BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)
Published: March 13, 2025
Language: Английский
Nano Select, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 30, 2025
ABSTRACT The applications of nanoparticles (NPs) have shown tremendous growth during the last decade in field biomedicine. Although chemical and physical methods dominate large‐scale NP synthesis, such are also known for their adverse impact on environment health. In contrast, use biological systems provides a sustainable alternative producing functional NPs by biomineralization process. transformative power artificial intelligence (AI) has been proven prudent diagnosis, drug development, therapy, clinical decision‐making. AI can be utilized tailored design, scale‐up biomedical applications. present review an overview process its advantages over other eco‐friendly synthesis opportunities. Specific emphasis is provided application cancer therapy how biologically compatible improve management. Finally, to best our knowledge, potential integrating comprehensively analyzed first time. Additionally, help surpass conventionally synthesized toxicity toxicology material science provided.
Language: Английский
Citations
4
Chemistry - An Asian Journal, Journal Year: 2024, Volume and Issue: 19(21)
Published: Aug. 10, 2024
Abstract This review portrays a comparison between green protocols and conventional nanoparticle (NP) synthesis strategies, highlighting each method's advantages limitations. Various top‐down bottom‐up methods in NP are described detail. The chemistry principles emphasized for designing safe processes nanomaterial synthesis. Among the biogenic sources plant extracts, vitamins, enzymes, polysaccharides, fungi (Molds mushrooms), bacteria, yeast, algae, lichens discussed. Limitations reproducibility of terms availability raw material, variation synthetic protocol, selection material due to geographical differences elaborated. Finally, conclusion is drawn utilizing chemical principles, & circular economy strategy minimize waste generation, offering promising framework NPs emphasizing sustainability.
Language: Английский
Citations
15
Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: 12(5), P. 114022 - 114022
Published: Sept. 3, 2024
Environmental degradation is a growing concern, driving researchers to explore eco-friendly nanoparticle (NP) synthesis, for diverse applications. Within this context, the employment of olive oil waste (OOW) as green source synthesis NPs has emerged viable alternative conventional techniques. The industry significant impact in Mediterranean region, and alongside it, comes OOW, where most it cannot be left untreated. In present review, comprehensive overview NPs' derived from OOW its potential applications both environmental health areas have been assessed, outlining major challenges outcomes future research. Both principles methods were also explored, focusing on unique properties an effective agent reduction stabilization, well characterization techniques used characterizing synthesized NPs. OOW-derived can wide variety including water purification, pollutant degradation, remediation contaminated environments. field, include drug delivery systems, antimicrobial activity cancer therapy. These successfully efficient vehicles cells, enhancing treatment potentially minimizing side effects. However, imperative point out importance performing in-depth toxicity assessments, particularly at higher concentrations
Language: Английский
Citations
14
Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)
Published: March 14, 2024
Language: Английский
Citations
13
Biotechnology and Bioengineering, Journal Year: 2024, Volume and Issue: 121(7), P. 2050 - 2056
Published: April 25, 2024
Abstract Arsenic with the scientific name AS is an element that exists everywhere. It fourth among abundant elements in water, twelfth human body, and twentieth earth's crust. This sulfide, carbonate, elemental forms. Different names of arsenic are known as white (As 2 O 3 ), yellow S red 4 ). Nowadays, due to its unique properties, has received much attention from researchers for use synthesis nanoparticles. According various studies, nanoparticles synthesized by methods, including biological, physical, chemical, it been shown synthetic method used very important because a significant effect on their shape, size, biological function. have attracted particle potential well anticancer, antitumor, cytotoxic, antimicrobial applications. Therefore, aim this study investigate biosynthesized different chemical methods biomedical
Language: Английский
Citations
10
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 949, P. 174940 - 174940
Published: July 22, 2024
Language: Английский
Citations
10
Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)
Published: Jan. 16, 2025
Abstract Phytonanoparticles have emerged as a promising class of biomaterials for enhancing bone regeneration and osseointegration, offering unique advantages in biocompatibility, multifunctionality, sustainability. This comprehensive review explores the synthesis, characterization, applications phytonanoparticles tissue engineering. The green synthesis approach, utilizing plant extracts reducing stabilizing agents, yields nanoparticles with intrinsic bioactive properties that can synergistically promote osteogenesis. We examine mechanisms by which phytonanoparticles, particularly those derived from gold, silver, zinc oxide, influence key molecular pathways osteogenesis, including RUNX2 Osterix signaling. discusses advanced strategies phyto-nanoparticle design, such surface functionalization stimuli-responsive release mechanisms, enhance their efficacy applications. Preclinical studies demonstrating improved osteoblast proliferation, differentiation, mineralization are critically analyzed, along emerging clinical data. Despite results, scalability, standardization, regulatory approval challenges persist. also addresses economic environmental implications production. Looking ahead, we identify research directions, developing personalized therapies, combination approaches stem cells or gene delivery, long-term safety assessments. By harnessing power plant-derived nanomaterials, represent an innovative approach to addressing complex regeneration, potential spanning dental, orthopedic, maxillofacial surgery. Graphical abstract
Language: Английский
Citations
1
Published: Jan. 1, 2025
Language: Английский
Citations
1
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1999 - 2019
Published: Feb. 1, 2025
Hyperphosphorylation and aggregation of the microtubule-associated tau protein, which plays a critical role in many neurodegenerative diseases (ie, tauopathies) including Alzheimer's disease (AD), are known to be regulated by variety environmental factors temperature. In this study we evaluated effects FDA-approved poly (D,L-lactide-co-glycolic) acid (PLGA) nanoparticles, can inhibit amyloid-β aggregation/toxicity cellular/animal models AD, on temperature-dependent 0N4R isoforms vitro. We have used biophysical (Thioflavin T kinetics, dynamic light scattering asymmetric-flow field-flow fractionation), structural (fluorescence imaging transmission electron microscopy) biochemical (Filter-trap assay detection soluble protein) approaches, evaluate native PLGA nanoparticles aggregation. Our results show that propensity increases significantly dose-dependent manner with rise temperature from 27°C 40°C, as measured lag time rate. Additionally, 2N4R manner. Native inhibits at all temperatures concentration-dependent manner, possibly interacting aggregation-prone hydrophobic hexapeptide motifs tau. is able trigger disassembly preformed aggregates function 40°C. These results, taken together, suggest not only attenuate but also promote aggregates, increased Given evidence influence pathology, believe may unique potential regulate abnormalities associated AD-related pathology.
Language: Английский
Citations
1
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: July 29, 2024
Abstract Cerium oxide nanoparticles possess unique properties that make them promising candidates in various fields, including cancer treatment. Among the proposed synthesis methods for CNPs, biosynthesis using natural extracts, offers an eco-friendly and convenient approach producing particularly biomedical applications. In this study, a novel method of aqueous extract Eucalyptus camaldulensis leaves was used to synthesize CNPs. Scanning electron microscopy Transmission (TEM) techniques revealed synthesized CNPs exhibit flower-like morphology. The particle size obtained Powder X-ray diffraction peaks TEM as 13.43 39.25 nm. Energy-dispersive spectroscopy Fourier transform infrared confirmed effect biomolecules during process formation cytotoxicity biosynthesized samples evaluated MTT demonstrating potential these inhibit MCF-7 cancerous cells. viability cell line conducted by live/dead imaging assay indicated their Furthermore, successful uptake cells, demonstrated confocal microscopy, provides evidence intracellular pathway contributes anticancer activity general, results indicate significant against line, attributed high surface area.
Language: Английский
Citations
7