
are
a
source
of
phenolic
compounds
that
can
be
recovered
and
used
in
the
nutraceutical,
pharmaceutical,
or
cosmetic
industries.
This
study
aimed
to
evaluate
compounds’
extraction
using
green
techniques
(GETs)
saffron
explore
influence
selected
on
phytochemical
composition
extracts.
Specifically,
ultrasound-assisted
(UAE),
subcritical
water
(SWE),
deep
eutectic
solvents
(DESE)
were
used.
Phenolic
identified
with
(HR)
LC-ESI-QTOF
MS/MS
analysis,
quantitative
analysis
was
performed
HPLC-PDA.
Concerning
techniques,
UAE
showed
highest
amount
for
both
anthocyanins
flavonoids
50:50%
v/v
ethanol/water
as
solvent
(93.43
±
4.67
mg/g
dry
plant,
dp).
Among
SWE,
96%
ethanol
t
=
125
°C
gave
best
results.
The
16
different
mixtures
DESE
(110.95
5.55–73.25
3.66
dp),
while
better
extracted
choline
chloride:butane-1,4-diol
(16.0
0.80
Consequently,
GETs
employed
extract
bioactive
from
by-products,
implementing
recycling
reduction
waste
fitting
into
broader
circular
economy
discussion.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(12), P. e33066 - e33066
Published: June 1, 2024
An
efficient
and
environmentally
friendly
extraction
method
utilizing
an
ultrasonic-assisted
natural
deep
eutectic
solvent
(UAE-NADES)
was
developed
for
the
of
anthocyanins
from
