Management of Fatigue in Adult Survivors of Cancer: ASCO–Society for Integrative Oncology Guideline Update

Journal of Clinical Oncology, Journal Year: 2024, Volume and Issue: 42(20), P. 2456 - 2487

Published: May 16, 2024

ASCO–Society for Integrative Oncology (SIO) Guidelines provide recommendations with comprehensive review and analyses of the relevant literature each recommendation, following guideline development process as outlined in ASCO Methodology Manual . ASCO-SIO follow Conflict Interest Policy Clinical Practice other guidance (“Guidance”) provided by SIO is not a or definitive guide to treatment options. It intended voluntary use providers should be used conjunction independent professional judgment. Guidance may applicable all patients, interventions, diseases stages diseases. based on analysis literature, statement standard care. do endorse third-party drugs, devices, services, therapies assumes no responsibility any harm arising from related this information. See complete disclaimer Appendix 1 2 (online only) more. PURPOSE To update management cancer-related fatigue (CRF) adult survivors cancer. METHODS A multidisciplinary panel medical oncology, geriatric internal medicine, psychology, psychiatry, exercise integrative behavioral nursing, advocacy experts was convened. Guideline involved systematic randomized controlled trials (RCTs) published 2013-2023. RESULTS The evidence base consisted 113 RCTs. Exercise, cognitive therapy (CBT), mindfulness-based programs led improvements CRF both during after completion cancer treatment. Tai chi, qigong, American ginseng showed benefits treatment, whereas yoga, acupressure, moxibustion helped manage Use dietary supplements did improve In patients at end life, CBT corticosteroids benefits. Certainty quality were low moderate interventions. RECOMMENDATIONS Clinicians recommend exercise, CBT, programs, tai chi qigong reduce severity Psychoeducation recommended adults undergoing For clinicians programs; particular, have shown efficacy managing severe Yoga, also recommended. Patients life offered corticosteroids. L-carnitine, antidepressants, wakefulness agents, routinely psychostimulants symptoms CRF. There insufficient make against psychosocial, integrative, pharmacological interventions fatigue. Additional information available www.asco.org/survivorship-guidelines

Language: Английский

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Integrative Therapies in Cancer Care: An Update on the Guidelines

American Society of Clinical Oncology Educational Book, Journal Year: 2024, Volume and Issue: 44(3)

Published: May 31, 2024

INTRODUCTION ASCO and the Society for Integrative Oncology have collaborated to develop guidelines application of integrative approaches in management anxiety, depression, fatigue use cannabinoids cannabis patients with cancer. These provide evidence-based recommendations improve outcomes quality life by enhancing conventional cancer treatment modalities. METHODS All studies that informed guideline were reviewed an Expert Panel which was made up a patient advocate, methodologist, oncology providers, medicine experts. members each trial evidence, determined grade assessment label, concluded strength recommendations. RESULTS Strong during given both in-person or web-based mindfulness-based stress reduction, cognitive therapy, tai chi qigong. after programs. Clinicians should recommend against using as cancer-directed unless within context clinical trial. The recommended modalities managing anxiety included Mindfulness-Based Interventions (MBIs), yoga, hypnosis, relaxation therapies, music reflexology, acupuncture, chi, lavender essential oils. strongest recommendation is MBIs be offered people cancer, active post-treatment, address depression. CONCLUSION evidence interventions care growing, research now supporting benefits across continuum.

Language: Английский

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Integration of ion-mobility high-resolution liquid chromatography/mass spectrometry-based untargeted metabolomics and desorption electrospray ionization-mass spectrometry imaging to unveil the ginsenosides variation induced by steaming for Panax ginseng, P. quinquefolius and P. notoginseng

Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(6), P. 105781 - 105781

Published: April 7, 2024

The raw and steamed products of ginseng exhibit different efficacy, elucidation the underlying chemical transformation is significant for their rational application quality control. This work was designed to holistically depict variation Panax (PG), P. quinquefolius (PQ), notoginseng (PN) induced by steaming, unveil steaming-associated markers diagnostic differentiating between processed products, following a three-step strategy: 1) systematic ginsenosides characterization hybrid scan (namely HDDIDDA) available on Vion™ ion mobility-quadrupole time-of-flight mass spectrometer coupled with reversed-phase ultra-high performance liquid chromatography; 2) holistic depiction discovery potential pattern recognition untargeted metabolomics analysis; 3) construction steaming-induced network combined desorption electrospray ionization-mass spectrometry imaging (DESI-MSI). Consequently, 542 were characterized from PG/PQ/PN. Steaming at 1–10 h could cause variation, separately 26, 28, 18 found steaming PG, PQ, PN. Steaming-induced mainly involved hydration malonyl group, hydrolysis glycosyl moiety, dehydration C-20. DESI-MSI further revealed spatial distribution marker saponins in cork layer, phloem, xylem, primarily confirmed reactions occurring steaming. Conclusively, established strategy practical processing, which useful control both herbal medicines foods.

Language: Английский

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Computational Assessment of the Phytochemicals of Panax ginseng C.A. Meyer Against Dopamine Receptor D1 for Early Huntington’s Disease Prophylactics

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 82(4), P. 3413 - 3423

Published: July 24, 2024

Language: Английский

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Indigenous Knowledge and Phytochemistry: Deciphering the Healing Power of Herbal Medicine

Reference series in phytochemistry, Journal Year: 2024, Volume and Issue: unknown, P. 1953 - 2005

Published: Jan. 1, 2024

Language: Английский

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Examining the Alterations in Metabolite Constituents and Antioxidant Properties in Mountain-Cultivated Ginseng (Panax ginseng C.A. Meyer) Organs during a Two-Month Maturation Period

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 612 - 612

Published: May 17, 2024

The current research was the first to prove existence of fluctuations in metabolite constituents and antioxidant properties different organs (leaves, stems, roots) mountain-cultivated ginseng (MCG) plant during a two-month maturation period. Four metabolites, including fatty acids, amino ginsenosides, phenolic phytochemicals, exhibited considerable differences times with following order: leaves > stems roots. predominant contents were found leaves, acid (1057.9 mg/100 g) on 31 May, (1989.2 13 July, ginsenosides (88.7 mg/g) phytochemical (638.3 μg/g) May. Interestingly, ginsenoside content highest, 84.8 → 88.7 82.2 78.3 mg/g. Specifically, Re, Rd, F2 showed abundant ranging from 19.1 16.9 mg/g, 8.5 14.8 9.5 13.1 respectively. Phenolic phytochemicals remarkable compared periods, highest total flavonoid recorded at 9.48 GAE 1.30 RE mg/g capacities radical, FRAP, DNA protection differed significantly, May exhibiting values: 88.4% (DPPH), 89.5% (ABTS), 0.84 OD593 nm (FRAP) 500 μg/mL, 100% 50 μg/mL. Furthermore, principal cluster analysis revealed variability as follows: (83.3%) (71.8%) (61.1%) (58.8%). A clustering heatmap highlighted significant changes components under for each organ. Our findings suggest that MCG may be potential source developing nutraceuticals, offering highly beneficial strong antioxidants.

Language: Английский

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Ginsenosides 20R-Rg3 and Rg5 enriched black ginseng inhibits colorectal cancer tumor growth by activating the Akt/Bax/caspase-3 pathway and modulating gut microbiota in mice

Current Research in Food Science, Journal Year: 2025, Volume and Issue: 10, P. 100978 - 100978

Published: Jan. 1, 2025

Language: Английский

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Gintonin-Enriched Panax ginseng Extract Induces Apoptosis in Human Melanoma Cells by Causing Cell Cycle Arrest and Activating Caspases

Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 381 - 381

Published: Jan. 24, 2025

Gintonin, a non-saponin glycolipoprotein from Panax ginseng, acts as lysophosphatidic acid ligand. However, its anticancer effects, especially in melanoma, remain unclear. This study investigated the anti-proliferative effects and intracellular signaling mechanisms of gintonin-enriched fraction (GEF) ginseng human melanoma cell lines. In vitro, GEF treatment significantly inhibited proliferation, reduced clonogenic potential, delayed wound healing cells. Flow cytometry terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) staining showed that induced apoptosis, evidenced by increased apoptotic populations nuclear changes. also caused cycle arrest G1 phase for A375 cells G2/M A2058 It triggered via activation caspase-3, -9, poly (ADP-ribose) polymerase cleavage, downregulation B lymphoma-2 (Bcl-2). raised reactive oxygen species (ROS) levels mitochondrial stress, which were mitigated N-acetyl cysteine (NAC), an ROS inhibitor. vivo, suppressed tumor growth A375- A2058-xenografted mice without toxicity. These findings suggest has potential antitumor inducing apoptosis arrest, presenting promising therapeutic avenue.

Language: Английский

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Effects of different types of ginseng on intercellular wireless communication networks and central carbon metabolism pathways

Journal of Future Foods, Journal Year: 2025, Volume and Issue: 5(6), P. 572 - 581

Published: Jan. 29, 2025

Language: Английский

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Tetraploidization Altered Phenotypic Traits and Metabolite Profile of Java Ginseng (Talinum paniculatum (Jacq.) Gaertn.)

Plants, Journal Year: 2025, Volume and Issue: 14(3), P. 480 - 480

Published: Feb. 6, 2025

Polyploidization is a beneficial technique for enhancing the biomass of and secondary metabolite concentrations in plants. Java ginseng (Talinum paniculatum (Jacq.) Gaertn.) can be used as an alternative source nutrition has both ornamental medicinal value. To improve content ingredients, this study established vitro system that was to induce polyploidy java ginseng. Tetraploids were successfully produced by exposing axillary buds colchicine. The most favorable medium inducing Murashige Skoog devoid hormonal substances, while immersing stem segments solution 1-3 mg/mL colchicine 48 h could achieve tetraploidy induction with maximum rate 18.03%. distinguished from diploids flow cytometry, tetraploids exhibiting darker thicker leaves, bigger fruit pollen, larger stomata but lower stomatal density, aboveground yield reduced significantly compared diploids. Tetraploidization also altered profile, 22 being increased (p < 0.05) 74 decreased leaves tetraploids. autotetraploid provide novel insights into artificial polyploid breeding utilized germplasm generate new polyploids.

Language: Английский

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